LOCUS AY236073 6138 bp DNA linear BCT 26-JUL-2016 DEFINITION Klebsiella pneumoniae strain 11978 insertion sequence IS1999, complete sequence. ACCESSION AY236073 VERSION AY236073.2 KEYWORDS . SOURCE Klebsiella pneumoniae ORGANISM Klebsiella pneumoniae Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella; Klebsiella pneumoniae complex. REFERENCE 1 (bases 1 to 6138) AUTHORS Naas,T., Poirel,L., Karim,A. and Nordmann,P. TITLE Molecular characterization of In50, a class 1 integron encoding the gene for the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa JOURNAL FEMS Microbiol. Lett. 176 (2), 411-419 (1999) PUBMED 10427724 REFERENCE 2 (bases 1 to 6138) AUTHORS Poirel,L., Heritier,C., Tolun,V. and Nordmann,P. TITLE Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae JOURNAL Antimicrob. Agents Chemother. 48 (1), 15-22 (2004) PUBMED 14693513 REFERENCE 3 (bases 1 to 6138) AUTHORS Aubert,D., Naas,T., Heritier,C., Poirel,L. and Nordmann,P. TITLE Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of beta-lactam resistance genes JOURNAL J. Bacteriol. 188 (18), 6506-6514 (2006) PUBMED 16952941 REFERENCE 4 (bases 1 to 6138) AUTHORS Poirel,L., Heritier,C., Tolun,V. and Nordmann,P. TITLE Direct Submission JOURNAL Submitted (13-FEB-2003) Service de Bacteriologie-Virologie, Hopital de Bicetre, 78, rue du General Leclerc, Le Kremlin Bicetre 94275, France REFERENCE 5 (bases 1 to 6138) AUTHORS Aubert,D., Naas,T., Heritier,C., Poirel,L. and Nordmann,P. TITLE Direct Submission JOURNAL Submitted (09-JUN-2004) Service de Bacteriologie-Virologie, Hopital de Bicetre, 78, rue du general Leclerc, Le Kremlin-Bicetre 94 275, France REMARK Nucleotide sequence updated by submitter COMMENT On Jul 6, 2005 this sequence version replaced AY236073.1. FEATURES Location/Qualifiers source 1..6138 /organism="Klebsiella pneumoniae" /mol_type="genomic DNA" /strain="11978" /db_xref="taxon:573" mobile_element 1..6138 /mobile_element_type="insertion sequence:IS1999" gene complement(<1..290) /gene="pemK" CDS complement(<1..290) /gene="pemK" /note="plasmid stable inheritance protein; similar to IncL/M plasmid R446b PemK in GenBank Accession Number AF027767" /codon_start=1 /transl_table=11 /product="PemK" /protein_id="AAZ03778.1" /translation="MRRRLVRRKSDMERGEIWLVSLDPTAGHEQQGTRPVLIVTPAAF NRVTRLPVVVPVTSGGNFARTAGFAVSLDGAGIRTTGVVRCDQPRTIDMKARG" gene complement(259..552) /gene="pemI" CDS complement(259..552) /gene="pemI" /note="plasmid stable inheritance protein; similar to IncL/M plasmid R446b PemI in GenBank Accession Number AF027767" /codon_start=1 /transl_table=11 /product="PemI" /protein_id="AAZ03779.1" /translation="MLYLNITFMEVKMHTTRLKKVGGSVMLTVPPALLNALSLGTDNE VGMVIDNGRLIVEPHRRPQYSLAELLAQCDPNAEISAEEREWLDAPAAGQEEI" gene complement(607..833) /gene="tir" /note="similar to Tir of plasmid R100; responsible for inhibition of RP4 transfer; disrupted at 3' end" repeat_region 825..833 /note="target site duplication" repeat_region 834..854 /note="right repeat" /rpt_type=inverted gene complement(847..2055) /gene="tnpA" CDS complement(847..2055) /gene="tnpA" /note="TnpA" /codon_start=1 /transl_table=11 /product="transposase" /protein_id="AAP70011.2" /translation="MREANILQHSLHQYCPELHLKRLNSLMLASKALIECKTLTLTEL GRNLPTTARTKHNIKRIDRLLGNTHLHQERLAVYQWHASLICSGNPMPIVLVDWSDIR EHKRIMALRASIAFNGRSITLYEKSYPLSEQCSKASHNGFLADLAKILPLHVTPLIVT DAGFKVPWYKEVEAHGWFWLSRIRGTVQFADIGAENWRAVRSTHDLANGQAKSLGCKT LTKTNPINCHLTLYRSKPKGRTNQRSTRTNCHHPSAKTYSTSAKEPWVLASNLPPESR SPKQLVNLYAKRMQIEETFRDLKSPAYGFGLRQSRTNSPERFDIILLIALMVQCLLWL VGLHAQQQGWDKHFQANTIGHRTVLSTIRLGLEVLRRPDYQITEKELLAAWVLFANQL LKYGYAMADL" regulatory 2012..2017 /regulatory_class="minus_35_signal" /note="Pout" regulatory 2035..2040 /regulatory_class="minus_10_signal" /note="Pout" regulatory complement(2088..2093) /regulatory_class="minus_10_signal" /note="Pin" regulatory complement(2111..2116) /regulatory_class="minus_35_signal" /note="Pin" repeat_region 2141..2161 /note="left repeat" /rpt_type=inverted repeat_region 2162..2170 /note="target site duplication" gene 2188..2985 /gene="bla OXA-48" CDS 2188..2985 /gene="bla OXA-48" /note="class D carbapenem-hydrolyzing beta-lactamase" /codon_start=1 /transl_table=11 /product="OXA-48" /protein_id="AAP70012.1" /translation="MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVV VLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDI ATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDG GIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPK IGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP" gene complement(3288..4202) /gene="lysR" CDS complement(3288..4202) /gene="lysR" /note="transcriptional regulator; LysR family" /codon_start=1 /transl_table=11 /product="LysR-like protein" /protein_id="AAP70013.2" /translation="MPDLNGMMLFAAVVRAKGFSQAARETGHPKSTISRKIAQLEEQL GVRLLQRDTRNLSLTQVGALFYQHCDSIRNEVEAAKAVIESTHDDVSGSLRIAIPVSF SQELIANLCSGFMRLYPNVELDVQFTDNDIGLVGEGYDIAIKYGPLQSSDLVARLLFE RQPILVASPGYLKARGTPATPKELSDHSGILLGTSRSAPIWPLGKGARKTMVNFQRKV RVNSPIMVKQLALDDFGIAMLSNSACKTELANGQLVPILQEWPIEPFKVYGVYSSRRQ LATNISAFLDFFVKRFSSQESLQSLMLG" gene 4325..4398 /gene="acetyl-CoA carboxylase multifunctional enzyme" /note="similar to Shewanella oneidensis MR-1 protein in GenBank Accession Number AE015528; disrupted at 3' end" repeat_region 4390..4398 /gene="acetyl-CoA carboxylase multifunctional enzyme" /note="target site duplication" repeat_region 4399..4419 /note="left repeat" /rpt_type=inverted regulatory 4444..4449 /regulatory_class="minus_35_signal" /note="Pin" regulatory 4467..4472 /regulatory_class="minus_10_signal" /note="Pin" gene 4505..5713 /gene="tnpA" CDS 4505..5713 /gene="tnpA" /note="TnpA" /codon_start=1 /transl_table=11 /product="transposase" /protein_id="AAZ03780.1" /translation="MREANILQHSLHQYCPELHLKRLNSLMLASKALIECKTLTLTEL GRNLPTTARTKHNIKRIDRLLGNTHLHQERLAVYQWHASLICSGNPMPIVLVDWSDIR EHKRIMALRASIAFNGRSITLYEKSYPLSEQCSKASHNGFLADLAKILPLHVTPLIVT DAGFKVPWYKEVEAHGWFWLSRIRGTVQFADIGAENWRAVRSTHDLANGQAKSLGCKT LTKTNPINCHLTLYRSKPKGRTNQRSTRTNCHHPSAKTYSTSAKEPWVLASNLPPESR SPKQLVNLYAKRMQIEETFRDLKSPAYGFGLRQSRTNSPERFDIILLIALMVQCLLWL VGLHAQQQGWDKHFQANTIGHRTVLSTIRLGLEVLRRPDYQITEKELLAAWVLFANQL LKYGYAMADL" regulatory complement(4520..4525) /regulatory_class="minus_10_signal" /note="Pout" regulatory complement(4543..4548) /regulatory_class="minus_35_signal" /note="Pout" repeat_region 5706..5726 /note="right repeat" /rpt_type=inverted gene complement(5727..>6138) /gene="tir" /note="similar to Tir of plasmid R100; responsible for inhibition of RP4 transfer; disrupted at 3' end" repeat_region 5727..5735 /note="target site duplication" BASE COUNT 1631 a 1486 c 1476 g 1545 t ORIGIN 1 ccgcgggctt tcatatcgat cgtccggggt tgatcgcaac gcacaacgcc ggtggtacgt 61 atgccggcgc cgtcaagcga cacagcaaag cctgctgtgc gggcaaaatt gcctccgctg 121 gtcacgggca caacaacagg caggcgggtc acgcggttaa aagcagccgg cgtgacaatc 181 agtaccggcc gcgttccctg ctgctcatga cctgcggtag ggtcaagcga gacaagccag 241 atttcccctc tttccatgtc agatttcctc ctgaccagcc gccggcgcat ccagccattc 301 acgttcttct gccgagattt cagcgttcgg atcgcactgt gccaacagct cagccagtga 361 atactgcggg cgtctgtgcg gctccacaat cagccggcca ttatcaatga ccatgccaac 421 ttcattatct gtacccagcg acagcgcatt cagcagtgcc ggtgggacgg tcagcatgac 481 tgagccgcca accttcttca gtcgagtggt atgcattttc acctccataa aagttatatt 541 taaatataac attcacaaaa aaacatacca gcctttaacg cacaatattt aataaaaata 601 taactttcag cccaacagta aacccagcgc ggtagcttcc atatgcagca ataccggcag 661 cagcaggccg ccacttctga tccgggcagc tgatgtaatc agccccacca ggaacatttc 721 tgccagggtc agcaggttct gatactgcat atgcacggcg gcaaacagca aagacgttat 781 cagcgcgccc agccacatcg tccagttgta cctcgaacgg aagacgttca gcactgaagg 841 atcccctcat aaatcagcca tagcatagcc atatttgagc aactgattgg cgaataatac 901 ccaggccgcc agcaattctt tctccgtgat ttgataatca ggccgcctga gtacctccaa 961 tcccaagcga atcgttgaga gtaccgttcg atgcccaatg gtattggcct gaaaatgctt 1021 atcccagccc tgttgctgtg cgtgtaaacc aactagccac aacaggcatt gaaccatcaa 1081 cgctatcagt aggatgatgt cgaatcgctc tggactgttg gtacgacttt ggcgtaagcc 1141 aaagccgtat gccgggcttt tgaggtcacg aaaggtttcc tctatttgca tacgtttggc 1201 gtacaggttt accagctgct ttgggctccg agattctggt ggtaaattgc tggctaacac 1261 ccaaggctct ttcgccgatg ttgagtacgt ttttgccgat ggatggtggc aattagtcct 1321 cgttgaacgc tgatttgtac gccccttagg tttgctacga taaagcgtga gatggcaatt 1381 gatagggtta gttttggtca aagtcttaca acccaggctc ttcgcttgac cgttggccaa 1441 gtcatgtgta cttcgaactg cacgccaatt ttcagcgcca atatctgcaa attgaactgt 1501 accgcgaata cggcttagcc aaaaccaacc atgcgcctca acctctttgt accaaggcac 1561 tttgaacccc gcgtcagtca cgatgagagg ggtaacatgc aaaggtaaaa tcttggctaa 1621 gtccgctaaa aaaccgttgt gggaggcctt agagcattgt tctgataggg gataggactt 1681 ctcatacagg gtaatagagc ggccattgaa ggctattgag gcgcgcagag ccatgatgcg 1741 tttatgctct cggatgtctg accaatcgac gagcacaatc ggcatagggt taccagaaca 1801 gatgaggctg gcatgccatt ggtagacagc taaccgttct tgatgcagat gcgtgttgcc 1861 gagcaaacga tcaatgcgct tgatgttgtg cttggttcgg gccgtggttg gtaaatttcg 1921 acctaactca gtcaaggtca gtgtcttaca ttcaatcagc gccttagagg ccagcatcaa 1981 gctgtttaat cgttttaggt gaagttctgg gcagtattgg tgtaaagaat gttgtaggat 2041 attggcttcg cgcatcttgt tgtccaagtg tagtttttag cgaaaccatt tgatcatgca 2101 acaagatgcg cttccaccct aatttgatga tttatttgta aatcatcagg ggattcttca 2161 gtatattgca ttaagcaagg ggacgttatg cgtgtattag ccttatcggc tgtgtttttg 2221 gtggcatcga ttatcggaat gcctgcggta gcaaaggaat ggcaagaaaa caaaagttgg 2281 aatgctcact ttactgaaca taaatcacag ggcgtagttg tgctctggaa tgagaataag 2341 cagcaaggat ttaccaataa tcttaaacgg gcgaaccaag catttttacc cgcatctacc 2401 tttaaaattc ccaatagctt gatcgccctc gatttgggcg tggttaagga tgaacaccaa 2461 gtctttaagt gggatggaca gacgcgcgat atcgccactt ggaatcgcga tcataatcta 2521 atcaccgcga tgaaatattc agttgtgcct gtttatcaag aatttgcccg ccaaattggc 2581 gaggcacgta tgagcaagat gctacatgct ttcgattatg gtaatgagga catttcgggc 2641 aatgtagaca gtttctggct cgacggtggt attcgaattt cggccacgga gcaaatcagc 2701 tttttaagaa agctgtatca caataagtta cacgtatcgg agcgcagcca gcgtattgtc 2761 aaacaagcca tgctgaccga agccaatggt gactatatta ttcgggctaa aactggatac 2821 tcgactagaa tcgaacctaa gattggctgg tgggtcggtt gggttgaact tgatgataat 2881 gtgtggtttt ttgcgatgaa tatggatatg cccacatcgg atggtttagg gctgcgccaa 2941 gccatcacaa aagaagtgct caaacaggaa aaaattattc cctagaagtg gttagcgcgt 3001 atttgtgtga aatagccgtc atataagctg taaagatata tggacaaaat gctgatgctc 3061 gatgcgcttg tagttaatgg ctcatactta atcggttagg cctaatcgac ttaagctccg 3121 cgcgttaact ttttagcctg agcattagca tcacattcct caacgtaaaa agcctagcca 3181 atttgctagg cttttttgtt atctaaatgg tcatggtcac tcaacattgg gatgtgtata 3241 aaggaatggc gatgtcagta aaggtgaatg ccgctgcgat aaagtgccta gcccaacatc 3301 aaggattgta ggctttcttg gctgctaaag cgtttgacga aaaagtccaa gaaggcgctg 3361 atattggtgg ctaattgtct gcggctcgaa tacaccccgt agaccttaaa gggttcaatc 3421 ggccattcct gtaagattgg cactagctgg ccgttggcga gttcggtttt gcaggcggag 3481 tttgatagca ttgcaatccc aaagtcatcg agggctaact gcttaaccat aatcgggcta 3541 ttgaccctga ctttacgctg aaagtttacc atggttttgc gagcaccttt gcctaagggc 3601 catatgggtg ctgagcggga tgttcctagc agaataccac tatgatcgct cagctcctta 3661 ggtgttgcgg gggtgccgcg tgcttttaaa tagccagggc ttgctaccag aattggttga 3721 cgctcgaaca gtaatcttgc aacaagatca gaggattgca gtggcccata tttgatagct 3781 atgtcatatc cttcacccac caaacctata tcgttgtcgg taaactggac atctaattcc 3841 acattgggat ataaacgcat gaatccgcta cagaggttag caattaattc ttggctaaaa 3901 gagaccggaa tggctatccg taatgatcct gatacatcat catgggtact ctcgataaca 3961 gccttggccg cttccacctc attgcgaatg gaatcacagt gttgataaaa gagtgccccg 4021 acttgggtaa gactcaggtt acgggtgtcg cgttgtaaca atcgcacgcc tagttgttct 4081 tcaagctgcg cgattttgcg acttatggtg gattttgggt ggccggtttc acgtgcagct 4141 tgggagaatc cctttgctct cactacggct gcaaatagca tcataccgtt taaatctggc 4201 atgtttttcc cactgtctca tatttggaac atagcgtctt atgcagttta atggcatttg 4261 gcgggataac aaagttatat ttattggcta aaaattttca gaggctaaag cagaggatct 4321 tttgatgacc agcaataatc agcccaaaca catgactcaa gcccaaacgc ccgatccgct 4381 ttttttacag gccgagcact gaagaatccc ctgatgattt acaaataaat catcaaatta 4441 gggtggaagc gcatcttgtt gcatgatcaa atggtttcgc caaaaactac acttggacaa 4501 caagatgcgc gaagccaata tcctacaaca ttctttacac caatactgcc cagaacttca 4561 cctaaaacga ttaaacagct tgatgctggc ctctaaggcg ctgattgaat gtaagacact 4621 gaccttgact gagttaggtc gaaatttacc aaccacggcc cgaaccaagc acaacatcaa 4681 gcgcattgat cgtttgctcg gcaacacgca tctgcatcaa gaacggttag ctgtctacca 4741 atggcatgcc agcctcatct gttctggtaa ccctatgccg attgtgctcg tcgattggtc 4801 agacatccga gagcataaac gcatcatggc tctgcgcgcc tcaatagcct tcaatggccg 4861 ctctattacc ctgtatgaga agtcctatcc cctatcagaa caatgctcta aggcctccca 4921 caacggtttt ttagcggact tagccaagat tttacctttg catgttaccc ctctcatcgt 4981 gactgacgcg gggttcaaag tgccttggta caaagaggtt gaggcgcatg gttggttttg 5041 gctaagccgt attcgcggta cagttcaatt tgcagatatt ggcgctgaaa attggcgtgc 5101 agttcgaagt acacatgact tggccaacgg tcaagcgaag agcctgggtt gtaagacttt 5161 gaccaaaact aaccctatca attgccatct cacgctttat cgtagcaaac ctaaggggcg 5221 tacaaatcag cgttcaacga ggactaattg ccaccatcca tcggcaaaaa cgtactcaac 5281 atcggcgaaa gagccttggg tgttagccag caatttacca ccagaatctc ggagcccaaa 5341 gcagctggta aacctgtacg ccaaacgtat gcaaatagag gaaacctttc gtgacctcaa 5401 aagcccggca tacggctttg gcttacgcca aagtcgtacc aacagtccag agcgattcga 5461 catcatccta ctgatagcgt tgatggttca atgcctgttg tggctagttg gtttacacgc 5521 acagcaacag ggctgggata agcattttca ggccaatacc attgggcatc gaacggtact 5581 ctcaacgatt cgcttgggat tggaggtact caggcggcct gattatcaaa tcacggagaa 5641 agaattgctg gcggcctggg tattattcgc caatcagttg ctcaaatatg gctatgctat 5701 ggctgattta tgaggggatc cttcagcgtt cagcatgaca ccacggaaca ggatttcctc 5761 attcagcggg gcaaggataa agacggccag caacgtcagg atcacatcgg gtatggactt 5821 atcggcaaaa agtttcgtca taaatggctc agcgggcagg tccagcactt tacccagcag 5881 aaattcaccg acatacacca cggccatcgc gccaaccagc cacagtgcgc caacgttgct 5941 cagctggcca acgaccggta gcggagcaac ccagcggcgg tataccagga aaacacacag 6001 gaggtacacc agtacagcac catgactgaa gaacagcgta tttttcccca gcccatagag 6061 cagaacagcc tgccccatga caaacatggc cccccaggct atggcccagg ctgccagcag 6121 aaccagcata aactgcag //