LOCUS       APA95588.1               268 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae Anthracycline biosynthesis protein DnrV protein.
ACCESSION   CP017839-1497
PROTEIN_ID  APA95588.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /geo_loc_name="South Korea"
                     /collection_date="2015-05-06"
     protein         /locus_tag="NS506_01517"
                     /function="Antibiotic biosynthesis."
                     /note="Involved in the biosynthesis of the anthracyclines
                     carminomycin and daunorubicin (daunomycin) which are
                     aromatic polyketide antibiotics that exhibit high
                     cytotoxicity and are widely applied in the chemotherapy of
                     a variety of cancers. In vivo, it acts jointly with DoxA
                     in the conversion of 13- deoxycarminomycin and
                     13-deoxydaunorubicin to yield carminomycin and
                     daunorubicin, respectively. In vitro, it also acts jointly
                     with DoxA in the C-14 hydroxylation of daunorubicin to
                     form doxorubicin, although this strain is not a
                     doxorubicin producer"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:Q9ZAU2"
BEGIN
        1 MPVREEAWPP GTPCWVDCQV DDPAKAGEFY AALFGWDVQG GGEDAGGYLM AMREGRAVAG
       61 IGPKPEAGVP SVWTTYFAVA DADKSAEQVT AAGGKLLVPA FDVMEFGRMF VAADASGAPF
      121 AVWEARAHDG AAVHNEHGSY VWNDLHTGDF AAAKSFYGDV FGFTFTEFDE ENLRYATFTP
      181 PGGTEAVGGI NDDSVGGVAA EVPYWLTWFQ FEGIDTGIAS AVELGATVLM SATDGPFGRM
      241 AIMAAPQGEL FGLLDPTTTV AAEPAADD
//