LOCUS       APA94760.1              1124 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae Lysine--tRNA ligase protein.
ACCESSION   CP017839-669
PROTEIN_ID  APA94760.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /geo_loc_name="South Korea"
                     /collection_date="2015-05-06"
     protein         /locus_tag="NS506_00681"
                     /EC_number="6.1.1.6"
                     /function="Aminoacyl-tRNA synthetase; Antibiotic
                     resistance; ATP-binding; Cell membrane; Ligase; Lipid
                     metabolism; Magnesium; Membrane; Metal-binding;
                     Multifunctional enzyme; Nucleotide-binding; Transferase;
                     Transmembrane; Transmembrane helix; Virulence."
                     /note="Catalyzes the production of
                     L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl
                     group from L-lysyl-tRNA(Lys) to membrane-bound
                     phosphatidylglycerol (PG), which produces
                     lysylphosphatidylglycerol (LPG), one of the components of
                     the bacterial membrane with a positive net charge. LPG
                     synthesis contributes to the resistance to cationic
                     antimicrobial peptides (CAMPs) and likely protects M.
                     tuberculosis against the CAMPs produced by competiting
                     microorganisms (bacteriocins). In fact, the modification
                     of anionic phosphatidylglycerol with positively charged
                     L-lysine results in repulsion of the peptides (By
                     similarity); In the N-terminal sectio; belongs to the LPG
                     synthetase family; In the C-terminal sectio; belongs to
                     the class-II aminoacyl-tRNA synthetase family; KEGG:
                     nbr:O3I_000295 lysyl-tRNA synthetase, class II"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:Q5Z3P6"
BEGIN
        1 MGKGNIHTGA VTSTQDRPQH DADQRTEPRS PEVPHRGHGR LREVPHIAGT ALGVFSVLCF
       61 AWSLSPGLRF LTSHLRHFVD TYYFDAPDTS LVWALVVGLL AGATASRKRI AWWLLVGYMA
      121 AYALANALDF AAEGDVNALV ALIIHIAAIG VLIAAWSEFY THVQRGAVWR ALGVLAGGLA
      181 LGSLVGWGLV ELFPGTLPDH TERALWSVSR VTGAILVSNE DFDGHPPHPV NLLLGLFGAI
      241 ALLAAVITLF RSQRSSNALT GLDESAIRGL LERSDVEDSL GYFATRRDKA VVFAPSGKAA
      301 ITYRVELGVC LASGDPIGQK EAWGQAIDAW LRLADQYGWA PAVMGASELG ATAYRRAGLS
      361 ALRLGDEAIL ETRTFSLAGA DMKQVRQAAN RLGKQGITVR VRRHKEISFE EMQDVMRRAA
      421 AWRDTETERG FSMALDRLGD PLDGDCLLVE AVSPGGHVLG MLSLVPWGRT GVSLDLMRRD
      481 RTGPNGLMEL MISRLALTSE QYGITRISLN FAVFRAVFEE GGRIGAGPVL RLWRGVLMFF
      541 SRWYQLEALY RSNVKYQPEW VPRFSLFEER RHLVRVATAS ALAEGFLPRF GRQHDASTHT
      601 GLRPSVPITM TGLHADGSTP DLPPEELAET GPRRPEQVRV RMDKLEKLER SGVEAYPVAY
      661 PPTHTVAAAR HCPQGTTVRV CGRLLRIRDY GGVIFAVLRD WSGDIQLLID RGRMGVERSP
      721 EFTAYFDLGD LIEVSGQLGR SRRGELSLLA QDWRMIGKCL HPLPDKWKGL SDPEARVRQR
      781 YVDMAINTDI REVMTKRSAV VRSLRDTLHG WGFLEVETPV LQQVHGGANA TPFTTHINAY
      841 DLDLYLRIAP ELYLKKLCVG GMEKVFELGR VFRNEGVDYS HNPEFTILEA YEAHSDYERM
      901 MHACRQLIQE AALAANGRMV ALRPGPDGAM TEVDISGDWP VKTVHGAVSD AIGETITPET
      961 DAERLRLLCE KAGVPFQLGW DEGQLVLEMY EHLVESATGE PTFYIDFPTS VSPLTRAHRH
     1021 IRGVTERWDL VAWGVELATA YSELTDPVDQ RRRLTEQSML AAGGDPEAME LDEDFLQALE
     1081 HAMPPTGGLG VGVDRVVMLL IGRSIRETLP FPLVKPRNAP GDSR
//