LOCUS       Z34820                  6566 bp    mRNA    linear   HUM 21-OCT-2008
DEFINITION  H.sapiens (HLCC89) mRNA for voltage-dependent L-type Ca channel
            alpha 1 subunit (splice variant).
ACCESSION   Z34820
VERSION     Z34820.1
KEYWORDS    calcium channel alpha-1 subunit; L-type calcium channel; L-type
            calcium channel alpha-1 subunit; L-type voltage-dependent calcium
            channel; L-type voltage-dependent calcium channel alpha 1 subunit;
            voltage dependent calcium channel alpha 1 subunit;
            voltage-dependent calcium channel alpha 1 subunit.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6566)
  AUTHORS   Soldatov N.M.
  TITLE     Molecular diversity of L-type Ca2+ channel transcripts in human
            fibroblasts
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
   PUBMED   1316612
REFERENCE   2  (bases 1 to 6566)
  AUTHORS   Soldatov N.M.
  TITLE     Genomic structure of human L-type Ca2+ channel
  JOURNAL   Genomics 22(1), 77-87(1994).
   PUBMED   7959794
REFERENCE   3  (bases 1 to 6566)
  AUTHORS   Soldatov N.M.
  TITLE     Functional Expression of Splice Variants of Human L-type Calcium
            Channel (isoform 1 gene)
  JOURNAL   Unpublished.
REFERENCE   4  (bases 1 to 6515)
  AUTHORS   Soldatov N.
  JOURNAL   Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov,
            Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
            CH-3010, Switzerland
FEATURES             Location/Qualifiers
     source          1..6566
                     /db_xref="H-InvDB:HIT000326979"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="fetal"
                     /cell_line="CRL 1475 (ATCC)"
                     /cell_type="fibroblast"
                     /db_xref="taxon:9606"
     CDS             1..6468
                     /standard_name="CACNL1A1 isoform 1"
                     /product="voltage-dependent L-type Ca channel alpha 1
                     subunit"
                     /function="L-type calcium channel (clone HLCC89) splice
                     variant"
                     /note="composed of exons 1-20, 22-32, 34-44, 46-50"
                     /db_xref="GOA:Q13936"
                     /db_xref="H-InvDB:HIT000326979.12"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="InterPro:IPR002077"
                     /db_xref="InterPro:IPR005446"
                     /db_xref="InterPro:IPR005451"
                     /db_xref="InterPro:IPR005821"
                     /db_xref="InterPro:IPR014873"
                     /db_xref="InterPro:IPR027359"
                     /db_xref="InterPro:IPR031649"
                     /db_xref="InterPro:IPR031688"
                     /db_xref="PDB:1T0J"
                     /db_xref="PDB:2BE6"
                     /db_xref="PDB:2F3Y"
                     /db_xref="PDB:2F3Z"
                     /db_xref="PDB:2LQC"
                     /db_xref="PDB:3G43"
                     /db_xref="PDB:3OXQ"
                     /db_xref="PDB:5V2P"
                     /db_xref="PDB:5V2Q"
                     /db_xref="PDB:6C0A"
                     /db_xref="PDB:6DAD"
                     /db_xref="PDB:6DAE"
                     /db_xref="PDB:6DAF"
                     /db_xref="UniProtKB/Swiss-Prot:Q13936"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAA84351.1"
                     /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
                     TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
                     ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
                     RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
                     DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
                     FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
                     GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
                     SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
                     NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
                     WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
                     FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
                     LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
                     QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
                     NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
                     SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
                     PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
                     ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL
                     DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
                     NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
                     RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
                     IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
                     KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
                     TVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVV
                     GSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP
                     YVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ
                     DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD
                     NFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP
                     HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIW
                     KRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSL
                     QAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSY
                     YQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANI
                     NNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM
                     AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSP
                     KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQR
                     SHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETT
                     PGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIE
                     VTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAG
                     CVRARGAPSEEELQDSRVYVSSL"
     exon            <1..49
                     /number=1
     exon            50..371
                     /number=2
     exon            372..477
                     /number=3
     exon            478..617
                     /number=4
     exon            618..757
                     /number=5
     exon            758..916
                     /number=6
     exon            917..1113
                     /number=7
     exon            1114..1216
                     /number=8
     exon            1217..1390
                     /number=9
     exon            1391..1481
                     /number=10
     exon            1482..1508
                     /number=11
     exon            1509..1669
                     /number=12
     exon            1670..1895
                     /number=13
     exon            1896..2103
                     /number=14
     exon            2104..2224
                     /number=15
     exon            2225..2339
                     /number=16
     exon            2340..2460
                     /number=17
     exon            2461..2530
                     /number=18
     exon            2531..2663
                     /number=19
     exon            2664..2793
                     /number=20
     exon            2794..2853
                     /number=22
                     /note="alternative"
     exon            2854..2965
                     /number=23
     exon            2966..3048
                     /number=24
     exon            3049..3156
                     /number=25
     exon            3157..3209
                     /number=26
     exon            3210..3356
                     /number=27
     exon            3357..3558
                     /number=28
     exon            3559..3717
                     /number=29
     exon            3718..3828
                     /number=30
     exon            3829..3912
                     /number=31
                     /note="alternative"
     exon            3913..3996
                     /number=32
                     /note="alternative"
     exon            3997..4125
                     /number=34
     exon            4126..4191
                     /number=35
     exon            4192..4283
                     /number=36
     exon            4284..4449
                     /number=37
     exon            4450..4577
                     /number=38
     exon            4578..4674
                     /number=39
     exon            4675..4777
                     /number=40
     exon            4778..4879
                     /number=41
     exon            4880..5007
                     /number=42
     exon            5008..5142
                     /number=43
     exon            5143..5495
                     /number=44
     exon            5496..5624
                     /number=46
     exon            5625..5731
                     /number=47
     exon            5732..5835
                     /number=48
     exon            5836..6168
                     /number=49
     exon            6169..>6566
                     /number=50
     3'UTR           6466..6566
BASE COUNT         1480 a         1928 c         1773 g         1385 t
ORIGIN      
        1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
       61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
      121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
      181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
      241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
      301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
      361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
      421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
      481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
      541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
      601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
      661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
      721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
      781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
      841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
      901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
      961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
     1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
     1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
     1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
     1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
     1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
     1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
     1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
     1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
     1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
     1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
     1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
     1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
     1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
     1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
     1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
     1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
     1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
     2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
     2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
     2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
     2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
     2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
     2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
     2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
     2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
     2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
     2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
     2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
     2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
     2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc
     2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac
     2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
     2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
     3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
     3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
     3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
     3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
     3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
     3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
     3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
     3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
     3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
     3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
     3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
     3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
     3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
     3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt
     3841 gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc
     3901 agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg
     3961 ggtagcattg ttgatatagc aatcaccgag gtaaacaacg cagaggaaaa ctcccgcatc
     4021 tccatcacct tcttccgcct gttccgggtc atgcgtctgg tgaagctgct gagccgtggg
     4081 gagggcatcc ggacgctgct gtggaccttc atcaagtcct tccaggccct gccctatgtg
     4141 gccctcctga tcgtgatgct gttcttcatc tacgcggtga tcgggatgca ggtgtttggg
     4201 aaaattgccc tgaatgatac cacagagatc aaccggaaca acaactttca gaccttcccc
     4261 caggccgtgc tgctcctctt caggtgtgcc accggggagg cctggcagga catcatgctg
     4321 gcctgcatgc caggcaagaa gtgtgcccca gagtccgagc ccagcaacag cacggagggt
     4381 gaaacaccct gtggtagcag ctttgctgtc ttctacttca tcagcttcta catgctctgt
     4441 gccttcctga tcatcaacct ctttgtagct gtcatcatgg acaactttga ctacctgaca
     4501 agggactggt ccatccttgg tccccaccac ctggatgagt ttaaaagaat ctgggcagag
     4561 tatgaccctg aagccaaggg tcgtatcaaa cacctggatg tggtgaccct cctccggcgg
     4621 attcagccgc cactaggttt tgggaagctg tgccctcacc gcgtggcttg caaacgcctg
     4681 gtctccatga acatgcctct gaacagcgac gggacagtca tgttcaatgc caccctgttt
     4741 gccctggtca ggacggccct gaggatcaaa acagaaggga acctagaaca agccaatgag
     4801 gagctgcggg cgatcatcaa gaagatctgg aagcggacca gcatgaagct gctggaccag
     4861 gtggtgcccc ctgcaggtga tgatgaggtc accgttggca agttctacgc cacgttcctg
     4921 atccaggagt acttccggaa gttcaagaag cgcaaagagc agggccttgt gggcaagccc
     4981 tcccagagga acgcgctgtc tctgcaggct ggcttgcgca cactgcatga catcgggcct
     5041 gagatccgac gggccatctc tggagatctc accgctgagg aggagctgga caaggccatg
     5101 aaggaggctg tgtccgctgc ttctgaagat gacatcttca ggagggccgg tggcctgttc
     5161 ggcaaccacg tcagctacta ccaaagcgac ggccggagcg ccttccccca gaccttcacc
     5221 actcagcgcc cgctgcacat caacaaggcg ggcagcagcc agggcgacac tgagtcgcca
     5281 tcccacgaga agctggtgga ctccaccttc accccgagca gctactcgtc caccggctcc
     5341 aacgccaaca tcaacaacgc caacaacacc gccctgggtc gcctccctcg ccccgccggc
     5401 taccccagca cggtcagcac tgtggagggc cacgggcccc ccttgtcccc tgccatccgg
     5461 gtgcaggagg tggcgtggaa gctcagctcc aacaggtgcc actcccggga gagccaggca
     5521 gccatggcgg gtcaggagga gacgtctcag gatgagacct atgaagtgaa gatgaaccat
     5581 gacacggagg cctgcagtga gcccagcctg ctctccacag agatgctctc ctaccaggat
     5641 gacgaaaatc ggcaactgac gctcccagag gaggacaaga gggacatccg gcaatctccg
     5701 aagaggggtt tcctccgctc tgcctcacta ggtcgaaggg cctccttcca cctggaatgt
     5761 ctgaagcgac agaaggaccg agggggagac atctctcaga agacagtcct gcccttgcat
     5821 ctggttcatc atcaggcatt ggcagtggca ggcctgagcc ccctcctcca gagaagccat
     5881 tcccctgcct cattccctag gccttttgcc accccaccag ccacacctgg cagccgaggc
     5941 tggcccccac agcccgtccc caccctgcgg cttgaggggg tcgagtccag tgagaaactc
     6001 aacagcagct tcccatccat ccactgcggc tcctgggctg agaccacccc cggtggcggg
     6061 ggcagcagcg ccgcccggag agtccggccc gtctccctca tggtgcccag ccaggctggg
     6121 gccccaggga ggcagttcca cggcagtgcc agcagcctgg tggaagcggt cttgatttca
     6181 gaaggactgg ggcagtttgc tcaagatccc aagttcatcg aggtcaccac ccaggagctg
     6241 gccgacgcct gcgacatgac catagaggag atggagagcg cggccgacaa catcctcagc
     6301 gggggcgccc cacagagccc caatggcgcc ctcttaccct ttgtgaactg cagggacgcg
     6361 gggcaggacc gagccggggg cgaggaggac gcgggctgtg tgcgcgcgcg gggtgcaccg
     6421 agtgaggagg agctccagga cagcagggtc tacgtcagca gcctgtagtg ggcgctgcca
     6481 gatgcgggct tttttttttt tatttgtttc aatgttccta atgggttcgt ttcagaagtg
     6541 cctcactgtt ctcgtgacct ggagtt
//