LOCUS Z34820 6566 bp mRNA linear HUM 21-OCT-2008 DEFINITION H.sapiens (HLCC89) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34820 VERSION Z34820.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6566) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6566) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 3 (bases 1 to 6566) AUTHORS Soldatov N.M. TITLE Functional Expression of Splice Variants of Human L-type Calcium Channel (isoform 1 gene) JOURNAL Unpublished. REFERENCE 4 (bases 1 to 6515) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland FEATURES Location/Qualifiers source 1..6566 /db_xref="H-InvDB:HIT000326979" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /db_xref="taxon:9606" CDS 1..6468 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC89) splice variant" /note="composed of exons 1-20, 22-32, 34-44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326979.12" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84351.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF TVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVV GSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP YVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ DIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMD NFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCP HRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIW KRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSL QAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSY YQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANI NNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAM AGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSP KRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQR SHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETT PGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIE VTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAG CVRARGAPSEEELQDSRVYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=22 /note="alternative" exon 2854..2965 /number=23 exon 2966..3048 /number=24 exon 3049..3156 /number=25 exon 3157..3209 /number=26 exon 3210..3356 /number=27 exon 3357..3558 /number=28 exon 3559..3717 /number=29 exon 3718..3828 /number=30 exon 3829..3912 /number=31 /note="alternative" exon 3913..3996 /number=32 /note="alternative" exon 3997..4125 /number=34 exon 4126..4191 /number=35 exon 4192..4283 /number=36 exon 4284..4449 /number=37 exon 4450..4577 /number=38 exon 4578..4674 /number=39 exon 4675..4777 /number=40 exon 4778..4879 /number=41 exon 4880..5007 /number=42 exon 5008..5142 /number=43 exon 5143..5495 /number=44 exon 5496..5624 /number=46 exon 5625..5731 /number=47 exon 5732..5835 /number=48 exon 5836..6168 /number=49 exon 6169..>6566 /number=50 3'UTR 6466..6566 BASE COUNT 1480 a 1928 c 1773 g 1385 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc 2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac 2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt 3841 gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc 3901 agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg 3961 ggtagcattg ttgatatagc aatcaccgag gtaaacaacg cagaggaaaa ctcccgcatc 4021 tccatcacct tcttccgcct gttccgggtc atgcgtctgg tgaagctgct gagccgtggg 4081 gagggcatcc ggacgctgct gtggaccttc atcaagtcct tccaggccct gccctatgtg 4141 gccctcctga tcgtgatgct gttcttcatc tacgcggtga tcgggatgca ggtgtttggg 4201 aaaattgccc tgaatgatac cacagagatc aaccggaaca acaactttca gaccttcccc 4261 caggccgtgc tgctcctctt caggtgtgcc accggggagg cctggcagga catcatgctg 4321 gcctgcatgc caggcaagaa gtgtgcccca gagtccgagc ccagcaacag cacggagggt 4381 gaaacaccct gtggtagcag ctttgctgtc ttctacttca tcagcttcta catgctctgt 4441 gccttcctga tcatcaacct ctttgtagct gtcatcatgg acaactttga ctacctgaca 4501 agggactggt ccatccttgg tccccaccac ctggatgagt ttaaaagaat ctgggcagag 4561 tatgaccctg aagccaaggg tcgtatcaaa cacctggatg tggtgaccct cctccggcgg 4621 attcagccgc cactaggttt tgggaagctg tgccctcacc gcgtggcttg caaacgcctg 4681 gtctccatga acatgcctct gaacagcgac gggacagtca tgttcaatgc caccctgttt 4741 gccctggtca ggacggccct gaggatcaaa acagaaggga acctagaaca agccaatgag 4801 gagctgcggg cgatcatcaa gaagatctgg aagcggacca gcatgaagct gctggaccag 4861 gtggtgcccc ctgcaggtga tgatgaggtc accgttggca agttctacgc cacgttcctg 4921 atccaggagt acttccggaa gttcaagaag cgcaaagagc agggccttgt gggcaagccc 4981 tcccagagga acgcgctgtc tctgcaggct ggcttgcgca cactgcatga catcgggcct 5041 gagatccgac gggccatctc tggagatctc accgctgagg aggagctgga caaggccatg 5101 aaggaggctg tgtccgctgc ttctgaagat gacatcttca ggagggccgg tggcctgttc 5161 ggcaaccacg tcagctacta ccaaagcgac ggccggagcg ccttccccca gaccttcacc 5221 actcagcgcc cgctgcacat caacaaggcg ggcagcagcc agggcgacac tgagtcgcca 5281 tcccacgaga agctggtgga ctccaccttc accccgagca gctactcgtc caccggctcc 5341 aacgccaaca tcaacaacgc caacaacacc gccctgggtc gcctccctcg ccccgccggc 5401 taccccagca cggtcagcac tgtggagggc cacgggcccc ccttgtcccc tgccatccgg 5461 gtgcaggagg tggcgtggaa gctcagctcc aacaggtgcc actcccggga gagccaggca 5521 gccatggcgg gtcaggagga gacgtctcag gatgagacct atgaagtgaa gatgaaccat 5581 gacacggagg cctgcagtga gcccagcctg ctctccacag agatgctctc ctaccaggat 5641 gacgaaaatc ggcaactgac gctcccagag gaggacaaga gggacatccg gcaatctccg 5701 aagaggggtt tcctccgctc tgcctcacta ggtcgaaggg cctccttcca cctggaatgt 5761 ctgaagcgac agaaggaccg agggggagac atctctcaga agacagtcct gcccttgcat 5821 ctggttcatc atcaggcatt ggcagtggca ggcctgagcc ccctcctcca gagaagccat 5881 tcccctgcct cattccctag gccttttgcc accccaccag ccacacctgg cagccgaggc 5941 tggcccccac agcccgtccc caccctgcgg cttgaggggg tcgagtccag tgagaaactc 6001 aacagcagct tcccatccat ccactgcggc tcctgggctg agaccacccc cggtggcggg 6061 ggcagcagcg ccgcccggag agtccggccc gtctccctca tggtgcccag ccaggctggg 6121 gccccaggga ggcagttcca cggcagtgcc agcagcctgg tggaagcggt cttgatttca 6181 gaaggactgg ggcagtttgc tcaagatccc aagttcatcg aggtcaccac ccaggagctg 6241 gccgacgcct gcgacatgac catagaggag atggagagcg cggccgacaa catcctcagc 6301 gggggcgccc cacagagccc caatggcgcc ctcttaccct ttgtgaactg cagggacgcg 6361 gggcaggacc gagccggggg cgaggaggac gcgggctgtg tgcgcgcgcg gggtgcaccg 6421 agtgaggagg agctccagga cagcagggtc tacgtcagca gcctgtagtg ggcgctgcca 6481 gatgcgggct tttttttttt tatttgtttc aatgttccta atgggttcgt ttcagaagtg 6541 cctcactgtt ctcgtgacct ggagtt //