LOCUS       AM114016                 387 bp    mRNA    linear   VRT 09-APR-2006
DEFINITION  Macrovipera lebetina mRNA for disintegrin lebein-2 alpha precursor,
            clone ML2,8,15.
ACCESSION   AM114016
VERSION     AM114016.1
KEYWORDS    disintegrin lebein-2 alpha precursor.
SOURCE      Macrovipera lebetina (Levantine viper)
  ORGANISM  Macrovipera lebetina
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
            Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae;
            Macrovipera.
REFERENCE   1  (bases 1 to 387)
  AUTHORS   Calvete J.J.
  JOURNAL   Submitted (12-OCT-2005) to the INSDC. Calvete J.J., Departmente de
            Genomica y Proteomica, Instituto de Biomedicina de Valencia, Jaime
            Roig 11, 46010 Valencia, SPAIN.
REFERENCE   2
  AUTHORS   Sanz L., Bazaa A., Marrakchi N., Perez A., Chenik M.,
            Bel Lasfer Z., El Ayeb M., Calvete J.J.
  TITLE     Molecular cloning of disintegrins from Cerastes vipera and
            Macrovipera lebetina transmediterranea venom gland cDNA libraries:
            insight into the evolution of the snake venom integrin-inhibition
            system
  JOURNAL   Biochem. J. 395(2), 385-392(2006).
   PUBMED   16411889
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Macrovipera lebetina"
                     /mol_type="mRNA"
                     /geo_loc_name="Tunisia"
                     /clone_lib="cDNA-Ml"
                     /clone="ML2,8,15"
                     /tissue_type="venom gland"
                     /db_xref="taxon:8709"
     CDS             1..387
                     /product="disintegrin lebein-2 alpha precursor"
                     /function="integrin a3b1, a6b1, a7b1 inhibition"
                     /db_xref="GOA:Q3BK13"
                     /db_xref="InterPro:IPR001762"
                     /db_xref="InterPro:IPR018358"
                     /db_xref="InterPro:IPR036436"
                     /db_xref="UniProtKB/Swiss-Prot:Q3BK13"
                     /protein_id="CAJ34940.1"
                     /translation="MIQVLLVTICLAVFPFHGSSIILESGNVNDYEVVYPKKVTLLPT
                     GAMNSANPCCDPITCKPRKGEHCVSGPCCRNCKFLNPGTICKRTMLDGLNDYCTGITS
                     DCPRNPWKSEEDEMKWSATAKGSVLM"
     sig_peptide     1..141
     mat_peptide     142..384
                     /product="disintegrin lebein-2 alpha"
     misc_feature    265..273
                     /note="MLD peptide motif"
BASE COUNT          122 a           69 c           89 g          107 t
ORIGIN      
        1 atgatccagg ttctcttggt aactatatgc ttagcagttt ttccatttca cgggagctct
       61 ataatcctgg aatctgggaa tgttaatgat tatgaagtag tgtatccaaa aaaagtcact
      121 ttgttgccca caggagcaat gaattctgca aatccgtgct gtgatcctat aacgtgtaaa
      181 ccaagaaaag gggaacattg tgtatctgga ccgtgttgtc gtaactgcaa atttctgaac
      241 ccaggaacaa tatgcaagag aacaatgctt gatggcttga atgattactg cactggcata
      301 acttctgact gtcccagaaa tccctggaaa agtgaagaag atgagatgaa atggtctgca
      361 acagcaaaag gcagtgtgtt gatgtaa
//