LOCUS       AY040822                2153 bp    mRNA    linear   HUM 18-MAR-2002
DEFINITION  Homo sapiens U4/U6 snRNP-associated 61 kDa protein mRNA, complete
            cds.
ACCESSION   AY040822
VERSION     AY040822.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Makarova,O.V., Makarov,E.M., Liu,S., Vornlocher,H.P. and
            Luhrmann,R.
  TITLE     Protein 61K, encoded by a gene (PRPF31) linked to autosomal
            dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP
            formation and pre-mRNA splicing
  JOURNAL   EMBO J. 21 (5), 1148-1157 (2002)
   PUBMED   11867543
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Makarova,O.V., Makarov,E.M. and Luhrmann,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JUN-2001) Department of Cellular Biochemistry, Max
            Planck Institute of Biophysical Chemistry, Am Fassberg 11,
            Goettingen 37077, Germany
FEATURES             Location/Qualifiers
     source          1..2153
                     /db_xref="H-InvDB:HIT000083629"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             358..1857
                     /note="similar to yeast Prp31p; essential for U4/U6.U5
                     tri-snRNP formation and pre-mRNA splicing"
                     /codon_start=1
                     /product="U4/U6 snRNP-associated 61 kDa protein"
                     /protein_id="AAK77986.1"
                     /translation="MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLS
                     GDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVE
                     IENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILT
                     NATIMVVSVTASTTQGQQLSEEELERLDEACDMALELNASKHRIYEYVESRMSFIAPN
                     LSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYH
                     SDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEP
                     PPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDL
                     GFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTAS
                     SVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST"
BASE COUNT          521 a          589 c          658 g          385 t
ORIGIN      
        1 gcacgaggcg aatccctgct taaaggcctt gctttcttgt ctaacgccgc aaccagtcct
       61 ctgagttgcc aacgtctttc ttcttgtctc gacgccccgt cgtccggcca cagcgattct
      121 ctgcttagca ggatcggtcc acagcgggac gtgagtccct ttcctcctcg cggcttaccg
      181 cctctctccg cctagtgcca ggtgctaata aagttgttgt ttcaaatgcg gccaggaaca
      241 tcgcgagcgg ggaccaatca gagagtagct ttgcctctat aacggcgcga gagtgagacg
      301 tcatcggtga gcgactaacg ctagaaacag tggtgcgcgg agaggagagg cctcgggatg
      361 tctctggcag atgagctctt agctgatctc gaagaggcag cagaagagga ggaaggagga
      421 agctatgggg aggaagaaga ggagccagcg atcgaggatg tgcaggagga gacacagctg
      481 gatctttccg gggattcagt caagaccatc gccaagctat gggatagtaa gatgtttgct
      541 gagattatga tgaagattga ggagtatatc agcaagcaag ccaaagcttc agaagtgatg
      601 ggaccagtgg aggccgcgcc tgaataccgc gtcatcgtgg atgccaacaa cctgaccgtg
      661 gagatcgaaa acgagctgaa catcatccat aagttcatcc gggataagta ctcaaagaga
      721 ttccctgaac tggagtcctt ggtccccaat gcactggatt acatccgcac ggtcaaggag
      781 ctgggcaaca gcctggacaa gtgcaagaac aatgagaacc tgcagcagat cctcaccaat
      841 gccaccatca tggtcgtcag cgtcaccgcc tccaccaccc aggggcagca gctgtcggag
      901 gaggagctgg agcggctgga tgaggcctgc gacatggcgc tggagctgaa cgcctccaag
      961 caccgcatct acgagtatgt ggagtcccgg atgtccttca tcgcacccaa cctgtccatc
     1021 attatcgggg catccacggc cgccaagatc atgggtgtgg ccggcggcct gaccaacctc
     1081 tccaagatgc ccgcctgcaa catcatgctg ctcggggccc agcgcaagac gctgtcgggc
     1141 ttctcgtcta cctcagtgct gccccacacc ggctacatct accacagtga catcgtgcag
     1201 tccctgccac cggatctgcg gcggaaagcg gcccggctgg tggccgccaa gtgcacactg
     1261 gcagcccgtg tggacagttt ccacgagagc acagaaggga aggtgggcta cgaactgaag
     1321 gatgagatcg agcgcaaatt cgacaagtgg caggagccgc cgcctgtgaa gcaggtgaag
     1381 ccgctgcctg cgcccctgga tggacagcgg aagaagcgag gcggccgcag gtaccgcaag
     1441 atgaaggagc ggctggggct gacggagatc cggaagcagg ccaaccgtat gagcttcgga
     1501 gagatcgagg aggacgccta ccaggaggac ctgggattca gcctgggcca cctgggcaag
     1561 tcgggcagtg ggcgtgtgcg gcagacacag gtaaacgagg ccaccaaggc caggatctcc
     1621 aagacgctgc agcggaccct gcagaagcag agcgtcgtat atggcgggaa gtccaccatc
     1681 cgcgaccgct cctcgggcac ggcctccagc gtggccttca ccccactcca gggcctggag
     1741 attgtgaacc cacaggcggc agagaagaag gtggctgagg ccaaccagaa gtatttctcc
     1801 agcatggctg agttcctcaa ggtcaagggc gagaagagtg gccttatgtc cacctgaatg
     1861 actgcgtgtg tccaaggtgg cttcccactg aagggacaca gaggtccagt ccttctgaag
     1921 ggctaggatc gggttctggc agggagaacc tgccctgcca ctggccccat tgctgggact
     1981 gcccagggag gaggccttgg aagagtccgg cctggcctcc cccaggaccg agatcaccgc
     2041 ccagtatggg ctagagcagg ttttcatcat gccttgtctt ttttaactga gaaaggagat
     2101 tttttgaaaa gagtacaatt aaaaggacat tgtcaaaaaa aaaaaaaaaa aaa
//