LOCUS       AF523360                1587 bp    mRNA    linear   HUM 02-OCT-2002
DEFINITION  Homo sapiens histamine N-methyltransferase variant 3 (HNMT) mRNA,
            complete cds; alternatively spliced.
ACCESSION   AF523360
VERSION     AF523360.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Barnes,W.G., Grinde,E., Crawford,D.R., Herrick-Davis,K. and
            Hough,L.B.
  TITLE     Further Characterization of the Histamine N-Methyltransferase Gene:
            A New mRNA Species and Several 3'-UTR Variants From Human Brain
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1587)
  AUTHORS   Barnes,W.G. and Hough,L.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-JUN-2002) Center for Neuropharmacology and
            Neuroscience, Albany Medical College, 47 New Scotland Ave., Albany,
            NY 12208, USA
FEATURES             Location/Qualifiers
     source          1..1587
                     /db_xref="H-InvDB:HIT000081224"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
                     /tissue_type="brain"
     gene            1..1587
                     /gene="HNMT"
     5'UTR           1..181
                     /gene="HNMT"
     CDS             182..1060
                     /gene="HNMT"
                     /note="HNMT-3; histamine-methylating enzyme"
                     /codon_start=1
                     /product="histamine N-methyltransferase variant 3"
                     /protein_id="AAN33018.1"
                     /translation="MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGII
                     GRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELV
                     AKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHS
                     LLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECY
                     DLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKE
                     GKVLFNNTLSFIVIEA"
     3'UTR           1061..1587
                     /gene="HNMT"
                     /note="alternatively spliced"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNMT"
                     /note="putative"
BASE COUNT          511 a          286 c          316 g          474 t
ORIGIN      
        1 gactcagtaa tgagctctac aagccagcct ttgtggcatg ttaaattcaa aacaagctta
       61 gcattttttt tttttttttg gatagaaact ggtgggggtg gggaaagaaa gagggaactg
      121 ggaagagaag gaggggaact taaaccttgc ttcctgctct gtctttctca gaaaaccaaa
      181 tatggcatct tccatgagga gcttgttttc tgaccacggg aaatatgttg aatctttccg
      241 gaggtttctc aaccattcca cggaacacca gtgcatgcag gaattcatgg acaagaagct
      301 gccaggcata ataggaagga ttggagacac aaaatcagaa attaagattc taagcatagg
      361 cggaggtgca ggtgaaattg atcttcaaat tctctccaaa gttcaggctc aatacccagg
      421 agtttgtatc aacaatgaag ttgttgagcc aagtgctgaa caaattgcca aatacaaaga
      481 gcttgtagcc aagacatcga acctcgagaa cgtaaagttt gcttggcata aggagacatc
      541 atctgaatac caaagtagaa tgttggagaa aaaggagctt caaaagtggg actttattca
      601 tatgattcaa atgctgtatt atgtaaaaga catcccagct accctgaaat tcttccatag
      661 tctcttaggt accaatgcta agatgctcat tattgttgtg tcaggaagca gtggctggga
      721 caagctgtgg aaaaagtacg gatcacgctt tccccaggat gacctctgcc agtatatcac
      781 atcagatgac ctcactcaga tgctggacaa cctagggctt aagtatgagt gctatgacct
      841 tttgtccacc atggatatat ctgactgctt tattgatggt aatgaaaatg gagacctgct
      901 ttgggatttt ttgactgaaa cctgcaactt taatgccaca gcaccacctg atctcagagc
      961 agagcttggg aaagatctac aagagcctga atttagtgct aagaaagagg ggaaggttct
     1021 ttttaataat actctgagtt tcatagtgat tgaggcataa ctatcaatca caaaagtata
     1081 ttcaaaaatt atattttgaa caactcgaat cactcattta tttccatatt aaaatcacaa
     1141 actcatccat taatgtagat aaagcactgt ttggatatga gatgtagcaa attccaatac
     1201 attattggac ttccatttgg aatcatatgg gatactgctg gtcttatcct gtccctcctc
     1261 caggtagaga gaccacaagc aggctcaaca taacataagc tagaaaaatt agatgactga
     1321 atttctatgg catattgata ataaaattca ttccatttgc tgattgtctg aaattttcta
     1381 gaatactaat aaaatacata ctatagattc tttattagtg aagtatgcac taatcaatac
     1441 tttgaacaca aagcctgtgt tactgatttg gccgttttgt gaagaaacat ttatctttgt
     1501 acgttcttct attgtgcttt ctatctaatt tttattaatt tgtaagagta agcaccttta
     1561 gaatattaaa aattaattct ttatcac
//