LOCUS       WQZ29947.1               546 aa    PRT              BCT 29-DEC-2023
DEFINITION  Helicobacter pylori chaperonin GroEL protein.
ACCESSION   CP079244-8
PROTEIN_ID  WQZ29947.1
SOURCE      Helicobacter pylori
  ORGANISM  Helicobacter pylori
            Bacteria; Campylobacterota; Epsilonproteobacteria;
            Campylobacterales; Helicobacteraceae; Helicobacter.
REFERENCE   1  (bases 1 to 1570870)
  AUTHORS   Thorell,K., Munoz-Ramirez,Z.Y., Wang,D., Sandoval-Motta,S., Boscolo
            Agostini,R., Ghirotto,S., Torres,R.C., Falush,D., Camargo,M.C. and
            Rabkin,C.S.
  CONSRTM   HpGP Research Network
  TITLE     The Helicobacter pylori Genome Project: insights into H. pylori
            population structure from analysis of a worldwide collection of
            complete genomes
  JOURNAL   Nat Commun 14 (1), 8184 (2023)
   PUBMED   38081806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1570870)
  AUTHORS   Camargo,M.C. and Rabkin,C.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JUL-2021) IIB, National Cancer Institute, 9609
            Medical Center Dr., Rm. 6E110, Bethesda, MD 20892, USA
COMMENT     The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            ##Genome-Assembly-Data-START##
            Assembly Method        :: HGAP v. 4
            Assembly Name          :: HpGP-TWN-021
            Genome Representation  :: Full
            Expected Final Version :: Yes
            Genome Coverage        :: 2661x
            Sequencing Technology  :: PacBio Sequel II
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI
            Annotation Date                   :: 07/16/2021 08:12:09
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Software revision      :: 5.2
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Genes (total)                     :: 1,497
            CDSs (total)                      :: 1,452
            Genes (coding)                    :: 1,391
            CDSs (with protein)               :: 1,391
            Genes (RNA)                       :: 45
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 36
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 61
            CDSs (without protein)            :: 61
            Pseudo Genes (ambiguous residues) :: 0 of 61
            Pseudo Genes (frameshifted)       :: 44 of 61
            Pseudo Genes (incomplete)         :: 11 of 61
            Pseudo Genes (internal stop)      :: 18 of 61
            Pseudo Genes (multiple problems)  :: 12 of 61
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Helicobacter pylori"
                     /mol_type="genomic DNA"
                     /strain="HpGP-TWN-021"
                     /isolation_source="Biopsy"
                     /host="Homo sapiens"
                     /db_xref="taxon:210"
                     /geo_loc_name="Taiwan"
                     /lat_lon="23.30 N 121.00 E"
                     /collected_by="Maria Camargo and Charles Rabkins"
     protein         /gene="groL"
                     /locus_tag="E5P95_00065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040316.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /transl_table=11
BEGIN
        1 MAKEIKFSDS ARNLLFEGVR QLHDAVKVTM GPRGRNVLIQ KSYGAPSITK DGVSVAKEIE
       61 LSCPVANMGA QLVKEVASKT ADAAGDGTTT ATVLAYSIFK EGLRNITAGA NPIEVKRGMD
      121 KAAEAIINEL KKASKKVGGK EEITQVATIS ANSDHNIGKL IADAMEKVGK DGVITVEEAK
      181 GIEDELDVVE GMQFDRGYLS PYFVTNAEKM TAQLDNAYIL LTDKKISSMK DILPLLEKTM
      241 KEGKPLLIIA EDIEGEALTT LVVNKLRGVL NIAAVKAPGF GDRRKEMLKD IAVLTGGQVI
      301 SEELGLTLEN AEVEFLGKAG RIVIDKDNTT IVDGKGHSHD VKDRVAQIKT QIASTTSDYD
      361 KEKLQERLAK LSGGVAVIKV GAASEVEMKE KKDRVDDALS ATKAAVEEGI VIGGGAALIR
      421 AAQKVHLNLH DDEKVGYEII MRAIKAPLAQ IAINAGYDGG VVVNEVQKHE GHFGFNASNG
      481 KYVDMFKEGI IDPLKVERIA LQNAVSVSSL LLTTEATVHE IKEEKATPAM PDMGGMGGMG
      541 GMGGMM
//