LOCUS AM055586 12003 bp DNA linear BCT 03-JUN-2006 DEFINITION Streptomyces cattleya fluorometabolite biosynthesis gene cluster. ACCESSION AM055586 VERSION AM055586.1 KEYWORDS 5'-fluoro-5'-deoxy-adenosine phosphorylase; 5'-fluoro-5'-deoxy-adenosine synthase; adenosyl-homocysteine hydrolase; dehalogenase/phosphatase; DNA binding regulatory protein; flA gene; flB gene; flC gene; flD gene; flE gene; flF gene; flG gene; flH gene; flI gene; flJ gene; flK gene; flL gene; fluoroacetyl coenzyme A thioesterase; MFS permease; Na+/H+ antiporter; regulatory protein. SOURCE Streptomyces cattleya ORGANISM Streptomyces cattleya Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 12003) AUTHORS Huang F. JOURNAL Submitted (27-JUL-2005) to the INSDC. Huang F., University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, Cambridgeshire, UNITED KINGDOM. REFERENCE 2 AUTHORS Huang F., Haydock S.F., Spiteller D., Mironenko T., Li T.-L., O'Hagan D., Leadlay P.F., Spencer J.B. TITLE The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A JOURNAL Chem. Biol. 13(5), 475-484(2006). PUBMED 16720268 FEATURES Location/Qualifiers source 1..12003 /organism="Streptomyces cattleya" /mol_type="genomic DNA" /db_xref="taxon:29303" CDS complement(127..795) /transl_table=11 /gene="flE" /product="putative DNA binding regulatory protein" /db_xref="GOA:Q1EMW2" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="UniProtKB/TrEMBL:Q1EMW2" /protein_id="CAJ20002.1" /translation="MQRPAAVVHHVGVPAAIWLKLIETLPAILWVGFAAVVYFSLRQT IVQRMVPRLTAVRALGVELELARELLDQAQEESPTTVTPTARRTALGRLEHAADLLRG GNVLWVDDRPEGNSPLVELFRTAGMNVELALSTEEAVPLLRRRPYDIIISDFDRNGDS EAGIKMLRLLEQYHIDVPVLIYTGRFDPERGVDHRIFAGTSAPVELVHYVVDLMERAR LGSL" CDS complement(854..1504) /transl_table=11 /gene="flD" /product="putative dehalogenase/phosphatase" /db_xref="GOA:Q1EMW1" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="InterPro:IPR041492" /db_xref="UniProtKB/TrEMBL:Q1EMW1" /protein_id="CAJ20003.1" /translation="MRVPPQLVIFDCDGILVDSEPLAIRAHVAVGAELGWPLTEDEVV DLFVGRSNASVDELIAARLGAPAAATWRRRFEALHREAVDTELTAVPGITEALAAIPV PTCVASSGTHAKMRHTLGRTGLYDHFAGRIYSATDVRHGKPAPDLFLHAAASMGVPPS ACVVVEDSHHGLQAARAAAIPALAYASGVTPEARLRGPGTVVFREMRELPGLLGVG" CDS 1845..3038 /transl_table=11 /gene="flC" /product="putative MFS permease" /db_xref="GOA:Q1EMW0" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="UniProtKB/TrEMBL:Q1EMW0" /protein_id="CAJ20004.1" /translation="MGAGGRAPGPRPWVRVALAMFAVGWGANQFSPMLLVYHEQRRLS QVVLAAMFGCYALGLIPALLVAAALSDRMGRRRLMRPVLILSTVASLVLVAGAVATPA LFAGRLLAGVASGTAFAPGSAWVKELSADAPGGSGARRATVALSAGFGGGPLVAGAVA QWLPYPQVLPYLVHIAVMLVVAPLAWRAPETVTPGRRAGGGPGRGGVRAAVAHPVFLR TVVPTAPWVFATATVGFAVLPGLVIRGGDGLVLSGATAGLVLGTGVLVQPLARRVERW RAGAVLVAGVLVAAAGLLLAAVTAATAEPTLLIPAAVVLGAAYGLLLVAGLGRVQALA PPEDLAGVTAVFYCLIYLGFAAPYVVAAAGALLSPAALFCVAAGAVTATLPLLLGTGG VRAPR" CDS complement(3053..3952) /transl_table=11 /gene="flB" /product="5'-fluoro-5'-deoxy-adenosine phosphorylase" /function="catalyses phosphorolytic cleavage of 5'-fluoro-5'-deoxy-adenosine" /db_xref="GOA:Q1EMV9" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010044" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="UniProtKB/TrEMBL:Q1EMV9" /experiment="experimental evidence, no additional details recorded" /protein_id="CAJ20005.1" /translation="MRARKSGNEQRNADLGIIGGSGLYEFPGLTDPEEFPVETPYGPP SAPPVVGTVGGRWVAFLARHGTGHRIPPSRIPVRANLYALKALGVTEVVSVSAVGSLR EEYAPGHLVVPDQIIDRTRGGRPATFFSSGVVVHVSLADPYCPRLRAALTDAARAAHP TVHPAGTYLCMEGPQFSTRAESQLYRAWGMDVIGMTAQPEAKLAREAELCYAGLSLVT DYDCWHTGHDSVDARTVAEVMAANVIAARAVLSGLAHATAPADCACHHALDGAVLTDP LAAAQVPEEEVPALLRKGFARRG" CDS 4172..5071 /transl_table=11 /gene="flA" /product="5'-fluoro-5'-deoxy-adenosine synthase" /function="synthesis of 5'-fluoro-5'-deoxy-adenosine" /db_xref="GOA:Q70GK9" /db_xref="InterPro:IPR002747" /db_xref="InterPro:IPR023227" /db_xref="InterPro:IPR023228" /db_xref="InterPro:IPR030978" /db_xref="PDB:1RQP" /db_xref="PDB:1RQR" /db_xref="PDB:2C2W" /db_xref="PDB:2C4T" /db_xref="PDB:2C4U" /db_xref="PDB:2C5B" /db_xref="PDB:2C5H" /db_xref="PDB:2CBX" /db_xref="PDB:2CC2" /db_xref="PDB:2V7T" /db_xref="PDB:2V7U" /db_xref="PDB:2V7V" /db_xref="PDB:2V7W" /db_xref="PDB:2V7X" /db_xref="PDB:4CQJ" /db_xref="PDB:5FIU" /db_xref="UniProtKB/Swiss-Prot:Q70GK9" /experiment="experimental evidence, no additional details recorded" /protein_id="CAJ20006.1" /translation="MAANSTRRPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVC HSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQ WAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSRE MVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWT NIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIA RNAASLAYPYHLKEGMSARVEAR" CDS 5196..5753 /transl_table=11 /gene="flF" /product="putative DNA binding regulatory protein" /db_xref="GOA:Q1EMV7" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="UniProtKB/TrEMBL:Q1EMV7" /protein_id="CAJ20007.1" /translation="MERAEGVGVTVGAQVRRLREFRGLSVAELSRLSGVSRATLSMLE SGRGNPTIETVSAIAVALRLPLGDLLVDPTPPEPVLRPGTPRPQTSRQDLLDRIGAGG HSEIWRLRLCGAGRRVDSPPHTRGTLERVVALRGRLRLGPVDRPVVLATGDFVVFPAD EPHFYEAVDDEDVDAVIVMTYPAAS" CDS complement(5947..6651) /transl_table=11 /gene="flG" /product="putative DNA binding regulatory protein" /db_xref="GOA:Q1EMV6" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="UniProtKB/TrEMBL:Q1EMV6" /protein_id="CAJ20008.1" /translation="MTLHRGAATAAVRRQQAAIRLAVVDDNVFLRTGLAHVLAAEPAL EVVAESAHVREGLSALRARQPHVVLLGVASGGREPYGDVAELRRATPVSRIVAMLAHD DPGAVRRLLAAGAQAAIAQYSSPEELIGTIRGVAGHRDRVVLSVSQRTLAGLRETGPH LLTARELQVVALVARGLRNSQIARELVITEGTVKRHLSNVYAKLDAACRTEAVRKAVE RGMVRTPVPITDYDLA" CDS complement(6648..8051) /transl_table=11 /gene="flH" /product="putative Na+/H+ antiporter" /db_xref="GOA:Q1EMV5" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR038770" /db_xref="UniProtKB/TrEMBL:Q1EMV5" /protein_id="CAJ20009.1" /translation="MSLTTVELAHVLIALGLLTVLAHAGAQIFQLLRQPPVIGEIVGG LVLGPTVLGALWPTAETWLFPAKGATGEVLGAFYSIGMLLLVYLTGAELRGHVARSDR RTMVWVAGAGLFVPFAAGLLVANSVSLPGLSGPHGNPASLALVFGMAIAVTSVPVISR IMLDLGILRTVFARVVLAVAVLEDVVLYALLAVVLGIAQARAGDSYGVGGALSRVSLP WAVVFFSLVPVVFFGLFLWRGRAAFDALRSGRWNVLERRSPTAFRIAYLFALCLACSG LGIDPMFGALAAGLSAGGPVPGEERAAPAVPEAAADAAPGSYQTLRAISLAFFVPVYF AVVGLKLDLIRHFDPVFFLWFLALACVVKSAGVWAGARLAGQDAASAGNIAVAMNARG GPGIILASVTYAAGVISEDFFTSLVVLSIVTSQAAGVWLGRTVRRHRPLMSQRRPTGG ERGTPDPETTRRKAETA" CDS 8317..9786 /transl_table=11 /gene="flI" /product="adenosyl-homocysteine hydrolase" /function="catalyses reversible hydrolysis of adenosyl-homocysteine" /db_xref="GOA:Q1EMV4" /db_xref="InterPro:IPR000043" /db_xref="InterPro:IPR015878" /db_xref="InterPro:IPR020082" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR042172" /db_xref="UniProtKB/TrEMBL:Q1EMV4" /experiment="experimental evidence, no additional details recorded" /protein_id="CAJ20010.1" /translation="MAVVPSGSGAQRPVPEFKVADLSLAEFGRKEITLAEHEMPGLMA MRAEYAGSRPLRGARVSGSLHMTVQTAVLIETLTALGASVRWASCNIFSTQDHAAAAV VVGPHGTPEEPRGVPVFAWKGESLEEYWWCTRQALTWPEGGPQLIVDDGGDATLLVHL GVEYEKAGAVPDPATAGSEEEAVILRLLAGTLREQPRLWTTVARDVIGVSEETTTGVH RLYERERDGTLLFPAINVNDSVTKSKFDNRYGVRHSLVDGINRGTDVLIGGKVAVVCG YGDVGKGCAEALRGQGAKVTVTEVDPICALQAAMDGYPVATLEDMLPTADIVITATGN RDIVRVEHMAAMKHLAIVGNIGHFDNEIDMAGLAGFPGIRRVNIKPQVDQWTFPDGHA VLVLSEGRLLNLGNATGHPSFVMSNSFANQVIAQLELFTRAEEYPVGVHRLPKRLDEK VARLHLSALGARLTKLTKRQADYIGVPVEGPYKPDHYRY" CDS 9802..10197 /transl_table=11 /gene="flJ" /product="putative regulatory protein" /db_xref="InterPro:IPR003793" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="UniProtKB/TrEMBL:Q1EMV3" /protein_id="CAJ20011.1" /translation="MEAPRPRPAGALRRLTVFTDLADRCAGRPRYAEIVRLGRQRGLR GMSVLRGIGGYGRSGVVREGGLLRPPRDLPVMVVAVDTAEAIESFLPVLERIAPENLI VLDEVRAVRFPAPGRGPGPDPLSRPGSSA" CDS complement(10172..10591) /transl_table=11 /gene="flK" /product="fluoroacetyl coenzyme A thioesterase" /function="catalyses hydrolysis of fluoroacetyl coenzyme A" /db_xref="GOA:Q1EMV2" /db_xref="InterPro:IPR025540" /db_xref="InterPro:IPR029069" /db_xref="PDB:3KUV" /db_xref="PDB:3KUW" /db_xref="PDB:3KV7" /db_xref="PDB:3KV8" /db_xref="PDB:3KVI" /db_xref="PDB:3KVU" /db_xref="PDB:3KVZ" /db_xref="PDB:3KW1" /db_xref="PDB:3KX7" /db_xref="PDB:3KX8" /db_xref="PDB:3P2Q" /db_xref="PDB:3P2R" /db_xref="PDB:3P2S" /db_xref="PDB:3P3F" /db_xref="PDB:3P3I" /db_xref="UniProtKB/Swiss-Prot:Q1EMV2" /experiment="experimental evidence, no additional details recorded" /protein_id="CAJ20012.1" /translation="MKDGMRVGERFTHDFVVPPHKTVRHLYPESPEFAEFPEVFATGF MVGLMEWACVRAMAPYLEPGEGSLGTAICVTHTAATPPGLTVTVTAELRSVEGRRLSW RVSAHDGVDEIGSGTHERAVIHLEKFNAKVRQKTPAG" CDS complement(10696..11373) /transl_table=11 /gene="flL" /product="putative DNA binding regulatory protein" /db_xref="GOA:Q1EMV1" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="UniProtKB/TrEMBL:Q1EMV1" /protein_id="CAJ20013.1" /translation="MVTTIALCDPNLLIRGGLRAILAGEPDIEVVAEVADGEQALRTV RRLRPDLLFTALDLPGGHGFEVARALARAPETRSTGVVFLAQSFDPALAVQGLMAGGR AFVSTGDPPRRLVTAARAVAAGYAVLPPAVLADGPWLTGSGGAARPGAAPGVPGLTGR ELEVLRLMAAGMSNAEIAGHLSLGEATVKSHVSRLLGKLGLRNRSQAIACAYRTGLVT VPVPGRG" BASE COUNT 1628 a 4012 c 4747 g 1616 t ORIGIN 1 tgcgggaaga gcccttgccg ccgcttacgg catacacacg ggacgccaaa gaacgccgtc 61 tggccggtca agacgcgact caaagcaacg caggtcctgg tcccgcctcg ggatcctcgg 121 acggcatcac aacgagccca gacgggcacg ctccataagg tcgacaacat aatggaccag 181 ttctaccggc gccgaagtac cggcgaagat cctgtggtcg actcctcgct caggatcgaa 241 tctgccggtg tagatcaata cgggtacgtc gatgtggtat tgctcaagca gacggagcat 301 tttgattccc gcctcgctgt cgccattccg atcgaagtcg ctgatgatga tgtcgtacgg 361 tctccgccga agcagcggca cggcctcctc ggtggacagg gcgagttcta cgttcatgcc 421 ggcggtccgg aagagttcga ccagcgggga gttgccctcc gggcggtcgt cgacccacag 481 cacgttgcca ccccgcagca ggtcagcggc gtgttcgagc ctgcccaacg ccgtgcgcct 541 ggcggtgggc gtgacggttg tcgggctctc ttcctgggcc tggtcgagca gttcacgtgc 601 gagttcgagt tcgacaccca gcgcccgtac ggcagtcagc cggggcacca tgcgctgcac 661 aatcgtctgc cgtagcgaga aatacacgac agcggcgaac cccacccaga ggatggccgg 721 aagtgtctcg atcagcttga gccagatggc ggcgggcacg ccgacatgat ggacgacggc 781 agccggacgc tgcattcact tcgggaaatt cggctcaagc gaggatgccc ccgcgcccgc 841 tcagcacccc ccctcacccc acccccaaca accccggcaa ctccctcatc tcgcggaaca 901 ccaccgtccc cgggcccctc agccgggcct ccggggtgac gccggaggcg taggcgaggg 961 cggggatggc ggcggcgcgg gcggcttgga ggccgtggtg gctgtcttcg acgacgacgc 1021 aggcggacgg ggggacgccc atggaggcgg cggcgtggag gaagaggtcg ggggcgggtt 1081 tgccgtggcg gacatcggtg gcgctgtaga tgcggccggc gaagtggtcg tacaggccgg 1141 tgcggcccag ggtgtggcgc atcttggcgt gggtgccgct ggaggcgacg caggtgggga 1201 cggggatggc ggccagggcc tcggtgatgc cggggacggc ggtcagctcg gtgtcgacgg 1261 cctcgcggtg cagcgcctcg aagcgccggc gccaggtggc ggcggccggg gcgccgaggc 1321 gggcggctat cagctcgtcc accgaggcgt tggagcggcc cacgaagagg tcgacgacct 1381 cgtcctcggt cagcggccag ccgagttcgg cgccgacggc gacatgggcg cggatggcga 1441 gcggttcgct gtcgaccagg attccgtcgc agtcgaatat gaccagctgg ggcggcacac 1501 gcatgccgca accctaggcc ctgtcgtcaa aaaatctcgc ctgccccgcg gggtccggca 1561 cgcgcgctcg cggcgttgtc ggtcgtcggc ccgcacggtc gggctccgcc cgggggtacc 1621 cccggacccc gcgggacacc gccctccggg cggccggcga tctcttgacg acagggccgg 1681 cgccgctccc ccggcgcgtc cggcgccgcc gccctacagt ggtgcgggca ccagtaacca 1741 ttccaccggt taccgaggga gcggccatgc gagcccgccg gacgggtacg gaacggacgg 1801 gtacggaacg gcaaagagag cgggaacggg aacgggcgct cgcggtgggc gccggggggc 1861 gggcgccggg gccgcggccc tgggtgcggg tggcgctggc gatgttcgcg gtggggtggg 1921 gggccaacca gttctcgccg atgctgctcg tctaccacga gcagcggcgg ctgtcccagg 1981 tggtgctggc ggcgatgttc ggctgctacg cgctcgggct gatccccgcg ctgctggtgg 2041 ccgcggcgct gtcggaccgg atgggacggc ggcggttgat gcggccggtg ctgatcttgt 2101 cgacggtggc ctcgctggtg ctggtcgccg gggcggtggc gacgccggcg ctcttcgcgg 2161 ggcggctgct ggccggggtg gcctcgggga cggcgttcgc gccgggcagc gcgtgggtca 2221 aggagctgtc ggcggacgcg cccgggggca gcggggcgcg gcgggcgacg gtggcgctct 2281 ccgcggggtt cggcggcggg ccgctggtgg ccggggcggt ggcgcagtgg ctgccgtatc 2341 cgcaggtgct gccgtatctg gtgcacatcg cggtgatgct ggtggtggcg ccgttggcgt 2401 ggcgggcgcc ggagacggtg accccggggc ggcgggcggg cggtggtccg ggccgcggcg 2461 gggtacgggc ggccgtggcc catccggtct tcctgcggac cgtggtgccg accgcgccgt 2521 gggtgttcgc caccgccacg gtgggtttcg cggtactgcc ggggctggtg atacgcggcg 2581 gtgacgggct ggtgctcagc ggggcgacgg cggggctggt gctgggcacc ggggtgctgg 2641 tgcaaccgct ggcccggcgg gtggaacggt ggcgggcggg ggccgtgctg gtggccgggg 2701 tgctggtggc ggcggccggg ctgctgctgg ccgcggtgac cgccgccacc gccgagccga 2761 cgttgctgat cccggcggcc gtggtgctcg gggcggcgta cgggttgctg ctggtggcgg 2821 ggctgggccg ggtgcaggcg ctggcgccgc cggaggacct ggccggggtg accgcggtct 2881 tctactgcct gatctacctg gggttcgccg cgccgtacgt ggtggcggcg gccggcgccc 2941 tgctctcccc ggcggcgttg ttctgcgtgg cggccggggc ggtgaccgcc accttgccgc 3001 tgctgctggg taccggaggc gtccgggccc cgcgctgacc gccgggccgc cctcagccgc 3061 gccgggcgaa ccccttgcgc agcagcgccg gcacctcctc ctcggggacc tgggccgcgg 3121 cgagcggatc ggtcagcacg gcgccgtcca gcgcgtggtg gcaggcgcag tcggctgggg 3181 cggtggcgtg ggcgaggccg gagagcacgg cgcgggcggc gatgacgttg gcggccatca 3241 cctcggcgac ggtgcgggcg tccaccgagt cgtgtccggt gtgccagcag tcgtagtcgg 3301 tgaccaacga cagcccggcg tagcacagtt cggcctcgcg ggcgagtttc gcctcgggct 3361 gggcggtcat gccgatgacg tccatgcccc aggcgcggta cagctgggac tcggcccggg 3421 tggagaactg cgggccctcc atgcacaggt aggtgccggc cgggtggacg gtggggtggg 3481 cggcccgggc ggcgtcggtg agggcggcgc gcagccgggg gcagtagggg tcggccagcg 3541 agacgtggac gacgacgccg gaggagaaga aggtcgcggg ccggccgccc cgggtgcggt 3601 cgatgatctg gtcggggacg acgaggtggc cgggggcgta ctcctcgcgc aggctgccga 3661 ccgcgctgac gctgacgacc tcggtgaccc cgagcgcctt gagcgcgtag aggtttgccc 3721 gcaccgggat gcgggagggc ggtatgcggt ggccggtgcc gtggcgggcc aggaaggcca 3781 cccagcgtcc gccgacggtg ccgacgaccg gcggtgcgct gggcgggccg tacggcgtct 3841 cgaccgggaa ttcctcgggg tcggtcaggc ccgggaattc gtacagtccg ctgccgccga 3901 tgatgccgag atcggcgttc cgctgctcgt tccccgattt ccgtgcccgc atgcgcgcac 3961 ctccggtcgt agctgatcgc ggatccgcgc aatctaacag gcggcggctg cgggcgacag 4021 cgccggaatt cgcaacctgt gccggggaac catgccgact acacccttcg gtgcagggtt 4081 ggtgtgccct tgggccgatt tcccttgtcg ttcccggcat ttatggtcga tcgggtctga 4141 tccaccagga gcgatcgcag gaggaattca cgtggctgcg aacagcacac gtcgccccat 4201 catcgcgttc atgagcgacc tggggaccac ggacgactcc gtcgcccagt gcaaggggct 4261 catgtacagc atctgcccgg acgtcacggt ggtggacgtc tgccactcga tgacgccctg 4321 ggacgtcgag gagggcgccc gctacatcgt ggaccttccg cgcttcttcc ccgagggaac 4381 ggtcttcgcc accaccacct atccggcgac cggcaccacc acccgctcgg tggcggtgcg 4441 catcaagcag gccgccaagg gcggtgcccg cggccagtgg gcgggctcgg gggccggctt 4501 cgagcgcgcc gagggctcgt acatctacat cgcgcccaac aacgggctgc tgaccaccgt 4561 gctggaggag cacggctacc tggaggcgta cgaggtcacc tcgccgaagg tcatccccga 4621 gcagcccgaa ccgaccttct acagccggga gatggtggcc atcccctccg cgcacctggc 4681 cgccggcttc ccgctgtccg aggtcggccg tccgctggag gaccacgaga tcgtccgctt 4741 caaccgcccg gccgtcgagc aggacgggga ggcgctggtg ggcgtggtct ccgccatcga 4801 ccacccgttc ggcaacgtgt ggaccaacat ccaccgcacc gacctggaga aggcgggcat 4861 cggctacggc gcccggctgc ggctgacgct ggacggcgtg ctgccgttcg aggcgccgct 4921 gaccccgacg ttcgccgacg ccggtgagat cggcaacatc gccatctacc tcaacagccg 4981 cggttacctg tccatcgcgc gcaacgcggc cagcctcgcc tacccgtacc acctcaagga 5041 gggcatgtcc gcccgggtcg aggcccgctg acccccttcc ggccgtcccg tccgcgccgg 5101 cgggcggggc ggccggaacg cgcgacgacg taccctcgtg cggcgtgagg gacggcgtgg 5161 cggacggtgt ggcgggacgg gtacgggggc gcgggatgga gcgggccgag ggggtcgggg 5221 tgaccgtcgg tgcgcaggtg cgccggctgc gggagttccg cgggctgtcg gtggcggagt 5281 tgtcccggct gtcgggggtg agccgggcga cgttgtcgat gctggagtcg gggcggggca 5341 acccgacgat cgagacggtc tcggcgatcg cggtggcgct gcggctgccg ctgggcgatc 5401 tgctggtgga ccccaccccg ccggagccgg tgctgcggcc gggcacgccg cgtccgcaga 5461 ccagccggca ggacctgctg gaccggatcg gggcgggcgg gcacagcgag atatggcggc 5521 tgcggctgtg cggggcgggc cgccgggtcg acagcccgcc gcacacccgc ggcaccctgg 5581 agcgggtggt ggcgctgcgc ggccggctgc ggctgggccc ggtggaccgc ccggtggtgc 5641 tggccaccgg tgacttcgtg gtcttcccgg cggacgaacc gcacttctac gaggcggtgg 5701 acgacgagga cgtggacgcg gtgatcgtga tgacctatcc ggcggcgtcg taggccctgt 5761 cgtcgaaagg tcgccgcccg cccggagggc ggtgccccgc ggcttccacg ggggtccccc 5821 caggtgaggc ggagcccgac cgtgcgggcc gacggccgac aacgccgcga gcgcgcgggg 5881 cagacgtcgc ggggcagacg tcgcggggca gacgtcgcgg ggcaggcgac atgttgacga 5941 cagggcctag gccaggtcgt agtcggtgat cggtaccggg gtgcggacca tgccgcgttc 6001 caccgccttg cggacggcct cggtgcggca ggcggcgtcc aacttggcgt agacgttgga 6061 cagatggcgt ttgacggtgc cctcggtgat gaccagttcg cgggcgatct gtgagttgcg 6121 caggcccctg gcgaccaggg cgacgacctg gagttcgcgg gcggtcagca ggtgcgggcc 6181 ggtctcgcgc agcccggcca gggtgcgctg ggagaccgag agcaccaccc ggtcgcggtg 6241 gccggccacc ccgcggatgg tgccgatcag ttcctcgggg ctgctgtact gggcgatcgc 6301 ggcctgggcg ccggccgcca ggagtctgcg gaccgcgccg gggtcgtcgt gggcgagcat 6361 cgccacgatc cggctgaccg gggtggcccg gcgcaactcg gcgacgtcgc cgtagggttc 6421 ccggccgccg gaggcgacgc cgagcagcac gacgtggggc tggcgggcgc gcagcgcgga 6481 gagcccctcg cgtacgtggg ccgactcggc gactacttcg agggcgggtt cggcggcgag 6541 cacgtgggcc agtccggtgc gcaggaagac gttgtcgtcg acgacggcga gccggatcgc 6601 cgcctgctgc cggcggactg cggccgtcgc ggcgccgcgg tggagggtca tgcggtttcc 6661 gcctttcgcc tggtggtctc ggggtccggc gtcccccgtt caccgccggt cggtcggcgt 6721 tgcgacatca gcgggcggtg gcggcgcacg gtgcggccga gccagacgcc cgcggcctgg 6781 gaggtgacga tggagagcac caccaggctg gtgaagaagt cctcgctgat gacgccggcc 6841 gcgtaggtga ccgacgccag gatgatgccg gggccgccgc gggcgttcat ggccaccgcg 6901 atgttcccgg ccgacgcggc gtcctgcccg gccaaccgtg cccccgccca caccccggcc 6961 gacttgacca cgcaggccag cgccaggaac cacaggaaga acaccgggtc gaagtggcgg 7021 atcaggtcga gcttgaggcc gacgacggcg aagtagacgg ggacgaagaa ggcgagcgag 7081 atggcccgca gggtctggta cgaccccggg gcggcgtccg cggcggcctc cggcacggcg 7141 ggcgccgcgc gttcctcgcc gggcaccggg ccgccggcgc tcagcccggc cgccagcgcg 7201 ccgaacatcg ggtcgatgcc gaggccggag caggccaggc agagcgcgaa gaggtaggcg 7261 atccggaacg cggtcgggct gcgccgttcc aggacgttcc agcggccgga gcgcagcgcg 7321 tcgaaggcgg cccggccgcg ccacaggaag agcccgaaga agaccaccgg gacgagggag 7381 aagaagacca ccgcccacgg cagcgacacc cggctgagcg ccccgccgac gccgtaggag 7441 tcgcccgccc tggcctgggc gatgccgagg acgacggcga gcagcgcgta gagcaccacg 7501 tcctccagga ccgcgacggc gagcaccacg cgggcgaaga cggtgcgcag gatgcccagg 7561 tcgagcatga tccgggagat caccgggacg ctggtgacgg cgatcgccat gccgaagacg 7621 agggcgaggc tggccgggtt gccgtgcggc ccggaaaggc cgggcaggga tacggagttg 7681 gccaccagca gcccggcggc gaacgggacg aagaggccgg cgccggccac ccagaccatg 7741 gtgcgccggt cggagcgggc gacgtggccg cgcagttcgg cgccggtgag gtagaccagc 7801 agcagcatcc cgatgctgta gaaggcgccg agcacctcgc cggtggcgcc cttggccggg 7861 aagagccacg tctcggcggt gggccacagc gcgccgagca cggtggggcc cagcaccagg 7921 ccgccgacga tctcaccgat caccggtggc tgccgcaaca gttggaagat ctgggcgccg 7981 gcgtgggcca gcaccgtcaa cagcccgagg gcgatgagga catgggcgag ttcgacggtt 8041 gtcagggaca ccgggcacct cccgaaggcc gggccgaaac cgcatcaggt gaattcctat 8101 cggagcggtt cgccggtgtc catcgcccgg tcggctattc cttgcgggct ttccgttccg 8161 ccgtgcggat tccgtctccg ggtggagttc gcggggcgtt caccacctgg cggcggaggg 8221 cgactttccg catcgcgacg gatgcgccag ggcaccggtc gcggcaggct ggcccggaca 8281 accacacagg caccaccggc agtcgaaggc tggagcatgg cagtcgtacc atccgggtcc 8341 ggggcgcagc ggccggttcc ggaattcaag gtggccgatc tttccctggc ggaattcgga 8401 cgcaaggaaa tcacgctggc cgagcatgaa atgccggggc tgatggcgat gcgggcggaa 8461 tacgccggga gccggccgct gcgcggggcg cgggtcagcg gttcgctgca catgacggtg 8521 cagacggcgg tgctgatcga gacgctgacc gcgctgggcg cctcggtgcg ctgggcgagc 8581 tgcaacatct tctccaccca ggaccacgcc gcggcggccg tggtggtggg cccgcacggc 8641 acccccgagg aaccgcgcgg ggtgccggtg ttcgcgtgga agggggagag cctggaggag 8701 tactggtggt gcacccggca ggcgctgacc tggccggagg ggggcccgca gctgatcgtg 8761 gacgacggcg gcgacgccac cttgctggtg cacctggggg tggagtacga gaaggcgggc 8821 gcggtgcccg acccggccac cgccggctcg gaggaggagg cggtgatcct gcggctgctc 8881 gccggcacgc tgcgcgaaca gccgcggctg tggacgacgg tggcccggga cgtcatcggg 8941 gtctcggagg agaccaccac cggggtgcac cggctctacg agcgggagcg cgacggcacg 9001 ctgctgttcc cggcgatcaa cgtcaacgac tcggtgacca agtcgaagtt cgacaaccgc 9061 tacggggtgc gccactcgct ggtggacggg atcaaccggg gcaccgatgt gctcatcggc 9121 ggcaaggtgg cggtggtctg cggctacggg gacgtgggca aggggtgcgc ggaggcgctg 9181 cgcggccagg gcgccaaggt gacggtgacc gaggtcgacc cgatctgcgc gctccaggcg 9241 gccatggacg gctacccggt ggccaccttg gaggacatgc tgcccaccgc ggacatcgtg 9301 atcaccgcca ccggcaaccg ggacatcgtg cgggtggagc acatggccgc gatgaagcac 9361 ctggcgatcg tgggcaacat cggccacttc gacaacgaga tcgacatggc cgggctcgcc 9421 ggcttcccgg ggatccgccg cgtgaacatc aagccgcagg tggaccagtg gacgttcccg 9481 gacggccacg cggtgctggt gctcagcgag ggccggctgc tcaacctggg gaacgccacc 9541 gggcatccga gcttcgtgat gtccaacagc ttcgccaacc aggtgatcgc gcagctggag 9601 ttgttcaccc gggccgagga gtacccggtg ggcgtccacc ggctgcccaa gcggctcgac 9661 gagaaggtgg cccggctcca cctgtcggca ctgggcgccc ggctgactaa gctgaccaag 9721 cgtcaggccg actacatcgg ggtccccgtg gagggcccgt acaagccgga ccactaccga 9781 tactgagggg ggacgcccgg gatggaagcg ccccgtcccc ggccggccgg cgcgttgcgc 9841 cgcctgaccg tcttcacgga tctggccgac cggtgcgcgg ggcgcccgcg gtacgccgag 9901 atcgtccgcc tcggccgtca gcgcgggtta cgcgggatga gcgtgctgcg cggcatcggc 9961 ggctacggcc gctccggggt ggtgcgcgag ggcgggctgc tgcgcccgcc ccgcgacctg 10021 ccggtgatgg tggtggcggt ggacaccgcc gaggccatcg agtcgttcct gccggtgctg 10081 gagcggatcg cgccggagaa cctgatcgtg ctggacgagg tgcgggcggt gcgcttcccg 10141 gcgccggggc gcgggccggg gccggatccg ctcagccggc cggggtcttc tgcctgacct 10201 tggcgttgaa cttctccagg tggatcacgg cgcgctcgtg ggtgccggag ccgatctcgt 10261 ccaccccgtc gtgggcgctg acccgccagc tgagccgccg tccctcgacc gagcgcagtt 10321 cggcggtgac ggtgacggtc aggcccggcg gggtggcggc ggtgtgggtg acgcagatgg 10381 cggtgccgag gctgccctcg ccgggttcga ggtagggcgc catggcccgc acgcacgccc 10441 actccatcag ccccaccatg aacccggtgg cgaacacctc gggaaattcg gcgaattcgg 10501 gggactcggg gtacaggtgg cgcaccgtct tgtgcggcgg gaccacgaag tcgtgggtga 10561 accgctcgcc gacccgcatg ccgtccttca tgggccactc ctcactggtg ccggggcgaa 10621 gggaccgatc tcgccgttcc catggtgccc cgggggcccg ctccggcggt ggctttccgg 10681 ccgggtggcg gccggtcagc cccggccggg gacggggacg gtgaccagtc cggtgcggta 10741 ggcgcaggcg atggcctggg agcggttgcg caggcccagt ttgcccagca ggcgggagac 10801 gtgggacttg acggtggcct cgccgaggga gaggtggccg gcgatctcgg cgttggacat 10861 cccggcggcc atcagccgca gcacctccag ttcgcggccg gtcagcccgg ggacgccggg 10921 ggcggcaccg ggccgggcgg cgccgccgga tccggtcagc cacggcccgt ccgccagcac 10981 cgccgggggc agcacggcgt acccggcggc caccgcgcgg gccgccgtca ccaggcggcg 11041 cggcgggtcg ccggtggaga cgaaggcccg gccgccggcc atcagcccct gcaccgccag 11101 cgccgggtcg aagctctgcg cgaggaagac caccccggtg ctgcgggtct ccggggcgcg 11161 ggcgagggcg cgggccacct cgaagccgtg gccgccgggc aggtcgaggg cggtgaagag 11221 caggtcgggg cggagccgcc ggaccgtccg cagcgcctgt tccccgtcgg ccacctcggc 11281 gaccacctcg atgtccggct cgccggccag gatggcgcgc agcccgccgc ggatgaggag 11341 gttggggtcg cacagcgcga tggtggtcac catgggtccc tccggacgag ggcgggggcc 11401 gggcctggcc cggaggtggc atccgccgta cgccaagtgg tgtacacacg gcgtgccatg 11461 gcgaatatgc cgtaagcaac agagggccac aacgcgcatt ccggacagtc tcggcggtcc 11521 cggcctcccc agccggtggc ccgtgccaca gccgccgtgc cccgcgcgcc ggtgacgacc 11581 gcccgacgag cgggtatccg ccctgtgcgg gggagcgtgc cggtggcgtg ttccggaccg 11641 ttccggccgg gccgggacgg cggggcgggc ccggctcggc gatgctgtgg acgccggacc 11701 ggaaccgtcc gtgacgacac cggaaggttg cccttcccga tcggccgtga ccgcggtacg 11761 tccccaacat gaccggccac cgctgtccgc cgtgcggggt cccccacgcc gaaggcggaa 11821 gtacccgatg agcgctcgca aaccgttgtc gtgggtcgcc gccgtgctcg accagctcac 11881 cgaccggctg gcgggcgcgg ccggcggcca tccggcggcc tggggcgggg ccgaccggcg 11941 tccgcccagc ctcggcgaac tcgacctgca tttgatcggc cgcggccggc acgagcggct 12001 gtg //