LOCUS       Z34821                  6659 bp    mRNA    linear   HUM 21-OCT-2008
DEFINITION  H.sapiens (HLCC90) mRNA for voltage-dependent L-type Ca channel
            alpha 1 subunit (splice variant).
ACCESSION   Z34821
VERSION     Z34821.1
KEYWORDS    calcium channel alpha-1 subunit; L-type calcium channel; L-type
            calcium channel alpha-1 subunit; L-type voltage-dependent calcium
            channel; L-type voltage-dependent calcium channel alpha 1 subunit;
            voltage dependent calcium channel alpha 1 subunit;
            voltage-dependent calcium channel alpha 1 subunit.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6659)
  AUTHORS   Soldatov N.M.
  TITLE     Molecular diversity of L-type Ca2+ channel transcripts in human
            fibroblasts
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
   PUBMED   1316612
REFERENCE   2  (bases 1 to 6659)
  AUTHORS   Soldatov N.M.
  TITLE     Genomic structure of human L-type Ca2+ channel
  JOURNAL   Genomics 22(1), 77-87(1994).
   PUBMED   7959794
REFERENCE   3  (bases 1 to 6659)
  AUTHORS   Soldatov N.M.
  TITLE     Functional Expression of Splice Variants of Human L-type Calcium
            Channel (isoform 1 gene)
  JOURNAL   Unpublished.
REFERENCE   4  (bases 1 to 6659)
  AUTHORS   Soldatov N.
  JOURNAL   Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov,
            Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
            CH-3010, Switzerland
FEATURES             Location/Qualifiers
     source          1..6659
                     /db_xref="H-InvDB:HIT000326980"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="fetal"
                     /cell_line="CRL 1475 (ATCC)"
                     /cell_type="fibroblast"
                     /db_xref="taxon:9606"
     CDS             1..6561
                     /standard_name="CACNL1A1 isoform 1"
                     /product="voltage-dependent L-type Ca channel alpha 1
                     subunit"
                     /function="L-type calcium channel (clone HLCC90) splice
                     variant"
                     /note="composed of exons 1-44, 46-50"
                     /db_xref="GOA:Q13936"
                     /db_xref="H-InvDB:HIT000326980.14"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="InterPro:IPR002077"
                     /db_xref="InterPro:IPR005446"
                     /db_xref="InterPro:IPR005451"
                     /db_xref="InterPro:IPR005821"
                     /db_xref="InterPro:IPR014873"
                     /db_xref="InterPro:IPR027359"
                     /db_xref="InterPro:IPR031649"
                     /db_xref="InterPro:IPR031688"
                     /db_xref="PDB:1T0J"
                     /db_xref="PDB:2BE6"
                     /db_xref="PDB:2F3Y"
                     /db_xref="PDB:2F3Z"
                     /db_xref="PDB:2LQC"
                     /db_xref="PDB:3G43"
                     /db_xref="PDB:3OXQ"
                     /db_xref="PDB:5V2P"
                     /db_xref="PDB:5V2Q"
                     /db_xref="PDB:6C0A"
                     /db_xref="PDB:6DAD"
                     /db_xref="PDB:6DAE"
                     /db_xref="PDB:6DAF"
                     /db_xref="UniProtKB/Swiss-Prot:Q13936"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAA84352.1"
                     /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
                     TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
                     ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
                     RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
                     DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
                     FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
                     GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
                     SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
                     NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
                     WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
                     FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
                     LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
                     QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
                     NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
                     SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
                     PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
                     ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM
                     TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAIN
                     RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE
                     CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID
                     SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDK
                     NQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYG
                     QSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL
                     SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL
                     FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN
                     DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP
                     CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY
                     DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATL
                     FALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYA
                     TFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEE
                     LDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSS
                     QGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGH
                     GPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPS
                     LLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDR
                     GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQP
                     VPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPG
                     RQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG
                     GAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL"
     exon            <1..49
                     /number=1
     exon            50..371
                     /number=2
     exon            372..477
                     /number=3
     exon            478..617
                     /number=4
     exon            618..757
                     /number=5
     exon            758..916
                     /number=6
     exon            917..1113
                     /number=7
     exon            1114..1216
                     /number=8
     exon            1217..1390
                     /number=9
     exon            1391..1481
                     /number=10
     exon            1482..1508
                     /number=11
     exon            1509..1669
                     /number=12
     exon            1670..1895
                     /number=13
     exon            1896..2103
                     /number=14
     exon            2104..2224
                     /number=15
     exon            2225..2339
                     /number=16
     exon            2340..2460
                     /number=17
     exon            2461..2530
                     /number=18
     exon            2531..2663
                     /number=19
     exon            2664..2793
                     /number=20
     exon            2794..2853
                     /number=21
                     /note="alternative"
     exon            2854..2913
                     /number=22
                     /note="alternative"
     exon            2914..3025
                     /number=23
     exon            3026..3108
                     /number=24
     exon            3109..3216
                     /number=25
     exon            3217..3269
                     /number=26
     exon            3270..3416
                     /number=27
     exon            3417..3618
                     /number=28
     exon            3619..3777
                     /number=29
     exon            3778..3888
                     /number=30
     exon            3889..3972
                     /number=31
                     /note="alternative"
     exon            3973..4056
                     /number=32
                     /note="alternative"
     exon            4057..4089
                     /number=33
                     /note="alternative"
     exon            4090..4218
                     /number=34
     exon            4219..4284
                     /number=35
     exon            4285..4376
                     /number=36
     exon            4377..4542
                     /number=37
     exon            4543..4670
                     /number=38
     exon            4671..4767
                     /number=39
     exon            4768..4870
                     /number=40
     exon            4871..4956
                     /number=41
     exon            4957..5100
                     /number=42
     exon            5101..5235
                     /number=43
     exon            5236..5588
                     /number=44
     exon            5589..5717
                     /number=46
     exon            5718..5824
                     /number=47
     exon            5825..5928
                     /number=48
     exon            5929..6261
                     /number=49
     exon            6262..>6659
                     /number=50
     3'UTR           6559..6659
BASE COUNT         1502 a         1951 c         1784 g         1422 t
ORIGIN      
        1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
       61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
      121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
      181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
      241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
      301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
      361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
      421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
      481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
      541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
      601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
      661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
      721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
      781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
      841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
      901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
      961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
     1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
     1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
     1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
     1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
     1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
     1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
     1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
     1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
     1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
     1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
     1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
     1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
     1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
     1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
     1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
     1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
     1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
     2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
     2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
     2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
     2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
     2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
     2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
     2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
     2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
     2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
     2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
     2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
     2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
     2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt
     2821 accaccattt tcaccattga aattgctctg aagatcctag gcaatgcaga ctatgtcttc
     2881 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac
     2941 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
     3001 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
     3061 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
     3121 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
     3181 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
     3241 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
     3301 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
     3361 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
     3421 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
     3481 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
     3541 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
     3601 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
     3661 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
     3721 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
     3781 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
     3841 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt
     3901 gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc
     3961 agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg
     4021 ggtagcattg ttgatatagc aatcaccgag gtaaacccag ctgaacatac ccaatgctct
     4081 ccctctatga acgcagagga aaactcccgc atctccatca ccttcttccg cctgttccgg
     4141 gtcatgcgtc tggtgaagct gctgagccgt ggggagggca tccggacgct gctgtggacc
     4201 ttcatcaagt ccttccaggc cctgccctat gtggccctcc tgatcgtgat gctgttcttc
     4261 atctacgcgg tgatcgggat gcaggtgttt gggaaaattg ccctgaatga taccacagag
     4321 atcaaccgga acaacaactt tcagaccttc ccccaggccg tgctgctcct cttcaggtgt
     4381 gccaccgggg aggcctggca ggacatcatg ctggcctgca tgccaggcaa gaagtgtgcc
     4441 ccagagtccg agcccagcaa cagcacggag ggtgaaacac cctgtggtag cagctttgct
     4501 gtcttctact tcatcagctt ctacatgctc tgtgccttcc tgatcatcaa cctctttgta
     4561 gctgtcatca tggacaactt tgactacctg acaagggact ggtccatcct tggtccccac
     4621 cacctggatg agtttaaaag aatctgggca gagtatgacc ctgaagccaa gggtcgtatc
     4681 aaacacctgg atgtggtgac cctcctccgg cggattcagc cgccactagg ttttgggaag
     4741 ctgtgccctc accgcgtggc ttgcaaacgc ctggtctcca tgaacatgcc tctgaacagc
     4801 gacgggacag tcatgttcaa tgccaccctg tttgccctgg tcaggacggc cctgaggatc
     4861 aaaacagaag ggaacctaga acaagccaat gaggagctgc gggcgatcat caagaagatc
     4921 tggaagcgga ccagcatgaa gctgctggac caggtggtgc cccctgcagg tgatgatgag
     4981 gtcaccgttg gcaagttcta cgccacgttc ctgatccagg agtacttccg gaagttcaag
     5041 aagcgcaaag agcagggcct tgtgggcaag ccctcccaga ggaacgcgct gtctctgcag
     5101 gctggcttgc gcacactgca tgacatcggg cctgagatcc gacgggccat ctctggagat
     5161 ctcaccgctg aggaggagct ggacaaggcc atgaaggagg ctgtgtccgc tgcttctgaa
     5221 gatgacatct tcaggagggc cggtggcctg ttcggcaacc acgtcagcta ctaccaaagc
     5281 gacggccgga gcgccttccc ccagaccttc accactcagc gcccgctgca catcaacaag
     5341 gcgggcagca gccagggcga cactgagtcg ccatcccacg agaagctggt ggactccacc
     5401 ttcaccccga gcagctactc gtccaccggc tccaacgcca acatcaacaa cgccaacaac
     5461 accgccctgg gtcgcctccc tcgccccgcc ggctacccca gcacggtcag cactgtggag
     5521 ggccacgggc cccccttgtc ccctgccatc cgggtgcagg aggtggcgtg gaagctcagc
     5581 tccaacaggt gccactcccg ggagagccag gcagccatgg cgggtcagga ggagacgtct
     5641 caggatgaga cctatgaagt gaagatgaac catgacacgg aggcctgcag tgagcccagc
     5701 ctgctctcca cagagatgct ctcctaccag gatgacgaaa atcggcaact gacgctccca
     5761 gaggaggaca agagggacat ccggcaatct ccgaagaggg gtttcctccg ctctgcctca
     5821 ctaggtcgaa gggcctcctt ccacctggaa tgtctgaagc gacagaagga ccgaggggga
     5881 gacatctctc agaagacagt cctgcccttg catctggttc atcatcaggc attggcagtg
     5941 gcaggcctga gccccctcct ccagagaagc cattcccctg cctcattccc taggcctttt
     6001 gccaccccac cagccacacc tggcagccga ggctggcccc cacagcccgt ccccaccctg
     6061 cggcttgagg gggtcgagtc cagtgagaaa ctcaacagca gcttcccatc catccactgc
     6121 ggctcctggg ctgagaccac ccccggtggc gggggcagca gcgccgcccg gagagtccgg
     6181 cccgtctccc tcatggtgcc cagccaggct ggggccccag ggaggcagtt ccacggcagt
     6241 gccagcagcc tggtggaagc ggtcttgatt tcagaaggac tggggcagtt tgctcaagat
     6301 cccaagttca tcgaggtcac cacccaggag ctggccgacg cctgcgacat gaccatagag
     6361 gagatggaga gcgcggccga caacatcctc agcgggggcg ccccacagag ccccaatggc
     6421 gccctcttac cctttgtgaa ctgcagggac gcggggcagg accgagccgg gggcgaggag
     6481 gacgcgggct gtgtgcgcgc gcggggtgca ccgagtgagg aggagctcca ggacagcagg
     6541 gtctacgtca gcagcctgta gtgggcgctg ccagatgcgg gctttttttt ttttatttgt
     6601 ttcaatgttc ctaatgggtt cgtttcagaa gtgcctcact gttctcgtga cctggagtt
//