LOCUS Z34818 6575 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens (HLCC87) mRNA for voltage-dependent L-type Ca channel
alpha 1 subunit (splice variant).
ACCESSION Z34818
VERSION Z34818.1
KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type
calcium channel alpha-1 subunit; L-type voltage-dependent calcium
channel; L-type voltage-dependent calcium channel alpha 1 subunit;
voltage dependent calcium channel alpha 1 subunit;
voltage-dependent calcium channel alpha 1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6575)
AUTHORS Soldatov N.M.
TITLE Molecular diversity of L-type Ca2+ channel transcripts in human
fibroblasts
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
PUBMED 1316612
REFERENCE 2 (bases 1 to 6575)
AUTHORS Soldatov N.M.
TITLE Genomic structure of human L-type Ca2+ channel
JOURNAL Genomics 22(1), 77-87(1994).
PUBMED 7959794
REFERENCE 3 (bases 1 to 6575)
AUTHORS Soldatov N.M.
TITLE Functional Expression of Splice Variants of Human L-type Calcium
Channel (isoform 1 gene)
JOURNAL Unpublished.
REFERENCE 4 (bases 1 to 6575)
AUTHORS Soldatov N.
JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov,
Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
CH-3010, Switzerland
FEATURES Location/Qualifiers
source 1..6575
/db_xref="H-InvDB:HIT000326977"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="fetal"
/cell_line="CRL 1475 (ATCC)"
/cell_type="fibroblast"
/db_xref="taxon:9606"
CDS 1..6477
/standard_name="CACNL1A1 isoform 1"
/product="voltage-dependent L-type Ca channel alpha 1
subunit"
/function="L-type calcium channel (clone HLCC87) splice
variant"
/note="composed of exons 1-30, 32-44, 46-50"
/db_xref="GOA:Q13936"
/db_xref="H-InvDB:HIT000326977.12"
/db_xref="HGNC:HGNC:1390"
/db_xref="InterPro:IPR002077"
/db_xref="InterPro:IPR005446"
/db_xref="InterPro:IPR005451"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR014873"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR031649"
/db_xref="InterPro:IPR031688"
/db_xref="PDB:1T0J"
/db_xref="PDB:2BE6"
/db_xref="PDB:2F3Y"
/db_xref="PDB:2F3Z"
/db_xref="PDB:2LQC"
/db_xref="PDB:3G43"
/db_xref="PDB:3OXQ"
/db_xref="PDB:5V2P"
/db_xref="PDB:5V2Q"
/db_xref="PDB:6C0A"
/db_xref="PDB:6DAD"
/db_xref="PDB:6DAE"
/db_xref="PDB:6DAF"
/db_xref="UniProtKB/Swiss-Prot:Q13936"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA84349.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM
TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAIN
RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE
CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID
SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDK
NQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYG
QSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI
TEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ
ALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGE
AWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAV
IMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK
LCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIK
KIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNA
LSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNH
VSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSN
ANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQ
AAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIR
QSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPL
LQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWA
ETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPK
FIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEE
DAGCVRARGAPSEEELQDSRVYVSSL"
exon <1..49
/number=1
exon 50..371
/number=2
exon 372..477
/number=3
exon 478..617
/number=4
exon 618..757
/number=5
exon 758..916
/number=6
exon 917..1113
/number=7
exon 1114..1216
/number=8
exon 1217..1390
/number=9
exon 1391..1481
/number=10
exon 1482..1508
/number=11
exon 1509..1669
/number=12
exon 1670..1895
/number=13
exon 1896..2103
/number=14
exon 2104..2224
/number=15
exon 2225..2339
/number=16
exon 2340..2460
/number=17
exon 2461..2530
/number=18
exon 2531..2663
/number=19
exon 2664..2793
/number=20
exon 2794..2853
/number=21
/note="alternative"
exon 2854..2913
/number=22
/note="alternative"
exon 2914..3025
/number=23
exon 3026..3108
/number=24
exon 3109..3216
/number=25
exon 3217..3269
/number=26
exon 3270..3416
/number=27
exon 3417..3618
/number=28
exon 3619..3777
/number=29
exon 3778..3888
/number=30
exon 3889..3972
/number=32
/note="alternative"
exon 3973..4005
/number=33
/note="alternative"
exon 4066..4134
/number=34
exon 4135..4200
/number=35
exon 4201..4292
/number=36
exon 4293..4458
/number=37
exon 4459..4586
/number=38
exon 4587..4683
/number=39
exon 4684..4786
/number=40
exon 4787..4888
/number=41
exon 4889..5016
/number=42
exon 5017..5151
/number=43
exon 5152..5504
/number=44
exon 5505..5633
/number=46
exon 5634..5740
/number=47
exon 5741..5844
/number=48
exon 5845..6177
/number=49
exon 6178..>6575
/number=50
3'UTR 6475..6575
BASE COUNT 1482 a 1935 c 1767 g 1391 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt
2821 accaccattt tcaccattga aattgctctg aagatcctag gcaatgcaga ctatgtcttc
2881 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac
2941 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
3001 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3061 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3121 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3181 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3241 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3301 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3361 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3421 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3481 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3541 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3601 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3661 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3721 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3781 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3841 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt
3901 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
3961 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac
4021 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg
4081 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg
4141 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag
4201 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag
4261 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac
4321 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc
4381 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac
4441 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac
4501 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc
4561 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc
4621 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc
4681 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc
4741 accctgtttg ccctggtcag gacggccctg aggatcaaaa cagaagggaa cctagaacaa
4801 gccaatgagg agctgcgggc gatcatcaag aagatctgga agcggaccag catgaagctg
4861 ctggaccagg tggtgccccc tgcaggtgat gatgaggtca ccgttggcaa gttctacgcc
4921 acgttcctga tccaggagta cttccggaag ttcaagaagc gcaaagagca gggccttgtg
4981 ggcaagccct cccagaggaa cgcgctgtct ctgcaggctg gcttgcgcac actgcatgac
5041 atcgggcctg agatccgacg ggccatctct ggagatctca ccgctgagga ggagctggac
5101 aaggccatga aggaggctgt gtccgctgct tctgaagatg acatcttcag gagggccggt
5161 ggcctgttcg gcaaccacgt cagctactac caaagcgacg gccggagcgc cttcccccag
5221 accttcacca ctcagcgccc gctgcacatc aacaaggcgg gcagcagcca gggcgacact
5281 gagtcgccat cccacgagaa gctggtggac tccaccttca ccccgagcag ctactcgtcc
5341 accggctcca acgccaacat caacaacgcc aacaacaccg ccctgggtcg cctccctcgc
5401 cccgccggct accccagcac ggtcagcact gtggagggcc acgggccccc cttgtcccct
5461 gccatccggg tgcaggaggt ggcgtggaag ctcagctcca acaggtgcca ctcccgggag
5521 agccaggcag ccatggcggg tcaggaggag acgtctcagg atgagaccta tgaagtgaag
5581 atgaaccatg acacggaggc ctgcagtgag cccagcctgc tctccacaga gatgctctcc
5641 taccaggatg acgaaaatcg gcaactgacg ctcccagagg aggacaagag ggacatccgg
5701 caatctccga agaggggttt cctccgctct gcctcactag gtcgaagggc ctccttccac
5761 ctggaatgtc tgaagcgaca gaaggaccga gggggagaca tctctcagaa gacagtcctg
5821 cccttgcatc tggttcatca tcaggcattg gcagtggcag gcctgagccc cctcctccag
5881 agaagccatt cccctgcctc attccctagg ccttttgcca ccccaccagc cacacctggc
5941 agccgaggct ggcccccaca gcccgtcccc accctgcggc ttgagggggt cgagtccagt
6001 gagaaactca acagcagctt cccatccatc cactgcggct cctgggctga gaccaccccc
6061 ggtggcgggg gcagcagcgc cgcccggaga gtccggcccg tctccctcat ggtgcccagc
6121 caggctgggg ccccagggag gcagttccac ggcagtgcca gcagcctggt ggaagcggtc
6181 ttgatttcag aaggactggg gcagtttgct caagatccca agttcatcga ggtcaccacc
6241 caggagctgg ccgacgcctg cgacatgacc atagaggaga tggagagcgc ggccgacaac
6301 atcctcagcg ggggcgcccc acagagcccc aatggcgccc tcttaccctt tgtgaactgc
6361 agggacgcgg ggcaggaccg agccgggggc gaggaggacg cgggctgtgt gcgcgcgcgg
6421 ggtgcaccga gtgaggagga gctccaggac agcagggtct acgtcagcag cctgtagtgg
6481 gcgctgccag atgcgggctt tttttttttt atttgtttca atgttcctaa tgggttcgtt
6541 tcagaagtgc ctcactgttc tcgtgacctg gagtt
//