LOCUS Z50053 3047 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for alpha2i-subunit of soluble guanylyl cyclase.
ACCESSION Z50053
VERSION Z50053.1
KEYWORDS alpha2i-subunit of guanylyl cyclase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3047)
AUTHORS Behrends S., Harteneck C., Schultz G., Koesling D.
TITLE A variant of the alpha 2 subunit of soluble guanylyl cyclase
contains an insert homologous to a region within adenylyl cyclases
and functions as a dominant negative protein
JOURNAL J Biol Chem 270(36), 21109-21113(1995).
PUBMED 7673142
REFERENCE 2 (bases 1 to 3047)
AUTHORS Behrends S.
JOURNAL Submitted (13-JUL-1995) to the INSDC. Behrends S., Free University
Berlin, Institute of Pharmacology, Thielallee 69-73, Berlin,
Berlin, Germany, 14195
FEATURES Location/Qualifiers
source 1..3047
/db_xref="H-InvDB:HIT000327506"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="HL-60, Y-79"
/db_xref="taxon:9606"
CDS 391..2682
/product="alpha2i-subunit of soluble guanylyl cyclase"
/function="inhibits NO-sensitive guanylyl cyclase"
/db_xref="GOA:P33402"
/db_xref="H-InvDB:HIT000327506.14"
/db_xref="HGNC:HGNC:4684"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR011644"
/db_xref="InterPro:IPR011645"
/db_xref="InterPro:IPR018297"
/db_xref="InterPro:IPR024096"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR038158"
/db_xref="InterPro:IPR042463"
/db_xref="UniProtKB/Swiss-Prot:P33402"
/protein_id="CAA90393.1"
/translation="MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPG
PLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSP
QTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTAN
ILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQA
TLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKL
CSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFD
PSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKP
EASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATR
DVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQ
GQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVE
TIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPV
SIQLVPDQHQSETDLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGS
HPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPS
LSSSRIKKVSYNIGTMFLRETSL"
BASE COUNT 758 a 803 c 780 g 706 t
ORIGIN
1 tgggccgcag ccctccccgc cccgccgacc gcggtcacac actctcggag cctccccgtg
61 agcgggagcg cggcgcacgg cgatgcgccg aggcgggcgc tgaggcggcg ccgcgcgagc
121 agcagcagag gcggcggcgg cccccagccc agcccggcgc cgccgccgag cccgggcccc
181 aaggtgcggc ggcgccccaa gttcccgcca tgagcagccg gctcgggggg ctccgcggcc
241 ccggggactc ccgccccgcc gggcgcgacc gcagcgcccc gcggccccga cgcgcttaac
301 gttgtcgctt gccggtcccg ccaccgccgc ctccgccgcc gctcgcgtcc tcgccgccac
361 cgcctcggcc gctgcagctc cgccggcagc atgtctcgaa ggaagatttc gtccgagtcc
421 ttcagctccc tgggctccga ctacctggag accagcccgg aggaggaggg ggagtgcccc
481 ctgtctaggc tctgctggaa tggcagccgg agcccgcccg ggccgctgga gcccagcccg
541 gccgcagctg ccgctgccgc cgccccggcc ccgaccccgg ctgcttctgc cgccgccgcc
601 gctgccactg ccggggccag gagggtgcag cgccggaggc gggtcaacct ggactcgctg
661 ggcgagagca tcagccgcct gacggcgccc tcgcctcaga cgatacagca gactctcaag
721 aggacactgc agtattatga acatcaagtt attggttaca gggatgcaga aaagaatttc
781 cacaatatct ctaacagatg ctcctatgca gaccactcca acaaagaaga aattgaagat
841 gtctcaggaa ttcttcagtg tactgctaat atactcggtt tgaagtttga ggaaattcaa
901 aaaagatttg gtgaagagtt ctttaatata tgctttcatg agaatgagag agtccttcga
961 gctgtaggtg gcactttgca ggactttttt aacggctttg atgctttgtt ggaacacatt
1021 agaacttctt ttggaaaaca ggccactctg gagtcaccat ctttcctatg caaagagctc
1081 cctgaaggta ctctcatgct ccactacttc caccctcacc atattgtggg gtttgcaatg
1141 ctggggatga ttaaggctgc aggaaagaag atctatcggc tggatgtgga agtggaacag
1201 gttgcaaatg agaagctatg ctctgatgtt tcaaacccag gcaattgtag ctgtcttact
1261 ttccttatca aagaatgtga aaatactaat atcatgaaga accttccaca gggaacctcc
1321 caagttcctg cggacctcag aattagcatc aacaccttct gtagagcctt ccctttccac
1381 ttgatgtttg atcccagcat gtcagtcctt cagttggggg aaggtctaag gaagcagctt
1441 cgatgtgaca ctcacaaagt gctcaagttt gaggactgct tcgagattgt atctccaaag
1501 gttaatgcca cctttgaaag ggtcctgctg cgactgtcta ccccgtttgt gattagaacc
1561 aagcctgagg cttctggctc tgaaaataaa gacaaggtga tggaagtcaa aggacaaatg
1621 atccatgttc cagaatcaaa ttccatttta tttttgggct ctccatgtgt ggacaagttg
1681 gatgaactca tgggccgagg gctacatctc tcagacatcc ctatccatga tgccacccga
1741 gatgtcattt tggttggtga gcaggcaaag gcccaagatg ggttgaagaa aaggatggat
1801 aaattaaagg caactttaga aagaactcac caggccctgg aagaagagaa aaagaagaca
1861 gtggatcttc tatattctat tttccctggt gatgtagccc agcaattatg gcaagggcag
1921 caagtacagg ccagaaagtt tgatgatgtc accatgctct tttcagacat tgttggcttc
1981 acagccatat gtgcccagtg tactcccatg caagtaatca gcatgctgaa tgaactgtac
2041 accagatttg accaccagtg tggatttttg gatatttata aggtggaaac aataggtgat
2101 gcctactgtg ttgcagcagg gctccacaga aaaagcctct gccatgctaa acccattgct
2161 ctgatggcct tgaagatgat ggaactttca gaagaggtgc tgacacctga tggaagaccg
2221 attcagcccc agaggagtga actccttttc tcctttcctg tttccatcca gctggttcca
2281 gatcagcatc aaagtgaaac ggatttgggt actgaaaaga tgaggatagg aattcactca
2341 ggctccgtgc tggctggagt tgttggggtg cgaatgccac gttattgcct gtttggaaat
2401 aatgtcacac tggcaagcaa attcgagtcg ggaagtcacc ctcggcgcat caatgtcagc
2461 ccaaccactt accaattatt aaaacgagaa gaaagtttca cattcattcc gcggtctcgt
2521 gaagagcttc cagacaactt tccaaaggaa attcctggga tctgctattt cctggaggta
2581 aggactggtc caaagccacc aaagccttct ctttcttcgt cgagaataaa aaaggtttcc
2641 tacaacatcg gcaccatgtt cctccgggag acaagcctct gagacctgct acagatcaaa
2701 gactcctcca aaaagcacaa gcccagaaca tgggtcacca atggggggtg gaaagagatt
2761 gtgtctcttt cattgctttg ttgagaacaa gcagcaaaat ttctgtatta tgtcaggcaa
2821 taatcctact aaaaggtgga ggtgaccgct gtcaataaaa agccggagga tgagggaaat
2881 aagatgtgtc cattcatatg agtggttttg gtcatatata tacacatata ttttaattac
2941 aagtgtgggt cccctttcag aactaaccaa taaatagatt ccatgttttc ttgtttatca
3001 cacatacaag tatctttccc tatatatttg taccactttt gagagcc
//