LOCUS Z74615 6728 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for prepro-alpha1(I) collagen.
ACCESSION Z74615
VERSION Z74615.1
KEYWORDS alpha1(I)-collagen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 36)
AUTHORS Chu M., de Wet W., Bernard M., Ramirez F.
TITLE Fine structural analysis on the human pro-alpha1(I) collagen gene
JOURNAL J Biol Chem 260(4), 2315-2320(1985).
PUBMED 2857713
REFERENCE 2 (bases 37 to 1536)
AUTHORS Tromp G., Kuivaniemi H., Stacey A., Shikata H., Baldwin C.T.,
Jaenisch R., Prockop D.J.
TITLE Structure of a full-length cDNA clone for the prepro alpha 1(I)
chain of human type I procollagen
JOURNAL Biochem. J. 253(3), 919-922(1988).
PUBMED 3178743
REFERENCE 3 (bases 1537 to 3803)
AUTHORS Bernard M.P., Chu M., Myers J.C., Ramirez F., Eikenberry E.F.,
Prockop D.J.
TITLE Nucleotide sequences of complementary deoxyribonucleic acids for
the pro alpha 1 chain of human type I procollagen. Statistical
evaluation of structures that are conserved during evolution
JOURNAL Biochemistry 22(22), 5213-5223(1983).
PUBMED 6689127
REFERENCE 4 (bases 3804 to 4481)
AUTHORS Makela J.K., Raassina M., Virta A., Vuorio E.
TITLE Human pro alpha 1(I) collagen: cDNA sequence for the C-propeptide
domain
JOURNAL Nucleic Acids Res. 16(1), 349-349(1988).
PUBMED 3340531
REFERENCE 5 (bases 4482 to 6728)
AUTHORS Maatta A., Bornstein P., Penttinen R.P.
TITLE Highly conserved sequences in the 3'-untranslated region of the
COL1A1 gene bind cell-specific nuclear proteins
JOURNAL FEBS Lett. 279(1), 9-13(1991).
PUBMED 1995349
REFERENCE 6 (bases 1 to 6728)
AUTHORS Dalgleish R.
JOURNAL Submitted (01-JUL-1996) to the INSDC. Raymond Dalgleish, Department
of Genetics, University of Leicester, University Road, Leicester,
LE1 7RH, United Kingdom
REFERENCE 7 (bases 1 to 6728)
AUTHORS Dalgleish R.
TITLE The human type I collagen mutation database
JOURNAL Nucleic Acids Res. 25(1), 181-187(1997).
PUBMED 9016532
FEATURES Location/Qualifiers
source 1..6728
/db_xref="H-InvDB:HIT000328003"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR 1..119
exon 1..222
/number=1
CDS 120..4514
/product="prepro-alpha1(I) collagen"
/db_xref="GOA:P02452"
/db_xref="H-InvDB:HIT000328003.14"
/db_xref="HGNC:HGNC:2197"
/db_xref="InterPro:IPR000885"
/db_xref="InterPro:IPR001007"
/db_xref="InterPro:IPR008160"
/db_xref="PDB:1Q7D"
/db_xref="PDB:2LLP"
/db_xref="PDB:3EJH"
/db_xref="PDB:3GXE"
/db_xref="PDB:5CTD"
/db_xref="PDB:5CTI"
/db_xref="PDB:5CVA"
/db_xref="PDB:5CVB"
/db_xref="PDB:5K31"
/db_xref="PDB:5OU8"
/db_xref="PDB:5OU9"
/db_xref="UniProtKB/Swiss-Prot:P02452"
/protein_id="CAA98968.1"
/translation="MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNG
LRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESP
TDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFA
PQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMG
PRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGA
KGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPP
GPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADG
QPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPA
GERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPG
PPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGP
AGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFP
GERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPG
PKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGA
PGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNV
GAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETG
PAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGF
PGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPAAEGSPGRDGSP
GAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAG
PQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGS
AGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQP
PQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDL
KMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKD
KRHVWFGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMD
QQTGNLKKALLLKGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKSSR
LPIIDVAPLDVGAPDQEFGFDVGPVCFL"
sig_peptide 120..185
misc_feature 186..602
/note="N_propeptide"
exon 223..417
/number=2
exon 418..452
/number=3
exon 453..488
/number=4
exon 489..590
/number=5
exon 591..662
/number=6
misc_feature 603..653
/note="N_telopeptide"
misc_feature 654..3695
/note="triple_helix"
exon 663..707
/number=7
exon 708..761
/number=8
exon 762..815
/number=9
exon 816..869
/number=10
exon 870..923
/number=11
exon 924..977
/number=12
exon 978..1022
/number=13
exon 1023..1076
/number=14
exon 1077..1121
/number=15
exon 1122..1175
/number=16
exon 1176..1274
/number=17
exon 1275..1319
/number=18
exon 1320..1418
/number=19
exon 1419..1472
/number=20
exon 1473..1580
/number=21
exon 1581..1634
/number=22
exon 1635..1733
/number=23
exon 1734..1787
/number=24
exon 1788..1886
/number=25
exon 1887..1940
/number=26
exon 1941..1994
/number=27
exon 1995..2048
/number=28
exon 2049..2102
/number=29
exon 2103..2147
/number=30
exon 2148..2246
/number=31
exon 2247..2354
/number=32
exon 2355..2462
/note="exons 33-34"
exon 2463..2516
/number=35
exon 2517..2570
/number=36
exon 2571..2678
/number=37
exon 2679..2732
/number=38
exon 2733..2786
/number=39
exon 2787..2948
/number=40
exon 2949..3056
/number=41
exon 3057..3164
/number=42
exon 3165..3218
/number=43
exon 3219..3326
/number=44
exon 3327..3380
/number=45
exon 3381..3488
/number=46
exon 3489..3542
/number=47
exon 3543..3650
/number=48
old_sequence 3569..3571
/replace="cnc"
/citation=[4]
exon 3651..3933
/number=49
misc_feature 3696..3773
/note="C_telopeptide"
misc_feature 3774..4511
/note="C_propeptide"
exon 3934..4124
/number=50
exon 4125..4367
/number=51
misc_feature 4212..4220
/note="carbohydrate attachment site"
exon 4368..5921
/number=52
regulatory 4763..4775
/regulatory_class="polyA_signal_sequence"
polyA_site 4798
regulatory 5891..5896
/regulatory_class="polyA_signal_sequence"
polyA_site 5921
BASE COUNT 1213 a 2144 c 1971 g 1400 t
ORIGIN
1 agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc
61 atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca
121 tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc
181 acggccaaga ggaaggccaa gtcgagggcc aagacgaaga catcccacca atcacctgcg
241 tacagaacgg cctcaggtac catgaccgag acgtgtggaa acccgagccc tgccggatct
301 gcgtctgcga caacggcaag gtgttgtgcg atgacgtgat ctgtgacgag accaagaact
361 gccccggcgc cgaagtcccc gagggcgagt gctgtcccgt ctgccccgac ggctcagagt
421 cacccaccga ccaagaaacc accggcgtcg agggacccaa gggagacact ggcccccgag
481 gcccaagggg acccgcaggc ccccctggcc gagatggcat ccctggacag cctggacttc
541 ccggaccccc cggacccccc ggacctcccg gaccccctgg cctcggagga aactttgctc
601 cccagctgtc ttatggctat gatgagaaat caaccggagg aatttccgtg cctggcccca
661 tgggtccctc tggtcctcgt ggtctccctg gcccccctgg tgcacctggt ccccaaggct
721 tccaaggtcc ccctggtgag cctggcgagc ctggagcttc aggtcccatg ggtccccgag
781 gtcccccagg tccccctgga aagaatggag atgatgggga agctggaaaa cctggtcgtc
841 ctggtgagcg tgggcctcct gggcctcagg gtgctcgagg attgcccgga acagctggcc
901 tccctggaat gaagggacac agaggtttca gtggtttgga tggtgccaag ggagatgctg
961 gtcctgctgg tcctaagggt gagcctggca gccctggtga aaatggagct cctggtcaga
1021 tgggcccccg tggcctgcct ggtgagagag gtcgccctgg agcccctggc cctgctggtg
1081 ctcgtggaaa tgatggtgct actggtgctg ccgggccccc tggtcccacc ggccccgctg
1141 gtcctcctgg cttccctggt gctgttggtg ctaagggtga agctggtccc caagggcccc
1201 gaggctctga aggtccccag ggtgtgcgtg gtgagcctgg cccccctggc cctgctggtg
1261 ctgctggccc tgctggaaac cctggtgctg atggacagcc tggtgctaaa ggtgccaatg
1321 gtgctcctgg tattgctggt gctcctggct tccctggtgc ccgaggcccc tctggacccc
1381 agggccccgg cggccctcct ggtcccaagg gtaacagcgg tgaacctggt gctcctggca
1441 gcaaaggaga cactggtgct aagggagagc ctggccctgt tggtgttcaa ggaccccctg
1501 gccctgctgg agaggaagga aagcgaggag ctcgaggtga acccggaccc actggcctgc
1561 ccggaccccc tggcgagcgt ggtggacctg gtagccgtgg tttccctggc gcagatggtg
1621 ttgctggtcc caagggtccc gctggtgaac gtggttctcc tggccccgct ggccccaaag
1681 gatctcctgg tgaagctggt cgtcccggtg aagctggtct gcctggtgcc aagggtctga
1741 ctggaagccc tggcagccct ggtcctgatg gcaaaactgg cccccctggt cccgccggtc
1801 aagatggtcg ccccggaccc ccaggcccac ctggtgcccg tggtcaggct ggtgtgatgg
1861 gattccctgg acctaaaggt gctgctggag agcccggcaa ggctggagag cgaggtgttc
1921 ccggaccccc tggcgctgtc ggtcctgctg gcaaagatgg agaggctgga gctcagggac
1981 cccctggccc tgctggtccc gctggcgaga gaggtgaaca aggccctgct ggctcccccg
2041 gattccaggg tctccctggt cctgctggtc ctccaggtga agcaggcaaa cctggtgaac
2101 agggtgttcc tggagacctt ggcgcccctg gcccctctgg agcaagaggc gagagaggtt
2161 tccctggcga gcgtggtgtg caaggtcccc ctggtcctgc tggaccccga ggggccaacg
2221 gtgctcccgg caacgatggt gctaagggtg atgctggtgc ccctggagct cccggtagcc
2281 agggcgcccc tggccttcag ggaatgcctg gtgaacgtgg tgcagctggt cttccagggc
2341 ctaagggtga cagaggtgat gctggtccca aaggtgctga tggctctcct ggcaaagatg
2401 gcgtccgtgg tctgaccggc cccattggtc ctcctggccc tgctggtgcc cctggtgaca
2461 agggtgaaag tggtcccagc ggccctgctg gtcccactgg agctcgtggt gcccccggag
2521 accgtggtga gcctggtccc cccggccctg ctggctttgc tggcccccct ggtgctgacg
2581 gccaacctgg tgctaaaggc gaacctggtg atgctggtgc caaaggcgat gctggtcccc
2641 ctgggcctgc cggacccgct ggaccccctg gccccattgg taatgttggt gctcctggag
2701 ccaaaggtgc tcgcggcagc gctggtcccc ctggtgctac tggtttccct ggtgctgctg
2761 gccgagtcgg tcctcctggc ccctctggaa atgctggacc ccctggccct cctggtcctg
2821 ctggcaaaga aggcggcaaa ggtccccgtg gtgagactgg ccctgctgga cgtcctggtg
2881 aagttggtcc ccctggtccc cctggccctg ctggcgagaa aggatcccct ggtgctgatg
2941 gtcctgctgg tgctcctggt actcccgggc ctcaaggtat tgctggacag cgtggtgtgg
3001 tcggcctgcc tggtcagaga ggagagagag gcttccctgg tcttcctggc ccctctggtg
3061 aacctggcaa acaaggtccc tctggagcaa gtggtgaacg tggtcccccc ggtcccatgg
3121 gcccccctgg attggctgga ccccctggtg aatctggacg tgagggggct cctgctgccg
3181 aaggttcccc tggacgagac ggttctcctg gcgccaaggg tgaccgtggt gagaccggcc
3241 ccgctggacc ccctggtgct cctggtgctc ctggtgcccc tggccccgtt ggccctgctg
3301 gcaagagtgg tgatcgtggt gagactggtc ctgctggtcc cgccggtccc gtcggccccg
3361 tcggcgcccg tggccccgcc ggaccccaag gcccccgtgg tgacaagggt gagacaggcg
3421 aacagggcga cagaggcata aagggtcacc gtggcttctc tggcctccag ggtccccctg
3481 gccctcctgg ctctcctggt gaacaaggtc cctctggagc ctctggtcct gctggtcccc
3541 gaggtccccc tggctctgct ggtgctcctg gcaaagatgg actcaacggt ctccctggcc
3601 ccattgggcc ccctggtcct cgcggtcgca ctggtgatgc tggtcctgtt ggtccccccg
3661 gccctcctgg acctcctggt ccccctggtc ctcccagcgc tggtttcgac ttcagcttcc
3721 tgccccagcc acctcaagag aaggctcacg atggtggccg ctactaccgg gctgatgatg
3781 ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac cctcaagagc ctgagccagc
3841 agatcgagaa catccggagc ccagagggaa gccgcaagaa ccccgcccgc acctgccgtg
3901 acctcaagat gtgccactct gactggaaga gtggagagta ctggattgac cccaaccaag
3961 gctgcaacct ggatgccatc aaagtcttct gcaacatgga gactggtgag acctgcgtgt
4021 accccactca gcccagtgtg gcccagaaga actggtacat cagcaagaac cccaaggaca
4081 agaggcatgt ctggttcggc gagagcatga ccgatggatt ccagttcgag tatggcggcc
4141 agggctccga ccctgccgat gtggccatcc agctgacctt cctgcgcctg atgtccaccg
4201 aggcctccca gaacatcacc taccactgca agaacagcgt ggcctacatg gaccagcaga
4261 ctggcaacct caagaaggcc ctgctcctca agggctccaa cgagatcgag atccgcgccg
4321 agggcaacag ccgcttcacc tacagcgtca ctgtcgatgg ctgcacgagt cacaccggag
4381 cctggggcaa gacagtgatt gaatacaaaa ccaccaagtc ctcccgcctg cccatcatcg
4441 atgtggcccc cttggacgtt ggtgccccag accaggaatt cggcttcgac gttggccctg
4501 tctgcttcct gtaaactccc tccatcccaa cctggctccc tcccacccaa ccaactttcc
4561 ccccaacccg gaaacagaca agcaacccaa actgaacccc cccaaaagcc aaaaaatggg
4621 agacaatttc acatggactt tggaaaatat ttttttcctt tgcattcatc tctcaaactt
4681 agtttttatc tttgaccaac cgaacatgac caaaaaccaa aagtgcattc aaccttacca
4741 aaaaaaaaaa aaaaaaaaaa agaataaata aataagtttt taaaaaagga agcttggtcc
4801 acttgcttga agacccatgc gggggtaagt ccctttctgc ccgttgggtt atgaaacccc
4861 aatgctgccc tttctgctcc tttctccaca ccccccttgg cctcccctcc actccttccc
4921 aaatctgtct ccccagaaga cacaggaaac aatgtattgt ctgcccagca atcaaaggca
4981 atgctcaaac acccaagtgg cccccaccct cagcccgctc ctgcccgccc agcaccccca
5041 ggccctgggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat
5101 ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc
5161 ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg
5221 ggaacgcgtg tcatcccttg tgccgcaggc tgggcgggag agactgttct gttctgttcc
5281 ttgtgtaact gtgttgctga aagactacct cgttcttgtc ttgatgtgtc accggggcaa
5341 ctgcctgggg gcggggatgg gggcagggtg gaagcggctc cccattttta taccaaaggt
5401 gctacatcta tgtgatgggt ggggtgggga gggaatcact ggtgctatag aaattgagat
5461 gcccccccag gccagcaaat gttccttttt gttcaaagtc tatttttatt ccttgatatt
5521 ttttctttct tttttttttt ttttgtggat ggggacttgt gaatttttct aaaggtgcta
5581 tttaacatgg gaggagagcg tgtgcgctcc agcccagccc gctgctcact ttccaccctc
5641 tctccacctg cctctggctt ctcaggcctc tgctctccga cctctctcct ctgaaaccct
5701 cctccacagc tgcagcccat cctcccggct ccctcctagt ctgtcctgcg tcctctgtcc
5761 ccgggtttca gagacaactt cccaaagcac aaagcagttt ttccctaggg gtgggaggaa
5821 gcaaaagact ctgtacctat tttgtatgtg tataataatt tgagatgttt ttaattattt
5881 tgattgctgg aataaagcat gtggaaatga cccaaacata atccgcagtg gcctcctaat
5941 ttccttcttt ggagttgggg gaggggtaga catggggaag gggccttggg gtgatgggct
6001 tgccttccat tcctgccctt tccctcccca ctattctctt ctagatccct ccataacccc
6061 actccccttt ctctcaccct tcttataccg caaacctttc tacttcctct ttcattttct
6121 attcttgcaa tttccttgca ccttttccaa atcctcttct cccctgcaat accatacagg
6181 caatccacgt gcacaacaca cacacacact cttcacatct ggggttgtcc aaacctcata
6241 cccactcccc ttcaagccca tccactctcc accccctgga tgccctgcac ttggtggcgg
6301 tgggatgctc atggatactg ggagggtgag gggagtggaa cccgtgagga ggacctgggg
6361 gcctctcctt gaactgacat gaagggtcat ctggcctctg ctcccttctc acccacgctg
6421 acctcctgcc gaaggagcaa cgcaacagga gaggggtctg ctgagcctgg cgagggtctg
6481 ggagggacca ggaggaaggc gtgctccctg ctcgctgtcc tggccctggg ggagtgaggg
6541 agacagacac ctgggagagc tgtggggaag gcactcgcac cgtgctcttg ggaaggaagg
6601 agacctggcc ctgctcacca cggactgggt gcctcgacct cctgaatccc cagaacacaa
6661 cccccctggg ctggggtggt ctggggaacc atcgtgcccc cgcctcccgc ctactccttt
6721 ttaagctt
//