LOCUS AM989473 6393 bp mRNA linear HUM 04-NOV-2008 DEFINITION Homo sapiens mRNA for L-protein KIAA1549:BRAF 16_11 (KIAA1549:BRAF gene), isolated from brain. ACCESSION AM989473 VERSION AM989473.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6393) AUTHORS Jones D.T.W. JOURNAL Submitted (22-APR-2008) to the INSDC. Jones D.T.W., Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 0QQ, UNITED KINGDOM. REFERENCE 2 AUTHORS Jones D.T.W., Kocialkowski S., Liu L., Pearson D.M., Backlund L.M., Ichimura K., Collins V.P. TITLE Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas JOURNAL Cancer Res. 68(21), 8673-8677(2008). PUBMED 18974108 FEATURES Location/Qualifiers source 1..6393 /organism="Homo sapiens" /map="7q34" /mol_type="mRNA" /tissue_type="brain" /db_xref="taxon:9606" 5'UTR 1..49 /gene="KIAA1549:BRAF" CDS 50..6283 /gene="KIAA1549:BRAF" /product="L-protein KIAA1549:BRAF 16_11" /db_xref="GOA:P15056" /db_xref="GOA:Q9HCM3" /db_xref="HGNC:HGNC:1097" /db_xref="HGNC:HGNC:22219" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR001245" /db_xref="InterPro:IPR002219" /db_xref="InterPro:IPR003116" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="InterPro:IPR020454" /db_xref="InterPro:IPR024606" /db_xref="InterPro:IPR029071" /db_xref="PDB:1UWH" /db_xref="PDB:1UWJ" /db_xref="PDB:2FB8" /db_xref="PDB:2L05" /db_xref="PDB:3C4C" /db_xref="PDB:3D4Q" /db_xref="PDB:3IDP" /db_xref="PDB:3II5" /db_xref="PDB:3NY5" /db_xref="PDB:3OG7" /db_xref="PDB:3PPJ" /db_xref="PDB:3PPK" /db_xref="PDB:3PRF" /db_xref="PDB:3PRI" /db_xref="PDB:3PSB" /db_xref="PDB:3PSD" /db_xref="PDB:3Q4C" /db_xref="PDB:3Q96" /db_xref="PDB:3SKC" /db_xref="PDB:3TV4" /db_xref="PDB:3TV6" /db_xref="PDB:4CQE" /db_xref="PDB:4DBN" /db_xref="PDB:4E26" /db_xref="PDB:4E4X" /db_xref="PDB:4EHE" /db_xref="PDB:4EHG" /db_xref="PDB:4FC0" /db_xref="PDB:4FK3" /db_xref="PDB:4G9C" /db_xref="PDB:4G9R" /db_xref="PDB:4H58" /db_xref="PDB:4JVG" /db_xref="PDB:4KSP" /db_xref="PDB:4KSQ" /db_xref="PDB:4MBJ" /db_xref="PDB:4MNE" /db_xref="PDB:4MNF" /db_xref="PDB:4PP7" /db_xref="PDB:4R5Y" /db_xref="PDB:4RZV" /db_xref="PDB:4RZW" /db_xref="PDB:4WO5" /db_xref="PDB:4XV1" /db_xref="PDB:4XV2" /db_xref="PDB:4XV3" /db_xref="PDB:4XV9" /db_xref="PDB:4YHT" /db_xref="PDB:5C9C" /db_xref="PDB:5CSW" /db_xref="PDB:5CSX" /db_xref="PDB:5CT7" /db_xref="PDB:5FD2" /db_xref="PDB:5HI2" /db_xref="PDB:5HID" /db_xref="PDB:5HIE" /db_xref="PDB:5ITA" /db_xref="PDB:5J17" /db_xref="PDB:5J18" /db_xref="PDB:5J2R" /db_xref="PDB:5JRQ" /db_xref="PDB:5JSM" /db_xref="PDB:5JT2" /db_xref="PDB:5VAL" /db_xref="PDB:5VAM" /db_xref="PDB:5VR3" /db_xref="PDB:5VYK" /db_xref="PDB:6B8U" /db_xref="PDB:6CAD" /db_xref="PDB:6NSQ" /db_xref="UniProtKB/Swiss-Prot:P15056" /db_xref="UniProtKB/Swiss-Prot:Q9HCM3" /protein_id="CAQ43112.1" /translation="MPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGL LLPGLWLLLLARPASCAPDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQ HSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNF LPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQ PAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEG VETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLE ETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSE LHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAET LCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGIS AEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILL DSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRGALDFAS SFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQ LSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDS EAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATP FPLPTELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSA APPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIIT AIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLI LSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYN LTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGY PVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVS TRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINK MDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILY WKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLP GPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGA VNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPI PAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDD LSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVNGC PADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPF PASQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQ EERRATQWGSFYSPAQTANNPCSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYK GKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW CEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT VKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLY ELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERP LFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAF PVH" 3'UTR 6284..6393 /gene="KIAA1549:BRAF" BASE COUNT 1541 a 1844 c 1528 g 1480 t ORIGIN 1 gacccgagag ccgctgagcc gcgaggccgg gccggggcgc cggccgggaa tgccgggggc 61 gcggcgccga cgccgaggcg cggccatgga ggggaagccc cgcgccgggg tcgcgctggc 121 cccggggccg agcggccgac ggccttccgc ccgctgcgcc cgccgccgcc gcccggggct 181 gctgcttcct ggcctctggc tgctgctgct ggcccggccg gcctcgtgcg ccccagatga 241 gctctctccg gaacagcaca acctttcttt atactccatg gagctcgtgc tgaagaaaag 301 cactgggcac agcgctgcac aagtggcctt aacagaaact gctcccggct cccagcacag 361 cagtcctctc catgtcacag ccccgccgtc tgccactact tttgatacag ccttttttaa 421 ccaaggaaaa cagaccaaaa gtacagcaga tcccagcatc tttgtggcaa cttacgtgtc 481 agtgacgagt aaagaggtgg ccgtcaatga cgatgagatg gataactttc tgccagatac 541 tcactggacc actccacgga tggtttctcc aatacagtat atcacagtca gcccaccagg 601 gctgcccagg gaagcattag aacctatgct cactccatca ttacccatgg tttctttaca 661 agatgaagaa gtgacatcgg gctggcagaa cacaacgcga caaccagcgg catatgctga 721 gtccgccagt catttccaca cctttcggtc agcttttcgc acctctgagg gcatcgttcc 781 aactcctggc aggaatttgg tgctttatcc tactgatgct tacagtcatt tatcaagcag 841 gactctgcca gagattgtgg cttccctaac agagggtgtg gaaaccaccc tttttttaag 901 ctcccggtct ttaatgccac agccgttagg cgacggcatt actataccgt tgccctcctt 961 gggggaggtc tcacagcctc cagaggaggt ttgggccaca agtgcagaca gatacactga 1021 tgtgaccact gtgttgagtc aaagcctaga agaaaccatc tctccaagaa cataccccac 1081 tgtgactgca tcgcacgcag cccttgcatt cagcaggaca cattctccat tgctttcaac 1141 tcctcttgca tttgcgtcct ctgcttcacc aactgatgtt tcatctaacc cctttctccc 1201 tagcgactcc agcaaaacat ccgaattgca tagcaattca gccctccccg gtcctgtgga 1261 caacactcat atcctgagcc cggtgtcctc attcagacca tacacttggt gtgcggcctg 1321 cactgtgcct tcacctcagc aagttctggc cacgagcctc atggagaaag acgtgggatc 1381 aggggatggt gccgagactc tgtgcatgac cgtgctggaa gaaagcagca tctctctaat 1441 gagtagcgtc gtagcagact tctctgaatt tgaggaagat cctcaagtat ttaatacgct 1501 tttcccctcc agacctatcg tcccactttc ttctagatcc atggaaatct cagagacgag 1561 tgttggcatt tctgccgagg tggatatgag tagtgttaca accacacagg ttccccctgc 1621 ccacggccgc ctctctgtgc cggcgtcact tgatcctact gctggctcct tgtctgttgc 1681 tgaaacccaa gtgacgccat ccagcgtgac cactgcattt ttctcggtca tcaccagcat 1741 tctccttgac tcatctttct ctgtcatagc aaacaaaaac acaccgtcgc ttgccgtcag 1801 agacccgagt gtttttacgc cttatagtct ggttccttca gtggagtctt cacttttctc 1861 tgaccaagaa cgttccagtt tttctgagca taaacccaga ggtgctttgg attttgcatc 1921 cagctttttc tcaacacccc cgctggaact cagcggctcc atctcttcgc cttcggaagc 1981 acctgcgtct ctgtctctga tgccgagtga cttgtccccc ttcacatctc agtctttttc 2041 tcccttggtt gagacattta cattgtttga ctctagtgat ctgcagtcat ctcagctgtc 2101 tcttcccagt tccacaaatc ttgagttttc gcagctccag ccaagttccg agctgccttt 2161 aaacaccatc atgttgctac ctagccgttc tgaggtgtca ccatggtcaa gcttcccttc 2221 tgattctctc gagtttgttg aagcgtctac ggtttcactg acggattcag aagctcattt 2281 tacctcagct ttcattgaaa ctacctccta tcttgagtct tcactcattt cccatgaatc 2341 cgcagtcact gcactggtgc cccccggctc tgagtctttt gacattttga ctgccgggat 2401 tcaagcaaca tcaccattga ccactgtcca cacaacgccc attttaactg agtcttcttt 2461 gttctcaact ctgacacctc ctgacgacca aatcagtgct ctagacggtc acgtgtctgt 2521 cctggcctct ttctccaaag ccattcccac tggtacggtg ttgatcactg acgcgtacct 2581 gccatcagga tcctcgtttg tttctgaagc aacccccttc cctctgccca cagagctgac 2641 cgtcgtgggc ccatcactca cacccacaga ggtgccactg aacacctcca cggaagtgag 2701 cacaaccagc accggtgctg ccactggtgg tcccctcgac tccaccctga tgggtgacgc 2761 cgcaagtcag agccccccag agagtagtgc tgctcctccc ctgccatccc tgcgtcccgt 2821 gactgccttc actctcgaag caacagtcga cacaccaaca ctggctactg ccaagccgcc 2881 atatgtttgt gatatcacag tccccgatgc ctatctgatc acaactgtgc tggccagaag 2941 agctgtgcag gagtacatca ttacagcaat caaagaagta ctgaggattc acttcaaccg 3001 tgcagtggaa ctgaaggttt acgaactatt tactgacttc acttttctgg taacatccgg 3061 tcctttcgtt tacacggcaa tatccgtcat aaatgtgctt ataaacagta agcttgtccg 3121 tgaccagact cctttaatcc tgtctgtgaa accttctttc cttgtgccag agtccaggtt 3181 ccaagttcaa acagtacttc agtttgtgcc tccgagtgtg gatactggct tctgcaactt 3241 cacccagcgc attgagaaag gcctaatgac agctctcttt gaagtgagaa aacaccacca 3301 gggaacgtat aacctcacgg tgcagatctt gaatatcacc atcagttcct caagggtgac 3361 tcctcggcgg ggcccggtga atatcatctt tgcggttaaa agcacacagg gatttttgaa 3421 tgggtcggaa gtgagcgagc tgctcagaaa cttgagtgtg gtggagttca gtttctatct 3481 gggataccca gtgctgcaga tcgcagagcc cttccagtat ccacagctca acttatctca 3541 gttgctgaag tcctcttggg tcagaacagt tctcctgggc gtcatggaga agcaactcca 3601 gaatgaagtg tttcaagccg agatggaacg caagctggcc cagctgctca gcgaggtttc 3661 caccagaagg cggatgtgga gaagggccac tgtagctgca gggaacagtg tggtgcaggt 3721 ggtaaatgtg tcgaggctgg agggagatga caatccggta cagctcatct actttgtgga 3781 ggatcaagat ggagaaagac tcagtgcagt caagtcttcg gacctgatta acaaaatgga 3841 cctccagaga gcagccatca tcttgggtta ccgaattcaa ggtgtcattg cccagcctgt 3901 cgacagggtg aagaggccgt ctccggaatc ccagagcaac aacttgtggg tcattgttgg 3961 cgtggtcatc ccagtgctgg tggtgatggt gattgttgtc atcctctact ggaaactatg 4021 ccgcacagac aagctagact ttcagcctga cactgtggcc aacattcagc agcgtcagaa 4081 gctgcagatc cctagtgtga agggcttcga ttttgctaag cagcatctgg gtcagcacaa 4141 taaagacgac atattgatta ttcatgagcc agcgccactg ccaggacctc tgaaggacca 4201 caccacgccc tcggaaaatg gagacgtgcc aagccccaag tcaaagatcc cttccaagaa 4261 tgttcgtcac agaggaagag tttctccctc agatgctgac tctacggtca gtgaagagtc 4321 cagcgagagg gacgcaggag ataagacgcc gggagccgtc aacgatggca ggtcccacag 4381 agctccgcag agcgggccac cactgcccag ttcgggaaat gagcagcact catcagcctc 4441 catcttcgag cacgtggaca ggatctcccg ccccccggag gctagccggc gggtccccag 4501 taagatccag cttatcgcca tgcagccgat cccggcacct cccgtccagc gcccctcccc 4561 agccgaccga gtggcggaaa gcaataaaat caacaaagag attcagaccg cgctgcggca 4621 caagtctgag atcgagcacc atcgcaacaa gatccgcctg cgcgccaagc gccgcgggca 4681 ctacgagttc ccggtggtag acgacctgtc ctcgggcgac actaaggagc gacaccgggt 4741 gtaccgcagg gcacagatgc agatcgacaa gatcctggac cccacggcca gcgtgccctc 4801 cgtgttcata gagcccagga agagctcacg gataaaacgt tctcccaagc ctcgccggaa 4861 acaccaggtc aacggctgtc ctgccgacgc tgagaaggac cggctcatca ccacagacag 4921 cgatggcacc tacaggaggc cccccggcgt ccacaactca gcctacatcg gatgcccatc 4981 ggatcctgac ctcccagccg atgtgcagac accatcctcg gtggaactgg ggaggtatcc 5041 agcccttccc ttcccggcct cccagtacat cccaccccag ccgtccatcg aggaggcacg 5101 ccagaccatg cactccctcc tggacgacgc ctttgccctc gtggccccca gcagccagcc 5161 tgccagcacc gcaggtgtag gccccggagt cccacccggc ctgcccgcaa acagcacccc 5221 ttcccaggaa gagaggcgag ccacccagtg ggggtccttc tacagcccag cccagacggc 5281 caacaatccc tgcagtaaaa cacttggtag acgggactcg agtgatgatt gggagattcc 5341 tgatgggcag attacagtgg gacaaagaat tggatctgga tcatttggaa cagtctacaa 5401 gggaaagtgg catggtgatg tggcagtgaa aatgttgaat gtgacagcac ctacacctca 5461 gcagttacaa gccttcaaaa atgaagtagg agtactcagg aaaacacgac atgtgaatat 5521 cctactcttc atgggctatt ccacaaagcc acaactggct attgttaccc agtggtgtga 5581 gggctccagc ttgtatcacc atctccatat cattgagacc aaatttgaga tgatcaaact 5641 tatagatatt gcacgacaga ctgcacaggg catggattac ttacacgcca agtcaatcat 5701 ccacagagac ctcaagagta ataatatatt tcttcatgaa gacctcacag taaaaatagg 5761 tgattttggt ctagctacag tgaaatctcg atggagtggg tcccatcagt ttgaacagtt 5821 gtctggatcc attttgtgga tggcaccaga agtcatcaga atgcaagata aaaatccata 5881 cagctttcag tcagatgtat atgcatttgg aattgttctg tatgaattga tgactggaca 5941 gttaccttat tcaaacatca acaacaggga ccagataatt tttatggtgg gacgaggata 6001 cctgtctcca gatctcagta aggtacggag taactgtcca aaagccatga agagattaat 6061 ggcagagtgc ctcaaaaaga aaagagatga gagaccactc tttccccaaa ttctcgcctc 6121 tattgagctg ctggcccgct cattgccaaa aattcaccgc agtgcatcag aaccctcctt 6181 gaatcgggct ggtttccaaa cagaggattt tagtctatat gcttgtgctt ctccaaaaac 6241 acccatccag gcagggggat atggtgcgtt tcctgtccac tgaaacaaat gagtgagaga 6301 gttcaggaga gtagcaacaa aaggaaaata aatgaacata tgtttgctta tatgttaaat 6361 tgaataaaat actctctttt tttttaaggt gaa //