LOCUS       CAQ84181.1              1634 aa    PRT              BCT 27-FEB-2015
DEFINITION  Photorhabdus asymbiotica cytotoxic necrotizing factor protein.
ACCESSION   FM162591-2088
PROTEIN_ID  CAQ84181.1
SOURCE      Photorhabdus asymbiotica
  ORGANISM  Photorhabdus asymbiotica
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Photorhabdus.
REFERENCE   1  (bases 1 to 5064808)
  AUTHORS   Crossman L.C.
  JOURNAL   Submitted (21-MAY-2008) to the INSDC. Crossman L.C., Pathogen
            Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton,
            Cambridge, Cambridgeshire, CB10 1SA, UNITED KINGDOM.
REFERENCE   2
  AUTHORS   Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
            Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
            Doggett J., Ormond D., Mayho M., Bason N., Smith F., Simmonds M.,
            Arrowsmith C., Churcher C., Harris D., Thompson N.R., Quail M.,
            Parkhill J., Ffrench-Constant R.H.
  TITLE     Comparative genomics of the emerging human pathogen Photorhabdus
            asymbiotica with the insect pathogen Photorhabdus luminescens
  JOURNAL   BMC Genomics 10(1), 302-302(2009).
   PUBMED   19583835
FEATURES             Qualifiers
     source          /organism="Photorhabdus asymbiotica"
                     /isolate="ATCC43949"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:291112"
     protein         /transl_table=11
                     /gene="dnt"
                     /locus_tag="PAU_02089"
                     /old_locus_tag="PAT3392"
                     /note="cytotoxic necrotizing factor proteins alter host
                     cell actin cytoskeleton and promote bacterial invasion of
                     the blood-brain barrier endothelial cells. CNF1 belongs to
                     a unique group of large cytotoxins that cause constitutive
                     activation of Rho guanosine triphosphatases (GTPases),
                     which are key regulators of the actin cytoskeleton"
                     /db_xref="EnsemblGenomes-Gn:PAU_02089"
                     /db_xref="EnsemblGenomes-Tr:CAQ84181"
                     /db_xref="InterPro:IPR028208"
                     /db_xref="UniProtKB/TrEMBL:C7BJB3"
                     /inference="similar to DNA sequence:INSD:BX640449"
                     /inference="similar to DNA sequence:INSD:BX571867"
BEGIN
        1 MSNSEYDIID KNDTYQVKNK EYTVVNGKYW QYEREGNENN NKTFISLMKG NQNDPIWITS
       61 DIKEMSLYII ENLFSYQKFS AELQHTLKNA VNAVFNEYSE IKYSELLHNI NNIFNLFFIK
      121 NYNTSDIDTA INILTAKIEI YDKLEKINQD KKDSNNTKVD IWEELGINAE EPLLKIYRQA
      181 FSTGDIDDEI YSDALLTFMS NGNIELGDKE KSDYNQRIKD KADLFKSYKK GIEKVASLVT
      241 SNNINPGIPI THSETEQSIN IGDDILLAQL AKEEITLKKQ NRTEYSQKDI FELQTLQAAK
      301 YHLLILSSLG ALLYQIAPKV EKITKGHGDY RDIIFAQDQA EVLFKKHNIQ YDTNHVLSQE
      361 SKHIEMEGCI ILTAAIIYRM RKENANTEQA LNYSTLETIK LFENDKQKLN PFNKNNVKPV
      421 GYFSFIDFKK RDKFDSQYNF NEQFNVYKNK YSHYESISLS KLILSSPAAQ LTVKEIINPP
      481 EEAFLYSVEQ GMGNVAMIKM YQGNWLVIST IQGGVKAKKY SPQQVDSHPI LRAMSKPNAL
      541 FLIERKMEIG MGILMPNMMV NTGKRLLPTG YERAKTLSGF AQTSRYKYSY DAFWNDYYGI
      601 TSGMNVGISF TGSPKFNFYK EENLLSVTAT VIQQGLNDIA IKSKQALDIT SGWHIAATIL
      661 IPFYNVIYKS TTDSEYTLTG EDIGSIVFDT ANVLLVVATL GMSLTESMAA KVTQTTLRLR
      721 QAGLTGRALI TAVVRTLPEH GIITLRQSSG IILSGLIDLI EPLPIRSTLT LTYRGVISAV
      781 GAMRNSIKLE KSFADIFGKS TRGLGKLKNE WKVNNLPLDG IVPHSNGGEI YKGIYSIRPT
      841 NVESAIKQNY YIKESGANYQ VKWDDANHTW RVVNPTYPEQ FSYWPAVKLD KDGHWITHAD
      901 VSNKFLILEQ SKRIEQELEA ARSNINNNNI LDAFIHINTA FKDYERYDVD KLSDITDTLT
      961 HFFEKSIKLG DKKAILSAEI MSIQQAWIRD VVLPLQNNLS ISVEKINAIK TELPYLLRKV
     1021 FPVENQLSNQ LAANKIALAI EEIPTALMPQ YTSGNISKTV QYTSLESNYI NIPPVGITIT
     1081 GNDEFINQVT HALNEIDEIP SGNIVIQELK KQGLNIRPPT MSAIIREKDG KFYASNSAGS
     1141 SIAFDPENHL IGTEEKLIDE PWRARDPAIA LYHEMLHIYY NRYPTWFTSI DNKAIDQKVS
     1201 GGFSLLEESR IVGTKYYAND KNTLFDFSDP NYLLENNSAL LTENRFRAEY AIFKGKSEYV
     1261 IRPYSGKGDS QIPLTNTKIN LNESHRNVMG VGNGKPEKMP NESATDYRNR VREWRKANKQ
     1321 PETDIGIGDM RKTKAEARVK LLKESYPQFE PQKIELGGAF QLWTVPNEPA NKLMLSSHGY
     1381 FFSDSAATQV PAGKTIQFLG PHGKTLLEAP ENPLNSPFDV TLGNSDFTVQ PYATIESGSK
     1441 SKVSSSSVKI GDKTFTVNDI QNMTTDDVEN YLLATGVEAN TSNHGKVRNY GIKYYEKMPD
     1501 EEVKAAIWKN RADETVTSKY DALLVSPEAG NRKKLSDIFA LMKTDERMSK YDEITFVACR
     1561 EELNRINMKS VHDTGLGGGY EPKLEPTVIL SRRRREAALT PDGAIIYSVI AVNLHHHYVT
     1621 EKIVSIAPFL LIDN
//