ID O88754_RAT Unreviewed; 147 AA.
AC O88754; A6I7C1;
DT 01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1998, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE SubName: Full=Epsilon 3 globin {ECO:0000313|EMBL:CAA39767.1};
DE SubName: Full=Globin b2 {ECO:0000313|EMBL:SAI82213.1};
DE SubName: Full=Hemoglobin subunit gamma 1 {ECO:0000313|Ensembl:ENSRNOP00000043418.2};
DE SubName: Full=Hemoglobin, gamma A {ECO:0000313|EMBL:AAI57811.1};
GN Name=Hbg1 {ECO:0000313|EMBL:AAI57811.1,
GN ECO:0000313|Ensembl:ENSRNOP00000043418.2, ECO:0000313|RGD:620306};
GN Synonyms=epsilon 3 {ECO:0000313|EMBL:CAA39767.1}, Glnb2
GN {ECO:0000313|EMBL:SAI82213.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:SAI82213.1};
RN [1] {ECO:0000313|EMBL:CAA39767.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar {ECO:0000313|EMBL:CAA39767.1};
RA Hiroyuki S.;
RL Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAA39767.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wistar {ECO:0000313|EMBL:CAA39767.1};
RX PubMed=10196478; DOI=10.1016/S0378-1119(99)00055-4;
RA Sato H., Inokuchi N., Nagae Y., Okazaki T.;
RT "Molecular cloning and characterization of two sets of alpha-theta genes in
RT the rat alpha-like globin gene cluster.";
RL Gene 230:91-99(1999).
RN [3] {ECO:0000313|EMBL:AAI57811.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung {ECO:0000313|EMBL:AAI57811.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000043418.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043418.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [5] {ECO:0000313|EMBL:SAI82213.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2016.10.009;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian globin genes.";
RL Gene Rep 5:163-166(2016).
RN [6] {ECO:0000313|EMBL:SAI82213.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [7] {ECO:0000313|Ensembl:ENSRNOP00000043418.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043418.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR EMBL; BC157810; AAI57811.1; -; mRNA.
DR EMBL; X56328; CAA39767.1; -; Genomic_DNA.
DR EMBL; LT548166; SAI82213.1; -; Genomic_DNA.
DR RefSeq; NP_742090.1; NM_172093.1.
DR STRING; 10116.ENSRNOP00000043418; -.
DR PaxDb; 10116-ENSRNOP00000043418; -.
DR Ensembl; ENSRNOT00000039946.5; ENSRNOP00000043418.2; ENSRNOG00000030879.5.
DR GeneID; 94164; -.
DR KEGG; rno:94164; -.
DR AGR; RGD:620306; -.
DR CTD; 3047; -.
DR RGD; 620306; Hbg1.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000164134; -.
DR HOGENOM; CLU_003827_10_0_1; -.
DR OMA; ETAIMGN; -.
DR OrthoDB; 5356926at2759; -.
DR TreeFam; TF333268; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000030879; Expressed in thymus.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IDA:RGD.
DR GO; GO:0020037; F:heme binding; IDA:RGD.
DR GO; GO:0031721; F:hemoglobin alpha binding; IDA:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0015671; P:oxygen transport; ISO:RGD.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11442:SF7; HEMOGLOBIN SUBUNIT EPSILON; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|RuleBase:RU000356}; Iron {ECO:0000256|RuleBase:RU000356};
KW Metal-binding {ECO:0000256|RuleBase:RU000356};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621,
KW ECO:0000256|RuleBase:RU000356};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transport {ECO:0000256|RuleBase:RU000356}.
FT DOMAIN 2..147
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
SQ SEQUENCE 147 AA; 16540 MW; 39BF594C21B3DC1E CRC64;
MVHFTAEEKA AIISIWEKVD LEKIGGETLG RLLIVYPWTQ RFFDKFGNLS SALAIMGNPR
IRAHGKKVLT SLGSAVENMD NLKETFAHLS ELHCDKLHVD PQNFKLLGNM LVIVLSTHFA
KEFTPEVQAA WQKLVMGVAN ALSHKYH
//