LOCUS AB065187 15384 bp RNA linear VRL 22-JUN-2023 DEFINITION Respirovirus muris genomic RNA, complete genome, clone:E15cl2, viral complementary sequence. ACCESSION AB065187 VERSION AB065187.1 KEYWORDS . SOURCE Respirovirus muris ORGANISM Respirovirus muris Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Feraresvirinae; Respirovirus. REFERENCE 1 (bases 1 to 15384) AUTHORS Sakaguchi,T., Fujii,Y. and Yoshida,T. TITLE Direct Submission JOURNAL Submitted (09-JUL-2001) to the DDBJ/EMBL/GenBank databases. Contact:Takemasa Sakaguchi Hiroshima University School of Medicine, Department of Bacteriology; 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan REFERENCE 2 AUTHORS Fujii,Y., Sakaguchi,T., Kiyotani,K., Huang,C., Fukuhara,N., Egi,Y. and Yoshida,T. TITLE Involvement of the Leader Sequence in Sendai Virus Pathogenesis Revealed by Recovery of a Pathogenic Field Isolate from cDNA JOURNAL J. Virol. 76, 8540-8547 (2002) COMMENT FEATURES Location/Qualifiers source 1..15384 /clone="E15cl2" /db_xref="taxon:3052731" /mol_type="genomic RNA" /note="E15cl2 was obtained by a serial passage of E0 (AB039658) in embryonated chicken eggs through 15 generations and by a plaque cloning using LLC-MK2 cells." /organism="Respirovirus muris" /strain="Hamamatsu" regulatory 1..52 /note="3' leader sequence" /regulatory_class="promoter" repeat_region 56..65 /function="transcription start" /note="R1 sequence" CDS 120..1694 /codon_start=1 /function="RNA binding" /gene="N" /product="nucleocapsid protein" /protein_id="BAC07505.1" /transl_table=1 /translation="MAGLLSTFDTFSSRRSESINKSGGGAVIPGQRSTVSVFVLGPSV TDDADKLFIATTFLAHSLDTDKQHSQRGGFLVSLLAMAYSSPELYLTTNGVNADVKYV IYNIEKDPKRTKTDGFIVKTRDMEYERTTEWLFGPMVNKSPLFQGQRDAADPDTLLQI YGYPACLGAIIVQVWIVLVKAITSSAGLRKGFFNRLEAFRQDGTVKGALVFTGETVEG IGSVMRSQQSLVSLMVETLVTMNTARSDLTTLEKNIQIVGNYIRDAGLASFMNTIKYG VETKMAALTLSNLRPDINKLRSLIDTYLSKGPRAPFICILKDPVHGEFAPGNYPALWS YAMGVAVVQNKAMQQYVTGRTYLDMEMFLLGQAVAKDAESKISSALEDELGVTDTAKE RLRHHLANLSGGDGAYHKPTGGGAIEVALDNADIDLEPEAHTDQDARGWGGDSGDRWA RSTSSGHFITLHGAERLEEETNDEDVSDIERRIARRLAERRQEDATTHEDEGRNNGVD HDEEDDAAAAAGMGGI" repeat_region 1729..1737 /function="poly A signal" /note="R2 sequence" repeat_region 1741..1750 /function="transcription start" /note="R1 sequence" CDS 1844..3550 /codon_start=1 /function="RNA polymerase cofactor" /gene="P" /product="phosphoprotein" /protein_id="BAC07506.1" /transl_table=1 /translation="MDQDALISKEDSEVEREASGGRESLSDVIGFLDAVLSSEPTDIG GDRSWLHNTINTLQRPGSTHRAKGEGEGEVSTSSTQDNRSGEESRVSGGTSEPEAEAH ARNVDKQNIHWATGRGASTDSVPQDLGNGRDSGILEDPPNEGGYPRSGAEDENREMAA NPDKRGEDQAEGLPEEIRRSAPLPDEGEGRADNNGRGVESGSPHSARVTGVLVIPSPE LEEAVLQRNKRRPANSGSRSLTPVVVPSTRSPPPDHDNSTRSPPRKPPTTQDEHTNPR NTPAVRIKDRRPPTGTRSAPDRPTDGYPTHPGPETDATKKGIGENTSSMKEMATLLTS LGVIQSAQEFESSRDASYVFARRALKSANYAEMTFNVCGLILSAEKSFANRVDENKQL LKQIQESVESFRDIYKRFSEYQKEQNSLLMSNLSTLHIITDRGGKTDNPDSPTRSPSV FAKTKENKTKATRFDPSMETMGDMKYKPDLLREDEFRDEIRNPVYQERDTEPRASNAS RLLPSREKPTIHSLRLVIESSPLSRAEKAAYVKSLSKCKTDQEVKAVMELVEEDIESL TN" CDS 1844..2952 /codon_start=1 /exception="RNA editing" /gene="V" /note="A non-templated G residue is inserted into the V mRNA during transcription due to RNA editing. Thus the P and V proteins are amino-coterminal, but have distinct carboxyl termini." /product="V protein" /protein_id="BAC07507.1" /transl_table=1 /translation="MDQDALISKEDSEVEREASGGRESLSDVIGFLDAVLSSEPTDIG GDRSWLHNTINTLQRPGSTHRAKGEGEGEVSTSSTQDNRSGEESRVSGGTSEPEAEAH ARNVDKQNIHWATGRGASTDSVPQDLGNGRDSGILEDPPNEGGYPRSGAEDENREMAA NPDKRGEDQAEGLPEEIRRSAPLPDEGEGRADNNGRGVESGSPHSARVTGVLVIPSPE LEEAVLQRNKRRPANSGSRSLTPVVVPSTRSPPPDHDNSTRSPPRKPPTTQDEHTNPR NTPAVRIKDRRPPTGTRSAPDRPTDGYPTHPGPETDATKKGHRREHIIYERDGYIVNE SWCNPVCSRIRVISRRELCVCKACPKICKLCRDDI" CDS 1854..2468 /codon_start=1 /function="anti-interferon" /gene="C" /product="C protein" /protein_id="BAC07508.1" /transl_table=1 /translation="MPSFLKKILKLRGRRQEDESRSRMLSDSSTQSYQVNQLTSEETE AGSTIPSTPSKGQALPTEPKVRAREKSRHRRPKIIDQVRRVESLGEQASQRQKHMLET LINKIYTGPLGEELVQTLYLRIWAMEETPESLKILQMREDIRDQVLKMKTERWLRTLI RGEKTKLKDFQKRYEEVHPYLMKEKVEQIIMEEAWSLAAHIVQE" misc_feature 2791..2793 /note="A non-templated G residue is inserted into the V mRNA during transcription due to RNA editing between 2791 and 2793." repeat_region 3625..3633 /function="poly A signal" /note="R2 sequence" repeat_region 3637..3646 /function="transcription start" /note="R1 sequence" CDS 3669..4715 /codon_start=1 /gene="M" /product="matrix protein" /protein_id="BAC07509.1" /transl_table=1 /translation="MADIYRFPKFSYEDNGTVEPLPLRTGPDKKAIPHIRIVKVGDPP KHGVRYLDLLLLGFFETPKQTASLGSVSDLTEHTGYSICGSGSLPIGVAKYHGSDQEL LKACTDLRITVRRTVRAGEMIVYMVDSIGAPLLPWSGRLRQGMIFNANKVALAPQCLP VDKDIRFRVVFVNGTSLGAITIAKIPKTLADLALPNSISVNLLVTLKTGIPTEQKGVL PVLDDQGEKKLNFMVHLGLIRRKVGKIYSVEYCKSKIERMRLIFSLGLIGGISFHVQV TGTLSKTFMSQLAWKRAVCFPLMDVNPHMNLVIWAASVEITDVDAVFQPAIPRDFRYY PNVVAKNIGRIRKL" repeat_region 4801..4809 /function="poly A signal" /note="R2 sequence" repeat_region 4813..4822 /function="transcription start" /note="R1 sequence" CDS 4866..6563 /codon_start=1 /gene="F" /product="fusion protein" /protein_id="BAC07510.1" /transl_table=1 /translation="MATYIQRVQCISALLSVVLTTLVSCQIPRDRLSNIGVIVDEGKS LKIAGSHESRYIVLSLVPGVDLENGCGTAQVIQYKSLLNRLLIPLRDALDLQEALITV TNDTMTSADVPQSRFFGAVIGTIALGVATSAQITAGIALAEAREAKRDIALIKESMTK THKSIELLQNAVGEQILALKTLQDFVNDEIKPAISELGCETAALRLGIKLTQHYSELL TAFGSNFGTIGEKSLTLQALSSLYSANITEIMTTIRTGQSNIYDVIYTEQIKGTVIDV DLERYMVTLSVKIPILSEVPGVLIHKASSISYNIDGEEWYVTVPSHILSRASFLGGAN IADCVESRLTYICPRDPAQLIPDSQQKCILGDTTRCPVTKVVDNLIPKFAFVNGGVVA NCIASTCTCGTGRRPISQDRSKGVVFLTHDNCGLIGVNGIELYANRKGHDATWGVQNL TVGPAIAIRPVDISLNLAAATDFLQDSRAELEKARKILSEVGRWYNSGATLITIIVVM IVVLVVIIVIVIVLYRLRRSMLMSNPAGRISRDTYTLEPKIRHMYTNGGFDAMTEKR" repeat_region 6625..6633 /function="poly A signal" /note="R2 sequence" repeat_region 6637..6646 /function="transcription start" /note="R1 sequence" CDS 6693..8420 /codon_start=1 /gene="HN" /product="hemagglutinin-neuraminidase" /protein_id="BAC07511.1" /transl_table=1 /translation="MDGDRSKRDSYWSTSPGGSTTKLVSDSERSGKVDTWLLILAFTQ WALSIATVIICIVIAARQGYSMERYSMTVEALNTSNKEVKESLTSLIRQEVITRAVNI QSSVQTGIPVLLNKNSRDVIQLIEKSCNRQELTQLCDSTIAVHHAEGIAPLEPHSFWR CPAGEPYLSSDPEVSLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCAD IGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPTV DERTDYSSDGIEDLVLDILDLKGRTKSHRYSNSEIDLDHPFSALYPSVGSGIATEGSL IFLGYGGLTTPLQGDTKCRIQGCQQVSQDTCNEALKITWLGGKQVVSVLIQVNDYLSE RPRIRVTTVPITQNYLGAEGRLLKLGDQVYIYTRSSGWHSQLQIGVLDVSHPLTISWT PHEALSRPGNEDCNWYNTCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIM YSNTTNIINMLRIKDVKLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTS IPKLCKAES" repeat_region 8516..8524 /function="poly A signal" /note="R2 sequence" repeat_region 8528..8537 /function="transcription start" /note="R1 sequence" CDS 8556..15242 /codon_start=1 /gene="L" /product="large protein" /protein_id="BAC07512.1" /transl_table=1 /translation="MDGQESSQNPSDILYPECHLNSPIVRGKIAQLHVLLDVNQPYIL KDDSIINITKHKIRNGGLSPRQIKIRSLGKALQRTIKDLDRYTFEPYPTYSQELLRLD IPEICDKIRSVFAVSDRLTKELSNGFQDLWLNIFKQLGNIEGREGYDPLQDISTIPEI TERYSRNKWYRPFLTWFSIKYDMRWMQKTRPGGPLDTSNSHNLLECKSYTLVTYGDLV MILNKLTLTGYILTPELVLMYCDVVEGRWNMSAAGQLDKRSTGITSKGEELWELVDSL FSSLGEEIYNVIALLEPLSLALIQLSDPVIPLRGAFMRHVLTELQTVLTSKDVYTDPE ADAIVESLLAIFHGTSIDEKAEIFSFFRTFGHPSLEAVTAADKVRAHMYAQKAIKLKT LHECHAVFCTIIINGYRERHGGQWPPCDFPDHVCLELRNAQGSNTAISYECAVDNYTS FIGFKFRKFIEPQLDEDLTIYMKDKALSPRKEAWDSVYPDSNLYYKVPESEETRRLIE VFINDENFNPEDIIDYVESGDWLKDEKFNISYSLKEKEIKQEGRLFAKMTYKMRAVQV LAETLLAKGIGELFSENGMVKGEIDLLKRLTTLSVSGVPRTDSVYNNPRSSEKRNEGM KKRNSKGYWDEKKRSRHEFKATDSSTDGYETLSCFLTTDLKKYCLNWRFESTALFGQR CNEIFGFKTFFNWMHPVLEKCTIYVGDPYCPVADRMHRQLQDHADSGIFIHNPRGGIE GYCQKLWTLISISAIHLAAVRVGVRVSAMVQGDNQAIAVTSRVPVAQTYKQKKNHVYE EITRYFGALRHVMFDIGHELKLNETIISSKMFVYSKRIYYDGKILPQCLKALTRCVFW SETLVDENRSACSNISTSIAKAIENGYSPILGYCIALYKTCQQVCISLGMTINPTISP TVRDQYFKGKNWLRCAVLIPANVGGFNYMSTSRCFVRNIGDPAVAALADLKRFIRADL LDKQVLYRVMNQEPGDSSFLDWASDPYSCNLPHSQSITTIIKNITARSVLQESPNPLL SGLFTETSGEEDLNLASFLMDRKVILPRVAHEILGNSLTGVREAIAGMLDTTKSLVRA SVKRGGLSYGILRRLVNYDLLQYETLTRTLRKPVKDNIEYEYMCSVELAVGLRQKMWI HLTYGRPIHGLETPDPLELLRGTFIEGSEVCKLCRSEGADPIYTWFYLPDNIDLDTLT NGCPAIRIPYFGSATDERSEAQLGYVRNLSKPAKAAIRIAMVYTWAYGTDEISWMEAA LIAQTRANLSLENLKLLTPVSTSTNLSHRLKDTATQMKFSSATLVRASRFITISNDNM ALKEAGESKDTNLVYQQIMLTGLSLFEFNMRYKKGSLEKPLILHLHLNNGCCIMESPQ EANIPPRSTLDLEITQENNKLIYDPDPLRDVDLELFSKVRDVVHTVDMTYWSDDEVIR ATSICTAMTIADTMSQLDRDNLKEMIALVNDDDVNSLITEFMVIDVPLFCSTFGGILV NQFAYSLYGLNIRGREEIWGHVVRILKDTSHAVLKVLSNALSHPKIFKRFWNAGVVEP VYGPNLSNQDKTLLALSVCEYSVDLFMHDWQGGVPLEVFICDNDPDVADMRRSSFLAR HLAYLCSLAEISRDGPRLESMNSLERLETLKSYLELTFLDDPVLRYSQLTGLVIKVFP STLTYIRKSSIKVLRTRGIGVPEVLEDWDPEADNALLDGIAAEIQQNIPLGHQTRAPF WGLRVSKSQVLRLRGYEEITRGEVGRSGVGLTLPFDGRYLSHQLRLFGVNSTSCLKAL ELTYLLSPLVDKDKDRLFLGEGAGAMLSCYDATLGPCINYYNSGVYSCDVNGQRELNI YPAEVALVGKKLNNVTSLGQRVKVLFNGNPGSTWIGNDECEALIWNELQNSSIGLVHC DMEGGDHKDDQVVLHEHYSVIRIAYLVGDRDVVLISKIAPRLGTDWTRQLSLYLRYWD EVNLVVLKTSNPASTEMYLLSRHPKSDIIEDSKTVLASLHPLSKEDSIKIEKWILIEK AKAHEWVTRELREGSSSSGMLRPYHQALQTFGFEPNLYKLSRDFLSTMNIADTHNCMT AFNRVLKDTIFEWARITESDKRLKLTGKYDLYPVRDSGKLKTISRRLVLSWVSLSMST RLVTGSFPDQKFEARLQLGIVSLSSREIRNLRVITKTILDRFENTIHSITYRFLTKEI KILMKILGAVKMFGARQNEYTTVVDDGSLDDIEPYDSL" repeat_region 15319..15327 /function="poly A signal" /note="R2 sequence" regulatory 15331..15384 /note="5' trailer sequence" /regulatory_class="promoter" BASE COUNT 4577 a 3308 c 3805 g 3694 t ORIGIN 1 accaaacaag agaagaaaca tgtatggaat atataatgaa gttagacagg attttagggt 61 caaagtatcc accctgaaga gcaggttcca gacccttaac tttgctgcca aagttcacga 121 tggctgggtt gttgagcacc ttcgacacgt ttagctctag gaggagtgag agtattaata 181 agtcaggagg aggtgctgtt atccccggcc agaggagcac agtctcagtg ttcgtactag 241 gcccaagtgt gactgatgat gcagacaagt tattcattgc aaccaccttc ttagctcact 301 cattagacac agataagcag cactctcaga gaggagggtt cctagtctcc ctacttgcca 361 tggcttacag tagtccagaa ttatacttga caacaaatgg agtaaatgcc gatgttaagt 421 acgtgatcta caacatagag aaggacccta agaggacgaa gacggatgga ttcattgtga 481 agacaaggga catggaatat gagaggacca cagagtggct gtttggacct atggtcaaca 541 agagtccgct tttccagggg caacgagatg ctgcagaccc tgatacgctc cttcaaatct 601 atgggtatcc ggcatgccta ggggcaatta ttgtccaggt ctggattgtg ctggtgaagg 661 caatcacgag tagtgccggc ctaaggaaag gatttttcaa tagattagag gctttcagac 721 aagatggcac tgtgaaaggt gccttagttt tcactgggga gacagttgag gggataggct 781 cggtcatgcg atcccagcaa agcttggtat ctctcatggt tgagaccctt gtgactatga 841 acactgcgag gtccgatctc actacactag agaagaacat ccagatcgtt gggaactaca 901 tccgagatgc aggactagcc tctttcatga ataccatcaa atatggggta gagacaaaga 961 tggcggcctt aacgctgtca aacctgaggc ccgacatcaa caagctgaga agcctcatag 1021 acacctacct gtcaaaagga cccagggctc cttttatttg tatcctaaag gaccctgtcc 1081 atggtgagtt tgcaccaggc aactatccag cactctggag ctatgcaatg ggagtcgccg 1141 ttgtacagaa caaggcgatg cagcagtacg tcacagggag aacatacctt gatatggaga 1201 tgttcttact aggacaagct gtagcaaagg acgctgagtc caagatcagc agtgctctgg 1261 aggacgagct aggagtgaca gatacggcta aggagaggct cagacatcat ttggcaaatc 1321 tgtccggtgg ggatggcgcg taccacaagc caacaggcgg cggtgcaatc gaggtagctc 1381 tagacaatgc cgacatagac ctggagcctg aagctcacac agatcaggac gccagaggtt 1441 ggggtgggga tagcggtgac agatgggctc gctcgacgag tagtggccac tttatcacac 1501 tacatggggc agaacggttg gaggaggaga ccaatgatga agatgtctcc gacatagaga 1561 gaagaatagc taggaggctt gcagagagac ggcaagagga cgctacaacc cacgaagacg 1621 aaggccgtaa taacggtgtt gatcatgacg aagaggatga tgccgcggca gcagctggga 1681 tgggaggaat ctaagatcac acgaggattt aggatacatg acccgtagta agaaaaactt 1741 agggtgaaag ctcatccacc gatccgccca gaccaggcca catccaactc cattgactac 1801 gcccagcagt ccagacaacc acggcttcgg ctacacttcc cgcatggatc aagatgccct 1861 catttctaaa gaagattctg aagttgagag ggaggcgtca ggaggacgag agtcgctctc 1921 ggatgttatc ggattcctcg acgcagtcct atcaagtgaa ccaactgaca tcggaggaga 1981 cagaagctgg ctccacaata ccatcaacac cctccaaagg ccaggctcta cccacagagc 2041 caaaggtgag ggcgagggag aagtctcgac atcgtcgacc caagataatc gatcaggtga 2101 ggagagtaga gtctctgggg gaacaagcga gccagaggca gaagcacatg ctagaaacgt 2161 tgataaacaa aatatacact gggccactgg gagaggagct agtacagact ctgtacctca 2221 ggatctgggc aatggaagag actccggaat ccttgaagat cctccaaatg agggaggata 2281 tccgagatca ggtgctgaag atgaaaaccg agagatggct gcgaaccctg ataagagggg 2341 agaagaccaa gctgaaggac ttccagaaga gatacgaaga agtgcacccc tacctgatga 2401 aggagaaggt agagcagata ataatggaag aggcgtggag tctggcagcc cacatagtgc 2461 aagagtgact ggagtcttgg tgatccccag tcctgagctc gaagaggccg tgctacaaag 2521 gaacaagaga cgacccgcca acagcgggtc cagatctctc accccagtgg tcgtgcctag 2581 cactcggtct ccaccaccgg accatgacaa tagtacaagg tcaccaccaa ggaaaccccc 2641 aaccacgcag gatgagcaca ccaaccccag gaacaccccc gccgtcagga tcaaggatcg 2701 gagaccccca acagggactc gctccgcccc agaccgcccg accgacggct atccaaccca 2761 cccaggtcca gagaccgacg caacaaaaaa gggcatagga gagaacacat catctatgaa 2821 agagatggct acattgttaa cgagtcttgg tgtaatccag tctgctcaag aattcgagtc 2881 atctcgagac gcgagttatg tgtttgcaag gcgtgcccta aaatctgcaa actatgcaga 2941 gatgacattt aatgtatgcg gcttgatcct ttctgctgag aaatctttcg ccaatagagt 3001 agacgagaat aaacagctgc ttaaacagat ccaagaaagt gtagagtcat ttcgggacat 3061 atacaagaga ttctctgagt atcagaagga acagaactca ctgctgatgt ctaacctatc 3121 tacacttcat attatcacag acagaggtgg caagactgac aatccagatt ctcccacaag 3181 gtccccctct gtttttgcaa aaacaaaaga gaacaagacc aaagcaacta ggtttgaccc 3241 gtctatggag accatggggg atatgaagta taaaccagac ctactccgag aggatgaatt 3301 tagagatgag atccgcaacc cggtgtacca ggaaagagat accgaaccca gagcatccaa 3361 tgcatcacgt ctgcttccat caagagagaa gcctacaata cactccctca ggctcgtcat 3421 agagagcagt cccctaagca gagctgaaaa ggcagcatat gtgaaatcat tatccaaatg 3481 caagacagac caagaggtta aggcagtcat ggagcttgta gaagaagaca tagaatcact 3541 gactaattaa gaactaggtg aggcatctaa tcatcctcag tagtggagcg acctaattca 3601 tcattagcat cagccagtag agattaagaa aaacttaggg tgaaagaaat ttcacctaat 3661 aagatacaat ggccgacatc tatagattcc ccaagttctc atatgaggat aacggtactg 3721 tagagcctct gcctctgaga actggtccgg ataagaaggc catccctcat atcaggattg 3781 tcaaggtagg agaccctcca aagcatggag tgagatacct agatttattg ctcttaggct 3841 tctttgagac gccgaagcaa acggccagct tagggagtgt gtccgacctg acagagcaca 3901 ccggctactc aatctgtggc tccggatcgt tacccatagg tgtagctaaa taccacgggt 3961 ctgatcagga actcttaaag gcctgcactg atctcagaat tacagtgagg aggactgttc 4021 gagcagggga gatgatagta tacatggtgg attcgatcgg tgctccactc ctaccatggt 4081 cgggcaggct gagacaggga atgatattta atgccaacaa ggtcgcgctt gccccccagt 4141 gcctcccggt ggacaaggac ataagattca gagtggtgtt tgtcaatggg acatccctgg 4201 gggcgatcac tatagccaag atcccaaaga ctcttgcaga ccttgcattg cctaattcta 4261 tctctgttaa cctactagtg acactcaaga ccgggatccc cacggagcaa aagggggtac 4321 tcccagtact cgatgatcaa ggagagaaga agctcaattt tatggtgcat cttgggttga 4381 tcagaagaaa agtcgggaag atatactccg ttgagtactg caagagcaag atcgagagga 4441 tgcggctgat cttctcactt gggttaattg gcggcataag cttccatgtc caggtcactg 4501 ggaccctatc taagacattc atgagccagc tcgcatggaa aagagcggtc tgcttcccat 4561 tgatggacgt gaatcctcat atgaacctgg tgatttgggc ggcgtctgtt gagatcacag 4621 acgttgatgc ggttttccag ccggccatcc ctcgtgattt ccgctactac cctaatgtcg 4681 tggcaaagaa catagggagg atcaggaagc tgtaaatgtg catccatcag ggacctacga 4741 caatgcctag agcagacacc acttggcagc cggagccata gcattgctct ttgtattaag 4801 taagaaaaac ttagggataa agtcccttgc gcgtgccctg tcgtagaact ttccttttgg 4861 ggaaaatggc gacttatatc cagagggtac agtgcatatc tgcattattg tcagttgtgc 4921 tcacaacact ggtctcgtgt caaattccta gagataggct ctctaatata ggggtcatag 4981 tcgacgaagg gaaatcactg aagattgccg ggtcccacga atctaggtac atcgtattaa 5041 gtctggtccc aggggtagac ctcgaaaatg ggtgcggaac agctcaggtt atccagtata 5101 agagcctact gaaccggttg ttaatcccat tgagagatgc cttagatctt caggaggctc 5161 tgataactgt cactaatgac acgatgacca gtgctgatgt cccacagtca agattcttcg 5221 gcgccgtgat tgggaccata gcacttggag tggcaacatc agcacagata accgcaggga 5281 tcgcgctagc tgaggcgagg gaggccaaga gagacatagc actcataaaa gaatcaatga 5341 caaagacaca caaatctata gaactgctgc aaaacgctgt gggggaacaa attcttgctc 5401 taaagacgct ccaggatttc gtgaatgatg agatcaaacc cgcgataagc gaattgggtt 5461 gtgagactgc cgctttaaga ctggggataa aactgacaca acattactcc gagctgctga 5521 ctgcatttgg ctctaacttt ggaaccatcg gagagaagag cctcacactg caggcactgt 5581 cttcactcta ctctgctaac atcactgaga ttatgaccac gatcaggaca gggcagtcca 5641 acatctatga cgtcatttat acggagcaga tcaagggaac tgtgattgat gtagatctag 5701 agagatacat ggttaccctg tctgtgaaaa tccccattct ttctgaagtt ccaggtgtgc 5761 ttatacacaa ggcatcgtct atttcttaca atatagacgg ggaggagtgg tatgtgactg 5821 tccccagtca catactcagt cgtgcctcct tcctgggggg tgcaaacata gctgattgtg 5881 tagagtccag attgacctac atatgcccta gggatcctgc acaattgata cctgacagcc 5941 agcaaaaatg tatcttgggg gacacaacaa ggtgtcctgt cacaaaggtt gtggataacc 6001 tcatccccaa atttgccttt gtaaatggag gtgtcgtcgc gaactgcata gcatccacat 6061 gtacctgcgg gacaggccga aggccaatca gtcaggatcg ctctaaaggt gtagtattct 6121 taactcatga taactgtgga ctcataggag tcaatgggat agaattgtat gctaatagga 6181 aagggcatga tgccacttgg ggggtccaga atttgacagt cggtcctgca atcgctatca 6241 gacccgtgga catttctctc aaccttgccg ctgctactga cttcctgcaa gactctagag 6301 ctgaacttga gaaggcacga aaaatcctct ctgaagtagg tagatggtac aattcagggg 6361 cgactttgat tacgatcata gtagtcatga ttgtagtatt ggtggtcatt atagtgattg 6421 tcattgtgct ctacagactc aggagatcaa tgctaatgag taatccagcc ggtcggatat 6481 caagagacac atatacatta gagccgaaga taaggcatat gtatactaac ggtgggttcg 6541 atgctatgac tgagaaaaga tgaccataac tcttgttaga tatttggtaa agcaggtatg 6601 gtatttgctg aggtctgtac ataataagaa aaacttaggg tgaaagttag gttgctcacc 6661 actatagctt tcacctcaaa taagtacaga tcatggatgg tgacagaagc aagcgggact 6721 cgtactggtc tacctcccct ggtggtagca ctacaaaatt ggtgtcagac tcagagaggt 6781 caggtaaagt tgatacctgg ctattgattc tcgcattcac ccaatgggct ttgtcaattg 6841 ccacggttat catttgcatc gtaatcgctg ctaggcaagg gtatagtatg gaaagatatt 6901 caatgaccgt ggaggcacta aacacaagca acaaagaagt gaaggagtca ctcactagtc 6961 taataaggca agaggttatc actagagccg ttaacattca gagttctgtg caaaccggga 7021 tcccagtctt gttgaacaag aacagcagag atgtcatcca gctgattgaa aagtcgtgca 7081 atagacagga gctcacgcaa ctttgcgata gcacaattgc agtccatcat gctgagggaa 7141 ttgccccact tgaaccgcat agcttctgga gatgccctgc aggagaaccg tatctaagtt 7201 cagaccctga agtctcattg ctgcctggcc caagcctgtt gtctggttcg acaacgatct 7261 ctggatgtgt taggctccct tcactctcaa ttggtgaggc gatctatgcc tattcgtcaa 7321 atctcattac acaaggctgt gctgacatag ggaagtcata tcaggtcctg cagctagggt 7381 atatatcact aaattcagat atgtttcctg accttaaccc cgtagtgtcc cacacttatg 7441 acatcaacga caaccggaaa tcgtgctcgg tagtggcaac cgggaccagg ggttatcagc 7501 tctgctccat gccgactgta gacgaaagaa ctgactactc gagtgatggt atcgaagatt 7561 tggtccttga cattctggat cttaaaggga ggactaaatc tcatcggtat agcaacagtg 7621 agatagatct tgaccacccg ttttctgcat tataccctag tgtgggcagc ggcattgcaa 7681 cagagggttc actgatattc cttgggtatg gtgggctaac caccccgcta caaggtgata 7741 cgaaatgtag gatccaagga tgccaacagg tgtcgcaaga cacatgcaat gaagctctga 7801 agattacatg gctgggcggg aaacaggtag tcagtgtgct catccaggtt aatgattatc 7861 tttcagagag accaagaata agagtcacaa ccgttccaat cactcagaac tacctcggag 7921 cagaaggcag attactaaaa ttgggtgatc aagtgtacat ctacacgaga tcatcaggtt 7981 ggcattccca actgcagata ggggtacttg atgtcagcca ccctctgact atcagctgga 8041 caccccatga agccttgtct aggccaggaa acgaagactg caattggtac aatacttgtc 8101 cgaaggaatg catatcaggt gtatataccg acgcttatcc cctgtctcct gatgcagcta 8161 atgtagccac cgttacgttg tatgccaaca cttcacgcgt caatccaaca atcatgtatt 8221 ccaacaccac taacattata aatatgttaa ggataaaaga tgtcaaatta gaggctgcat 8281 ataccacgac atcatgtatc acgcactttg gcaaaggcta ctgtttccac atcatcgaga 8341 tcaaccaaaa gagcttgaac accctgcaac ctatgctctt taagaccagc attccgaagt 8401 tatgcaaggc cgagtcgtga atttcaccga tcaacaggct agtcggctct gccgacacag 8461 gggtcatcac tggataccca caacatctcc tagtctctca cattctccac agtattaaga 8521 aaaacccagg gtgaatggga agcctgtcat tggctatgga cgggcaagag tcctcccaaa 8581 acccttctga catactctat ccagaatgtc acctgaactc ccctatagtg aggggaaaga 8641 tagcacaatt acacgttttg ttagatgtta accagcccta cattctgaaa gacgacagta 8701 taattaatat cacaaagcac aaaatcagga atgggggttt gtcccctcgt cagattaaga 8761 tcagatctct aggcaaggct cttcaacgca caataaagga tctagaccgg tacacgtttg 8821 aaccgtaccc aacctactcc caggagttac ttaggctcga tataccagag atatgtgaca 8881 agatccgatc tgttttcgcg gtctcggatc ggctgactaa ggagctgtct aatgggttcc 8941 aggatctctg gttgaatatc tttaagcaac taggtaacat agaagggaga gaggggtacg 9001 acccattgca ggatattagc accatcccag agataactga gaggtatagc aggaacaaat 9061 ggtataggcc attcctaact tggttcagta tcaaatatga tatgcggtgg atgcagaaaa 9121 ctagaccagg gggacctcta gatacctcta actcacataa ccttctagaa tgcaaatcat 9181 acactctagt aacatatgga gaccttgtca tgatactgaa caagttgaca ttgacagggt 9241 atatcctaac acctgagctg gttctgatgt attgtgatgt tgtggaaggg aggtggaata 9301 tgtctgctgc agggcagtta gataaaaggt ctactgggat aacaagcaaa ggagaggagt 9361 tgtgggagtt agtggattcc ctcttttcga gtctcgggga ggaaatatac aatgtcatcg 9421 cattactcga gcctctatca cttgctctca tacaattaag tgatcctgtt atacctctac 9481 gtggagcatt tatgaggcat gtgttgacag agctacagac tgttttgacg agtaaagacg 9541 tgtatacgga cccggaggca gatgctattg tggagtcgtt actagctata tttcatggga 9601 cttctattga tgagaaagca gagatctttt cattctttcg gacattcggt catcctagct 9661 tggaagctgt caccgctgcc gacaaggtga gagctcatat gtatgcacaa aaggcaataa 9721 agcttaagac cctacacgag tgtcatgcag tgttctgcac aatcatcata aatggatata 9781 gagagaggca tggcgggcag tggccccctt gcgacttccc tgatcacgtg tgcctggaac 9841 ttagaaatgc tcaagggtcc aatacggcca tctcttacga gtgtgcagta gacaactata 9901 caagtttcat aggcttcaag tttcggaagt ttatagaacc acaactggat gaagatctca 9961 cgatatatat gaaggacaaa gcattatcgc ccaggaagga agcgtgggac tctgtgtatc 10021 cagacagtaa cctgtactat aaagttccag agtctgaaga gaccaggagg ctcatcgaag 10081 tgttcataaa tgatgagaat ttcaacccag aagacatcat cgattacgtg gagtcaggag 10141 actggttaaa agatgagaag ttcaacatct cgtatagttt gaaagagaaa gagatcaagc 10201 aagagggccg tctgttcgca aagatgactt acaaaatgcg agctgtacag gtcctagcag 10261 agacactgtt ggcgaaagga ataggagagt tgttcagcga aaatggaatg gtgaaaggag 10321 agatagactt acttaaaaga ctaactactc tctctgtctc aggagttcct aggactgatt 10381 cagtgtacaa taatcctaga tcatcagaga agagaaatga aggcatgaag aagagaaact 10441 caaaagggta ctgggacgaa aagaagaggt cgagacatga atttaaagca acagattcat 10501 ccacagacgg ttatgagacg ttaagttgct tcctaacaac agacctcaag aagtactgct 10561 taaattggag atttgagagc actgcacttt tcgggcagag gtgcaacgag atatttggct 10621 tcaagacctt tttcaattgg atgcatccag tccttgaaaa gtgtacaata tatgttggag 10681 acccttactg tccggtcgcc gacaggatgc atcgacaact gcaagatcat gcagactctg 10741 gtattttcat acacaatcct aggggaggaa tagaaggtta ttgccagaaa ctatggacct 10801 taatctcaat cagtgcgatc cacctagcag ctgtgagggt aggtgtcagg gtctctgcaa 10861 tggttcaagg cgacaatcaa gctatagcag taacatcaag agtacccgta gcccagactt 10921 acaagcagaa gaaaaatcat gtctatgaag agatcactcg ttatttcggt gctctaagac 10981 atgtcatgtt tgatatagga catgagctaa aattgaacga gaccatcatt agtagtaaaa 11041 tgtttgtcta tagtaaaagg atatattatg atggaaagat cctaccgcaa tgtctgaagg 11101 ccttgactag atgtgtattc tggtccgaga cattggttga tgagaacaga tctgcttgtt 11161 ccaatatctc aacatccata gcaaaggcca tcgagaatgg gtattctcct atactaggct 11221 actgcattgc gttgtacaag acctgtcagc aagtgtgtat atcattaggg atgactataa 11281 atccaacaat cagcccgacc gtaagagatc aatactttaa gggtaaaaat tggctgagat 11341 gtgcagtgtt aattccggcc aatgttgggg gattcaacta catgtctaca tctaggtgct 11401 ttgtcaggaa tattggggat ccggcagtcg cagccctagc tgatctcaag agattcatca 11461 gagcagatct tctagataaa caggtgttgt atagggtcat gaatcaagag cctggtgatt 11521 ctagttttct agattgggct tcagatcctt attcatgcaa ccttccgcac tctcagagta 11581 taactacaat tataaagaat atcactgcta ggtctgtgct gcaggaatct ccgaatcctc 11641 tactgtctgg tctttttaca gagaccagtg gcgaagagga tctcaacctg gcctcgtttc 11701 ttatggaccg gaaagtcatc ctacctagag tggctcatga gatcttgggt aattccttaa 11761 caggggttag agaagcaatt gcagggatgc ttgatacaac caagtctcta gtgagagcga 11821 gtgttaagag gggaggattg tcatatggga tattgaggag acttgtcaat tatgatctgt 11881 tgcagtacga gacactgact aggactctca ggaagccggt gaaagacaac attgagtatg 11941 agtatatgtg ctcagttgag ctggctgtcg gtttaaggca gaagatgtgg atccacctga 12001 cgtatgggag acctatacac gggctagaaa caccagaccc tttagagctc ttgaggggaa 12061 catttattga aggctcagag gtgtgtaagc tttgcaggtc tgagggagcg gaccccatct 12121 atacatggtt ttacctccca gacaatatag acctggatac acttacaaac gggtgtccag 12181 ctatacggat tccctatttt ggatcagcaa ctgatgaaag atcagaagct caactcggat 12241 atgtaaggaa tctgagtaaa ccagcaaagg cggctatacg gatagctatg gtgtacacgt 12301 gggcttacgg gaccgatgag atatcgtgga tggaagctgc tctcatagcc cagacaaggg 12361 ctaatctgag cttagaaaat ctaaagctgc tgactcctgt ttcaacatca actaatctct 12421 ctcataggtt aaaagacacg gcaacccaga tgaagttctc cagtgcaaca ctagtccgtg 12481 caagtcggtt cataacaata tcaaatgaca acatggcact caaagaagca ggggagtcga 12541 aggacactaa tctcgtatat cagcagatta tgctcactgg gctaagcttg tttgagttca 12601 atatgaggta taagaaaggt tccttagaga agccactgat attacaccta catcttaata 12661 acgggtgctg tataatggaa tctccacagg aagcaaatat ccccccaaga tccactttgg 12721 atttggaaat cacacaagaa aacaacaaat tgatctatga tcccgatcca ctcagggatg 12781 tagacctaga gctatttagc aaggtcagag atgtcgtaca tacagttgac atgacctatt 12841 ggtcagacga tgaagttatc agggctacta gtatatgtac tgcaatgaca atagctgata 12901 caatgtctca attagataga gacaacttaa aggagatgat agcactggta aatgatgatg 12961 atgtcaacag cctgattact gagtttatgg tgattgatgt tcctctattt tgctcaacat 13021 tcggaggtat cctagtcaat cagtttgcat actcactcta cggcttgaat atcagaggaa 13081 gggaagaaat atggggacac gtagtccgga ttctgaaaga tacctcccac gcagtcttga 13141 aagtcttatc caatgctctg tcccatccca agatcttcaa acgattctgg aatgcaggtg 13201 ttgtagaacc tgtgtatggg cctaaccttt caaatcagga taagacacta ctagccctct 13261 ctgtatgtga gtattctgtg gacctattca tgcacgactg gcaaggaggt gtaccgcttg 13321 aggtctttat ctgtgataat gacccagatg tggctgacat gaggaggtcc tctttcttgg 13381 ctagacacct tgcatacctg tgcagcttgg cagagatatc tagggatggg ccaagactag 13441 agtcaatgaa ctctcttgag aggctagaga cattaaagag ttatctggaa ctcacgttcc 13501 ttgatgaccc tgtactgagg tacagtcaat tgactggctt agtcatcaaa gtattcccgt 13561 caactttgac ctacatccgg aagtcatcta taaaggtatt aagaacaaga ggaataggag 13621 tccccgaagt tttagaagat tgggaccccg aggcggataa tgcactgcta gacggcatcg 13681 cagcagaaat acaacagaat attcccttag gacatcagac tagagcccct ttttgggggc 13741 tgagggtatc caagtcacag gtactgcgtc tccgggggta cgaggagatc acaagaggtg 13801 aggtaggcag atcaggtgtt ggtctgacgt taccattcga tggaaggtat ctatctcacc 13861 agctgaggct ctttggtgtt aacagtacta gctgcttaaa agcacttgaa cttacctact 13921 tattaagccc cttggttgac aaggataagg ataggctgtt tttaggggaa ggagctgggg 13981 ctatgctctc ctgttatgac gctactcttg gcccatgcat caactattat aactcggggg 14041 tatactcttg tgatgtcaat gggcagagag agttaaatat atatcctgct gaagtggcat 14101 tagtgggaaa gaaattaaat aatgttacca gtctaggtca gagggttaag gtgttgttca 14161 acgggaatcc tggctcgaca tggatcggga atgatgaatg tgaggctttg atttggaatg 14221 aactacagaa tagttcgata ggcctagtcc actgtgacat ggaaggagga gatcataagg 14281 atgatcaagt tgtactgcat gagcattaca gtgtgatcag gattgcgtat ctggtggggg 14341 atagagacgt tgtgctgata agtaagattg ctcccaggct gggcacagat tggaccaggc 14401 agcttagcct ttacctgagg tactgggatg aggtcaacct ggtagtgctt aaaacatcta 14461 atcctgcttc tacagagatg tatctcctct caaggcatcc caaatctgac atcatagaag 14521 atagcaagac agtgctggcc agtcttcacc ctctgtcaaa ggaagacagc atcaagatag 14581 aaaagtggat cttgatagag aaagcaaagg ctcacgaatg ggttacccgg gagttgagag 14641 aaggaagctc gtcgtcaggg atgcttagac cttaccacca ggcactgcag acgtttggtt 14701 ttgaacccaa tttatataaa ctgagcaggg atttcctgtc cactatgaac atagctgaca 14761 ctcacaactg catgacagcc ttcaacagag ttttaaagga tacaatcttt gagtgggcta 14821 gaataaccga gtcagacaaa aggctcaaac taactggtaa gtatgacctg taccctgtta 14881 gagactcagg caagttgaag acaatttcta gaagacttgt actgtcttgg gtatcattat 14941 ctatgtctac aagactggta actgggtctt tccccgacca aaagtttgag gcaagactcc 15001 aattagggat agtttcactg tcatctcgtg aaatcaggaa cctgagggtt atcacaaaaa 15061 ctatattaga taggtttgag aatactatac atagtataac atatagattt ctcaccaaag 15121 aaataaagat tttgatgaag attttaggag ctgtcaagat gttcggggct aggcagaatg 15181 aatacacaac cgtggttgat gatggatcat tagatgacat cgagccatat gacagcttgt 15241 gataagtaat cattatcatg cagggttatt taaaattcac ggtgtctaga agtcttggac 15301 ttatccatat ggcaatagta agaaaaactt acaaggagac aagaaaattt gaaagaataa 15361 atatctctta aactcttgtc tggt //