LOCUS Z74996 6572 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for voltage-dependent L-type calcium channel, alpha
1C subunit (splice variant).
ACCESSION Z74996
VERSION Z74996.1
KEYWORDS CACNL1A1 gene; voltage-dependent calcium channel alpha-1C subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4726;4784 to 6572)
AUTHORS Soldatov N.M.
TITLE Molecular diversity of L-type Ca2+ channel transcripts in human
fibroblasts
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
PUBMED 1316612
REFERENCE 2 (bases 1 to 6572)
AUTHORS Soldatov N.M.
TITLE Genomic structure of human L-type Ca2+ channel
JOURNAL Genomics 22(1), 77-87(1994).
PUBMED 7959794
REFERENCE 3 (bases 1 to 6572)
AUTHORS Soldatov N.M.
TITLE Functional Expression of Splice Variants of Human L-type Calcium
Channel
JOURNAL Unpublished.
REFERENCE 4 (bases 1 to 6572)
AUTHORS Soldatov N.M.
JOURNAL Submitted (30-JUL-1996) to the INSDC. Nikolai M. Soldatov,
Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
CH-3010, Switzerland
FEATURES Location/Qualifiers
source 1..6572
/db_xref="H-InvDB:HIT000328040"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="fetal"
/cell_line="CRL 1475 (ATCC)"
/cell_type="fibroblast"
/tissue_type="hippocampus"
/db_xref="taxon:9606"
CDS 1..6474
/product="voltage-dependent L-type calcium channel alpha
1C subunit"
/function="L-type calcium channel (clone HLCC72) splice
variant"
/note="composed of exons 1-20, 22-30, 32-40, 41A, 42-44,
46-50"
/db_xref="GOA:Q13936"
/db_xref="H-InvDB:HIT000328040.12"
/db_xref="HGNC:HGNC:1390"
/db_xref="InterPro:IPR002077"
/db_xref="InterPro:IPR005446"
/db_xref="InterPro:IPR005451"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR014873"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR031649"
/db_xref="InterPro:IPR031688"
/db_xref="PDB:1T0J"
/db_xref="PDB:2BE6"
/db_xref="PDB:2F3Y"
/db_xref="PDB:2F3Z"
/db_xref="PDB:2LQC"
/db_xref="PDB:3G43"
/db_xref="PDB:3OXQ"
/db_xref="PDB:5V2P"
/db_xref="PDB:5V2Q"
/db_xref="PDB:6C0A"
/db_xref="PDB:6DAD"
/db_xref="PDB:6DAE"
/db_xref="PDB:6DAF"
/db_xref="UniProtKB/Swiss-Prot:Q13936"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA99284.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN
SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG
MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE
PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL
DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS
DGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK
IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNAL
SLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHV
SYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNA
NINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQA
AMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQ
SPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLL
QRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAE
TTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKF
IEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEED
AGCVRARGAPSEEELQDSRVYVSSL"
exon <1..49
/number=1
exon 50..371
/number=2
exon 372..477
/number=3
exon 478..617
/number=4
exon 618..757
/number=5
exon 758..916
/number=6
exon 917..1113
/number=7
exon 1114..1216
/number=8
exon 1217..1390
/number=9
exon 1391..1481
/number=10
exon 1482..1508
/number=11
exon 1509..1669
/number=12
exon 1670..1895
/number=13
exon 1896..2103
/number=14
exon 2104..2224
/number=15
exon 2225..2339
/number=16
exon 2340..2460
/number=17
exon 2461..2530
/number=18
exon 2531..2663
/number=19
exon 2664..2793
/number=20
exon 2794..2853
/number=22
/note="alternative"
exon 2854..2965
/number=23
exon 2966..3048
/number=24
exon 3049..3156
/number=25
exon 3157..3209
/number=26
exon 3210..3356
/number=27
exon 3357..3558
/number=28
exon 3559..3717
/number=29
exon 3718..3828
/number=30
exon 3829..3912
/number=32
/note="alternative"
exon 3913..3945
/number=33
/note="alternative"
exon 3946..4074
/number=34
exon 4075..4140
/number=35
exon 4141..4232
/number=36
exon 4233..4398
/number=37
exon 4399..4526
/number=38
exon 4527..4623
/number=39
exon 4624..4726
/number=40
exon 4727..4885
/number=41
/note="brain-specific exon 41A; extended by 57 nt upstream
of alternative splice acceptor site"
exon 4886..5013
/number=42
exon 5014..5148
/number=43
exon 5149..5501
/number=44
exon 5502..5630
/number=46
exon 5631..5737
/number=47
exon 5738..5841
/number=48
exon 5842..6174
/number=49
exon 6175..>6572
/number=50
3'UTR 6475..6572
BASE COUNT 1480 a 1946 c 1777 g 1369 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc
2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac
2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt
3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
3901 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac
3961 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg
4021 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg
4081 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag
4141 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag
4201 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac
4261 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc
4321 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac
4381 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac
4441 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc
4501 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc
4561 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc
4621 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc
4681 accctgtttg ccctggtcag gacggccctg aggatcaaaa cagaagaggg acccagccca
4741 tcagaggccc accaaggggc tgaggatcct ttccgccctg cagggaacct agaacaagcc
4801 aatgaggagc tgcgggcgat catcaagaag atctggaagc ggaccagcat gaagctgctg
4861 gaccaggtgg tgccccctgc aggtgatgat gaggtcaccg ttggcaagtt ctacgccacg
4921 ttcctgatcc aggagtactt ccggaagttc aagaagcgca aagagcaggg ccttgtgggc
4981 aagccctccc agaggaacgc gctgtctctg caggctggct tgcgcacact gcatgacatc
5041 gggcctgaga tccgacgggc catctctgga gatctcaccg ctgaggagga gctggacaag
5101 gccatgaagg aggctgtgtc cgctgcttct gaagatgaca tcttcaggag ggccggtggc
5161 ctgttcggca accacgtcag ctactaccaa agcgacggcc ggagcgcctt cccccagacc
5221 ttcaccactc agcgcccgct gcacatcaac aaggcgggca gcagccaggg cgacactgag
5281 tcgccatccc acgagaagct ggtggactcc accttcaccc cgagcagcta ctcgtccacc
5341 ggctccaacg ccaacatcaa caacgccaac aacaccgccc tgggtcgcct ccctcgcccc
5401 gccggctacc ccagcacggt cagcactgtg gagggccacg ggcccccctt gtcccctgcc
5461 atccgggtgc aggaggtggc gtggaagctc agctccaaca ggtgccactc ccgggagagc
5521 caggcagcca tggcgggtca ggaggagacg tctcaggatg agacctatga agtgaagatg
5581 aaccatgaca cggaggcctg cagtgagccc agcctgctct ccacagagat gctctcctac
5641 caggatgacg aaaatcggca actgacgctc ccagaggagg acaagaggga catccggcaa
5701 tctccgaaga ggggtttcct ccgctctgcc tcactaggtc gaagggcctc cttccacctg
5761 gaatgtctga agcgacagaa ggaccgaggg ggagacatct ctcagaagac agtcctgccc
5821 ttgcatctgg ttcatcatca ggcattggca gtggcaggcc tgagccccct cctccagaga
5881 agccattccc ctgcctcatt ccctaggcct tttgccaccc caccagccac acctggcagc
5941 cgaggctggc ccccacagcc cgtccccacc ctgcggcttg agggggtcga gtccagtgag
6001 aaactcaaca gcagcttccc atccatccac tgcggctcct gggctgagac cacccccggt
6061 ggcgggggca gcagcgccgc ccggagagtc cggcccgtct ccctcatggt gcccagccag
6121 gctggggccc cagggaggca gttccacggc agtgccagca gcctggtgga agcggtcttg
6181 atttcagaag gactggggca gtttgctcaa gatcccaagt tcatcgaggt caccacccag
6241 gagctggccg acgcctgcga catgaccata gaggagatgg agagcgcggc cgacaacatc
6301 ctcagcgggg gcgccccaca gagccccaat ggcgccctct taccctttgt gaactgcagg
6361 gacgcggggc aggaccgagc cgggggcgag gaggacgcgg gctgtgtgcg cgcgcggggt
6421 gcaccgagtg aggaggagct ccaggacagc agggtctacg tcagcagcct gtagtgggcg
6481 ctgccagatg cgggcttttt tttttttatt tgtttcaatg ttcctaatgg gttcgtttca
6541 gaagtgcctc actgttctcg tgacctggag tt
//