LOCUS BC037545 3677 bp mRNA linear HUM 04-AUG-2008
DEFINITION Homo sapiens poly (ADP-ribose) polymerase 1, mRNA (cDNA clone
MGC:40266 IMAGE:5193735), complete cds.
ACCESSION BC037545
VERSION BC037545.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3677)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3677)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (13-SEP-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 64 Row: g Column: 23
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 11496989.
FEATURES Location/Qualifiers
source 1..3677
/db_xref="H-InvDB:HIT000051928"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:40266 IMAGE:5193735"
/tissue_type="Brain, adult, 6 pooled whole brains"
/clone_lib="NIH_MGC_114"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3677
/gene="PARP1"
/gene_synonym="ADPRT1"
/gene_synonym="pADPRT-1"
/gene_synonym="PARP"
/gene_synonym="PARP-1"
/db_xref="GeneID:142"
/db_xref="HGNC:HGNC:270"
/db_xref="MIM:173870"
CDS 145..3189
/gene="PARP1"
/gene_synonym="ADPRT1"
/gene_synonym="pADPRT-1"
/gene_synonym="PARP"
/gene_synonym="PARP-1"
/codon_start=1
/product="poly (ADP-ribose) polymerase 1"
/protein_id="AAH37545.1"
/db_xref="GeneID:142"
/db_xref="HGNC:HGNC:270"
/db_xref="MIM:173870"
/translation="MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
DGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGI
GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHP
GCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDE
VAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGE
SAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSN
MKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSK
GQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
NSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGN
AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESM
KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI
PHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
TDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHN
RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
TGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
BASE COUNT 1023 a 834 c 1021 g 799 t
ORIGIN
1 cggtggccgg tgcggcgtgt tcggtggcgg ctctggccgc tcaggcgcct gcggctgggt
61 gagcgcacgc gaggcggcga ggcggcagcg tgtttctagg tcgtggcgtc gggcttccgg
121 agctttgccg gcagctaggg gaggatggcg gagtcttcgg ataagctcta tcgagtcgag
181 tacgccaaga gcgggcgcgc ctcttgcaag aaatgcagcg agagcatccc caaggactcg
241 ctccggatgg ccatcatggt gcagtcgccc atgtttgatg gaaaagtccc acactggtac
301 cacttctcct gcttctggaa ggtgggccac tccatccggc accctgacgt tgaggtggat
361 gggttctctg agcttcggtg ggatgatcag cagaaagtca agaagacagc ggaagctgga
421 ggagtgacag gcaaaggcca ggatggaatt ggtagcaagg cagagaagac tctgggtgac
481 tttgcagcag agtatgccaa gtccaacaga agtacgtgca aggggtgtat ggagaagata
541 gaaaagggcc aggtgcgcct gtccaagaag atggtggacc cggagaagcc acagctaggc
601 atgattgacc gctggtacca tccaggctgc tttgtcaaga acagggagga gctgggtttc
661 cggcccgagt acagtgcgag tcagctcaag ggcttcagcc tccttgctac agaggataaa
721 gaagccctga agaagcagct cccaggagtc aagagtgaag gaaagagaaa aggcgatgag
781 gtggatggag tggatgaagt ggcgaagaag aaatctaaaa aagaaaaaga caaggatagt
841 aagcttgaaa aagccctaaa ggctcagaac gacctgatct ggaacatcaa ggacgagcta
901 aagaaagtgt gttcaactaa tgacctgaag gagctactca tcttcaacaa gcagcaagtg
961 ccttctgggg agtcggcgat cttggaccga gtagccgatg gcatggtgtt cggtgccctc
1021 cttccctgcg aggaatgctc gggtcagctg gtcttcaaga gcgatgccta ttactgcact
1081 ggggacgtca ctgcctggac caagtgtatg gtcaagacac agacacccaa ccggaaggag
1141 tgggtaaccc caaaggaatt ccgagaaatc tcttacctca agaaattgaa ggttaaaaaa
1201 caggaccgta tattcccccc agaaaccagc gcctccgtgg cggccacgcc tccgccctcc
1261 acagcctcgg ctcctgctgc tgtgaactcc tctgcttcag cagataagcc attatccaac
1321 atgaagatcc tgactctcgg gaagctgtcc cggaacaagg atgaagtgaa ggccatgatt
1381 gagaaactcg gggggaagtt gacggggacg gccaacaagg cttccctgtg catcagcacc
1441 aaaaaggagg tggaaaagat gaataagaag atggaggaag taaaggaagc caacatccga
1501 gttgtgtctg aggacttcct ccaggacgtc tccgcctcca ccaagagcct tcaggagttg
1561 ttcttagcgc acatcttgtc cccttggggg gcagaggtga aggcagagcc tgttgaagtt
1621 gtggccccaa gagggaagtc aggggctgcg ctctccaaaa aaagcaaggg ccaggtcaag
1681 gaggaaggta tcaacaaatc tgaaaagaga atgaaattaa ctcttaaagg aggagcagct
1741 gtggatcctg attctggact ggaacactct gcgcatgtcc tggagaaagg tgggaaggtc
1801 ttcagtgcca cccttggcct ggtggacatc gttaaaggaa ccaactccta ctacaagctg
1861 cagcttctgg aggacgacaa ggaaaacagg tattggatat tcaggtcctg gggccgtgtg
1921 ggtacggtga tcggtagcaa caaactggaa cagatgccgt ccaaggagga tgccattgag
1981 cacttcatga aattatatga agaaaaaacc gggaacgctt ggcactccaa aaatttcacg
2041 aagtatccca aaaagttcta ccccctggag attgactatg gccaggatga agaggcagtg
2101 aagaagctga cagtaaatcc tggcaccaag tccaagctcc ccaagccagt tcaggacctc
2161 atcaagatga tctttgatgt ggaaagtatg aagaaagcca tggtggagta tgagatcgac
2221 cttcagaaga tgcccttggg gaagctgagc aaaaggcaga tccaggccgc atactccatc
2281 ctcagtgagg tccagcaggc ggtgtctcag ggcagcagcg actctcagat cctggatctc
2341 tcaaatcgct tttacaccct gatcccccac gactttggga tgaagaagcc tccgctcctg
2401 aacaatgcag acagtgtgca ggccaaggcg gaaatgcttg acaacctgct ggacatcgag
2461 gtggcctaca gtctgctcag gggagggtct gatgatagca gcaaggatcc catcgatgtc
2521 aactatgaga agctcaaaac tgacattaag gtggttgaca gagattctga agaagccgag
2581 atcatcagga agtatgttaa gaacactcat gcaaccacac acaatgcgta tgacttggaa
2641 gtcatcgata tctttaagat agagcgtgaa ggcgaatgcc agcgttacaa gccctttaag
2701 cagcttcata accgaagatt gctgtggcac gggtccagga ccaccaactt tgctgggatc
2761 ctgtcccagg gtcttcggat agccccgcct gaagcgcccg tgacaggcta catgtttggt
2821 aaagggatct atttcgctga catggtctcc aagagtgcca actactgcca tacgtctcag
2881 ggagacccaa taggcttaat cctgttggga gaagttgccc ttggaaacat gtatgaactg
2941 aagcacgctt cacatatcag caagttaccc aagggcaagc acagtgtcaa aggtttgggc
3001 aaaactaccc ctgatccttc agctaacatt agtctggatg gtgtagacgt tcctcttggg
3061 accgggattt catctggtgt gaatgacacc tctctactat ataacgagta cattgtctat
3121 gatattgctc aggtaaatct gaagtatctg ctgaaactga aattcaattt taagacctcc
3181 ctgtggtaat tgggagaggt agccgagtca cacccggtgg ctctggtatg aattcacccg
3241 aagcgcttct gcaccaactc acctggccgc taagttgctg atgggtagta cctgtactaa
3301 accacctcag aaaggatttt acagaaacgt gttaaaggtt ttctctaact tctcaagtcc
3361 cttgttttgt gttgtgtctg tggggagggg ttgttttggg gttgtttttg ttttttcttg
3421 ccaggtagat aaaactgaca tagagaaaag gctggagaga gattctgttg catagactag
3481 tcctatggaa aaaaccaagc ttcgttagaa tgtctgcctt actggtttcc ccagggaagg
3541 aaaaatacac ttccaccctt ttttctaagt gttcgtcttt agttttgatt ttggaaagat
3601 gttaagcatt tatttttagt taaaaataaa aactaatttc atactattta aaaaaaaaaa
3661 aaaaaaaaaa aaaaaaa
//