LOCUS Z34817 6518 bp mRNA linear HUM 14-NOV-2006 DEFINITION H.sapiens (HLCC86) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34817 VERSION Z34817.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4707;4960 to 6518) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6518) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 3 (bases 1 to 6518) AUTHORS Soldatov N.M. TITLE Functional Expression of Splice Variants of Human L-type Calcium Channel (isoform 1 gene) JOURNAL Unpublished. REFERENCE 4 (bases 1 to 6518) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland FEATURES Location/Qualifiers source 1..6518 /db_xref="H-InvDB:HIT000326976" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /tissue_type="hippocampus" /db_xref="taxon:9606" CDS 1..6420 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC86) splice variant" /note="composed of exons 1-20, 22-30, 32-39, 40A, 40B, 43A, 44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326976.12" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84348.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS DGTVMFNATLFALVRTALRETELSSQVQYQAKEASLLERRRKSSHPKSSTKPNKLLSS GGSTGWVEDARALEGQVLARGCGWLGSLEERERGPHHPPLGFQAGLRTLHDIGPEIRR AISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQ RPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAG YPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKM NHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASF HLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPA TPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVS LMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEE MESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDS RVYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=22 /note="alternative" exon 2854..2965 /number=23 exon 2966..3048 /number=24 exon 3049..3156 /number=25 exon 3157..3209 /number=26 exon 3210..3356 /number=27 exon 3357..3558 /number=28 exon 3559..3717 /number=29 exon 3718..3828 /number=30 exon 3829..3912 /number=32 /note="alternative" exon 3913..3945 /number=33 /note="alternative" exon 3946..4074 /number=34 exon 4075..4140 /number=35 exon 4141..4232 /number=36 exon 4233..4398 /number=37 exon 4399..4526 /number=38 exon 4527..4623 /number=39 exon 4624..4707 /number=40 /note="brain-specific alternatively spliced exon 40A produced by deletion of 19 nt from 3'-end of exon 40" exon 4708..4827 /note="brain-specific alternative exon 40A" exon 4828..5094 /number=43 /note="brain-specific exon 43A; exon 43 is extended by 132 nt in upstream direction due to use of alternative splice acceptor site" exon 5095..5447 /number=44 exon 5448..5576 /number=46 exon 5577..5683 /number=47 exon 5684..5787 /number=48 exon 5788..6120 /number=49 exon 6121..>6518 /number=50 3'UTR 6418..6518 BASE COUNT 1459 a 1931 c 1759 g 1369 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc 2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac 2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt 3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc 3901 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac 3961 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg 4021 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg 4081 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag 4141 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag 4201 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac 4261 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc 4321 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac 4381 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac 4441 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc 4501 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc 4561 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc 4621 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc 4681 accctgtttg ccctggtcag gacggccctc agagaaacag agctgtcatc ccaagtccag 4741 taccaagcca aagaagcttc tctcttggaa cgtagaagga agagctctca tcccaagtcc 4801 agtaccaagc caaacaagct tctctcttcc ggagggtcga ctggctgggt ggaggatgcc 4861 agggccctgg agggacaggt cttggcccga ggctgtggct ggctggggag cttggaggaa 4921 agggagcgtg gtcctcacca tcctcccctt ggattccagg ctggcttgcg cacactgcat 4981 gacatcgggc ctgagatccg acgggccatc tctggagatc tcaccgctga ggaggagctg 5041 gacaaggcca tgaaggaggc tgtgtccgct gcttctgaag atgacatctt caggagggcc 5101 ggtggcctgt tcggcaacca cgtcagctac taccaaagcg acggccggag cgccttcccc 5161 cagaccttca ccactcagcg cccgctgcac atcaacaagg cgggcagcag ccagggcgac 5221 actgagtcgc catcccacga gaagctggtg gactccacct tcaccccgag cagctactcg 5281 tccaccggct ccaacgccaa catcaacaac gccaacaaca ccgccctggg tcgcctccct 5341 cgccccgccg gctaccccag cacggtcagc actgtggagg gccacgggcc ccccttgtcc 5401 cctgccatcc gggtgcagga ggtggcgtgg aagctcagct ccaacaggtg ccactcccgg 5461 gagagccagg cagccatggc gggtcaggag gagacgtctc aggatgagac ctatgaagtg 5521 aagatgaacc atgacacgga ggcctgcagt gagcccagcc tgctctccac agagatgctc 5581 tcctaccagg atgacgaaaa tcggcaactg acgctcccag aggaggacaa gagggacatc 5641 cggcaatctc cgaagagggg tttcctccgc tctgcctcac taggtcgaag ggcctccttc 5701 cacctggaat gtctgaagcg acagaaggac cgagggggag acatctctca gaagacagtc 5761 ctgcccttgc atctggttca tcatcaggca ttggcagtgg caggcctgag ccccctcctc 5821 cagagaagcc attcccctgc ctcattccct aggccttttg ccaccccacc agccacacct 5881 ggcagccgag gctggccccc acagcccgtc cccaccctgc ggcttgaggg ggtcgagtcc 5941 agtgagaaac tcaacagcag cttcccatcc atccactgcg gctcctgggc tgagaccacc 6001 cccggtggcg ggggcagcag cgccgcccgg agagtccggc ccgtctccct catggtgccc 6061 agccaggctg gggccccagg gaggcagttc cacggcagtg ccagcagcct ggtggaagcg 6121 gtcttgattt cagaaggact ggggcagttt gctcaagatc ccaagttcat cgaggtcacc 6181 acccaggagc tggccgacgc ctgcgacatg accatagagg agatggagag cgcggccgac 6241 aacatcctca gcgggggcgc cccacagagc cccaatggcg ccctcttacc ctttgtgaac 6301 tgcagggacg cggggcagga ccgagccggg ggcgaggagg acgcgggctg tgtgcgcgcg 6361 cggggtgcac cgagtgagga ggagctccag gacagcaggg tctacgtcag cagcctgtag 6421 tgggcgctgc cagatgcggg cttttttttt tttatttgtt tcaatgttcc taatgggttc 6481 gtttcagaag tgcctcactg ttctcgtgac ctggagtt //