LOCUS AJ875405 11251 bp DNA linear BCT 23-OCT-2008 DEFINITION Klebsiella pneumoniae plasmid pCC416 traA gene (partial), tnpA gene, blaCMY-4 gene, blc gene, sugE gene, ORF1, ORF2, dsbC gene and traC gene (partial). ACCESSION AJ875405 VERSION AJ875405.3 KEYWORDS blaCMY-4 gene; blc gene; BLC protein; CMY-4; dsbC gene; DsbC protein; ISEcp1; ORF1; ORF2; sugE gene; SugE protein; tnpA gene; traA gene; TraA protein; traC gene; TraC protein. SOURCE Klebsiella pneumoniae ORGANISM Klebsiella pneumoniae Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella. REFERENCE 1 (bases 1 to 11251) AUTHORS Colinon C. JOURNAL Submitted (14-JAN-2005) to the INSDC. Colinon C., Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Ospedale "le Scotte", Viale Bracci, lottoV IoS, 53100 Siena, ITALY. REMARK revised by author [02-NOV-2005] REFERENCE 2 AUTHORS Colinon C., Miriagou V., Carattoli A., Luzzaro F., Rossolini G.M. TITLE Characterization of the IncA/C plasmid pCC416 encoding VIM-4 and CMY-4 beta-lactamases JOURNAL J. Antimicrob. Chemother. 60(2), 258-262(2007). PUBMED 17540674 FEATURES Location/Qualifiers source 1..11251 /organism="Klebsiella pneumoniae" /plasmid="pCC416" /isolate="VA-416/02" /mol_type="genomic DNA" /geo_loc_name="Italy:Lombardia" /db_xref="taxon:573" CDS <1..187 /codon_start=2 /transl_table=11 /gene="traA" /product="TraA" /function="sex pilus assembly" /db_xref="UniProtKB/TrEMBL:A6GV48" /protein_id="CAJ42040.1" /translation="ILVGVVGGIARQSLMAFAMGIGGGMGLYNSPTVVESIMSATLEH AEKVIPAVVQLSNGLGV" repeat_region 286..315 /rpt_type=TERMINAL /note="IRL ISEcp1" CDS 472..1734 /transl_table=11 /gene="tnpA" /product="ISEcp1" /function="transposase" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR025668" /db_xref="UniProtKB/TrEMBL:Q6SLK9" /protein_id="CAI44914.1" /translation="MINKIDFKAKNLTSNAGLFLLLENAKSNGIFDFIENDLVFDNDS TNKIKMNHIKTMLCGHFIGIDKLERLKLLQNDPLVNEFDISVKEPETVSRFLGNFNFK TTQMFRDINFKVFKKLLTKSKLTSITIDIDSSVINVEGHQEGASKGYNPKKLGNRCYN IQFAFCDELKAYVTGFVRSGNTYTANGAAEMIKEIVANIKSDDLEILFRMDSGYFDEK IIETIESLGCKYLIKAKSYSTLTSQATNSSIVFVKGEEGRETTELYTKLVKWEKDRRF VVSRVLKPEKERAQLSLLEGSEYDYFFFVTNTTLLSEKVVIYYEKRGNAENYIKEAKY DMAVGHLLLKSFWANEAVFQMMMLSYNLFLLFKFDSLDSSEYRQQIKTFRLKYVFLAA KIIKTARYVIMKLSENYPYKGVYEKCLV" repeat_region complement(1918..1941) /rpt_type=TERMINAL /note="IRR ISEcp1" CDS 2058..3203 /transl_table=11 /gene="blaCMY-4" /product="CMY-4" /function="cephamycinase" /db_xref="GOA:O53044" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR001586" /db_xref="InterPro:IPR012338" /db_xref="UniProtKB/TrEMBL:O53044" /experiment="experimental evidence, no additional details recorded" /protein_id="CAI44915.1" /translation="MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQA IPGMAVAVIYQGKPYYFTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDAIARGE IKLSDPVTKYWPELTGKQWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQP QWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPQNEQKD YARGYREGKPVHVSPGQLDAEAYGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQ SRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVH KTGSTGGFGSYVAFVPEKNLGIVMLANKSYPNPVRVEAAWRILEKLQ" CDS 3297..3830 /transl_table=11 /gene="blc" /product="BLC" /function="outer membrane lipoprotein" /db_xref="GOA:A6GV55" /db_xref="InterPro:IPR000566" /db_xref="InterPro:IPR002446" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR022271" /db_xref="InterPro:IPR022272" /db_xref="UniProtKB/TrEMBL:A6GV55" /protein_id="CAI44916.1" /translation="MRILPVVAAVTAAFLVVACSSPTPPKGVTVVNNFDAKRYLGTWY EIARFDHRFERGLDKVTATYSLRDDGGINVINKGYNPDREMWQKTEGKAYFTGDPSRA ALKVSFFGPFYGGYNVIALDREYRHALVCGPDRDYLWILSRTPTISDEMKQQMLAIAT REGFEVNKLIWVKQPGA" CDS complement(3827..4144) /transl_table=11 /gene="sugE" /product="SugE" /function="efflux transporter" /db_xref="GOA:A6GV56" /db_xref="InterPro:IPR000390" /db_xref="UniProtKB/TrEMBL:A6GV56" /protein_id="CAI44917.1" /translation="MSWIVLLIAGLLEVVWAIGLKYTHGFTRLTPSIITIAAMIVSIA MLSWAMRTLPVGTAYAVWTGIGAVGAAITGILLLGESASPARLLSLGLIVAGIIGLKL STH" misc_feature 4401..4766 /note="similar to response regulator EcnR" CDS 4860..8576 /transl_table=11 /gene="ORF1" /product="hypothetical protein" /note="similar to ORF131 from plasmid pCAR1 from entry AB088420" /db_xref="InterPro:IPR022038" /db_xref="InterPro:IPR025429" /db_xref="UniProtKB/TrEMBL:A6GV49" /protein_id="CAJ42041.1" /translation="MENAMINFKPKIPAMLGALAVLTAGAAHAELLEYTFKAPDGTQR SLTPNANYANPTGNISFALSAGIDRKVKISVLRSDGTVVSTATSHLLGATDRITVGGK SYYGAELQLPAPVGGAYTIRAEILASDGSTVQTDEYPLTVDVTPPTYSSLAPVYSNYG QVTSGDVWKLGLGGSEDNAFLLSGISDESPIKGVKAKLYRQDGSLYKDVSVNYDDANG QARQSFQSGFFPASDLDEVFTLQFEISDSAGNSYLSPRQKVMFDSITNAPSAPFGVYD PSSTNNLGPGLTGFVAYTEGMTVKTNPIKLAWRVPRDNWHEYREGGINMTNALGEMSK VGEDASYVYLVTTAPYGNTDGNYWRWVNFGQWGGGGIAYNLTLSPSAPKSPRLLGVDY NYSDIGWSSFYRYWVNNSVLPVTVSSIRVKVEPRPYVQTAVHRGSCEIPVGQDSCVIA NSFTMAKGTTGYVHDNATVFNPDKSLRSNPLWAEVNWNDQHYPQLSQQFDQNSKVFTL FVNQPGRGAYFDRLRLRSAWIEDSKGNKLSPTGGLIANNWENYTYQWDLKTLPEGQYS LVAAAEEMHGPLTRQPMFQITSDRTPPTMTLSVADGAAIQTLDDVVITLADAIDPSPK LTSIALVGGPANDKVQLSWREESKGRFRLEYPVMFPSLKEGESYTLTVSGEDAQGNAV QKAVGFEYKPRQVMLADGMDGKVMVPAVTHEFVHADGKRIIETKPLTLSDGAVVTGSY DVFATLRSDAKVPLVVNGVRIEPGQTMGIMSQHDFGASGGRLSIPVKPAVPDVVGSSS LLVMTSAPNSPILVVDINTWKGTAKLSAESWTIRQVIDPVKIYALPESGVPCRFTTKE DVAMAADPIRDPVCLLQWDRTPDEAEQTTQDNNGMKVAGLVGQAVSIGEQPVEYSLYL FSGDGSKVKVGSGSQNLTVTTAYGSVGYTPIDDIAQVNRVIEDFDVNFKQSKGPDCSI TLSADRAKKEAANKAVGSASRACLFEWQQIPDGLVQDPLSESPSLSGSLASNGVHPLG WRVSIFTRNGTRVTLNDETFNVEAVDPPAPTVELASDYNFKDNIYLVPMTGNYLGDAI INSERADLDIAISRNSDVLESETFTPGWGATNKVYRRINTDERALWEETTYKVNAAYN KVPDVKTEVVYRAISAPSDSIRPIVEVKGDTAIDTQALPVRVLIRDQYKPDGDYDANT MGVWKVRLIQQKAYNETVALTDYAKHRTVKLSSQ" CDS 8700..10358 /transl_table=11 /gene="ORF2" /product="hypothetical protein" /note="similar to ORF136 from plasmid pCAR1 from entry AB088420" /db_xref="UniProtKB/TrEMBL:A6GV50" /protein_id="CAJ42042.1" /translation="MVPSVLAWRLASCLVKLRYTAVFKLSLDDRQDLRATGQVVWETS KDDGKTWEQFIPEDRYKYQLVKTFDKGEYQVRAKVVNVNSGAEKYTEAVSVVAYDKPD IAVIGPTTLFVGSEGKYTANLTLNDEPISGGNAIVEWSTDGGKTYAQTGDSITLSSDE ETRYRLWARVRSATAPADDGYAYEVAKTAVDFRAVKAPRPYVTGPRVIETGKKYVFKA ETSLPYRGMDVKLNGFFTLPDGSIVQGDTAEVRTLYTDLNQATVETKYTTWIEGYRDQ GAEASHSLRSRVWQYVWPSFGMQVRKNADVAPATITASVRPIAFNGKLEEPTYEWELP EGAVIQDQRQDIVRSFVINEPGDYNIKVTVRDARGHETVIEQPLKIGQAAPYAIDLQY SGSNKYEREPLDVLLRPYISGGHPRDRISTRVYSVDGTPLESSGYYGRATLGAGEHSI KLKITSEMGHEAEGEVNINVAENKLPACSLSSRETVGSWIVYANCEDTDGRMKSYEWT IAGELQSISSDRVTISKGTYETMPTISLVGVDDSGGKSEAVTMN" CDS 10507..11214 /transl_table=11 /gene="dsbC" /product="DsbC" /function="disulfide bond isomerase" /db_xref="GOA:A6GV51" /db_xref="InterPro:IPR009094" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR018950" /db_xref="InterPro:IPR033954" /db_xref="InterPro:IPR036249" /db_xref="PDB:4ML1" /db_xref="PDB:4ML6" /db_xref="UniProtKB/TrEMBL:A6GV51" /protein_id="CAJ42043.1" /translation="MRTKLLGALMVFGIITGTAHASSKLEITDPRAAKIEDIVELPIK GVRAVQSDGQIMFLSENGRFVISGQIYDLWSKKPLNTMSQMRDVAERIHFKSMGMDVD TLNTVSMGRGDKEVVVFVDPRCAVCHQLMGDAKSLVDDYTFKFIVIPALGAESNRLAK NLYCAKDKTHALDALMNNTLGSLPSKETCDPGQYDQTLLTAHFIGIEGVPFVVAPDGR VSKGRPKNLKSWLESAE" CDS 11211..>11251 /transl_table=11 /gene="traC" /product="TraC" /function="sex pilus assembly" /db_xref="UniProtKB/TrEMBL:A6GV52" /protein_id="CAJ42044.1" /translation="MIVTIKKKLEETL" BASE COUNT 2999 a 2637 c 2837 g 2778 t ORIGIN 1 gatcctggtc ggtgttgttg gtggtatcgc tcgccagagc ctcatggctt tcgctatggg 61 tatcggtggc ggtatgggcc tgtacaactc cccgaccgta gtggaatcca tcatgtctgc 121 tactctggaa catgcagaga aggtcatccc ggctgttgtg caactcagca atggcctggg 181 ggtgtaaaag acaccttgcc gttaatcaac gggtgatagg ggcagcctaa aagctgccct 241 tattttttgg caaaaagtcc agtcataaca aattccaact atttccctag attctacgtc 301 agtacttcaa aaagcataat caaagccttg ataaatatgc attccttcga aattcagctt 361 tcacccattg ggtgaaagaa aagtgctcaa aaatatgtta aattatcagc ttttatgact 421 cgatatatgg taaaataata gtaagaaaag tagtaaaaag gggttctaat tatgattaat 481 aaaattgatt tcaaagctaa gaatctaaca tcaaatgcag gtctttttct gctccttgag 541 aatgcaaaaa gcaatgggat ttttgatttt attgaaaatg acctcgtatt tgataatgac 601 tcaacaaata aaatcaagat gaatcatata aagaccatgc tctgcggtca cttcattggc 661 attgataagt tagaacgtct aaagctactt caaaatgatc ccctcgtcaa cgagtttgat 721 atttccgtaa aagaacctga aacagtgtca cggtttctag gaaacttcaa cttcaagaca 781 acccaaatgt ttagagacat taattttaaa gtctttaaaa aactgctcac taaaagtaaa 841 ttgacatcca ttacgattga tattgatagt agtgtaatta acgtagaagg tcatcaagaa 901 ggtgcgtcaa aaggatataa tcctaagaaa ctgggaaacc gatgctacaa tatccaattt 961 gcattttgcg acgaattaaa agcatatgtt accggatttg taagaagtgg caatacttac 1021 actgcaaacg gtgctgcgga aatgatcaaa gaaattgttg ctaacatcaa atcagacgat 1081 ttagaaattt tatttcgaat ggatagtggc tactttgatg aaaaaattat cgaaacgata 1141 gaatctcttg gatgcaaata tttaattaaa gccaaaagtt attctacact cacctcacaa 1201 gcaacgaatt catcaattgt attcgttaaa ggagaagaag gtagagaaac tacagaactg 1261 tatacaaaat tagttaaatg ggaaaaagac agaagatttg tcgtatctcg cgtactgaaa 1321 ccagaaaaag aaagagcaca attatcactt ttagaaggtt ccgaatacga ctactttttc 1381 tttgtaacaa atactacctt gctttctgaa aaagtagtta tatactatga aaagcgtggt 1441 aatgctgaaa actatatcaa agaagccaaa tacgacatgg cggtgggtca tctcttgcta 1501 aagtcatttt gggcgaatga agccgtgttt caaatgatga tgctttcata taacctattt 1561 ttgttgttca agtttgattc cttggactct tcagaataca gacagcaaat aaagaccttt 1621 cgtttgaagt atgtatttct tgcagcaaaa ataatcaaaa ccgcaagata tgtaatcatg 1681 aagttgtcgg aaaactatcc gtacaaggga gtgtatgaaa aatgtctggt ataataagaa 1741 tatcatcaat aaaattgagt gttgctctgt ggataacttg cagagtttat taagtatcat 1801 tgcagcaaag atgaaatcaa tgatttatca aaaatgattg aaaggtggtt gtaaataatg 1861 ttacaatgtg tgagaagcag tctaaattct tcgtgaaata gtgatttttg aagctaataa 1921 aaaacacacg tggaatttag gaaaaactta tatctgctgc taaatttaac cgtttgtcaa 1981 cacggtgcaa atcaaacaca ctgattgcgt ctgacgggcc cggacacctt tttgctttta 2041 attacggaac tgatttcatg atgaaaaaat cgttatgctg cgctctgctg ctgacagcct 2101 ctttctccac atttgctgcc gcaaaaacag aacaacagat tgccgatatc gttaatcgca 2161 ccatcacccc gttgatgcag gagcaggcta ttccgggtat ggccgttgcc gttatctacc 2221 agggaaaacc ctattatttc acctggggta aagccgatat cgccaataac cacccagtca 2281 cgcagcaaac gctgtttgag ctaggatcgg ttagtaagac gtttaacggc gtgttgggcg 2341 gcgatgctat cgcccgcggc gaaattaagc tcagcgatcc ggtcacgaaa tactggccag 2401 aactgacagg caaacagtgg cagggtatcc gcctgctgca cttagccacc tatacggcag 2461 gcggcctacc gctgcagatc cccgatgacg ttagggataa agccgcatta ctgcattttt 2521 atcaaaactg gcagccgcaa tggactccgg gcgctaagcg actttacgct aactccagca 2581 ttggtctgtt tggcgcgctg gcggtgaaac cctcaggaat gagttacgaa gaggcaatga 2641 ccagacgcgt cctgcaacca ttaaaactgg cgcatacctg gattacggtt ccgcagaacg 2701 aacaaaaaga ttatgccagg ggctatcgcg aagggaagcc cgtacacgtt tctccgggac 2761 aacttgacgc cgaagcctat ggcgtgaaat ccagcgttat tgatatggcc cgctgggttc 2821 aggccaacat ggatgccagc cacgttcagg agaaaacgct ccagcagggc attgcgcttg 2881 cgcagtctcg ctactggcgt attggcgata tgtaccaggg attaggctgg gagatgctga 2941 actggccgct gaaagctgat tcgatcatca acggcagcga cagcaaagtg gcattggcag 3001 cgcttcccgc cgttgaggta aacccgcccg cccccgcagt gaaagcctca tgggtgcata 3061 aaacgggctc cactggtgga tttggcagct acgtagcctt cgttccagaa aaaaaccttg 3121 gcatcgtgat gctggcaaac aaaagctatc ctaaccctgt ccgtgtcgag gcggcctggc 3181 gcattcttga aaagctgcaa taactgacga tgaggcccag gatattgggc ctcctttctt 3241 tctctttttt tcctgttgtc atctacactt aacaaaaata cagcaaggaa aatcccatgc 3301 gcattttgcc cgtcgttgct gcagttacgg ctgcattcct ggttgtcgcg tgtagctccc 3361 cgacaccgcc gaaaggcgtt accgtggtaa ataactttga tgccaaacgc tatctgggaa 3421 cctggtatga aattgcgcgc ttcgaccatc gtttcgagcg cggattggat aaagtgaccg 3481 caacatacag cttgcgcgac gacggcggca tcaacgttat taacaagggc tataaccctg 3541 acagggagat gtggcagaaa acggaaggga aagcctattt caccggcgac ccaagcagag 3601 ccgcgcttaa ggtttctttt ttcggcccct tctatggcgg gtataacgta attgcactcg 3661 accgggaata tcgtcacgcg ctggtttgtg gtccggatcg cgactacctg tggatccttt 3721 cacggacccc tactatttca gatgaaatga aacagcaaat gttagccatc gcgacccggg 3781 aagggtttga agtgaataaa ctgatttggg tgaaacagcc tggcgcttag tgagtgctca 3841 gcttcagacc aataatgcca gcaacgatca gcccaaggct cagcaaacgt gccgggctgg 3901 cagactcacc cagcagcaaa atccctgtaa tggccgcccc aacagcgcca ataccggtcc 3961 agaccgcata agcggttcct acaggcaacg tgcgcattgc ccaagagagc atggcgatac 4021 tgacgatcat cgccgcaata gtgataatgc ttggcgtaag acgcgtaaaa ccgtgggtgt 4081 atttcaggcc aatcgcccag acaacttcga gcaaacctgc aattaataaa acgatccagg 4141 acatatcagg ctccagaaca atggggccgt ccccggtgaa agaagcgttt gcaggtcgtc 4201 ctgcaaagct aatgtgtgaa atggcatttt tgcccggaag aaaatgaatt tcaacctttt 4261 tattcaccgc ctgctaaaag caagaattaa gcataattag cggcgtagtt cccgcatttg 4321 gcactcatcg gagttctcta tgatgaaggg ctttctgaaa ccagaaagtc gattgcccct 4381 cttctgaatg cgaaacgttt atgcttaaaa ttttagtgat tgaccggtgc cactttaccc 4441 gcacagggat agaggccttg cttaatcatt ctggcaggtt cagctcctca tttctggtat 4501 caggaatcaa taatctcctg ttagcaaaag agcatatttt gcaatggaaa ccgcatctgg 4561 tgatcgcgga tttatacagt tttattagcg agacgcactc cagtccgcca attaaacctt 4621 tttttatgag ttgtggcgtc atcccactaa ttttactgca atcagcagac agacagcatg 4681 cacccatcgt gccctctcaa tccgtagccc attcggtctt gaccaagcac accacgctga 4741 acacactctc ccacacaatt caggatttcc ttatttgctc aaaaagggca cttccacagc 4801 ccatgtttat gcactccctc ccgtaacctc cagcattggg ttcttgtaac tcaaaacgaa 4861 tggagaatgc gatgatcaat ttcaagccta aaattccggc gatgcttggg gctctggcgg 4921 ttcttaccgc tggtgctgct catgcagagc tgctggaata cacctttaag gctccagatg 4981 gtacgcaacg gtctctgact ccgaatgcca actatgccaa cccaacgggc aatatctcgt 5041 ttgccttgag tgccggtatc gaccgaaagg taaagatttc ggtgcttcgg tcggatggaa 5101 cagtggtttc gacagcgacc agccaccttc ttggggctac tgatcgcatc acagtgggtg 5161 gaaaatccta ctatggtgcg gaacttcaac taccagctcc agttggtggg gcatacacta 5221 tcagggcgga aattcttgcc tctgatggtt ctacagtaca gacggatgaa taccctctta 5281 ctgtcgatgt gacgccgcca acctactctt cgcttgcccc ggtttatagt aactatgggc 5341 aggttactag cggtgatgtt tggaaactgg gtctaggtgg ctctgaggat aatgcctttt 5401 tgctgtcagg aatctctgat gagtcaccca tcaaaggcgt caaagcaaag ctgtatcgtc 5461 aagacggttc actctacaaa gatgtatccg tgaactacga tgacgctaac ggacaagcta 5521 gacagtcttt ccaatctggc tttttcccag cctctgactt ggatgaagtg tttacacttc 5581 agtttgagat aagcgatagc gctggaaata gctatctttc acctcgtcaa aaagtgatgt 5641 ttgatagcat aaccaatgct ccgtctgcac cttttggtgt ttatgaccct tcaagtacaa 5701 acaacttagg ccctggatta accggatttg ttgcttacac tgagggcatg acagttaaaa 5761 ctaacccaat caagttagct tggcgtgttc cgcgtgataa ctggcatgag tatagagaag 5821 gtgggataaa tatgaccaat gccttgggag agatgtccaa ggtaggagaa gatgccagct 5881 atgtttatct cgtcacaacc gcaccttatg gcaataccga cggcaattat tggcgttggg 5941 tgaacttcgg ccagtggggg ggaggcggta ttgcttataa cctcacactc tctccatcag 6001 cgcctaaaag tcccagactt ttgggtgtgg actacaatta cagtgatata ggatggtcta 6061 gtttttaccg ctactgggtg aacaattctg ttcttcctgt cactgttagt agtatccgtg 6121 tcaaagttga accaaggcct tacgttcaaa ctgccgttca caggggaagc tgtgaaattc 6181 ctgttggtca agatagctgc gtgattgcaa atagcttcac aatggctaaa ggcacaacag 6241 ggtacgtcca cgataatgcg acagttttca atccggataa atctcttcgc tcgaatcctc 6301 tttgggcaga ggttaactgg aacgatcagc actaccctca gctaagtcag cagttcgatc 6361 aaaatagcaa ggtatttacc ttattcgtta accagccagg acgaggcgct tactttgata 6421 ggctgcgtct gcgaagtgca tggattgaag atagcaaagg caacaagctg tctccaactg 6481 gtgggttaat agccaacaac tgggagaact acacttacca gtgggatctt aaaactctcc 6541 ctgaggggca atacagtctt gttgccgcag cagaggagat gcacgggcct ttaacgcgac 6601 aaccaatgtt ccagataacg tctgatagaa cgccaccaac catgacactc agtgtggcag 6661 atggagcagc tatccagact ctagatgatg ttgttattac cttggctgat gctatcgacc 6721 cttcacctaa attgacctct attgcccttg taggggggcc tgccaatgac aaggtgcagt 6781 tgtcttggcg tgaggagtcg aaaggtcgat tccgccttga gtacccggta atgttccctt 6841 ctttgaagga aggggaatct tacacgctga ctgtttccgg tgaggatgca caaggcaatg 6901 cggttcaaaa ggctgttggc ttcgagtaca aacctcgcca ggtaatgctg gcggatggga 6961 tggatggcaa ggtcatggtc cccgctgtca ctcatgaatt tgttcatgca gatggcaaac 7021 ggatcatcga aaccaagccg ctgacgctca gtgatggtgc tgtcgtgaca ggttcatacg 7081 acgtgtttgc gaccctacgt tctgatgcga aagtaccgct ggtggttaat ggggtgcgta 7141 tcgagccagg ccagaccatg gggatcatga gccaacatga tttcggtgcg tcaggtggtc 7201 gtttgagcat tccggttaaa cctgctgttc ctgatgtggt cggctcttcc agccttcttg 7261 tcatgacctc cgcgccgaac tcacccatct tggttgtgga catcaatacc tggaaaggga 7321 cggctaagct ctctgctgaa tcatggacaa ttcgccaggt cattgaccca gtgaaaatct 7381 atgccctgcc agagtcgggt gtgccttgcc ggttcaccac gaaagaggat gtggctatgg 7441 ccgcagaccc aattcgtgac ccggtgtgtt tgctccagtg ggacagaact ccagatgagg 7501 ctgaacaaac tacgcaggac aacaacggga tgaaagttgc tgggctggtg gggcaggctg 7561 tgagcattgg tgaacaacct gtcgaataca gcctgtacct gttcagtggt gacggttcca 7621 aggtaaaagt tgggtctggc tctcagaacc tgacggtaac tactgcctat ggctctgttg 7681 gctacacccc gattgatgac attgctcagg tgaatcgcgt cattgaagat tttgatgtga 7741 acttcaagca gagcaagggg ccagactgtt ctataaccct cagcgcagac cgtgcgaaaa 7801 aagaggccgc gaacaaggct gttggtagtg caagccgtgc ctgtctgttc gagtggcagc 7861 agatccccga tggattggtc caagacccgt tatcggaatc accttcgctc tctggttcat 7921 tggcctccaa cggcgttcat ccactggggt ggcgggtaag tattttcacc cgtaacggca 7981 ctagggtgac gttgaacgac gagactttca atgtcgaagc ggttgaccca ccagctccga 8041 ccgttgaact agcctccgac tacaacttca aagacaacat ctacttggtg ccgatgacag 8101 gtaactacct gggtgatgcc attatcaact ctgaacgagc tgatctggat attgccatat 8161 cgcgcaactc ggatgttctt gagtctgaga ccttcactcc gggatggggt gccaccaata 8221 aggtgtatcg ccgcatcaat accgatgagc gagcgttgtg ggaggagacc acctacaagg 8281 tgaacgcggc ctacaacaag gtgcctgatg tgaagactga ggttgtctac cgggctatct 8341 ctgcaccttc tgacagtatc cgtcctatcg ttgaagttaa aggtgatacc gcgattgaca 8401 cccaggcatt gccggttagg gttctcatcc gtgatcagta caaacctgat ggtgactatg 8461 acgctaacac gatgggggtg tggaaagtac gcctgatcca gcaaaaggcc tacaacgaga 8521 cggttgcgct cactgattat gcgaagcatc gaacggtgaa gctcagttct cagtagacct 8581 gtctggtgtg gatacttcct ccgtccgtat cgctgctgag gctgttctgg aaagccctgt 8641 tgagggttac aaccgcacag agttgtctat cagacctgcc ttcttgacag tgcttcgcgg 8701 tggtgccatc ggtgctggcg tggaggctcg caagttgtct ggtgaagctc cgttacactg 8761 ctgtgttcaa gctatctttg gacgaccgtc aggatctccg ggctaccggc caggttgtgt 8821 gggaaaccag taaggacgac ggtaaaacct gggagcagtt catcccagaa gatcgataca 8881 agtatcagct tgtgaagacc ttcgacaagg gggagtacca ggttcgggcc aaggtggtga 8941 acgtcaactc aggtgcggaa aagtacaccg aagcggtcag tgttgtcgct tacgacaaac 9001 ctgatattgc tgttatcggc ccgaccacgt tgtttgtcgg aagtgaaggc aagtacacag 9061 cgaacctgac gttgaacgat gagccaatct ccggtggcaa tgccattgtt gagtggtcta 9121 ctgacggtgg caaaacctac gcgcagacag gggatagcat cacgctttcg agcgatgaag 9181 aaacccgata ccgcctgtgg gctcgtgtgc gctctgccac ggcaccggct gatgacggct 9241 atgcctatga agttgcgaaa acggcggttg acttccgagc agtgaaggca cctcgtcctt 9301 acgtgacagg gccgcgagtt attgagaccg gtaagaagta tgtgttcaaa gccgaaacca 9361 gcctgcctta ccgtgggatg gacgtgaagc tgaacgggtt cttcacgctg cctgatggct 9421 cgattgtgca gggtgatact gctgaagtac gaaccctcta cactgacctc aatcaggcta 9481 ctgtagaaac gaagtacacc acctggatcg aaggataccg agatcagggt gcagaggctt 9541 cgcatagcct acgctcccgc gtttggcagt atgtatggcc gagcttcgga atgcaggtta 9601 ggaagaacgc agacgtggct cctgcgacga tcaccgcgtc agtgcggcca attgccttca 9661 acggcaagct ggaagagccg acctacgagt gggagttgcc ggaaggcgct gtgattcagg 9721 atcagcggca ggatattgtc cggtcctttg tgatcaatga gccgggtgat tacaacatca 9781 aggtcactgt ccgtgatgct cgcggccatg agaccgtgat cgagcaaccg ctcaagatcg 9841 gccaggcagc gccctatgcc attgacctgc aatactctgg ctcgaacaaa tacgagcgtg 9901 agcctctgga tgtgctgttg cgaccgtaca tttctggcgg ccacccacgc gaccgtattt 9961 cgactcgtgt ttattcggta gatggtacac cgttggaaag cagtggttac tacggcagag 10021 caactctggg cgctggtgag cacagcatca agctgaaaat aacctcagaa atggggcatg 10081 aagctgaggg cgaggtgaac atcaatgttg cagagaacaa gttgcctgca tgtagcctga 10141 gctcacgaga gaccgttggg tcgtggatcg tctatgcgaa ctgcgaagat accgatggcc 10201 gcatgaagtc ctacgaatgg accattgccg gtgagttgca gagcatcagc tctgatcgag 10261 tgactatcag caagggcacc tatgaaacga tgccgaccat ctctctggtt ggggtcgatg 10321 actctggggg caaatccgaa gctgttacca tgaactaagg ttcattcctc tcaaagcccg 10381 gttcagaccg ggcttttttt tgtatcgcgc tggaattgtc caaattgggc tattacagag 10441 gcgagtctat ttccatcccc cggatacact gcccagcatc cagtaatcca atcttagggg 10501 atagacatgc ggacaaaatt acttggggcg ctgatggtgt tcgggattat taccggcacg 10561 gctcatgcgt catcgaaatt ggaaatcacc gatcccagag cggcgaagat agaggacatt 10621 gtagagctac ccatcaaagg ggttcgagcc gtccaaagtg atgggcagat catgttcctc 10681 tctgaaaacg gacgatttgt tatttcagga caaatctacg acctgtggag caagaagccc 10741 ctcaacacga tgtcccaaat gagggatgta gcggagcgta tccacttcaa gagcatgggc 10801 atggatgtgg acacgctgaa cactgtgtcg atggggcgtg gtgacaaaga ggtggtggtc 10861 tttgttgatc ctaggtgcgc ggtttgccat cagctcatgg gtgatgccaa atcgctggtg 10921 gatgattaca cctttaaatt tatcgtgatt ccagctctgg gtgctgagtc caaccgcctg 10981 gcaaaaaact tgtactgcgc gaaagacaaa acccacgcgc ttgatgcgct gatgaacaac 11041 accctgggtt cccttccttc aaaagaaacc tgcgaccccg gccaatacga ccaaacgctg 11101 ctgacagctc atttcattgg gattgagggc gttccgttcg ttgttgctcc ggatggtcgt 11161 gtcagcaaag gacgtccgaa gaacctgaaa tcatggttgg agagtgctga atgatcgtaa 11221 ccatcaaaaa gaaactcgaa gaaacgttga t //