LOCUS Z46973 2990 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for phosphatidylinositol 3-kinase.
ACCESSION Z46973
VERSION Z46973.1
KEYWORDS phosphatidylinositol 3-kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 887)
AUTHORS Volinia S., Dhand R., Vanhaesebroeck B., MacDougall L.K.,
Zvelebil M.J., Domin J., Panaretou C., Waterfield M.D.
TITLE A human phosphatidylinositol 3-kinase complex related to the yeast
Vps34p-Vps15p protein sorting system
JOURNAL EMBO J. 14(14), 3339-3348(1995).
PUBMED 7628435
REFERENCE 2 (bases 1 to 2990)
AUTHORS Volinia S.
JOURNAL Submitted (21-DEC-1994) to the INSDC. Stefano Volinia PhD, Receptor
Studies, Ludwig Institute For Cancer, Research, 91 Riding House
Street, London, W1P 8BT, UK
FEATURES Location/Qualifiers
source 1..2990
/db_xref="H-InvDB:HIT000327306"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="Lambda Zap TF1, KG1a"
/clone="PITR-1"
/cell_line="TF-1, KG1a"
/db_xref="taxon:9606"
5'UTR 1..47
CDS 48..2711
/product="phosphatidylinositol 3-kinase"
/db_xref="GOA:Q8NEB9"
/db_xref="H-InvDB:HIT000327306.12"
/db_xref="HGNC:HGNC:8974"
/db_xref="InterPro:IPR000403"
/db_xref="InterPro:IPR001263"
/db_xref="InterPro:IPR002420"
/db_xref="InterPro:IPR008290"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR015433"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR018936"
/db_xref="InterPro:IPR035892"
/db_xref="InterPro:IPR036940"
/db_xref="InterPro:IPR042236"
/db_xref="PDB:3IHY"
/db_xref="PDB:3LS8"
/db_xref="PDB:4OYS"
/db_xref="PDB:4PH4"
/db_xref="PDB:4UWF"
/db_xref="PDB:4UWG"
/db_xref="PDB:4UWH"
/db_xref="PDB:4UWK"
/db_xref="PDB:4UWL"
/db_xref="PDB:5ANL"
/db_xref="PDB:5ENN"
/db_xref="PDB:6I3U"
/db_xref="UniProtKB/Swiss-Prot:Q8NEB9"
/protein_id="CAA87094.1"
/translation="MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYNAVLEDPML
KFSGLYQETCSDLYVTCQVFAEGKPSALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPR
NAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMSRQGMHDLKVWPNVEADGSEPTNTP
GRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESVKRSSNFMYLM
GGFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSLENLVESKHHNLPRS
LRSGPSDHDLKPYPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFRYYLTNQDKALTKIL
TSVIWDLPQGAKQALALLGKWNPMDVEDSLELISSHYTNPTVRRYAVARLRQADDEDL
LMYLSQLVQALKYENFDDIKNGLEPTKKDSQSSVSGNVSNSGINSAEIDSSQIITSPL
PSVSSPPPASKTKEVPDGENLEQDLCTFLISRASKNSTLANYLYWYVIVECEDQDTQQ
RDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNR
KKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFK
TEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFM
QFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILG
VGDRHLDNLVLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEF
RKQCYTAFLHLRRYSNLILNLFSLMVDPNIPDIALEPDKTVKKVQDKFRLDLSDEEAV
HYMQSLIDESVHALFAAVVEQIHKFAQYWRK"
3'UTR 2712..2990
BASE COUNT 949 a 566 c 678 g 797 t
ORIGIN
1 cctgtaccta agttcccgct gtaggtggta cctttgcaga cggtgcgatg ggggaagcag
61 agaagtttca ctacatctat agttgtgacc tggatatcaa cgtccagctt aagataggaa
121 gcttggaagg gaagagagaa caaaagagtt ataacgctgt cctggaagac ccaatgttga
181 agttctcagg actatatcaa gagacatgct ctgatcttta tgttacttgt caagtttttg
241 cagaagggaa gccttcggcc ttgccagtga gaacatccta caaagcattt agtacaagat
301 ggaactggaa tgaatggctg aaactaccag taaaataccc tgacctgccc aggaatgccc
361 aagtggccct caccatatgg gatgtgtatg gtcccggaaa agcagtgcct gtaggaggaa
421 caacggtttc gctctttgga aaatacggca tgtctcgcca agggatgcat gacttgaaag
481 tctggcctaa tgtagaagca gatggatcag aacccacaaa tactcctggc agaacaagta
541 gcactctctc agaagatcag atgagccgtc ttgccaagct caccaaagct catcgacaag
601 gacacatggt gaaagtagat tggctggata gattgacatt tagagaaata gaaatgataa
661 atgagagtgt gaaacgaagt tctaatttca tgtacctgat gggtggattt cgatgtgtca
721 agtgtgatga taaggaatat ggtattgttt attatgaaaa ggacggtgat gaatcatctc
781 caattttaac aagttttgaa ttagtgaaag ttcctgaccc ccagatgtcc ctggagaatt
841 tagttgagag caaacaccac aaccttcccc ggagtttaag aagtggacct tctgaccacg
901 atctgaaacc ctatccttcc ccgagagatc agttaaaaaa tattgtgagt tatcctccat
961 ccaagccacc cacatatgaa gaacaagatc ttgtttggga gtttagatat tatcttacga
1021 atcaagataa agccttgacc aaaatcctga catctgttat ttgggatcta cctcaggggg
1081 ccaaacaggc cttggcactt ctggggaaat ggaacccgat ggatgtagag gactccttgg
1141 agctgatatc ctctcattac accaacccaa ctgtgaggcg ttatgctgtt gcccggttgc
1201 gacaggccga tgatgaggat ttgttgatgt acctatcaca attggtccag gctctcaaat
1261 atgaaaattt tgatgatata aagaatggat tggaacctac caagaaggat agtcagagtt
1321 cagtgtcagg aaatgtgtca aattctggaa taaattctgc agaaatagat agctcccaaa
1381 ttataaccag cccccttcct tcagtctctt cacctcctcc tgcatcaaaa acaaaagaag
1441 ttccagatgg cgaaaatctg gaacaagatc tctgtacctt cttgatatcg agagcctcca
1501 aaaactcaac actggctaat tatttatact ggtatgtgat agtggaatgt gaagatcaag
1561 atactcagca gagagatcca aagacccatg agatgtactt gaacgtaatg agaagattca
1621 gccaagcatt gttgaagggt gataagtctg tcagagttat gcgttctttg ctggctgcac
1681 aacagacatt tgtagatcgg ttggtgcatc taatgaaggc agtacaacgc gaaagtggaa
1741 atcgtaagaa aaagaatgag agactacagg cattgcttgg agataatgaa aagatgaatt
1801 tgtcagatgt ggaacttatc ccgttgcctt tagaacccca agtgaaaatt agaggaataa
1861 ttccggaaac agctacactg tttaaaagtg cccttatgcc tgcacagttg ttttttaaga
1921 cggaagatgg aggcaaatat ccagttatat ttaagcatgg agatgattta cgtcaagatc
1981 aacttattct tcaaatcatt tcactcatgg acaagctgtt acggaaagaa aatctggact
2041 tgaaattgac accttataag gtgttagcca ccagtacaaa acatggcttc atgcagttta
2101 tccagtcagt tcctgtggct gaagttcttg atacagaggg aagcattcag aactttttta
2161 gaaaatatgc accaagtgag aatgggccaa atgggattag tgctgaggtc atggacactt
2221 acgttaaaag ctgtgctgga tattgcgtga tcacctatat acttggagtt ggagacaggc
2281 acctggataa ccttgtgcta acaaaaacag gcaaactctt ccacatagac tttggatata
2341 ttttgggtcg ggatccaaag cctcttcctc caccaatgaa gctgaataaa gaaatggtag
2401 aaggaatggg gggcacacag agtgagcagt accaagagtt ccgtaaacag tgttacacgg
2461 ctttcctcca cctgcggagg tattctaatc tgattttgaa cttgttttcc ttgatggttg
2521 atccaaacat tccagatatt gcacttgaac cagataaaac tgtgaaaaag gttcaggata
2581 aattccgctt agacctgtcg gatgaagagg ctgtgcatta catgcagagt ctgattgatg
2641 agagtgtcca tgctcttttt gctgcagtgg tggaacagat tcacaagttt gcccagtact
2701 ggagaaaatg aaactgggat tgacccatca agatgcttgg ctcaataaga aaaccacgtt
2761 aggagcaacc tttgtatatt ggagacttca gagtaaccag caaggaagag aaatcttaat
2821 cttcaagtta ccatattttc caaatattac atggtacctg agttctgctt ccttggatgt
2881 cattgcttaa atatagtctt gaagggcttg ttttgaaata ttgtatatat tttttcaaat
2941 gtatacattg ttaataaatt aagaaatgag aaaaaaaaaa aaaaaaaaaa
//