LOCUS Z37976 7000 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens mRNA for latent transforming growth factor-beta binding
protein (LTBP-2).
ACCESSION Z37976
VERSION Z37976.1
KEYWORDS latent transforming growth factor-beta binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7000)
AUTHORS Moren A., Olofsson A., Stenman G., Sahlin P., Kanzaki T.,
Claesson-Welsh L., ten Dijke P., Miyazono K., Heldin C.
TITLE Identification and characterization of LTBP-2, a novel latent
transforming growth factor-beta-binding protein
JOURNAL J Biol Chem 269(51), 32469-32478(1994).
PUBMED 7798248
REFERENCE 2 (bases 1 to 7000)
AUTHORS Miyazono K.
JOURNAL Submitted (27-SEP-1994) to the INSDC. Kohei Miyazono, Ludwig
Institute for Cancer Research, Husargatan, 3, Uppsala, S-751 24,
Sweden
FEATURES Location/Qualifiers
source 1..7000
/db_xref="H-InvDB:HIT000327171"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10 and lambda ZAPII libraries"
/clone="NY15B + F2-3"
/cell_line="AG1518"
/cell_type="human foreskin fibroblast"
/db_xref="taxon:9606"
CDS 389..5854
/codon_start=1
/product="LTBP-2 precursor"
/db_xref="GOA:Q14767"
/db_xref="H-InvDB:HIT000327171.13"
/db_xref="HGNC:HGNC:6715"
/db_xref="InterPro:IPR000152"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR001881"
/db_xref="InterPro:IPR009030"
/db_xref="InterPro:IPR013032"
/db_xref="InterPro:IPR017878"
/db_xref="InterPro:IPR018097"
/db_xref="InterPro:IPR036773"
/db_xref="UniProtKB/Swiss-Prot:Q14767"
/protein_id="CAA86030.1"
/translation="MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYE
PAGGDANRLRRPGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAE
ARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPR
GRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARC
EEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPA
GTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLE
HPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK
SGFRIYFCQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLE
APLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVE
TRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANP
LLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDIN
ECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGT
CTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLS
MRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVT
TSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVC
GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCQGKGRCINRVGSYSCFCY
PGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDIN
ECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEG
SFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDG
TACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC
LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA
PGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE
CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD
NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEE
YDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC
CCTQGATWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGP
GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCF
CSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECC
CQDGKAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSI
YGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPP
AGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGP
AVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE"
BASE COUNT 1437 a 2221 c 2112 g 1230 t
ORIGIN
1 aagaactgat ccccccggta atgagggggc tgagctgtcc ctccgaggag ggggcctggt
61 gtggataaaa gagacgaaaa agccggggga ggtttccaaa aataaaaccg tccgggtccc
121 cttcagacgg ctgcaggcac agggaggagg cgcgaaggtg cagcagccgt gcgagcccag
181 ctggagtagg agcgcggact cgaggctcgg ggcgcgcagc cctcgttccg ccgagagccg
241 ggcccccagt cggccgcttc agggccccct agactcagag aagctggccg ccgggcgggg
301 ccgggagaac agcccgcggg cgtccagcgt gccgaccaca aagctcttcg cggtgcccgc
361 gcgcaccact ctccagccgc cccgcgccat gaggccgcgg accaaagccc gcagcccggg
421 gcgcgccctg cggaacccct ggagaggctt cctgccgctc accctggctc tcttcgtggg
481 cgcgggtcat gcccaaaggg accccgtagg gagatacgag ccggctggtg gagacgcgaa
541 tcgactgcgg cgccctgggg gcagctaccc ggcagcggct gcagccaagg tgtacagtct
601 gttccgggag caggacgcgc ctgtcgcggg cttgcagccc gtggagcggg cccagccggg
661 ctgggggagc cccaggaggc ccaccgaggc ggaggccagg aggccgtccc gcgcgcagca
721 gtcgcggcgt gtccagccac ctgcgcagac ccggagaagc actcccctgg gccagcagca
781 accagcaccc cggacccggg ccgcgccggc tctcccacgc ctggggaccc cacagcggtc
841 tggggctgcg cccccaaccc cgccgcgagg gcggctcacg gggaggaacg tctgcggggg
901 acagtgctgc ccaggatgga caacagcaaa cagcaccaac cactgtatca aacccgtttg
961 cgagccgccg tgccagaacc ggggctcctg cagccgcccg cagctctgtg tctgccgctc
1021 tggtttccgt ggagcccgct gcgaggaggt cattcccgat gaggaatttg acccccagaa
1081 ctccaggctg gcacctcgac gctgggccga gcgttcaccc aacctgcgca ggagcagtgc
1141 ggctggagag ggcaccttgg ccagagcaca gccgccagca ccacagtcgc cgcccgcacc
1201 acagtcgcca ccagctggga ccctgagtgg cctcagccag acccaccctt cccagcagca
1261 cgtggggttg tcccgcactg tccgacttca cccgactgcc acggccagta gccagctctc
1321 ttccaacgcc ctgcccccgg gaccaggcct tgagcagaga gatggcaccc aacaggcggt
1381 acctctggag cacccctcat ccccctgggg gctgaacctc acggagaaaa tcaagaagat
1441 caagatcgtc ttcactccca ccatctgcaa gcagacctgt gcccgtggac actgtgccaa
1501 cagctgtgag aggggcgaca ccaccaccct gtacagccag ggcggccatg ggcacgatcc
1561 caagtctggc ttccgcatct atttctgcca gatcccctgc ctgaacggag gccgctgcat
1621 cggcagggac gaatgctggt gccccgccaa ctccaccggg aagttctgcc acctgcctat
1681 cccgcagccg gacagggagc ctccagggag ggggtcccgc cccagggcct tgctggaagc
1741 cccactgaag cagtccactt tcacactgcc gctctccaac cagctggcct ccgtgaaccc
1801 ctccctggtg aaggtgcaca ttcaccaccc acccgaggcc tcagtgcaga tccaccaggt
1861 ggcccaggtg cggggcgggg tggaggaggc cctagtggag aacagcgtgg agaccagacc
1921 cccgccctgg ctgcctgcca gccctggcca cagcctctgg gacagcaaca acatccctgc
1981 tcggtctgga gagccccctc ggccactgcc cccagcagca cccaggcctc gaggactgct
2041 gggccggtgt tacctgaaca ctgtgaacgg acagtgtgcc aaccctctgc tggagctgac
2101 tacccaggag gactgctgtg gcagtgtggg agccttctgg ggggtgactt tgtgtgcccc
2161 atgcccaccc agaccagcct ccccggtgat tgagaatggc cagctggagt gtcctcaggg
2221 gtacaagaga ctgaacctca ctcactgcca agatatcaac gagtgcttga ccctgggcct
2281 gtgcaaggac gcggagtgtg tgaataccag gggcagctac ctgtgcacat gcagacctgg
2341 cctcatgctg gatccatcgc ggagccgctg tgtgtcggac aaggcaatct ccatgctgca
2401 gggactgtgc taccggtcgc tggggcccgg cacctgcacc ctgcctttgg cccagcggat
2461 caccaagcag atatgctgct gcagccgcgt gggcaaagca tggggcagcg agtgtgagaa
2521 atgccctctg cctggcacag aggccttcag agagatctgc cctgccggcc acggctacac
2581 ctacgcgagc tccgacatcc gcctgtccat gaggaaagcc gaggaggagg aactggcaag
2641 gcccccaagg gagcaagggc agaggagcag cggggcactg cccgggccag cagagaggca
2701 gcccctccgg gtcgtcacgg acacctggct tgaggccggg accatccctg acaagggtga
2761 ctctcaggct ggccaggtca cgaccagtgt cacccatgca cctgcctggg tcacagggaa
2821 tgccacaacc ccaccaatgc ctgaacaggg gattgcagag atacaggaag aacaagtgac
2881 cccctccacc gatgtgctgg tgaccctgag caccccaggc attgacagat gcgctgctgg
2941 agccaccaac gtctgtggcc ctggaacctg cgtgaacctc cccgatggat acagatgtgt
3001 ctgcagccct ggctaccagc tgcaccccag ccaggcctac tgcacagatg acaacgagtg
3061 tctgagggac ccctgtcaag gaaaagggcg ctgcatcaac cgcgtggggt cctactcctg
3121 cttctgctac cctggctaca ctctggccac ctcaggggcg acacaggagt gtcaagatat
3181 caatgagtgt gagcagccag gggtgtgcag cggggggcag tgcaccaaca ccgagggctc
3241 gtaccactgc gagtgtgatc agggctacat catggtcagg aaaggacact gccaagatat
3301 caacgaatgc cgtcaccccg gtacctgccc tgatgggaga tgcgtcaatt cccctggctc
3361 ctacacttgt ctggcctgtg aggagggcta ccggggccag agtgggagct gtgtagatgt
3421 gaatgagtgt ctgactcccg gggtctgtgc ccatggaaag tgcaccaacc tagaaggctc
3481 cttcagatgc tcttgtgagc agggctatga ggtcacctca gatgagaagg gctgccaaga
3541 tgtggatgag tgtgccagcc gggcctcatg ccccacaggc ctctgcctca acacggaggg
3601 ctccttcgcc tgctctgcct gtgagaacgg gtactgggtg aatgaagacg gcactgcctg
3661 tgaagaccta gatgagtgtg ccttcccggg agtctgcccc tccggagtct gcaccaacac
3721 ggctggctcc ttctcctgca aggactgcga tgggggctac cggcccagcc ccctgggtga
3781 ctcctgtgaa gatgtggatg aatgtgaaga cccccagagc agctgcctgg gaggcgagtg
3841 caagaacact gtgggctcct accagtgcct ctgtccccag ggcttccagc tggccaatgg
3901 caccgtgtgt gaggatgtga atgagtgcat gggggaggag cactgcgcac cccacggcga
3961 gtgcctcaac agccacgggt ctttcttctg tctgtgcgcg cctggcttcg tcagcgcaga
4021 ggggggcacc agctgccagg atgtggacga gtgtgccacc acagacccgt gtgtgggagg
4081 gcactgtgtc aacaccgagg gctccttcaa ctgtctatgt gagactggct tccagccctc
4141 cccagagagt ggagagtgtg tggatattga cgagtgtgag gactatggag acccggtgtg
4201 tggcacctgg aagtgtgaaa acagccctgg ctcctaccgc tgtgttctgg gctgccagcc
4261 tggcttccac atggccccga acggagactg cattgacata gacgagtgcg ccaacgacac
4321 catgtgtggc agccacggct tctgtgacaa cactgatggc tccttccgct gcctctgtga
4381 ccagggcttc gagatctctc cctcaggctg ggactgtgtg gatgtgaacg agtgtgagct
4441 tatgctggcg gtatgtgggg ccgcgctctg tgagaacgtg gagggctcct tcctgtgcct
4501 ctgtgccagt gacctggagg agtacgatgc ccaggagggg cactgccgcc cacggggggc
4561 tggaggtcag agtatgtctg aggccccaac gggggaccat gccccggccc ccacccgcat
4621 ggactgctac tccgggcaga agggccatgc gccctgctcc agtgtcctgg gccggaacac
4681 cacacaggct gaatgctgct gcacccaggg cgctacgtgg ggagatgcct gtgacctctg
4741 cccgtctgag gactcagctg aattcagcga gatctgccct agtggaaaag gctacattcc
4801 tgtggaagga gcctggacgt ttggacagac catgtacaca gatgcggatg agtgtgtgat
4861 attcgggcct ggtctctgcc cgaacggccg gtgcctcaac accgtgcctg gttatgtctg
4921 cctgtgcaat cccggcttcc actacgatgc ttcccacaag aagtgtgagg atcacgatga
4981 gtgccaggac ctggcctgtg agaatggcga gtgcgtcaac acggagggct ccttccactg
5041 cttctgcagc cccccgctca ccctggacct cagccagcag cgctgcatga acagcaccag
5101 cagcacggag gacctccctg accacgacat ccacatggac atctgctgga aaaaagtcac
5161 caatgatgtg tgcagcgaac ccctgcgtgg gcaccgcacc acctacacgg aatgctgctg
5221 ccaggacggc aaggcctgga gccagcagtg tgctctgtgt cccccgagga gctctgaggt
5281 ctatgctcag ctgtgcaacg tggctcgcat tgaggcagag cgggaggccg gggtccactt
5341 ccggccaggc tatgagtatg gccccgggcc cgatgacctg cactacagca tctatggccc
5401 agatggggcc cccttctaca actacctggg ccccgaggac accgtccctg agcctgcctt
5461 ccccaacaca gccggtcact cagcggaccg cacacccatc cttgagtctc ctttgcagcc
5521 ctcagaactc cagccccact acgtggccag ccatccagag cccccagccg gcttcgaagg
5581 gcttcaggcg gaggagtgcg gcatcctgaa cggctgtgag aatggccgct gtgtgcgcgt
5641 gcgggagggc tacacctgtg actgttttga gggcttccag ctggatgcgg cccacatggc
5701 ctgcgtagat gtgaatgagt gtgatgactt gaacgggcct gctgtgctct gtgtccatgg
5761 ttactgcgag aacacagagg gctcctaccg ctgccactgc tccccgggat atgtggctga
5821 ggcagggccc ccccactgca ctgccaagga gtagcagtca ggggtcagtg tggcaactac
5881 ctggaaatgg cctccagtca caggcagggg cctgaggatg atttcctagc tgggaagaca
5941 ccgtgacatc aggccagagg tttccaatca gccttgcctg ctttcatctc tcccagctta
6001 gcctctggct gtaagcttcg gtcattgcct ccatgccctt gcttggctca agcaccacca
6061 atcgctttaa tgcttcagcc accgcatgag gccctgtcca ccacctttcc tggccttgct
6121 atgggatgct taccaaagga tggccctcat ccaccctccc aagctgtgcg agcatgcaag
6181 gccccatggc tcacactgca gacacccctt tccagccaca atccaccatc atcctgacga
6241 tcccacaact gggacagagg ctacatctgc cctagggagg tccttcagaa tctgtggagc
6301 aagaaaggat ttggggaagc ttggggactg actccagagc cccctcctaa gaaccatcac
6361 caccactcag ccaatctgtt ctgggccctg attttgccac acctccatcc tgtagcccat
6421 tctctgaccc caaggagtgg cagaagatcc cttcactcag agaagcaagg ctgatattag
6481 cttgttgaat gtaagagaca caaatgaaga agaacaaaga gcctgagaaa gcagcaagag
6541 gacatgatga aaaatacgtg gagttgatga gaaaggggag ccaaggcttt atacgtctaa
6601 agaaaatatt cagtagctga atccgcccag tgatagcctg tgggcaccac aggaagggct
6661 gccatgggat acagtaccca tctacaaaga cctctattac ataaacactg cttcttacag
6721 gaaacaaacc tcttctggga tctccttttg tgaaaaccag tttgatgtgc taaaagtaaa
6781 aagtctattt tccagtgtgg tcttgttcag aagcagccag atttccaatg ttgtttttcc
6841 cctccactca gaaacccctg ccctttccct tcagaaaacg atggcaggca ttcctctgag
6901 tttacaagca gagactcact ccaacccaaa ctagctggga gttcagaacc atggtggaat
6961 aaagaaatgt gcatctgctc gtgccgctcg tgccgaattc
//