LOCUS       AEC08619.1               865 aa    PRT              PLN 23-MAR-2023
DEFINITION  Arabidopsis thaliana DNA topoisomerase, type IA, core protein.
ACCESSION   CP002685-4428
PROTEIN_ID  AEC08619.1
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (bases 1 to 19698289)
  AUTHORS   Lin,X., Kaul,S., Rounsley,S., Shea,T.P., Benito,M.I., Town,C.D.,
            Fujii,C.Y., Mason,T., Bowman,C.L., Barnstead,M., Feldblyum,T.V.,
            Buell,C.R., Ketchum,K.A., Lee,J., Ronning,C.M., Koo,H.L.,
            Moffat,K.S., Cronin,L.A., Shen,M., Pai,G., Van Aken,S., Umayam,L.,
            Tallon,L.J., Gill,J.E., Adams,M.D., Carrera,A.J., Creasy,T.H.,
            Goodman,H.M., Somerville,C.R., Copenhaver,G.P., Preuss,D.,
            Nierman,W.C., White,O., Eisen,J.A., Salzberg,S.L., Fraser,C.M. and
            Venter,J.C.
  TITLE     Sequence and analysis of chromosome 2 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 402 (6763), 761-768 (1999)
   PUBMED   10617197
REFERENCE   2  (bases 1 to 19698289)
  AUTHORS   Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
  CONSRTM   TAIR
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
            Institution, 260 Panama Street, Stanford, CA, USA
REFERENCE   3  (bases 1 to 19698289)
  AUTHORS   Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
            Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
            Vaughn,M. and Town,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
            9704 Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Protein update by submitter
FEATURES             Qualifiers
     source          /organism="Arabidopsis thaliana"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:3702"
                     /chromosome="2"
                     /ecotype="Columbia"
     protein         /locus_tag="AT2G32000"
                     /gene_synonym="F22D22.25"
                     /gene_synonym="F22D22_25"
                     /inference="Similar to RNA sequence,
                     EST:INSD:BX836041.1,INSD:EL983284.1,INSD:EL995232.1,
                     INSD:EH947278.1,INSD:BP833842.1,INSD:EL990476.1,
                     INSD:ES176397.1"
                     /inference="similar to RNA sequence,
                     mRNA:INSD:AK221174.1,INSD:BX821034.1"
                     /note="DNA topoisomerase, type IA, core; FUNCTIONS IN: DNA
                     topoisomerase activity, DNA topoisomerase type I activity,
                     DNA binding, nucleic acid binding; INVOLVED IN: DNA
                     topological change, DNA unwinding involved in replication,
                     DNA metabolic process; LOCATED IN: endomembrane system,
                     chromosome; EXPRESSED IN: 22 plant structures; EXPRESSED
                     DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA
                     topoisomerase, type IA, core (InterPro:IPR000380), DNA
                     topoisomerase, type IA, DNA-binding (InterPro:IPR003602),
                     DNA topoisomerase, type IA, domain 2 (InterPro:IPR003601),
                     DNA topoisomerase, type IA, central (InterPro:IPR013497),
                     DNA topoisomerase, type IA, central region, subdomain 3
                     (InterPro:IPR013826), Toprim domain, subgroup
                     (InterPro:IPR006154), Toprim domain (InterPro:IPR006171),
                     DNA topoisomerase, type IA, central region, subdomain 1
                     (InterPro:IPR013824); BEST Arabidopsis thaliana protein
                     match is: topoisomerase 3alpha (TAIR:AT5G63920.1); Has
                     35333 Blast hits to 34131 proteins in 2444 species: Archae
                     - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991;
                     Plants - 531; Viruses - 0; Other Eukaryotes - 9610
                     (source: NCBI BLink)."
                     /db_xref="Araport:AT2G32000"
                     /db_xref="TAIR:AT2G32000"
     intron_pos      10:0 (1/14)
     intron_pos      29:0 (2/14)
     intron_pos      63:2 (3/14)
     intron_pos      95:0 (4/14)
     intron_pos      128:1 (5/14)
     intron_pos      209:2 (6/14)
     intron_pos      264:0 (7/14)
     intron_pos      304:0 (8/14)
     intron_pos      330:2 (9/14)
     intron_pos      423:2 (10/14)
     intron_pos      480:0 (11/14)
     intron_pos      523:0 (12/14)
     intron_pos      594:0 (13/14)
     intron_pos      654:0 (14/14)
BEGIN
        1 MANLLRVLMV AEKPSIALSI ASVLSHGQMS TRRGSTEVHE FDGMFRGFKA HYRVTSVIGH
       61 VFSVDFPEKY QNWATIDPQD LFDAPIIKKE SNPKAHICRH LSNEARGCSY MVLWLDCDRE
      121 GENICFEVIE STGFDMKDSK RKVYRARFSS VTEKDISKAM DNLVEPNRDE ALAVDARQEI
      181 DLKVGVAFSR FQTSYFQGKY QNLDCRVISY GPCQTPTLGF CVQRYMHINT FKPEKFWALR
      241 PYIRKDGYEL QLEWERRRLF DLEAATVFQK LVVEGRTAKV MDVSEKQEVK GRPAGLNTVN
      301 LLKVASSALG FGPQTAMHLA ERLYTQGFIS YPRTESTAYP SSFDFTDTLR AQVSNPVWGG
      361 YVQRLLSDGF HMPKSGTDAG DHPPITPMRA ATEVMVGGDA WRLYQYVCQH FLGTVSPNCK
      421 YIRTKVELSI GGETFHCTGQ RVTEKGFTAI MPWSAVDEKK LPSFLKGERI EVLRVELYEG
      481 NTAPPDYLTE SELISLMEKH GIGTDASIAV HINNIGERNY VQVQSGRKMV PTALGITLIR
      541 GYQCIDPDLC LPDIRSFIEQ QITLVAKGQA DHSHVVQHVI QQFRRKFSYF VQQIEHMDAL
      601 FEAQFSPLAD SGRALSKCGK CLRYMKHITA VPPRLFCGTC EEVYYLPQKG TVKLYKELTC
      661 PLDNFELVIY SVPGPEGKSF PLCPYCYNSP PFEGIDTLFG ASKTPNAPAK TKTGAGMPCS
      721 LCPHPTCQHS VRNQGVCACP ECEGTLVLDP VSFPKWKLNC NLCSCIVLLP EGAHRITTTS
      781 NRCPECDSAI IEIDFNKKTT PLENGATLHQ GCVLCDELLL SLVEVKHGRS FVRRGGRGRG
      841 RGRGRGRGGR RGSKSVDPKM SFRDF
//