LOCUS       APA96742.1               134 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae F420H(2)-dependent quinone reductase protein.
ACCESSION   CP017839-2651
PROTEIN_ID  APA96742.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /geo_loc_name="South Korea"
                     /collection_date="2015-05-06"
     protein         /locus_tag="NS506_02681"
                     /function="Cell membrane; Membrane; Oxidoreductase."
                     /note="Involved in a F420-dependent anti-oxidant mechanism
                     that protects M. tuberculosis against oxidative stress and
                     bactericidal agents. Catalyzes the F420H(2)-dependent
                     two-electron reduction of quinones to dihydroquinones,
                     thereby preventing the formation of cytotoxic semiquinones
                     obtained by the one-electron reduction pathway. In vitro,
                     catalyzes the reduction of menadione to menadio; since
                     menaquinone is the sole quinone electron carrier in the
                     respiratory chain in M. tuberculosis, the physiological
                     electron acceptor for Fqr-mediated F420H(2) oxidation is
                     therefore likely to be the endogenous menaquinone found in
                     the membrane fraction of M. tuberculosis; Belongs to the
                     F420H(2)-dependent quinone reductase family"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:P9WP12"
BEGIN
        1 MGAERKSVVF EMFGDSDWFA GVGKKLAVAD LFLQRRTGGR FGLLTLAKLP NIVLTTTGRK
       61 TGLPRHACLI YVPRGEDYVI VDSNWGQSRR PEWSANLLAN PRAQILERGH RTEVHARHLT
      121 GTDRDEVWGE LLEK
//