LOCUS Z34815 6515 bp mRNA linear HUM 07-OCT-2008 DEFINITION H.sapiens (HLCC77) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34815 VERSION Z34815.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6515) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6515) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 4 (bases 1 to 6515) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland REFERENCE 5 (bases 1 to 6515) AUTHORS Soldatov N.M., Bouron A., Reuter H. TITLE Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants JOURNAL J Biol Chem 270(18), 10540-10543(1995). PUBMED 7737988 FEATURES Location/Qualifiers source 1..6515 /db_xref="H-InvDB:HIT000326974" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /db_xref="taxon:9606" CDS 1..6417 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC77) splice variant" /note="composed of exons 1-20, 22-30, 32-44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326974.12" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84346.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS DGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRA ISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR PLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGY PSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMN HDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFH LECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPAT PGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSL MVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM ESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSR VYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=22 /note="alternative" exon 2854..2965 /number=23 exon 2966..3048 /number=24 exon 3049..3156 /number=25 exon 3157..3209 /number=26 exon 3210..3356 /number=27 exon 3357..3558 /number=28 exon 3559..3717 /number=29 exon 3718..3828 /number=30 exon 3829..3912 /number=32 /note="alternative" exon 3913..3945 /number=33 /note="alternative" exon 3946..4074 /number=34 exon 4075..4140 /number=35 exon 4141..4232 /number=36 exon 4233..4398 /number=37 exon 4399..4526 /number=38 exon 4527..4623 /number=39 exon 4624..4726 /number=40 exon 4727..4828 /number=41 exon 4829..4956 /number=42 exon 4957..5091 /number=43 exon 5092..5444 /number=44 exon 5445..5573 /number=46 exon 5574..5680 /number=47 exon 5681..5784 /number=48 exon 5785..6117 /number=49 exon 6118..>6515 /number=50 3'UTR 6415..6515 BASE COUNT 1468 a 1925 c 1760 g 1362 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc 2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac 2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt 3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc 3901 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac 3961 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg 4021 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg 4081 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag 4141 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag 4201 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac 4261 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc 4321 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac 4381 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac 4441 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc 4501 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc 4561 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc 4621 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc 4681 accctgtttg ccctggtcag gacggccctg aggatcaaaa cagaagggaa cctagaacaa 4741 gccaatgagg agctgcgggc gatcatcaag aagatctgga agcggaccag catgaagctg 4801 ctggaccagg tggtgccccc tgcaggtgat gatgaggtca ccgttggcaa gttctacgcc 4861 acgttcctga tccaggagta cttccggaag ttcaagaagc gcaaagagca gggccttgtg 4921 ggcaagccct cccagaggaa cgcgctgtct ctgcaggctg gcttgcgcac actgcatgac 4981 atcgggcctg agatccgacg ggccatctct ggagatctca ccgctgagga ggagctggac 5041 aaggccatga aggaggctgt gtccgctgct tctgaagatg acatcttcag gagggccggt 5101 ggcctgttcg gcaaccacgt cagctactac caaagcgacg gccggagcgc cttcccccag 5161 accttcacca ctcagcgccc gctgcacatc aacaaggcgg gcagcagcca gggcgacact 5221 gagtcgccat cccacgagaa gctggtggac tccaccttca ccccgagcag ctactcgtcc 5281 accggctcca acgccaacat caacaacgcc aacaacaccg ccctgggtcg cctccctcgc 5341 cccgccggct accccagcac ggtcagcact gtggagggcc acgggccccc cttgtcccct 5401 gccatccggg tgcaggaggt ggcgtggaag ctcagctcca acaggtgcca ctcccgggag 5461 agccaggcag ccatggcggg tcaggaggag acgtctcagg atgagaccta tgaagtgaag 5521 atgaaccatg acacggaggc ctgcagtgag cccagcctgc tctccacaga gatgctctcc 5581 taccaggatg acgaaaatcg gcaactgacg ctcccagagg aggacaagag ggacatccgg 5641 caatctccga agaggggttt cctccgctct gcctcactag gtcgaagggc ctccttccac 5701 ctggaatgtc tgaagcgaca gaaggaccga gggggagaca tctctcagaa gacagtcctg 5761 cccttgcatc tggttcatca tcaggcattg gcagtggcag gcctgagccc cctcctccag 5821 agaagccatt cccctgcctc attccctagg ccttttgcca ccccaccagc cacacctggc 5881 agccgaggct ggcccccaca gcccgtcccc accctgcggc ttgagggggt cgagtccagt 5941 gagaaactca acagcagctt cccatccatc cactgcggct cctgggctga gaccaccccc 6001 ggtggcgggg gcagcagcgc cgcccggaga gtccggcccg tctccctcat ggtgcccagc 6061 caggctgggg ccccagggag gcagttccac ggcagtgcca gcagcctggt ggaagcggtc 6121 ttgatttcag aaggactggg gcagtttgct caagatccca agttcatcga ggtcaccacc 6181 caggagctgg ccgacgcctg cgacatgacc atagaggaga tggagagcgc ggccgacaac 6241 atcctcagcg ggggcgcccc acagagcccc aatggcgccc tcttaccctt tgtgaactgc 6301 agggacgcgg ggcaggaccg agccgggggc gaggaggacg cgggctgtgt gcgcgcgcgg 6361 ggtgcaccga gtgaggagga gctccaggac agcagggtct acgtcagcag cctgtagtgg 6421 gcgctgccag atgcgggctt tttttttttt atttgtttca atgttcctaa tgggttcgtt 6481 tcagaagtgc ctcactgttc tcgtgacctg gagtt //