LOCUS       AY169314                1827 bp    mRNA    linear   HUM 05-JAN-2003
DEFINITION  Homo sapiens intramembrane protease (IMP3) mRNA, complete cds.
ACCESSION   AY169314
VERSION     AY169314.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Rogaev,E.I., Grigorenko,A., Ryazanskaya,N., Sherbatich,T.,
            Molyaka,Y., Korovaitseva,G.I. and Dvoryanchikov,G.
  TITLE     Evolution and modulation of Alzheimer's disease associated genes
            and families of related proteins
  JOURNAL   (in) ? (Ed.);
            6TH ANNUAL INTERNATIONAL HUMAN GENOME MEETING;
            (2001)
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Grigorenko,A.P., Moliaka,Y.K., Korovaitseva,G.I. and Rogaev,E.I.
  TITLE     Novel class of polytopic proteins with domains associated with
            putative protease activity
  JOURNAL   Biochemistry Mosc. 67 (7), 826-835 (2002)
   PUBMED   12139484
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Grigorenko,A.P., Moliaka,Y.K. and Rogaev,E.I.
  TITLE     Characterization of a novel class of conserved intra-membrane
            proteolysis associated proteins (IMPAS)
  JOURNAL   Unpublished
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Grigorenko,A.P., Moliaka,Y.K. and Rogaev,E.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2002) Laboratory of Molecular Brain Genetics,
            Mental Health Research Center, RAMS, Zagorodnoe sh., 2/3, Moscow
            113152, Russia
FEATURES             Location/Qualifiers
     source          1..1827
                     /db_xref="H-InvDB:HIT000084925"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
                     /cell_type="leukocyte"
                     /tissue_type="blood"
     gene            1..1827
                     /gene="IMP3"
     CDS             177..1739
                     /gene="IMP3"
                     /note="IMPAS"
                     /codon_start=1
                     /product="intramembrane protease"
                     /protein_id="AAO12539.1"
                     /translation="MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCML
                     YNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKAR
                     IAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKM
                     YSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTF
                     SPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQC
                     TIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKL
                     PNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKL
                     IYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMIL
                     TFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEE
                     NPVISGEQIVQQ"
BASE COUNT          476 a          378 c          422 g          551 t
ORIGIN      
        1 ggaagtcgcg ctgctgtggc ggccgctgta gcagcggcgg tccagtcgta gcccggccgc
       61 ccgcgcctgt ccggtccggt ccggccacgg aggcagcgca gcggcgggac tccgagccta
      121 ccccgccgag tgagctgcgc cgcaccgtgc cgtcccaccc ggcacccacc agtccgatgg
      181 ggccgcagcg gcggctgtcc cctgccgggg ccgccctact ctggggcttc ctgctccagc
      241 tgacagccgc tcaggaagca atcttgcatg cgtctggaaa tggcacaacc aaggactact
      301 gcatgcttta taacccttat tggacagctc ttccaagtac cctagaaaat gcaacttcca
      361 ttagtttgat gaatctgact tccacaccac tatgcaacct ttctgatatt cctcctgttg
      421 gcataaagag caaagcagtt gtggttccat ggggaagctg ccattttctt gaaaaagcca
      481 gaattgcaca gaaaggaggt gctgaagcaa tgttagttgt caataacagt gtcctatttc
      541 ctccctcagg taacagatct gaatttcctg atgtgaaaat actgattgca tttataagct
      601 acaaagactt tagagatatg aaccagactc taggagataa cattactgtg aaaatgtatt
      661 ctccatcgtg gcctaacttt gattatacta tggtggttat ttttgtaatt gcggtgttca
      721 ctgtggcatt aggtggatac tggagtggac tagttgaatt ggaaaacttg aaagcagtga
      781 caactgaaga tagagaaatg aggaaaaaga aggaagaata tttaactttt agtcctctta
      841 cagttgtaat atttgtggtc atctgctgtg ttatgatggt cttactttat ttcttctaca
      901 aatggttggt ttatgttatg atagcaattt tctgcatagc atcagcaatg agtctgtaca
      961 actgtcttgc tgcactaatt cataagatac catatggaca atgcacgatt gcatgtcgtg
     1021 gcaaaaacat ggaagtgaga cttatttttc tctctggact gtgcatagca gtagctgttg
     1081 tttgggctgt gtttcgaaat gaagacaggt gggcttggat tttacaggat atcttgggga
     1141 ttgctttctg tctgaattta attaaaacac tgaagttgcc caacttcaag tcatgtgtga
     1201 tacttctagg ccttctcctc ctctatgatg tattttttgt tttcataaca ccattcatca
     1261 caaagaatgg tgagagtatc atggttgaac tcgcagctgg accttttgga aataatgaaa
     1321 agttgccagt agtcatcaga gtaccaaaac tgatctattt ctcagtaatg agtgtgtgcc
     1381 tcatgcctgt ttcaatattg ggttttggag acattattgt accaggcctg ttgattgcat
     1441 actgtagaag atttgatgtt cagactggtt cttcttacat atactatgtt tcgtctacag
     1501 ttgcctatgc tattggcatg atacttacat ttgttgttct ggtgctgatg aaaaaggggc
     1561 aacctgctct cctctattta gtaccttgca cacttattac tgcctcagtt gttgcctgga
     1621 gacgtaagga aatgaaaaag ttctggaaag gtaacagcta tcagatgatg gaccatttgg
     1681 attgtgcaac aaatgaagaa aaccctgtga tatctggtga acagattgtc cagcaataat
     1741 attatgtgga actgctataa tgtgtcattg attttctaca aatagacttc gactttttaa
     1801 attgactttt gaattgacaa tctgaaa
//