LOCUS AF103905 2646 bp mRNA linear HUM 06-DEC-1998 DEFINITION Homo sapiens Rap1 guanine-nucleotide exchange factor mRNA, complete cds. ACCESSION AF103905 VERSION AF103905.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2646) AUTHORS de Rooij,J., Zwartkruis,F.J., Verheijen,M.H., Cool,R.H., Nijman,S.M., Wittinghofer,A. and Bos,J.L. TITLE Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP JOURNAL Nature 396 (6710), 474-477 (1998) PUBMED 9853756 REFERENCE 2 (bases 1 to 2646) AUTHORS de Rooij,J., Zwartkruis,F.J.T. and Bos,J.L. TITLE Direct Submission JOURNAL Submitted (02-NOV-1998) Laboratory for Physiological Chemistry, Utrecht University, Universiteitsweg 100, Utrecht 3584 CG, The Netherlands FEATURES Location/Qualifiers source 1..2646 /db_xref="H-InvDB:HIT000069399" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13" /tissue_type="muscle" CDS 1..2646 /note="contains cAMP binding domain; Epac" /codon_start=1 /product="Rap1 guanine-nucleotide exchange factor" /protein_id="AAC83381.1" /translation="MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFS ESLEQASTERVLRAGRQLHRHLLATCPNLTRDRKYHLRLYRQCCSGRELVDGILALGL GVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELA EAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAV LLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVND APRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS RPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQL CAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQK LSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGS SCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAG DAIGLQPDARGVATSLGLNERLFVVNPQEAHELIPHPDQLGPTVGSAEGLDLVSAKDL AGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPAST WAYVQQLKVIDNQRELSRLSRELEP" BASE COUNT 543 a 825 c 781 g 497 t ORIGIN 1 atggtgttga gaaggatgca ccggccccga agctgctcct accagctgct gctggagcac 61 cagcgtccga gctgcatcca ggggctgcgc tggacaccac tcaccaacag cgaggagtcc 121 ctggatttca gcgagagcct ggagcaggcc tccacagagc gggtgctcag ggctgggagg 181 cagctgcatc ggcatctgct ggccacctgc ccaaacctca cccgagaccg gaagtaccac 241 cttaggctct atcggcagtg ctgctctggc cgggagctgg tggatgggat cttggccctg 301 ggacttgggg tccattcccg gagccaagtt gtgggaatct gccaggtgct gctggatgaa 361 ggtgccctct gccatgtgaa acacgactgg gccttccagg accgagatgc ccaattctac 421 cggttccccg ggcccgagcc cgagcccgtg ggaactcatg agatggagga ggagttggcc 481 gaagctgtgg ccctgctctc ccagcggggg cctgacgccc tgctcactgt ggcacttcga 541 aagcccccag gtcagcgcac ggatgaagag ctggacctca tctttgagga gctgctgcac 601 atcaaggctg tggcccacct ctccaactcg gtgaagcgag aattagcggc tgttctgctc 661 tttgaaccac acagcaaggc agggaccgtg ttgttcagcc agggggacaa gggcacttcg 721 tggtacatta tctggaaggg atctgtcaac gtggtgaccc atggcaaggg gctggtgacc 781 accctgcatg agggagatga ttttggacag ctggctctgg tgaatgatgc accccgggca 841 gccaccatca tcctgcgaga agacaactgt catttcctgc gtgtggacaa gcaggacttc 901 aaccgtatca tcaaggatgt ggaggcaaag accatgcggc tggaagaaca tggcaaagtg 961 gtgctggtgc tggagagagc ctctcagggc gccggccctt cccgaccccc aaccccaggc 1021 aggaaccggt atacagtgat gtctggcacc ccagagaaga tcctagagct tctgttggag 1081 gccatgggac cagattccag tgctcatgac ccaacagaga cattcctcag cgacttcctc 1141 ctgacccaca gggtcttcat gcccagcgcc caactctgcg ctgcccttct gcaccacttc 1201 catgtggagc ctgcgggtgg cagcgagcag gagcgcagca cctacgtctg caacaagagg 1261 cagcagatct tgcggctggt cagccagtgg gtggccctgt atggctccat gctccacact 1321 gaccctgtgg ccaccagctt cctccagaaa ctctcagacc tggtgggcag ggacacccga 1381 ctcagcaacc tgctgaggga gcagtggcca gagaggcggc gatgccacag gttggagaat 1441 ggctgtggga atgcatctcc tcagatgaag gcccggaact tgcctgtttg gctccccaac 1501 caggacgagc cccttcctgg cagcagctgt gccatccaag ttggggataa agtcccctat 1561 gacatctgcc ggccagacca ctcagtgttg accctgcagc tgcctgtgac agcctccgtg 1621 agagaggtga tggcagcgtt ggcccaggag gatggctgga ccaaggggca ggtgctggtg 1681 aaggtcaatt ctgcaggtga tgccattggc ctgcagccag atgcccgtgg tgtggccaca 1741 tctctggggc tcaatgagcg tctctttgtt gtcaacccac aggaagcgca tgagctgatc 1801 ccacaccctg accagctggg gcccactgtg ggctctgctg aggggctgga cctggtgagt 1861 gccaaggacc tggcaggcca gctgacggac cacgactgga gcctcttcaa cagtatccac 1921 caggtggagc tgatccacta tgtgctgggc ccccagcatc tgcgggatgt caccaccgcc 1981 aacctggagc gcttcatgcg ccgcttcaat gagctgcagt actgggtggc caccgagctg 2041 tgtctctgcc ccgtgcccgg cccccgggcc cagctgctca ggaagttcat taagctggcg 2101 gcccacctca aggagcagaa gaatctcaat tccttctttg ccgtcatgtt tggcctcagc 2161 aactcggcca tcagccgcct agcccacacc tgggagcggc tgccccacaa agtccggaag 2221 ctgtactccg ccctcgagag gctgctggat ccctcatgga accaccgggt ataccgactg 2281 gccctcgcca agctctcccc tcctgtcatc cccttcatgc cccttcttct caaagacatg 2341 accttcattc atgagggaaa ccacacacta gtggagaatc tcatcaactt tgagaagatg 2401 agaatgatgg ccagagccgc gcggatgctg caccactgcc gaagccacaa ccctgtgcct 2461 ctctcaccac tcagaagccg agtttcccac ctccacgagg acagccaggt ggcgaggatt 2521 tccacatgct cggagcagtc cctgagcacc cggagtccag ccagcacctg ggcttatgtc 2581 cagcagctga aggtcattga caaccagcgg gaactctccc gcctctcccg agagctggag 2641 ccatga //