LOCUS CAQ85805.1 419 aa PRT BCT 27-FEB-2015 DEFINITION Photorhabdus asymbiotica PirB similarities with putative juvenile hormone esterase protein. ACCESSION FM162591-3712 PROTEIN_ID CAQ85805.1 SOURCE Photorhabdus asymbiotica ORGANISM Photorhabdus asymbiotica Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Morganellaceae; Photorhabdus. REFERENCE 1 (bases 1 to 5064808) AUTHORS Crossman L.C. JOURNAL Submitted (21-MAY-2008) to the INSDC. Crossman L.C., Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, UNITED KINGDOM. REFERENCE 2 AUTHORS Wilkinson P., Waterfield N.R., Crossman L., Corton C., Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L., Doggett J., Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Arrowsmith C., Churcher C., Harris D., Thompson N.R., Quail M., Parkhill J., Ffrench-Constant R.H. TITLE Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens JOURNAL BMC Genomics 10(1), 302-302(2009). PUBMED 19583835 FEATURES Qualifiers source /organism="Photorhabdus asymbiotica" /isolate="ATCC43949" /mol_type="genomic DNA" /db_xref="taxon:291112" protein /transl_table=11 /gene="PirB" /locus_tag="PAU_03717" /old_locus_tag="PAT0561" /note="This family contains insecticidal toxins produced by Bacillus species of bacteria. During spore formation the bacteria produce crystals of this protein. When an insect ingests these proteins they are activated by proteolytic cleavage. The N-terminus is cleaved in all of the proteins and a C-terminal extension is cleaved in some members. Once activated the endotoxin binds to the gut epithelium and causes cell lysis by the formation of cation-selective channels, which leads to death. The activated toxin is composed of three distinct domains: an N-terminal helical bundle domain involved in membrane insertion and pore formation; a beta-sheet domain involved in receptor binding; and a C-terminal beta-sandwich domain that interacts with the N-terminal domain to form a channel , . This entry represents the conserved N-terminal domain." /db_xref="EnsemblGenomes-Gn:PAU_03717" /db_xref="EnsemblGenomes-Tr:CAQ85805" /db_xref="GOA:C7BLU9" /db_xref="InterPro:IPR005639" /db_xref="InterPro:IPR036716" /db_xref="UniProtKB/TrEMBL:C7BLU9" /inference="similar to DNA sequence:INSD:BX571872" /inference="similar to DNA sequence:INSD:AF039135" BEGIN 1 MQTENVLDIR TIVANEYAVK TSALEWDVTD IVKNAIIGGI SFIPSVGPAI SFLVGLFWPQ 61 SKENIWEGIV KQIERMIEES ALKTIKGILA GDIAYIQERM ATVADLLEKH PGSAEARNAF 121 NNLAENIDGY HKKFNNFSDD VNYQILPMFS TTVMMQITYW VAGLERKEEI GLSDIDIEKV 181 RGLVKKTVEQ ANSYINNIYD RELNDALNNS TADTVVNNVM SVHGHCRLHG IEYISIWDRL 241 SETESVNNRI YVDVLSYSTF FDRQTAKARI QALTPEKDMT PPLKPALNGG KRRKINSLMG 301 HIVRIGGAPR VGGLTVVFDD GSRHQLGTIS GETASISLDS SRITSLEVWG NGAVDKAVFT 361 LSDGRSLSFG EPGTSRYRKF YVGESHYISG IYLSSDYSPL VGQAANIAVS YQLINDDEK //