LOCUS AF371337 13350 bp RNA linear VRL 15-APR-2002 DEFINITION Human metapneumovirus isolate 00-1, complete genome. ACCESSION AF371337 AF371346 AF371355 AF371364 AF371365 AF371366 AF371367 VERSION AF371337.2 KEYWORDS . SOURCE human metapneumovirus (HMPV) ORGANISM human metapneumovirus Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus; Metapneumovirus hominis. REFERENCE 1 (bases 1 to 13350) AUTHORS van den Hoogen,B.G., de Jong,J.C., Groen,J., Kuiken,T., de Groot,R., Fouchier,R.A. and Osterhaus,A.D. TITLE A newly discovered human pneumovirus isolated from young children with respiratory tract disease JOURNAL Nat. Med. 7 (6), 719-724 (2001) PUBMED 11385510 REFERENCE 2 (bases 1 to 13350) AUTHORS van den Hoogen,B.G., de Jong,J.C., Groen,J., Kuiken,T., de Groot,R., Fouchier,R.A. and Osterhaus,A.D. TITLE Direct Submission JOURNAL Submitted (18-APR-2001) Dept of Virology, Erasmus University, Dr. Molewaterplein 50, Rotterdam 3015 GE, The Netherlands REFERENCE 3 (bases 1 to 13350) AUTHORS van den Hoogen,B.G., de Jong,J.C., Groen,J., Kuiken,T., de Groot,R., Fouchier,R.A. and Osterhaus,A.D. TITLE Direct Submission JOURNAL Submitted (25-SEP-2001) Dept of Virology, Erasmus University, Dr. Molewaterplein 50, Rotterdam 3015 GE, The Netherlands REMARK Sequence update by submitter COMMENT On or before Apr 15, 2002 this sequence version replaced AF371365.1, AF371366.1, AF371367.1, AF371337.1. FEATURES Location/Qualifiers source 1..13350 /organism="human metapneumovirus" /mol_type="genomic RNA" /isolate="00-1" /db_xref="taxon:162145" gene 40..1224 /gene="N" CDS 40..1224 /gene="N" /codon_start=1 /product="nucleoprotein" /protein_id="AAK62966.1" /translation="MSLQGIHLSDLSYKHAILKESQYTIKRDVGTTTAVTPSSLQQEI TLLCGEILYAKHADYKYAAEIGIQYISTALGSERVQQILRNSGSEVQVVLTRTYSLGK IKNNKGEDLQMLDIHGVEKSWVEEIDKEARKTMATLLKESSGNIPQNQRPSAPDTPII LLCVGALIFTKLASTIEVGLETTVRRANRVLSDALKRYPRMDIPKIARSFYDLFEQKV YHRSLFIEYGKALGSSSTGSKAESLFVNIFMQAYGAGQTMLRWGVIARSSNNIMLGHV SVQAELKQVTEVYDLVREMGPESGLLHLRQSPKAGLLSLANCPNFASVVLGNASGLGI IGMYRGRVPNTELFSAAESYAKSLKESNKINFSSLGLTDEEKEAAEHFLNVSDDSQND YE" gene 1248..2132 /gene="P" CDS 1248..2132 /gene="P" /codon_start=1 /product="phosphoprotein" /protein_id="AAK62967.1" /translation="MSFPEGKDILFMGNEAAKLAEAFQKSLRKPGHKRSQSIIGEKVN TVSETLELPTISRPAKPTIPSEPKLAWTDKGGATKTEIKQAIKVMDPIEEEESTEKKV LPSSDGKTPAEKKLKPSTNTKKKVSFTPNEPGKYTKLEKDALDLLSDNEEEDAESSIL TFEERDTSSLSIEARLESIEEKLSMILGLLRTLNIATAGPTAARDGIRDAMIGVREEL IADIIKEAKGKAAEMMEEEMSQRSKIGNGSVKLTEKAKELNKIVEDESTSGESEEEEE PKDTQDNSQEDDIYQLIM" gene 2165..2929 /gene="M" CDS 2165..2929 /gene="M" /codon_start=1 /product="matrix protein" /protein_id="AAK62969.1" /translation="MESYLVDTYQGIPYTAAVQVDLIEKDLLPASLTIWFPLFQANTP PAVLLDQLKTLTITTLYAASQNGPILKVNASAQGAAMSVLPKKFEVNATVALDEYSKL EFDKLTVCEVKTVYLTTMKPYGMVSKFVSSAKSVGKKTHDLIALCDFMDLEKNTPVTI PAFIKSVSIKESESATVEAAISSEADQALTQAKIAPYAGLIMIMTMNNPKGIFKKLGA GTQVIVELGAYVQAESISKICKTWSHQGTRYVLKSR" gene 3052..4671 /gene="F" CDS 3052..4671 /gene="F" /codon_start=1 /product="fusion protein" /protein_id="AAK62968.2" /translation="MSWKVVIIFSLLITPQHGLKESYLEESCSTITEGYLSVLRTGWY TNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTVSADQLAREEQIENPRQSR FVLGAIALGVATAAAVTAGVAIAKTIRLESEVTAIKNALKKTNEAVSTLGNGVRVLAT AVRELKDFVSKNLTRAINKNKCDIADLKMAVSFSQFNRRFLNVVRQFSDNAGITPAIS LDLMTDAELARAVSNMPTSAGQIKLMLENRAMVRRKGFGFLIGVYGSSVIYMVQLPIF GVIDTPCWIVKAAPSCSGKKGNYACLLREDQGWYCQNAGSTVYYPNEKDCETRGDHVF CDTAAGINVAEQSKECNINISTTNYPCKVSTGRHPISMVALSPLGALVACYKGVSCSI GSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVK FPEDQFNVALDQVFESIENSQALVDQSNRILSSAEKGNTGFIIVIILIAVLGSTMILV SVFIIIKKTKKPTGAPPELSGVTNNGFIPHN" gene 4737..5463 /gene="M2" CDS 4737..5300 /gene="M2" /codon_start=1 /product="matrix protein 2-1" /protein_id="AAM12941.1" /translation="MSRKAPCKYEVRGKCNRGSECKFNHNYWSWPDRYLLIRSNYLLN QLLRNTDRADGLSIISGAGREDRTQDFVLGSTNVVQGYIDDNQSITKAAACYSLHNII KQLQEVEVRQARDNKLSDSKHVALHNLVLSYMEMSKTPASLINNLKRLPREKLKKLAK LIIDLSAGAENDSSYALQDSESTNQVQ" CDS 5248..5463 /gene="M2" /codon_start=1 /product="matrix protein 2-2" /protein_id="AAM12942.1" /translation="MTLHMPCKTVKALIKCSEHGPVFITIEVDDMIWTHKDLKEALSD GIVKSHTNIYNCYLENIEIIYVKAYLS" gene 5494..6045 /gene="SH" CDS 5494..6045 /gene="SH" /codon_start=1 /product="small hydrophobic protein" /protein_id="AAM12943.1" /translation="MITLDVIKSDGSSKTCTHLKKIIKDHSGKVLIVLKLILALLTFL TVTITINYIKVENNLQICQSKTESDKKDSSSNTTSVTTKTTLNHDITQYFKSLIQRYT NSAINSDTCWKINRNQCTNITTYKFLCFKSEDTKTNNCDKLTDLCRNKPKPAVGVYHI VECHCIYTVKWKCYHYPTDETQS" gene 6247..6957 /gene="G" CDS 6247..6957 /gene="G" /codon_start=1 /product="attachment glycoprotein" /protein_id="AAM12944.1" /translation="MEVKVENIRTIDMLKARVKNRVARSKCFKNASLVLIGITTLSIA LNIYLIINYKMQKNTSESEHHTSSSPMESSRETPTVPTDNSDTNSSPQHPTQQSTEGS TLYFAASASSPETEPTSTPDTTNRPPFVDTHTTPPSASRTKTSPAVHTKNNPRTSSRT HSPPRATTRTARRTTTLRTSSTRKRPSTASVQPDISATTHKNEEASPASPQTSASTTR IQRKSVEANTSTTYNQTS" gene 7167..13184 /gene="L" CDS 7167..13184 /gene="L" /codon_start=1 /product="RNA-dependent RNA polymerase" /protein_id="AAK62941.2" /translation="MDPLNESTVNVYLPDSYLKGVISFSETNAIGSCLLKRPYLKNDN TAKVAIENPVIEHVRLKNAVNSKMKISDYKIVEPVNMQHEIMKNVHSCELTLLKQFLT RSKNISTLKLNMICDWLQLKSTSDDTSILSFIDVEFIPSWVSNWFSNWYNLNKLILEF RKEEVIRTGSILCRSLGKLVFVVSSYGCIVKSNKSKRVSFFTYNQLLTWKDVMLSRFN ANFCIWVSNSLNENQEGLGLRSNLQGILTNKLYETVDYMLSLCCNEGFSLVKEFEGFI MSEILRITEHAQFSTRFRNTLLNGLTDQLTKLKNKNRLRVHGTVLENNDYPMYEVVLK LLGDTLRCIKLLINKNLENAAELYYIFRIFGHPMVDERDAMDAVKLNNEITKILRWES LTELRGAFILRIIKGFVDNNKRWPKIKNLKVLSKRWTMYFKAKSYPSQLELSEQDFLE LAAIQFEQEFSVPEKTNLEMVLNDKAISPPKRLIWSVYPKNYLPEKIKNRYLEETFNA SDSLKTRRVLEYYLKDNKFDQKELKSYVVKQEYLNDKDHIVSLTGKERELSVGRMFAM QPGKQRQIQILAEKLLADNIVPFFPETLTKYGDLDLQRIMEIKSELSSIKTRRNDSYN NYIARASIVTDLSKFNQAFRYETTAICADVADELHGTQSLFCWLHLIVPMTTMICAYR HAPPETKGEYDIDKIEEQSGLYRYHMGGIEGWCQKLWTMEAISLLDVVSVKTRCQMTS LLNGDNQSIDVSKPVKLSEGLDEVKADYSLAVKMLKEIRDAYRNIGHKLKEGETYISR DLQFISKVIQSEGVMHPTPIKKILRVGPWINTILDDIKTSAESIGSLCQELEFRGESI IVSLILRNFWLYNLYMHESKQHPLAGKQLFKQLNKTLTSVQRFFEIKKENEVVDLWMN IPMQFGGGDPVVFYRSFYRRTPDFLTEAISHVDILLRISANIRNEAKISFFKALLSIE KNERATLTTLMRDPQAVGSERQAKVTSDINRTAVTSILSLSPNQLFSDSAIHYSRNEE EVGIIADNITPVYPHGLRVLYESLPFHKAEKVVNMISGTKSITNLLQRTSAINGEDID RAVSMMLENLGLLSRILSVVVDSIEIPTKSNGRLICCQISRTLRETSWNNMEIVGVTS PSITTCMDVIYATSSHLKGIIIEKFSTDRTTRGQRGPKSPWVGSSTQEKKLVPVYNRQ ILSKQQREQLEAIGKMRWVYKGTPGLRRLLNKICLGSLGISYKCVKPLLPRFMSVNFL HRLSVSSRPMEFPASVPAYRTTNYHFDTSPINQALSERFGNEDINLVFQNAISCGISI MSVVEQLTGRSPKQLVLIPQLEEIDIMPPPVFQGKFNYKLVDKITSDQHIFSPDKIDM LTLGKMLMPTIKGQKTDQFLNKRENYFHGNNLIESLSAALACHWCGILTEQCIENNIF KKDWGDGFISDHAFMDFKIFLCVFKTKLLCSWGSQGKNIKDEDIVDESIDKLLRIDNT FWRMFSKVMFESKVKKRIMLYDVKFLSLVGYIGFKNWFIEQLRSAELHEVPWIVNAEG DLVEIKSIKIYLQLIEQSLFLRITVLNYTDMAHALTRLIRKKLMCDNALLTPIPSPMV NLTQVIDPTEQLAYFPKITFERLKNYDTSSNYAKGKLTRNYMILLPWQHVNRYNFVFS STGCKVSLKTCIGKLMKDLNPKVLYFIGEGAGNWMARTACEYPDIKFVYRSLKDDLDH HYPLEYQRVIGELSRIIDSGEGLSMETTDATQKTHWDLIHRVSKDALLITLCDAEFKD RDDFFKMVILWRKHVLSCRICTTYGTDLYLFAKYHAKDCNVKLPFFVRSVATFIMQGS KLSGSECYILLTLGHHNNLPCHGEIQNSKMKIAVCNDFYAAKKLDNKSIEANCKSLLS GLRIPINKKELNRQRRLLTLQSNHSSVATVGGSKVIESKWLTNKANTIIDWLEHILNS PKGELNYDFFEALENTYPNMIKLIDNLGNAEIKKLIKVTGYMLVSKK" BASE COUNT 5103 a 2307 c 2538 g 3402 t ORIGIN 1 gtataaatta gattccaaaa aaatatggga caagtgaaaa tgtctcttca agggattcac 61 ctgagtgatt tatcatacaa gcatgctata ttaaaagagt ctcagtacac aataaaaaga 121 gatgtgggta caacaactgc agtgacaccc tcatcattgc aacaagaaat aacactgttg 181 tgtggagaaa ttctgtatgc taaacatgct gactacaaat atgctgcaga aataggaata 241 caatatatta gcacagcttt aggatcagag agagtgcagc agattctgag gaactcaggc 301 agtgaagtcc aagtggtctt aaccagaacg tactctctgg ggaaaattaa aaacaataaa 361 ggagaagatt tacagatgtt agacatacac ggggtagaga agagctgggt agaagagata 421 gacaaagaag caaggaaaac aatggcaacc ttgcttaagg aatcatcagg taatatccca 481 caaaatcaga ggccctcagc accagacaca cccataatct tattatgtgt aggtgcctta 541 atattcacta aactagcatc aaccatagaa gtgggactag agaccacagt cagaagggct 601 aaccgtgtac taagtgatgc actcaagaga taccctagaa tggacatacc aaagattgcc 661 agatccttct atgacttatt tgaacaaaaa gtgtatcaca gaagtttgtt cattgagtat 721 ggcaaagcat taggctcatc atctacaggc agcaaagcag aaagtctatt tgttaatata 781 ttcatgcaag cttatggggc cggtcaaaca atgctaaggt ggggggtcat tgccaggtca 841 tccaacaata taatgttagg acatgtatcc gtccaagctg agttaaaaca ggtcacagaa 901 gtctatgact tggtgcgaga aatgggccct gaatctggac ttctacattt aaggcaaagc 961 ccaaaagctg gactgttatc actagccaac tgtcccaact ttgcaagtgt tgttctcgga 1021 aatgcctcag gcttaggcat aatcggtatg tatcgaggga gagtaccaaa cacagaatta 1081 ttttcagcag ctgaaagtta tgccaaaagt ttgaaagaaa gcaataaaat aaatttctct 1141 tcattaggac ttacagatga agagaaagag gctgcagaac atttcttaaa tgtgagtgac 1201 gacagtcaaa atgattatga gtaattaaaa aagtgggaca agtcaaaatg tcattccctg 1261 aaggaaaaga tattcttttc atgggtaatg aagcagcaaa attagcagaa gctttccaga 1321 aatcattaag aaaaccaggt cataaaagat ctcaatctat tataggagaa aaagtgaata 1381 ctgtatcaga aacattggaa ttacctacta tcagtagacc tgcaaaacca accataccgt 1441 cagaaccaaa gttagcatgg acagataaag gtggggcaac caaaactgaa ataaagcaag 1501 caatcaaagt catggatccc attgaagaag aagagtctac cgagaagaag gtgctaccct 1561 ccagtgatgg gaaaacccct gcagaaaaga aactgaaacc atcaactaac accaaaaaga 1621 aggtttcatt tacaccaaat gaaccaggga aatatacaaa gttggaaaaa gatgctctag 1681 atttgctctc agataatgaa gaagaagatg cagaatcttc aatcttaacc tttgaagaaa 1741 gagatacttc atcattaagc attgaggcca gattggaatc aatagaggag aaattaagca 1801 tgatattagg gctattaaga acactcaaca ttgctacagc aggacccaca gcagcaagag 1861 atgggatcag agatgcaatg attggcgtaa gagaggaatt aatagcagac ataataaagg 1921 aagctaaagg gaaagcagca gaaatgatgg aagaggaaat gagtcaacga tcaaaaatag 1981 gaaatggtag tgtaaaatta acagaaaaag caaaagagct caacaaaatt gttgaagatg 2041 aaagcacaag tggagaatcc gaagaagaag aagaaccaaa agacacacaa gacaatagtc 2101 aagaagatga catttaccag ttaattatgt agtttaataa aaataaacaa tgggacaagt 2161 aaaaatggag tcctacctag tagacaccta tcaaggcatt ccttacacag cagctgttca 2221 agttgatcta atagaaaagg acctgttacc tgcaagccta acaatatggt tccctttgtt 2281 tcaggccaac acaccaccag cagtgctgct cgatcagcta aaaaccctga caataaccac 2341 tctgtatgct gcatcacaaa atggtccaat actcaaagtg aatgcatcag cccaaggtgc 2401 agcaatgtct gtacttccca aaaaatttga agtcaatgcg actgtagcac tcgatgaata 2461 tagcaaactg gaatttgaca aactcacagt ctgtgaagta aaaacagttt acttaacaac 2521 catgaaacca tacgggatgg tatcaaaatt tgtgagctca gccaaatcag ttggcaaaaa 2581 aacacatgat ctaatcgcac tatgtgattt tatggatcta gaaaagaaca cacctgttac 2641 aataccagca ttcatcaaat cagtttcaat caaagagagt gagtcagcta ctgttgaagc 2701 tgctataagc agtgaagcag accaagctct aacacaggcc aaaattgcac cttatgcggg 2761 attaattatg atcatgacta tgaacaatcc caaaggcata ttcaaaaagc ttggagctgg 2821 gactcaagtc atagtagaac taggagcata tgtccaggct gaaagcataa gcaaaatatg 2881 caagacttgg agccatcaag ggacaagata tgtcttgaag tccagataac aaccaagcac 2941 cttggccaag agctactaac cctatctcat agatcataaa gtcaccattc tagttatata 3001 aaaatcaagt tagaacaaga attaaatcaa tcaagaacgg gacaaataaa aatgtcttgg 3061 aaagtggtga tcattttttc attgttaata acacctcaac acggtcttaa agagagctac 3121 ttagaagagt catgtagcac tataactgaa ggatatctca gtgttctgag gacaggttgg 3181 tacaccaatg tttttacact ggaggtaggc gatgtagaga accttacatg tgccgatgga 3241 cccagcttaa taaaaacaga attagacctg accaaaagtg cactaagaga gctcagaaca 3301 gtttctgctg atcaactggc aagagaggag caaattgaaa atcccagaca atctagattc 3361 gttctaggag caatagcact cggtgttgca actgcagctg cagttacagc aggtgttgca 3421 attgccaaaa ccatccggct tgaaagtgaa gtaacagcaa ttaagaatgc cctcaaaaag 3481 accaatgaag cagtatctac attggggaat ggagttcgtg tgttggcaac tgcagtgaga 3541 gagctgaaag attttgtgag caagaatcta acacgtgcaa tcaacaaaaa caagtgcgac 3601 attgctgacc tgaaaatggc cgttagcttc agtcaattca acagaaggtt cctaaatgtt 3661 gtgcggcaat tttcagacaa cgctggaata acaccagcaa tatctttgga cttaatgaca 3721 gatgctgaac tagccagagc tgtttccaac atgccaacat ctgcaggaca aataaaactg 3781 atgttggaga accgtgcaat ggtaagaaga aaagggttcg gattcctgat aggagtttac 3841 ggaagctccg taatttacat ggtgcaactg ccaatctttg gggttataga cacgccttgc 3901 tggatagtaa aagcagcccc ttcttgttca ggaaaaaagg gaaactatgc ttgcctctta 3961 agagaagacc aaggatggta ttgtcaaaat gcagggtcaa ctgtttacta cccaaatgaa 4021 aaagactgtg aaacaagagg agaccatgtc ttttgcgaca cagcagcagg aatcaatgtt 4081 gctgagcagt caaaggagtg caacataaac atatctacta ctaattaccc atgcaaagtt 4141 agcacaggaa gacatcctat cagtatggtt gcactatctc ctcttggggc tttggttgct 4201 tgctacaagg gagtgagctg ttccattggc agcaacagag tagggatcat caagcaactg 4261 aacaaaggct gctcttatat aaccaaccaa gacgcagaca cagtgacaat agacaacact 4321 gtataccagc taagcaaagt tgaaggcgaa cagcatgtta taaaaggaag gccagtgtca 4381 agcagctttg acccagtcaa gtttcctgaa gatcaattca atgttgcact tgaccaagtt 4441 ttcgagagca ttgagaacag tcaggccttg gtggatcaat caaacagaat cctaagcagt 4501 gcagagaaag gaaacactgg cttcatcatt gtaataattc taattgctgt ccttggctct 4561 accatgatcc tagtgagtgt ttttatcata ataaagaaaa caaagaaacc cacaggagca 4621 cctccagagc tgagtggtgt cacaaacaat ggcttcatac cacataatta gttaattaaa 4681 aataaagtaa attaaaataa attaaaatta aaaataaaaa tttgggacaa atcataatgt 4741 ctcgcaaggc tccgtgcaaa tatgaagtgc ggggcaaatg caatagagga agtgagtgca 4801 agtttaacca caattactgg agttggccag atagatactt attaataaga tcaaattatt 4861 tattaaatca acttttaagg aacactgata gagctgatgg cttatcaata atatcaggag 4921 caggcagaga agataggaca caagattttg tcctaggttc caccaatgtg gttcaaggtt 4981 atattgatga taaccaaagc ataacaaaag ctgcagcctg ttacagtcta cataatataa 5041 tcaaacaact acaagaagtt gaagttaggc aggctagaga taacaaacta tctgacagca 5101 aacatgtagc acttcacaac ttagtcctat cttatatgga gatgagcaaa actcctgcat 5161 ctttaatcaa caatctcaag agactgccga gagagaaact gaaaaaatta gcaaagctca 5221 taattgactt atcagcaggt gctgaaaatg actcttcata tgccttgcaa gacagtgaaa 5281 gcactaatca agtgcagtga gcatggtcca gttttcatta ctatagaggt tgatgacatg 5341 atatggactc acaaggactt aaaagaagct ttatctgatg ggatagtgaa gtctcatact 5401 aacatttaca attgttattt agaaaacata gaaattatat atgtcaaggc ttacttaagt 5461 tagtaaaaac acatcagagt gggataaatg acaatgataa cattagatgt cattaaaagt 5521 gatgggtctt caaaaacatg tactcacctc aaaaaaataa ttaaagacca ctctggtaaa 5581 gtgcttattg tacttaagtt aatattagct ttactaacat ttctcacagt aacaatcacc 5641 atcaattata taaaagtgga aaacaatctg caaatatgcc agtcaaaaac tgaatcagac 5701 aaaaaggact catcatcaaa taccacatca gtcacaacca agactactct aaatcatgat 5761 atcacacagt attttaaaag tttgattcaa aggtatacaa actctgcaat aaacagtgac 5821 acatgctgga aaataaacag aaatcaatgc acaaatataa caacatacaa atttttatgt 5881 tttaaatctg aagacacaaa aaccaacaat tgtgataaac tgacagattt atgcagaaac 5941 aaaccaaaac cagcagttgg agtgtatcac atagtagaat gccattgtat atacacagtt 6001 aaatggaagt gctatcatta cccaaccgat gaaacccaat cctaaatgtt aacaccagat 6061 taggatccat ccaagtctgt tagttcaaca atttagttat ttaaaaatat tttgaaaaca 6121 agtaagtttc tatgatactt cataataata agtaataatt aattgcttaa tcatcatcac 6181 aacattattc gaaaccataa ctattcaatt taaaaagtaa aaaacaataa catgggacaa 6241 gtagttatgg aggtgaaagt ggagaacatt cgaacaatag atatgctcaa agcaagagta 6301 aaaaatcgtg tggcacgcag caaatgcttt aaaaatgcct ctttggtcct cataggaata 6361 actacattga gtattgccct caatatctat ctgatcataa actataaaat gcaaaaaaac 6421 acatctgaat cagaacatca caccagctca tcacccatgg aatccagcag agaaactcca 6481 acggtcccca cagacaactc agacaccaac tcaagcccac agcatccaac tcaacagtcc 6541 acagaaggct ccacactcta ctttgcagcc tcagcaagct caccagagac agaaccaaca 6601 tcaacaccag atacaacaaa ccgcccgccc ttcgtcgaca cacacacaac accaccaagc 6661 gcaagcagaa caaagacaag tccggcagtc cacacaaaaa acaacccaag gacaagctct 6721 agaacacatt ctccaccacg ggcaacgaca aggacggcac gcagaaccac cactctccgc 6781 acaagcagca caagaaagag accgtccaca gcatcagtcc aacctgacat cagcgcaaca 6841 acccacaaaa acgaagaagc aagtccagcg agcccacaaa catctgcaag cacaacaaga 6901 atacaaagga aaagcgtgga ggccaacaca tcaacaacat acaaccaaac tagttaacaa 6961 aaaatacaaa ataactctaa gataaaccat gcagacacca acaatggaga agccaaaaga 7021 caattcacaa tctccccaaa aaggcaacaa caccatatta gctctgccca aatctccctg 7081 gaaaaaacac tcgcccatat accaaaaata ccacaaccac cccaagaaaa aaactgggca 7141 aaacaacacc caagagacaa ataacaatgg atcctctcaa tgaatccact gttaatgtct 7201 atcttcctga ctcatatctt aaaggagtga tttcctttag tgagactaat gcaattggtt 7261 catgtctctt aaaaagacct tacctaaaaa atgacaacac tgcaaaagtt gccatagaga 7321 atcctgttat cgagcatgtt agactcaaaa atgcagtcaa ttctaagatg aaaatatcag 7381 attacaagat agtagagcca gtaaacatgc aacatgaaat tatgaagaat gtacacagtt 7441 gtgagctcac attattaaaa cagtttttaa caaggagtaa aaatattagc actctcaaat 7501 taaatatgat atgtgattgg ctgcagttaa agtctacatc agatgatacc tcaatcctaa 7561 gttttataga tgtagaattt atacctagct gggtaagcaa ttggtttagt aattggtaca 7621 atctcaacaa gttgattctg gaattcagga aagaagaagt aataagaact ggttcaatct 7681 tgtgtaggtc attgggtaaa ttagtttttg ttgtatcatc atatggatgt atagtcaaga 7741 gcaacaaaag caaaagagtg agcttcttca catacaatca actgttaaca tggaaagatg 7801 tgatgttaag tagattcaat gcaaattttt gtatatgggt aagcaacagt ctgaatgaaa 7861 atcaagaagg gctagggttg agaagtaatc tgcaaggcat attaactaat aagctatatg 7921 aaactgtaga ttatatgctt agtttatgtt gcaatgaagg tttctcactt gtgaaagagt 7981 tcgaaggctt tattatgagt gaaattctta ggattactga acatgctcaa ttcagtacta 8041 gatttagaaa tactttatta aatggattaa ctgatcaatt aacaaaatta aaaaataaaa 8101 acagactcag agttcatggt accgtgttag aaaataatga ttatccaatg tacgaagttg 8161 tacttaagtt attaggagat actttgagat gtattaaatt attaatcaat aaaaacttag 8221 agaatgctgc tgaattatac tatatattta gaatattcgg tcacccaatg gtagatgaaa 8281 gagatgcaat ggatgctgtc aaattaaaca atgaaatcac aaaaatcctt aggtgggaga 8341 gcttgacaga actaagaggg gcattcatat taaggattat caaaggattt gtagacaaca 8401 acaaaagatg gcccaaaatt aaaaacttaa aagtgcttag taagagatgg actatgtact 8461 tcaaagcaaa aagttacccc agtcaacttg aattaagcga acaagatttt ttagagcttg 8521 ctgcaataca gtttgaacaa gagttttctg tccctgaaaa aaccaacctt gagatggtat 8581 taaatgataa agctatatca cctcctaaaa gattaatatg gtctgtgtat ccaaaaaatt 8641 acttacctga gaaaataaaa aatcgatatc tagaagagac tttcaatgca agtgatagtc 8701 tcaaaacaag aagagtacta gagtactatt tgaaagataa taaattcgac caaaaagaac 8761 ttaaaagtta tgttgttaaa caagaatatt taaatgataa ggatcatatt gtctcgctaa 8821 ctggaaaaga aagagaatta agtgtaggta gaatgtttgc tatgcaacca ggaaaacagc 8881 gacaaataca aatattggct gaaaaattgt tagctgataa tattgtacct tttttcccag 8941 aaaccttaac aaagtatggt gatctagatc ttcagagaat aatggaaatc aaatcggaac 9001 tttcttctat taaaactaga agaaatgata gttataataa ttacattgca agagcatcca 9061 tagtaacaga tttaagtaag ttcaaccaag cctttaggta tgaaactaca gcgatctgtg 9121 cggatgtagc agatgaacta catggaacac aaagcctatt ctgttggtta catcttatcg 9181 tccctatgac aacaatgata tgtgcctata gacatgcacc accagaaaca aaaggtgaat 9241 atgatataga taagatagaa gagcaaagtg gtttatatag atatcatatg ggtggtattg 9301 aaggatggtg tcaaaaactc tggacaatgg aagctatatc tctattagat gttgtatctg 9361 taaaaacacg atgtcaaatg acatctttat taaacggtga caaccaatca atagatgtaa 9421 gtaaaccagt taagttatct gagggtttag atgaagtgaa agcagattat agcttggctg 9481 taaaaatgtt aaaagaaata agagatgcat acagaaatat aggccataaa cttaaagaag 9541 gggaaacata tatatcaaga gatcttcagt ttataagtaa ggtgattcaa tctgaaggag 9601 taatgcatcc tacccctata aaaaagatct taagagtggg accatggata aacacaatat 9661 tagatgacat taaaaccagt gcagagtcaa tagggagtct atgtcaggaa ttagaattta 9721 ggggggaaag cataatagtt agtctgatat taaggaattt ttggctgtat aatttataca 9781 tgcatgaatc aaagcaacac cccctagcag ggaagcagtt attcaaacaa ctaaataaaa 9841 cattaacatc agtgcagaga ttttttgaaa taaaaaagga aaatgaagta gtagatctat 9901 ggatgaacat accaatgcag tttggaggag gagatccagt agtcttctat agatctttct 9961 atagaaggac ccctgatttt ttaactgaag caatcagtca tgtggatatt ctgttaagaa 10021 tatcagccaa cataagaaat gaagcgaaaa taagtttctt caaagcctta ctgtcaatag 10081 aaaaaaatga acgtgctaca ctgacaacac taatgagaga tcctcaagct gttggctcag 10141 agcgacaagc aaaagtaaca agtgatatca atagaacagc agttaccagc atcttaagtc 10201 tttctccaaa tcaacttttc agcgatagtg ctatacacta cagtagaaat gaagaagagg 10261 tcggaatcat tgctgacaac ataacacctg tttatcctca tggactgaga gttttgtatg 10321 aatcattacc ttttcataaa gctgaaaaag ttgtgaatat gatatcagga acgaaatcca 10381 taaccaactt attacagaga acatctgcta ttaatggtga agatattgac agagctgtat 10441 ccatgatgct ggagaaccta ggattattat ctagaatatt gtcagtagtt gttgatagta 10501 tagaaattcc aaccaaatct aatggtaggc tgatatgttg tcagatatct agaaccctaa 10561 gggagacatc atggaataat atggaaatag ttggagtaac atcccctagc atcactacat 10621 gcatggatgt catatatgca actagctctc atttgaaagg gataatcatt gaaaagttca 10681 gcactgacag aactacaaga ggtcaaagag gtccaaagag cccttgggta gggtcgagca 10741 ctcaagagaa aaaattagtt cctgtttata acagacaaat tctttcaaaa caacaaagag 10801 aacagctaga agcaattgga aaaatgagat gggtatataa agggacacca ggtttaagac 10861 gattactcaa taagatttgt cttggaagtt taggcattag ttacaaatgt gtaaaacctt 10921 tattacctag gtttatgagt gtaaatttcc tacacaggtt atctgtcagt agtagaccta 10981 tggaattccc agcatcagtt ccagcttata gaacaacaaa ttaccatttt gacactagtc 11041 ctattaatca agcactaagt gagagatttg ggaatgaaga tattaatttg gtcttccaaa 11101 atgcaatcag ctgtggaatt agcataatga gtgtagtaga acaattaact ggtaggagtc 11161 caaaacagtt agttttaata cctcaattag aagaaataga cattatgcca ccaccagtgt 11221 ttcaagggaa attcaattat aagctagtag ataagataac ttctgatcaa catatcttca 11281 gtccagacaa aatagatatg ttaacactgg ggaaaatgct catgcccact ataaaaggtc 11341 agaaaacaga tcagttcctg aacaagagag agaattattt ccatgggaat aatcttattg 11401 agtctttgtc agcagcgtta gcatgtcatt ggtgtgggat attaacagag caatgtatag 11461 aaaataatat tttcaagaaa gactggggtg acgggttcat atcggatcat gcttttatgg 11521 acttcaaaat attcctatgt gtctttaaaa ctaaactttt atgtagttgg gggtcccaag 11581 ggaaaaacat taaagatgaa gatatagtag atgaatcaat agataaactg ttaaggattg 11641 ataatacttt ttggagaatg ttcagcaagg ttatgtttga atcaaaggtt aagaaaagga 11701 taatgttata tgatgtaaaa tttctatcat tagtaggtta tatagggttt aagaattggt 11761 ttatagaaca gttgagatca gctgagttgc atgaggtacc ttggattgtc aatgccgaag 11821 gtgatctggt tgagatcaag tcaattaaaa tctatttgca actgatagag caaagtttat 11881 ttttaagaat aactgttttg aactatacag atatggcaca tgctctcaca agattaatca 11941 gaaagaagtt gatgtgtgat aatgcactat taactccgat tccatcccca atggttaatt 12001 taactcaagt tattgatcct acagaacaat tagcttattt ccctaagata acatttgaaa 12061 ggctaaaaaa ttatgacact agttcaaatt atgctaaagg aaagctaaca aggaattaca 12121 tgatactgtt gccatggcaa catgttaata gatataactt tgtctttagt tctactggat 12181 gtaaagttag tctaaaaaca tgcattggaa aacttatgaa agatctaaac cctaaagttc 12241 tgtactttat tggagaaggg gcaggaaatt ggatggccag aacagcatgt gaatatcctg 12301 acatcaaatt tgtatacaga agtttaaaag atgaccttga tcatcattat cctttggaat 12361 accagagagt tataggagaa ttaagcagga taatagatag cggtgaaggg ctttcaatgg 12421 aaacaacaga tgcaactcaa aaaactcatt gggatttgat acacagagta agcaaagatg 12481 ctttattaat aactttatgt gatgcagaat ttaaggacag agatgatttt tttaagatgg 12541 taattctatg gaggaaacat gtattatcat gcagaatttg cactacttat gggacagacc 12601 tctatttatt cgcaaagtat catgctaaag actgcaatgt aaaattacct ttttttgtga 12661 gatcagtagc cacctttatt atgcaaggta gtaaactgtc aggctcagaa tgctacatac 12721 tcttaacact aggccaccac aacaatttac cctgccatgg agaaatacaa aattctaaga 12781 tgaaaatagc agtgtgtaat gatttttatg ctgcaaaaaa acttgacaat aaatctattg 12841 aagccaactg taaatcactt ttatcagggc taagaatacc gataaataag aaagaattaa 12901 atagacagag aaggttatta acactacaaa gcaaccattc ttctgtagca acagttggag 12961 gtagcaaggt catagagtct aaatggttaa caaacaaggc aaacacaata attgattggt 13021 tagaacatat tttaaattct ccaaaaggtg aattaaatta tgattttttt gaagcattag 13081 aaaatactta ccctaatatg attaaactaa tagataatct agggaatgca gagataaaaa 13141 aactgatcaa agtaactgga tatatgcttg taagtaaaaa atgaaaaatg ataaaaatga 13201 taaaataggt gacaacttca tactattcca aagtaatcat ttgattatgc aattatgtaa 13261 tagttaatta aaaactaaaa atcaaaagtt agaaactaac aactgtcatt aagtttatta 13321 aaaataagaa attataattg gatgtatacg //