ID   O88753_RAT              Unreviewed;       147 AA.
AC   O88753;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 161.
DE   SubName: Full=Epsilon 2 globin {ECO:0000313|EMBL:CAA39766.1};
DE   SubName: Full=Globin b3 {ECO:0000313|EMBL:SAI82214.1};
DE   SubName: Full=Hemoglobin, epsilon 2 {ECO:0000313|Ensembl:ENSRNOP00000044821.1};
GN   Name=Hbe2 {ECO:0000313|Ensembl:ENSRNOP00000044821.1,
GN   ECO:0000313|RGD:1564524};
GN   Synonyms=epsilon 2 {ECO:0000313|EMBL:CAA39766.1}, Glnb3
GN   {ECO:0000313|EMBL:SAI82214.1}, Hbe2_predicted
GN   {ECO:0000313|RGD:1564524};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:CAA39766.1};
RN   [1] {ECO:0000313|EMBL:CAA39766.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wistar {ECO:0000313|EMBL:CAA39766.1};
RA   Hiroyuki S.;
RL   Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAA39766.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wistar {ECO:0000313|EMBL:CAA39766.1};
RX   PubMed=10196478; DOI=10.1016/S0378-1119(99)00055-4;
RA   Sato H., Inokuchi N., Nagae Y., Okazaki T.;
RT   "Molecular cloning and characterization of two sets of alpha-theta genes in
RT   the rat alpha-like globin gene cluster.";
RL   Gene 230:91-99(1999).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000044821.1, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044821.1,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [4] {ECO:0000313|EMBL:SAI82214.1}
RP   NUCLEOTIDE SEQUENCE.
RX   DOI=10.1016/j.genrep.2016.10.009;
RA   Premzl M.;
RT   "Comparative genomic analysis of eutherian globin genes.";
RL   Gene Rep 5:163-166(2016).
RN   [5] {ECO:0000313|EMBL:SAI82214.1}
RP   NUCLEOTIDE SEQUENCE.
RX   DOI=10.1016/j.genrep.2019.100414;
RA   Premzl M.;
RT   "Eutherian third-party data gene collections.";
RL   Gene Rep 16:100414-100414(2019).
RN   [6] {ECO:0000313|Ensembl:ENSRNOP00000044821.1}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044821.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the globin family.
CC       {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC       ECO:0000256|RuleBase:RU000356}.
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DR   EMBL; X56327; CAA39766.1; -; Genomic_DNA.
DR   EMBL; LT548167; SAI82214.1; -; Genomic_DNA.
DR   RefSeq; NP_001019976.1; NM_001024805.1.
DR   SMR; O88753; -.
DR   STRING; 10116.ENSRNOP00000044821; -.
DR   PaxDb; 10116-ENSRNOP00000044821; -.
DR   Ensembl; ENSRNOT00000048484.2; ENSRNOP00000044821.1; ENSRNOG00000030784.2.
DR   GeneID; 502359; -.
DR   KEGG; rno:502359; -.
DR   AGR; RGD:1564524; -.
DR   CTD; 502359; -.
DR   RGD; 1564524; Hbe2.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00940000164134; -.
DR   HOGENOM; CLU_003827_10_0_1; -.
DR   OMA; SELHCER; -.
DR   OrthoDB; 5356926at2759; -.
DR   TreeFam; TF333268; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000030784; Expressed in testis.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; Globins; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11442:SF47; HEMOGLOBIN SUBUNIT BETA-H0; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; Globin-like; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00238};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00238};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00238};
KW   Oxygen transport {ECO:0000256|ARBA:ARBA00022621, ECO:0000256|PROSITE-
KW   ProRule:PRU00238}; Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW   ProRule:PRU00238}.
FT   DOMAIN          2..147
FT                   /note="Globin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS01033"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   147 AA;  16388 MW;  8F83E066420FA556 CRC64;
     MVHFTAEEKA AIISIWEKVD LEKLGGETLG RLLIVYPWTQ RFFDKFGNLS SAPAIMGNPQ
     IRAHGKKVLV SLGLAVENMD NLKETFAHLS ELHCDKLHVD PENFKLLGNV LVIVLSSYFG
     KEFTAEVQAA WQKLVAGVAT ALSHKYH
//