LOCUS AH005874 6363 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens chromosome 18 deleted in pancreatic carcinoma (DPC4) gene, complete cds. ACCESSION AH005874 AF045438 AF045439 AF045440 AF045441 AF045442 AF045443 AF045444 AF045445 AF045446 AF045447 VERSION AH005874.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6363) AUTHORS Hahn,S.A., Schutte,M., Hoque,A.T., Moskaluk,C.A., da Costa,L.T., Rozenblum,E., Weinstein,C.L., Fischer,A., Yeo,C.J., Hruban,R.H. and Kern,S.E. TITLE DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 JOURNAL Science 271 (5247), 350-353 (1996) PUBMED 8553070 REFERENCE 2 (bases 1 to 6363) AUTHORS Moskaluk,C.A., Hruban,R.H., Schutte,M., Lietman,A.S., Smyrk,T., Fusaro,L., Fusaro,R., Lynch,J., Yeo,C.J., Jackson,C.E., Lynch,H.T. and Kern,S.E. TITLE Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma JOURNAL Diagn. Mol. Pathol. 6 (2), 85-90 (1997) PUBMED 9098646 REFERENCE 3 (bases 1 to 6363) AUTHORS Hahn,S.A., Schutte,M. and Kern,S.E. TITLE Direct Submission JOURNAL Submitted (30-JAN-1998) Oncology, Johns Hopkins Univ. Sch. of Med., 632 Ross Bldg., 720 Rutland Ave., Baltimore, MD 21205-2196, USA COMMENT On or before Jun 10, 2016 this sequence version replaced AF045438.1, AF045439.1, AF045440.1, AF045441.1, AF045442.1, AF045443.1, AF045444.1, AF045445.1, AF045446.1, AF045447.1, AH005874.1. FEATURES Location/Qualifiers source 1..6363 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="18" /map="18q21.1" gene <1..>6363 /gene="DPC4" mRNA join(<1..376,949..1123,1681..1710,2180..2392,2774..2893, 2988..3104,3486..3536,3993..4176,4421..4589,4848..4986, 5259..>6363) /gene="DPC4" /product="deleted in pancreatic carcinoma" exon <1..376 /gene="DPC4" /number=1 5'UTR <1..127 /gene="DPC4" CDS join(128..376,949..1123,1681..1710,2180..2392,2774..2893, 2988..3104,3486..3536,3993..4176,4421..4589,4848..4986, 5259..5470) /gene="DPC4" /note="tumor suppressor; similar to MADH4" /codon_start=1 /product="deleted in pancreatic carcinoma" /protein_id="AAC03051.1" /translation="MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLV KKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWP DLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKD EYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIP VASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPY TPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQ VGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECK GEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQ AATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKG WGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD" gap 514..613 /estimated_length=unknown exon 949..1123 /gene="DPC4" /number=2 gap 1382..1481 /estimated_length=unknown exon 1681..1710 /gene="DPC4" /number=3 gap 1902..2001 /estimated_length=unknown exon 2180..2392 /gene="DPC4" /number=4 gap 2537..2636 /estimated_length=unknown exon 2774..2893 /gene="DPC4" /number=5 exon 2988..3104 /gene="DPC4" /number=6 gap 3244..3343 /estimated_length=unknown exon 3486..3536 /gene="DPC4" /number=7 gap 3678..3777 /estimated_length=unknown exon 3993..4176 /gene="DPC4" /number=8 gap 4232..4331 /estimated_length=unknown exon 4421..4589 /gene="DPC4" /number=9 gap 4680..4779 /estimated_length=unknown exon 4848..4986 /gene="DPC4" /number=10 gap 5107..5206 /estimated_length=unknown exon 5259..>6363 /gene="DPC4" /number=11 3'UTR 5471..>6363 /gene="DPC4" BASE COUNT 1607 a 910 c 1054 g 1878 t ORIGIN 1 ggttatcctg aatacatgtc taacaatttt ccttgcaacg ttagctgttg tttttcactg 61 tttccaaagg atcaaaattg cttcagaaat tggagacata tttgatttaa aaggaaaaac 121 ttgaacaatg gacaatatgt ctattacgaa tacaccaaca agtaatgatg cctgtctgag 181 cattgtgcat agtttgatgt gccatagaca aggtggagag agtgaaacat ttgcaaaaag 241 agcaattgaa agtttggtaa agaagctgaa ggagaaaaaa gatgaattgg attctttaat 301 aacagctata actacaaatg gagctcatcc tagtaaatgt gttaccatac agagaacatt 361 ggatgggagg cttcaggtag tcttataaga ttttnctata tcctctatgg gtataccctc 421 tatggtggca gatttaaaaa cttnctacgt ttcctttcaa nctactacan nntaatttaa 481 tttntnctcc atctcttcac atactctgca tccnnnnnnn nnnnnnnnnn nnnnnnnnnn 541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 601 nnnnnnnnnn nnnggtcttg ccatgtgcca ggctggtctt gaactcctgg gctcaagcga 661 tcctccggcc ttggcctccc aaagtgatag gatcaacagg tgtgagccac catgcccagt 721 cactttttac atttttaaaa cctgagcaca ggccttgaaa ttataccaag gtttaaattc 781 taggtctgat gtatgacatg gccaagttag ttattgtgaa ttttagtttt gttatttatg 841 aaatggggat tgtaatactg agttggtagg attgtgagga ttaaacagaa tatataaaag 901 tgtcttgcat aatgtgacac atgaataaat ggtcgtttat ttttctaggt ggctggtcgg 961 aaaggatttc ctcatgtgat ctatgcccgt ctctggaggt ggcctgatct tcacaaaaat 1021 gaactaaaac atgttaaata ttgtcagtat gcgtttgact taaaatgtga tagtgtctgt 1081 gtgaatccat atcactacga acgagttgta tcacctggaa ttggtaagta gtttgtttca 1141 tcctaagaaa cataaaggga aaaggatctc aatagtgttt cantttttgt aagtnaaatt 1201 ataaatttgg aagatagccc gcgnctttaa ataaggttaa agaatcagca tttttaatat 1261 acgatttaaa tttganttta ggaacaaact tatattttga ctgctaaaac cgagtattgt 1321 agttgatatt ttgccccttt agaacattgt ttttgagaaa taagatggaa agcattataa 1381 annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngagaaataa gatggaaacg 1501 cattataaat ttgaatactt tgttatgtat tgttagatag cgtttatgct acttctgaat 1561 tgaaatggtt catgaacttt tgtaatcttt ggtttaaatt tagattctct gtttttaaat 1621 ggaaaatact ttcattgtaa tgattaatgt ttcatttgtt ttccccttta aagaattaag 1681 atctctcagg attaacactg cagagtaatg gtaggtaatc tgtttcttac tactttctct 1741 ttgttttgcc tatcctctct gtntttntgt tgacctagaa ttagtttgtg tgagcggcag 1801 gcagtaacat taacaagaaa ataacttact gctttggaaa tgtagatttt gaggttaggg 1861 gcatttaaaa ctggatttaa aactggattt aaattggcta tnnnnnnnnn nnnnnnnnnn 1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1981 nnnnnnnnnn nnnnnnnnnn naaatgactt ttgctggtaa agtagtatgc ttttaaaata 2041 atatgaaaaa attctgaatt aaggttagta atttacactg taattgattt taggtgttat 2101 tatattactt gctaataaga tttttttttc tgggaataga agcttataaa atttaaaata 2161 tgtttggttt tctatatagc tccatcaagt atgatggtga aggatgaata tgtgcatgac 2221 tttgagggac agccatcgtt gtccactgaa ggacattcaa ttcaaaccat ccagcatcca 2281 ccaagtaatc gtgcatcgac agagacatac agcaccccag ctctgttagc cccatctgag 2341 tctaatgcta ccagcactgc caactttccc aacattcctg tggcttccac aagtgagttc 2401 tagaatcaga tgtagtcagc aagttgagtt ttcctaatca ttcattattt atgtgtagtc 2461 acttggggga aactccaagt aagtaaacat taaaagtaac tgtactatct ttcataggta 2521 aacaggtatt aaacagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntggc 2641 catgggtgag ttacactttt tgcccatctt tatagttgtg cattatcaga taaaattggt 2701 ccttgattta gtatatgaaa tcataagatg acatctatga atgtaccatg ttaatgtctt 2761 cttgttcctc taggtcagcc tgccagtata ctggggggca gccatagtga aggactgttg 2821 cagatagcat cagggcctca gccaggacag cagcagaatg gatttactgg tcagccagct 2881 acttaccatc atagtatgta catactttaa aaaatctttt aaatagttga gaaaaagtag 2941 gcagccttta taaaagcaaa ttaacccatg tgggccttaa tttttagaca gcactaccac 3001 ctggactgga agtaggactg caccatacac acctaatttg cctcaccacc aaaacggcca 3061 tcttcagcac cacccgccta tgccgcccca tcccggacat tactgtaagc tcttgttttt 3121 gttgtaaggg ctattttttt tttttttttg gtagggcttt gttttctgtt ttttaaaaat 3181 gtttttacat cttttattca tcctgtgatt ttgtttcatt aaatagtgct tttcagtatt 3241 tttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnttttaag ttcttagaca 3361 ttgcataagc ttgttttaaa caattcctaa cctataatag ttatatttaa gtaagattta 3421 ctgaaagttt tagcattaga caacttttag taaataaaaa tggaattttg ttgtcttttc 3481 tttagggcct gttcacaatg agcttgcatt ccagcctccc atttccaatc atcctggtaa 3541 gtgtatttca aaattgattt cctgtattta gattgattta gtggtgattg aaacgacaaa 3601 cacaggcttt aatggaatta tggggtcact tctcagatga gtacaatact catcatgcat 3661 gagttaatca acagtttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaag 3781 aacagtgcta agtactgagc tagaaaatag aagacatgga aattcctacc ttttaatgca 3841 ttatgttatt ttaatccagt tgtttgggtg cattacattt ccatctcccc tccctttacc 3901 ctttctttta ggaaaaactg tgttgtggag tgcaagtgaa agccttatat ctttctcatg 3961 ggaggatgtt ctttcccatt tatttcctat agctcctgag tattggtgtt ccattgctta 4021 ctttgaaatg gatgttcagg taggagagac atttaaggtt ccttcaagct gccctattgt 4081 tactgttgat ggatacgtgg acccttctgg aggagatcgc ttttgtttgg gtcaactctc 4141 caatgtccac aggacagaag ccattgagag agcaaggtat tgattgtata gtcagatagt 4201 tactttaaaa aattgagcat agtacattgt cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4321 nnnnnnnnnn ncaatattaa gcatgctata caatctgaag taaaatttaa tttaaaatac 4381 attatcaaga taaaatgtaa tttctttttt tcttcctaag gttgcacata ggcaaaggtg 4441 tgcagttgga atgtaaaggt gaaggtgatg tttgggtcag gtgccttagt gaccacgcgg 4501 tctttgtaca gagttactac ttagacagag aagctgggcg tgcacctgga gatgctgttc 4561 ataagatcta cccaagtgca tatataaagg ttagttacaa ttttatttga atattttaga 4621 cttaaagctc tatttgttgt caaaagaatt gaaatctggg tggaaggaat ggaaaaatgn 4681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna ggcattggtt tttaatgtat 4801 ggaattttct ttatgaactc atagtatgaa atgttttttg ttaaaaggtc tttgatttgc 4861 gtcagtgtca tcgacagatg cagcagcagg cggctactgc acaagctgca gcagctgccc 4921 aggcagcagc cgtggcagga aacatccctg gcccaggatc agtaggtgga atagctccag 4981 ctatcagtaa gtatgctttt cattcttttt taaaggtata atagttgata tttttatctt 5041 gatttactca gttgattagt ttctttgagc agtaatagaa attaaagttt ttttttactg 5101 ggtgtgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntggg aagagatcac 5221 cctgtccctc tgatgtcttc caaactcttt tctgttaggt ctgtcagctg ctgctggaat 5281 tggtgttgat gaccttcgtc gcttatgcat actcaggatg agttttgtga aaggctgggg 5341 accggattac ccaagacaga gcatcaaaga aacaccttgc tggattgaaa ttcacttaca 5401 ccgggccctc cagctcctag acgaagtact tcataccatg ccgattgcag acccacaacc 5461 tttagactga ggtcttttac cgttggggcc cttaacctta tcaggatggt ggactacaaa 5521 atacaatcct gtttataatc tgaagatata tttcactttt cttctgcttt atcttttcat 5581 aaagggttga aaatgtgttt gctgccttgc tcctagcaga cagaaactgg attaaaacaa 5641 tttttttttc ctcttcagaa cttgtcaggc atggctcaga gcttgaagat taggagaaac 5701 acattcttat taattcttca cctgttatgt atgaaggaat cattccagtg ctagaaaatt 5761 tagcccttta aaacgtctta gagcctttta tctgcagaac atcgatatgt atatcattct 5821 acagaataat ccagtattgc tgattttaaa ggcagagaag ttctcaaagt taattcacct 5881 atgttatttt gtgtacaagt tgttattgtt gaacatactt caaaaataat gtgccatgtg 5941 ggtgagttaa ttttaccaag agtaacttta ctctgtgttt aaaaatgaag ttaataatgt 6001 attgtaatct ttcatccaaa atattttttg caagttatat tagtgaagat ggtttcaatt 6061 cagattgtct tgcaacttca gttttatttt tgccaaggca aaaaactctt aatctgtgtg 6121 tatattgaga atcccttaaa attaccagac aaaaaaattt aaaattacgt ttgttattcc 6181 tagtggatga ctgttgatga agtatacttt tcccctgtta aacagtagtt gtattcttct 6241 gtatttctag gcacaaggtt ggttgctaag aagcctataa gaggaatttc ttttccttca 6301 ttcataggga aaggttttgt attttttaaa acactaaaag cagcgtcact ctacctaatg 6361 tct //