ID Q63910_RAT Unreviewed; 142 AA.
AC Q63910; A0A0G2JSV6;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 2.
DT 27-MAR-2024, entry version 175.
DE SubName: Full=Globin c1 {ECO:0000313|EMBL:SAI82215.1};
DE SubName: Full=Hemoglobin alpha, adult chain 3 {ECO:0000313|Ensembl:ENSRNOP00000044081.2};
GN Name=Hba-a3 {ECO:0000313|RGD:1359209};
GN Synonyms=Glnc1 {ECO:0000313|EMBL:SAI82215.1}, Hba-a2
GN {ECO:0000313|Ensembl:ENSRNOP00000044081.2, ECO:0000313|RGD:1359364},
GN Hba2 {ECO:0000313|RGD:1359364};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000044081.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000044081.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044081.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:SAI82215.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2016.10.009;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian globin genes.";
RL Gene Rep 5:163-166(2016).
RN [3] {ECO:0000313|EMBL:SAI82215.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000044081.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044081.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues. {ECO:0000256|ARBA:ARBA00003705}.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR EMBL; LT548168; SAI82215.1; -; Genomic_DNA.
DR RefSeq; NP_001013875.1; NM_001013853.1.
DR STRING; 10116.ENSRNOP00000041451; -.
DR PaxDb; 10116-ENSRNOP00000041451; -.
DR Ensembl; ENSRNOT00000048977.4; ENSRNOP00000044081.2; ENSRNOG00000047321.3.
DR GeneID; 287167; -.
DR KEGG; rno:287167; -.
DR UCSC; RGD:1359209; rat.
DR AGR; RGD:1359209; -.
DR CTD; 287167; -.
DR RGD; 1359364; Hba-a2.
DR RGD; 1359209; Hba-a3.
DR VEuPathDB; HostDB:ENSRNOG00000029886; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000154590; -.
DR HOGENOM; CLU_003827_10_2_1; -.
DR OMA; LHACKLR; -.
DR OrthoDB; 2939502at2759; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000045989; Expressed in ovary and 18 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; ISO:RGD.
DR GO; GO:0005833; C:hemoglobin complex; IDA:RGD.
DR GO; GO:0020037; F:heme binding; IDA:RGD.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0043177; F:organic acid binding; IPI:RGD.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; ISO:RGD.
DR GO; GO:0030185; P:nitric oxide transport; ISO:RGD.
DR GO; GO:0015671; P:oxygen transport; ISO:RGD.
DR GO; GO:0042542; P:response to hydrogen peroxide; ISO:RGD.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR InterPro; IPR002339; Hemoglobin_pi.
DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11442:SF48; HEMOGLOBIN SUBUNIT ALPHA; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR PRINTS; PR00815; PIHAEM.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Heme {ECO:0000256|RuleBase:RU000356}; Iron {ECO:0000256|RuleBase:RU000356};
KW Metal-binding {ECO:0000256|RuleBase:RU000356};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621,
KW ECO:0000256|RuleBase:RU000356};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q63910};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transport {ECO:0000256|RuleBase:RU000356}.
FT DOMAIN 3..142
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
SQ SEQUENCE 142 AA; 15525 MW; 92B3CA50D9CD8619 CRC64;
MVLSEEDKNN IKKAWVKIGN HAAEIGAETI GRLFIVFPSS KTYFPHFNTS EGSDQVKAHG
KKVADALTNA ASHLDDLPGA LSTLSDLHAH KLRVDPVNFK FLSHCLLVTL ASHHPGDFTP
AMHASLDKFF ASVSTVLTSK YR
//