LOCUS       AJ001014                 800 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA encoding RAMP1.
ACCESSION   AJ001014
VERSION     AJ001014.1
KEYWORDS    RAMP1 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 800)
  AUTHORS   Fraser N.J.
  JOURNAL   Submitted (02-SEP-1997) to the INSDC. Fraser N.J., Receptor
            Systems, GlaxoWellcome , Medicines Research Centre, Gunnels Wood
            Road, Stevenage, Herts. SG1 2NY, U.K..
REFERENCE   2  (bases 33 to 479)
  AUTHORS   McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J.,
            Thompson N., Solari R., Lee M.G., Foord S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393(6683), 333-339(1998).
   PUBMED   9620797
COMMENT     Co-expression of RAMP1 with the calcitonin-receptor-like-receptor
            (CRLR Acc. No. U17473) results in the production of a functional
            calcitonin-gene-related peptide (CGRP) receptor.
FEATURES             Location/Qualifiers
     source          1..800
                     /db_xref="H-InvDB:HIT000243823"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="SK-N-MC"
                     /cell_type="Neuroblastoma"
                     /db_xref="taxon:9606"
     CDS             33..479
                     /codon_start=1
                     /gene="RAMP1"
                     /function="CRLR receptor-activity-modifying-protein"
                     /db_xref="GOA:O60894"
                     /db_xref="H-InvDB:HIT000243823.12"
                     /db_xref="HGNC:HGNC:9843"
                     /db_xref="InterPro:IPR006985"
                     /db_xref="InterPro:IPR038126"
                     /db_xref="PDB:2YX8"
                     /db_xref="PDB:3N7P"
                     /db_xref="PDB:3N7R"
                     /db_xref="PDB:3N7S"
                     /db_xref="PDB:4RWG"
                     /db_xref="PDB:5V6Y"
                     /db_xref="PDB:6D1U"
                     /db_xref="PDB:6E3Y"
                     /db_xref="UniProtKB/Swiss-Prot:O60894"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAA04472.1"
                     /translation="MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQF
                     QVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFR
                     SCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV"
     sig_peptide     33..108
                     /gene="RAMP1"
     mat_peptide     109..476
                     /gene="RAMP1"
BASE COUNT          139 a          253 c          263 g          145 t
ORIGIN      
        1 cgagcggact cgactcggca ccgctgtgca ccatggcccg ggccctgtgc cgcctcccgc
       61 ggcgcggcct ctggctgctc ctggcccatc acctcttcat gaccactgcc tgccaggagg
      121 ctaactacgg tgccctcctc cgggagctct gcctcaccca gttccaggta gacatggagg
      181 ccgtcgggga gacgctgtgg tgtgactggg gcaggaccat caggagctac agggagctgg
      241 ccgactgcac ctggcacatg gcggagaagc tgggctgctt ctggcccaat gcagaggtgg
      301 acaggttctt cctggcagtg catggccgct acttcaggag ctgccccatc tcaggcaggg
      361 ccgtgcggga cccgcccggc agcatcctct accccttcat cgtggtcccc atcacggtga
      421 ccctgctggt gacggcactg gtggtctggc agagcaagcg cactgagggc attgtgtagg
      481 cggggcccag gctgcccgcg ggtgcaccca ggctgcaggg tgaggccagg caggcctggg
      541 taggggcagc ttctggagcc ttgggacaga gcaggcccac aatgcccccc ttcttccagc
      601 caagaagagc tcacaggagt ccagagtagc cgaggctctg gtattaacct ggaagccccc
      661 ctggctggag gccaccgcca ccctaggaag ggggcaggga cgtgaccttg acttacctct
      721 ggaaagggtc ccagcctaga ctgcttaccc catagccaca tttgtggatg agtggtttgt
      781 gattaaaagg gatgttcttg
//