LOCUS Z34819 6599 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens (HLCC88) mRNA for voltage-dependent L-type Ca channel
alpha 1 subunit (splice variant).
ACCESSION Z34819
VERSION Z34819.1
KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type
calcium channel alpha-1 subunit; L-type voltage-dependent calcium
channel; L-type voltage-dependent calcium channel alpha 1 subunit;
voltage dependent calcium channel alpha 1 subunit;
voltage-dependent calcium channel alpha 1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6599)
AUTHORS Soldatov N.M.
TITLE Molecular diversity of L-type Ca2+ channel transcripts in human
fibroblasts
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
PUBMED 1316612
REFERENCE 2 (bases 1 to 6599)
AUTHORS Soldatov N.M.
TITLE Genomic structure of human L-type Ca2+ channel
JOURNAL Genomics 22(1), 77-87(1994).
PUBMED 7959794
REFERENCE 3 (bases 1 to 6599)
AUTHORS Soldatov N.M.
TITLE Functional Expression of Splice Variants of Human L-type Calcium
Channel (isoform 1 gene)
JOURNAL Unpublished.
REFERENCE 4 (bases 1 to 6599)
AUTHORS Soldatov N.
JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov,
Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
CH-3010, Switzerland
FEATURES Location/Qualifiers
source 1..6599
/db_xref="H-InvDB:HIT000326978"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="fetal"
/cell_line="CRL 1475 (ATCC)"
/cell_type="fibroblast"
/db_xref="taxon:9606"
CDS 1..6501
/codon_start=1
/standard_name="CACNL1A1 isoform 1"
/product="voltage-dependent L-type Ca channel alpha 1
subunit"
/function="L-type calcium channel (clone HLCC88) splice
variant"
/note="composed of exons 1-21, 23-44, 46-50"
/db_xref="GOA:Q13936"
/db_xref="H-InvDB:HIT000326978.12"
/db_xref="HGNC:HGNC:1390"
/db_xref="InterPro:IPR002077"
/db_xref="InterPro:IPR005446"
/db_xref="InterPro:IPR005451"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR014873"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR031649"
/db_xref="InterPro:IPR031688"
/db_xref="PDB:1T0J"
/db_xref="PDB:2BE6"
/db_xref="PDB:2F3Y"
/db_xref="PDB:2F3Z"
/db_xref="PDB:2LQC"
/db_xref="PDB:3G43"
/db_xref="PDB:3OXQ"
/db_xref="PDB:5V2P"
/db_xref="PDB:5V2Q"
/db_xref="PDB:6C0A"
/db_xref="PDB:6DAD"
/db_xref="PDB:6DAE"
/db_xref="PDB:6DAF"
/db_xref="UniProtKB/Swiss-Prot:Q13936"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA84350.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVV
GSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLL
WTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLL
LFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL
IINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRI
QPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQAN
EELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV
GKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRR
AGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPS
SYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSN
RCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLP
EEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQAL
AVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFP
SIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGL
GQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAG
QDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL"
exon <1..49
/number=1
exon 50..371
/number=2
exon 372..477
/number=3
exon 478..617
/number=4
exon 618..757
/number=5
exon 758..916
/number=6
exon 917..1113
/number=7
exon 1114..1216
/number=8
exon 1217..1390
/number=9
exon 1391..1481
/number=10
exon 1482..1508
/number=11
exon 1509..1669
/number=12
exon 1670..1895
/number=13
exon 1896..2103
/number=14
exon 2104..2224
/number=15
exon 2225..2339
/number=16
exon 2340..2460
/number=17
exon 2461..2530
/number=18
exon 2531..2663
/number=19
exon 2664..2793
/number=20
exon 2794..2853
/number=21
/note="alternative"
exon 2854..2965
/number=23
exon 2966..3048
/number=24
exon 3049..3156
/number=25
exon 3157..3209
/number=26
exon 3210..3356
/number=27
exon 3357..3558
/number=28
exon 3559..3717
/number=29
exon 3718..3828
/number=30
exon 3829..3912
/number=31
/note="alternative"
exon 3913..3996
/number=32
/note="alternative"
exon 3997..4029
/number=33
/note="alternative"
exon 4030..4158
/number=34
exon 4159..4224
/number=35
exon 4225..4316
/number=36
exon 4317..4482
/number=37
exon 4483..4610
/number=38
exon 4611..4707
/number=39
exon 4708..4810
/number=40
exon 4811..4912
/number=41
exon 4913..5040
/number=42
exon 5041..5175
/number=43
exon 5176..5528
/number=44
exon 5529..5657
/number=46
exon 5658..5764
/number=47
exon 5765..5868
/number=48
exon 5869..6201
/number=49
exon 6202..>6599
/number=50
3'UTR 6499..6599
BASE COUNT 1483 a 1939 c 1776 g 1401 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt
2821 accaccattt tcaccattga aattgctctg aagatgactg cttatggggc tttcttgcac
2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt
3841 gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc
3901 agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg
3961 ggtagcattg ttgatatagc aatcaccgag gtaaacccag ctgaacatac ccaatgctct
4021 ccctctatga acgcagagga aaactcccgc atctccatca ccttcttccg cctgttccgg
4081 gtcatgcgtc tggtgaagct gctgagccgt ggggagggca tccggacgct gctgtggacc
4141 ttcatcaagt ccttccaggc cctgccctat gtggccctcc tgatcgtgat gctgttcttc
4201 atctacgcgg tgatcgggat gcaggtgttt gggaaaattg ccctgaatga taccacagag
4261 atcaaccgga acaacaactt tcagaccttc ccccaggccg tgctgctcct cttcaggtgt
4321 gccaccgggg aggcctggca ggacatcatg ctggcctgca tgccaggcaa gaagtgtgcc
4381 ccagagtccg agcccagcaa cagcacggag ggtgaaacac cctgtggtag cagctttgct
4441 gtcttctact tcatcagctt ctacatgctc tgtgccttcc tgatcatcaa cctctttgta
4501 gctgtcatca tggacaactt tgactacctg acaagggact ggtccatcct tggtccccac
4561 cacctggatg agtttaaaag aatctgggca gagtatgacc ctgaagccaa gggtcgtatc
4621 aaacacctgg atgtggtgac cctcctccgg cggattcagc cgccactagg ttttgggaag
4681 ctgtgccctc accgcgtggc ttgcaaacgc ctggtctcca tgaacatgcc tctgaacagc
4741 gacgggacag tcatgttcaa tgccaccctg tttgccctgg tcaggacggc cctgaggatc
4801 aaaacagaag ggaacctaga acaagccaat gaggagctgc gggcgatcat caagaagatc
4861 tggaagcgga ccagcatgaa gctgctggac caggtggtgc cccctgcagg tgatgatgag
4921 gtcaccgttg gcaagttcta cgccacgttc ctgatccagg agtacttccg gaagttcaag
4981 aagcgcaaag agcagggcct tgtgggcaag ccctcccaga ggaacgcgct gtctctgcag
5041 gctggcttgc gcacactgca tgacatcggg cctgagatcc gacgggccat ctctggagat
5101 ctcaccgctg aggaggagct ggacaaggcc atgaaggagg ctgtgtccgc tgcttctgaa
5161 gatgacatct tcaggagggc cggtggcctg ttcggcaacc acgtcagcta ctaccaaagc
5221 gacggccgga gcgccttccc ccagaccttc accactcagc gcccgctgca catcaacaag
5281 gcgggcagca gccagggcga cactgagtcg ccatcccacg agaagctggt ggactccacc
5341 ttcaccccga gcagctactc gtccaccggc tccaacgcca acatcaacaa cgccaacaac
5401 accgccctgg gtcgcctccc tcgccccgcc ggctacccca gcacggtcag cactgtggag
5461 ggccacgggc cccccttgtc ccctgccatc cgggtgcagg aggtggcgtg gaagctcagc
5521 tccaacaggt gccactcccg ggagagccag gcagccatgg cgggtcagga ggagacgtct
5581 caggatgaga cctatgaagt gaagatgaac catgacacgg aggcctgcag tgagcccagc
5641 ctgctctcca cagagatgct ctcctaccag gatgacgaaa atcggcaact gacgctccca
5701 gaggaggaca agagggacat ccggcaatct ccgaagaggg gtttcctccg ctctgcctca
5761 ctaggtcgaa gggcctcctt ccacctggaa tgtctgaagc gacagaagga ccgaggggga
5821 gacatctctc agaagacagt cctgcccttg catctggttc atcatcaggc attggcagtg
5881 gcaggcctga gccccctcct ccagagaagc cattcccctg cctcattccc taggcctttt
5941 gccaccccac cagccacacc tggcagccga ggctggcccc cacagcccgt ccccaccctg
6001 cggcttgagg gggtcgagtc cagtgagaaa ctcaacagca gcttcccatc catccactgc
6061 ggctcctggg ctgagaccac ccccggtggc gggggcagca gcgccgcccg gagagtccgg
6121 cccgtctccc tcatggtgcc cagccaggct ggggccccag ggaggcagtt ccacggcagt
6181 gccagcagcc tggtggaagc ggtcttgatt tcagaaggac tggggcagtt tgctcaagat
6241 cccaagttca tcgaggtcac cacccaggag ctggccgacg cctgcgacat gaccatagag
6301 gagatggaga gcgcggccga caacatcctc agcgggggcg ccccacagag ccccaatggc
6361 gccctcttac cctttgtgaa ctgcagggac gcggggcagg accgagccgg gggcgaggag
6421 gacgcgggct gtgtgcgcgc gcggggtgca ccgagtgagg aggagctcca ggacagcagg
6481 gtctacgtca gcagcctgta gtgggcgctg ccagatgcgg gctttttttt ttttatttgt
6541 ttcaatgttc ctaatgggtt cgtttcagaa gtgcctcact gttctcgtga cctggagtt
//