LOCUS Z34821 6659 bp mRNA linear HUM 21-OCT-2008 DEFINITION H.sapiens (HLCC90) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34821 VERSION Z34821.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6659) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6659) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 3 (bases 1 to 6659) AUTHORS Soldatov N.M. TITLE Functional Expression of Splice Variants of Human L-type Calcium Channel (isoform 1 gene) JOURNAL Unpublished. REFERENCE 4 (bases 1 to 6659) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland FEATURES Location/Qualifiers source 1..6659 /db_xref="H-InvDB:HIT000326980" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /db_xref="taxon:9606" CDS 1..6561 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC90) splice variant" /note="composed of exons 1-44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326980.14" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84352.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAIN RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDK NQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYG QSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATL FALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYA TFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEE LDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSS QGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGH GPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPS LLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDR GGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQP VPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPG RQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG GAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=21 /note="alternative" exon 2854..2913 /number=22 /note="alternative" exon 2914..3025 /number=23 exon 3026..3108 /number=24 exon 3109..3216 /number=25 exon 3217..3269 /number=26 exon 3270..3416 /number=27 exon 3417..3618 /number=28 exon 3619..3777 /number=29 exon 3778..3888 /number=30 exon 3889..3972 /number=31 /note="alternative" exon 3973..4056 /number=32 /note="alternative" exon 4057..4089 /number=33 /note="alternative" exon 4090..4218 /number=34 exon 4219..4284 /number=35 exon 4285..4376 /number=36 exon 4377..4542 /number=37 exon 4543..4670 /number=38 exon 4671..4767 /number=39 exon 4768..4870 /number=40 exon 4871..4956 /number=41 exon 4957..5100 /number=42 exon 5101..5235 /number=43 exon 5236..5588 /number=44 exon 5589..5717 /number=46 exon 5718..5824 /number=47 exon 5825..5928 /number=48 exon 5929..6261 /number=49 exon 6262..>6659 /number=50 3'UTR 6559..6659 BASE COUNT 1502 a 1951 c 1784 g 1422 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt 2821 accaccattt tcaccattga aattgctctg aagatcctag gcaatgcaga ctatgtcttc 2881 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac 2941 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 3001 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3061 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3121 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3181 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3241 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3301 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3361 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3421 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3481 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3541 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3601 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3661 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3721 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3781 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3841 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt 3901 gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc 3961 agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg 4021 ggtagcattg ttgatatagc aatcaccgag gtaaacccag ctgaacatac ccaatgctct 4081 ccctctatga acgcagagga aaactcccgc atctccatca ccttcttccg cctgttccgg 4141 gtcatgcgtc tggtgaagct gctgagccgt ggggagggca tccggacgct gctgtggacc 4201 ttcatcaagt ccttccaggc cctgccctat gtggccctcc tgatcgtgat gctgttcttc 4261 atctacgcgg tgatcgggat gcaggtgttt gggaaaattg ccctgaatga taccacagag 4321 atcaaccgga acaacaactt tcagaccttc ccccaggccg tgctgctcct cttcaggtgt 4381 gccaccgggg aggcctggca ggacatcatg ctggcctgca tgccaggcaa gaagtgtgcc 4441 ccagagtccg agcccagcaa cagcacggag ggtgaaacac cctgtggtag cagctttgct 4501 gtcttctact tcatcagctt ctacatgctc tgtgccttcc tgatcatcaa cctctttgta 4561 gctgtcatca tggacaactt tgactacctg acaagggact ggtccatcct tggtccccac 4621 cacctggatg agtttaaaag aatctgggca gagtatgacc ctgaagccaa gggtcgtatc 4681 aaacacctgg atgtggtgac cctcctccgg cggattcagc cgccactagg ttttgggaag 4741 ctgtgccctc accgcgtggc ttgcaaacgc ctggtctcca tgaacatgcc tctgaacagc 4801 gacgggacag tcatgttcaa tgccaccctg tttgccctgg tcaggacggc cctgaggatc 4861 aaaacagaag ggaacctaga acaagccaat gaggagctgc gggcgatcat caagaagatc 4921 tggaagcgga ccagcatgaa gctgctggac caggtggtgc cccctgcagg tgatgatgag 4981 gtcaccgttg gcaagttcta cgccacgttc ctgatccagg agtacttccg gaagttcaag 5041 aagcgcaaag agcagggcct tgtgggcaag ccctcccaga ggaacgcgct gtctctgcag 5101 gctggcttgc gcacactgca tgacatcggg cctgagatcc gacgggccat ctctggagat 5161 ctcaccgctg aggaggagct ggacaaggcc atgaaggagg ctgtgtccgc tgcttctgaa 5221 gatgacatct tcaggagggc cggtggcctg ttcggcaacc acgtcagcta ctaccaaagc 5281 gacggccgga gcgccttccc ccagaccttc accactcagc gcccgctgca catcaacaag 5341 gcgggcagca gccagggcga cactgagtcg ccatcccacg agaagctggt ggactccacc 5401 ttcaccccga gcagctactc gtccaccggc tccaacgcca acatcaacaa cgccaacaac 5461 accgccctgg gtcgcctccc tcgccccgcc ggctacccca gcacggtcag cactgtggag 5521 ggccacgggc cccccttgtc ccctgccatc cgggtgcagg aggtggcgtg gaagctcagc 5581 tccaacaggt gccactcccg ggagagccag gcagccatgg cgggtcagga ggagacgtct 5641 caggatgaga cctatgaagt gaagatgaac catgacacgg aggcctgcag tgagcccagc 5701 ctgctctcca cagagatgct ctcctaccag gatgacgaaa atcggcaact gacgctccca 5761 gaggaggaca agagggacat ccggcaatct ccgaagaggg gtttcctccg ctctgcctca 5821 ctaggtcgaa gggcctcctt ccacctggaa tgtctgaagc gacagaagga ccgaggggga 5881 gacatctctc agaagacagt cctgcccttg catctggttc atcatcaggc attggcagtg 5941 gcaggcctga gccccctcct ccagagaagc cattcccctg cctcattccc taggcctttt 6001 gccaccccac cagccacacc tggcagccga ggctggcccc cacagcccgt ccccaccctg 6061 cggcttgagg gggtcgagtc cagtgagaaa ctcaacagca gcttcccatc catccactgc 6121 ggctcctggg ctgagaccac ccccggtggc gggggcagca gcgccgcccg gagagtccgg 6181 cccgtctccc tcatggtgcc cagccaggct ggggccccag ggaggcagtt ccacggcagt 6241 gccagcagcc tggtggaagc ggtcttgatt tcagaaggac tggggcagtt tgctcaagat 6301 cccaagttca tcgaggtcac cacccaggag ctggccgacg cctgcgacat gaccatagag 6361 gagatggaga gcgcggccga caacatcctc agcgggggcg ccccacagag ccccaatggc 6421 gccctcttac cctttgtgaa ctgcagggac gcggggcagg accgagccgg gggcgaggag 6481 gacgcgggct gtgtgcgcgc gcggggtgca ccgagtgagg aggagctcca ggacagcagg 6541 gtctacgtca gcagcctgta gtgggcgctg ccagatgcgg gctttttttt ttttatttgt 6601 ttcaatgttc ctaatgggtt cgtttcagaa gtgcctcact gttctcgtga cctggagtt //