LOCUS Z34814 6482 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens (HLCC76) mRNA for voltage-dependent L-type Ca channel
alpha 1 subunit (splice variant).
ACCESSION Z34814
VERSION Z34814.1
KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type
calcium channel alpha-1 subunit; L-type voltage-dependent calcium
channel; L-type voltage-dependent calcium channel alpha 1 subunit;
voltage dependent calcium channel alpha 1 subunit;
voltage-dependent calcium channel alpha 1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6482)
AUTHORS Soldatov N.M.
TITLE Molecular diversity of L-type Ca2+ channel transcripts in human
fibroblasts
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992).
PUBMED 1316612
REFERENCE 2 (bases 1 to 6482)
AUTHORS Soldatov N.M.
TITLE Genomic structure of human L-type Ca2+ channel
JOURNAL Genomics 22(1), 77-87(1994).
PUBMED 7959794
REFERENCE 4 (bases 1 to 6482)
AUTHORS Soldatov N.
JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov,
Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern,
CH-3010, Switzerland
REFERENCE 5 (bases 1 to 6482)
AUTHORS Soldatov N.M., Bouron A., Reuter H.
TITLE Different voltage-dependent inhibition by dihydropyridines of human
Ca2+ channel splice variants
JOURNAL J Biol Chem 270(18), 10540-10543(1995).
PUBMED 7737988
FEATURES Location/Qualifiers
source 1..6482
/db_xref="H-InvDB:HIT000326973"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="fetal"
/cell_line="CRL 1475 (ATCC)"
/cell_type="fibroblast"
/db_xref="taxon:9606"
CDS 1..6384
/standard_name="CACNL1A1 isoform 1"
/product="voltage-dependent L-type Ca channel alpha 1
subunit"
/function="L-type calcium channel (clone HLCC76) splice
variant"
/note="composed of exons 1-20, 22-30, 32, 34-44, 46-50"
/db_xref="GOA:Q13936"
/db_xref="H-InvDB:HIT000326973.12"
/db_xref="HGNC:HGNC:1390"
/db_xref="InterPro:IPR002077"
/db_xref="InterPro:IPR005446"
/db_xref="InterPro:IPR005451"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR014873"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR031649"
/db_xref="InterPro:IPR031688"
/db_xref="PDB:1T0J"
/db_xref="PDB:2BE6"
/db_xref="PDB:2F3Y"
/db_xref="PDB:2F3Z"
/db_xref="PDB:2LQC"
/db_xref="PDB:3G43"
/db_xref="PDB:3OXQ"
/db_xref="PDB:5V2P"
/db_xref="PDB:5V2Q"
/db_xref="PDB:6C0A"
/db_xref="PDB:6DAD"
/db_xref="PDB:6DAE"
/db_xref="PDB:6DAF"
/db_xref="UniProtKB/Swiss-Prot:Q13936"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA84345.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLF
RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALND
TTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC
GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYD
PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLF
ALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYAT
FLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEEL
DKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQ
GDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHG
PPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSL
LSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRG
GDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPV
PTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGR
QFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGG
APQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPSEEELQDSRVYVSSL"
exon <1..49
/number=1
exon 50..371
/number=2
exon 372..477
/number=3
exon 478..617
/number=4
exon 618..757
/number=5
exon 758..916
/number=6
exon 917..1113
/number=7
exon 1114..1216
/number=8
exon 1217..1390
/number=9
exon 1391..1481
/number=10
exon 1482..1508
/number=11
exon 1509..1669
/number=12
exon 1670..1895
/number=13
exon 1896..2103
/number=14
exon 2104..2224
/number=15
exon 2225..2339
/number=16
exon 2340..2460
/number=17
exon 2461..2530
/number=18
exon 2531..2663
/number=19
exon 2664..2793
/number=20
exon 2794..2853
/number=22
/note="alternative"
exon 2854..2965
/number=23
exon 2966..3048
/number=24
exon 3049..3156
/number=25
exon 3157..3209
/number=26
exon 3210..3356
/number=27
exon 3357..3558
/number=28
exon 3559..3717
/number=29
exon 3718..3828
/number=30
exon 3829..3912
/number=32
/note="alternative"
exon 3913..4041
/number=34
exon 4042..4107
/number=35
exon 4108..4199
/number=36
exon 4200..4365
/number=37
exon 4366..4493
/number=38
exon 4494..4590
/number=39
exon 4591..4693
/number=40
exon 4694..4795
/number=41
exon 4796..4923
/number=42
exon 4924..5058
/number=43
exon 5059..5411
/number=44
exon 5412..5540
/number=46
exon 5541..5647
/number=47
exon 5648..5751
/number=48
exon 5752..6084
/number=49
exon 6085..>6482
/number=50
3'UTR 6382..6482
BASE COUNT 1460 a 1912 c 1756 g 1354 t
ORIGIN
1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat
61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct
121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg
181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag
241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg
301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt
361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc
421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa
481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc
541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt
601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg
661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc
721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc
781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc
841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac
901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg
961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag
1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc
1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg
1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt
1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat
1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg
1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag
1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct
1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca
1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca
1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc
1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac
1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg
1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc
1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga
1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg
1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc
1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat
2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt
2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc
2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga
2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag
2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg
2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag
2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag
2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca
2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga
2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt
2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg
2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag
2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc
2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac
2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc
2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg
3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag
3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag
3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac
3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag
3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat
3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg
3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg
3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc
3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt
3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg
3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac
3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac
3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc
3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt
3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
3901 accgaggtaa acaacgcaga ggaaaactcc cgcatctcca tcaccttctt ccgcctgttc
3961 cgggtcatgc gtctggtgaa gctgctgagc cgtggggagg gcatccggac gctgctgtgg
4021 accttcatca agtccttcca ggccctgccc tatgtggccc tcctgatcgt gatgctgttc
4081 ttcatctacg cggtgatcgg gatgcaggtg tttgggaaaa ttgccctgaa tgataccaca
4141 gagatcaacc ggaacaacaa ctttcagacc ttcccccagg ccgtgctgct cctcttcagg
4201 tgtgccaccg gggaggcctg gcaggacatc atgctggcct gcatgccagg caagaagtgt
4261 gccccagagt ccgagcccag caacagcacg gagggtgaaa caccctgtgg tagcagcttt
4321 gctgtcttct acttcatcag cttctacatg ctctgtgcct tcctgatcat caacctcttt
4381 gtagctgtca tcatggacaa ctttgactac ctgacaaggg actggtccat ccttggtccc
4441 caccacctgg atgagtttaa aagaatctgg gcagagtatg accctgaagc caagggtcgt
4501 atcaaacacc tggatgtggt gaccctcctc cggcggattc agccgccact aggttttggg
4561 aagctgtgcc ctcaccgcgt ggcttgcaaa cgcctggtct ccatgaacat gcctctgaac
4621 agcgacggga cagtcatgtt caatgccacc ctgtttgccc tggtcaggac ggccctgagg
4681 atcaaaacag aagggaacct agaacaagcc aatgaggagc tgcgggcgat catcaagaag
4741 atctggaagc ggaccagcat gaagctgctg gaccaggtgg tgccccctgc aggtgatgat
4801 gaggtcaccg ttggcaagtt ctacgccacg ttcctgatcc aggagtactt ccggaagttc
4861 aagaagcgca aagagcaggg ccttgtgggc aagccctccc agaggaacgc gctgtctctg
4921 caggctggct tgcgcacact gcatgacatc gggcctgaga tccgacgggc catctctgga
4981 gatctcaccg ctgaggagga gctggacaag gccatgaagg aggctgtgtc cgctgcttct
5041 gaagatgaca tcttcaggag ggccggtggc ctgttcggca accacgtcag ctactaccaa
5101 agcgacggcc ggagcgcctt cccccagacc ttcaccactc agcgcccgct gcacatcaac
5161 aaggcgggca gcagccaggg cgacactgag tcgccatccc acgagaagct ggtggactcc
5221 accttcaccc cgagcagcta ctcgtccacc ggctccaacg ccaacatcaa caacgccaac
5281 aacaccgccc tgggtcgcct ccctcgcccc gccggctacc ccagcacggt cagcactgtg
5341 gagggccacg ggcccccctt gtcccctgcc atccgggtgc aggaggtggc gtggaagctc
5401 agctccaaca ggtgccactc ccgggagagc caggcagcca tggcgggtca ggaggagacg
5461 tctcaggatg agacctatga agtgaagatg aaccatgaca cggaggcctg cagtgagccc
5521 agcctgctct ccacagagat gctctcctac caggatgacg aaaatcggca actgacgctc
5581 ccagaggagg acaagaggga catccggcaa tctccgaaga ggggtttcct ccgctctgcc
5641 tcactaggtc gaagggcctc cttccacctg gaatgtctga agcgacagaa ggaccgaggg
5701 ggagacatct ctcagaagac agtcctgccc ttgcatctgg ttcatcatca ggcattggca
5761 gtggcaggcc tgagccccct cctccagaga agccattccc ctgcctcatt ccctaggcct
5821 tttgccaccc caccagccac acctggcagc cgaggctggc ccccacagcc cgtccccacc
5881 ctgcggcttg agggggtcga gtccagtgag aaactcaaca gcagcttccc atccatccac
5941 tgcggctcct gggctgagac cacccccggt ggcgggggca gcagcgccgc ccggagagtc
6001 cggcccgtct ccctcatggt gcccagccag gctggggccc cagggaggca gttccacggc
6061 agtgccagca gcctggtgga agcggtcttg atttcagaag gactggggca gtttgctcaa
6121 gatcccaagt tcatcgaggt caccacccag gagctggccg acgcctgcga catgaccata
6181 gaggagatgg agagcgcggc cgacaacatc ctcagcgggg gcgccccaca gagccccaat
6241 ggcgccctct taccctttgt gaactgcagg gacgcggggc aggaccgagc cgggggcgag
6301 gaggacgcgg gctgtgtgcg cgcgcggggt gcaccgagtg aggaggagct ccaggacagc
6361 agggtctacg tcagcagcct gtagtgggcg ctgccagatg cgggcttttt tttttttatt
6421 tgtttcaatg ttcctaatgg gttcgtttca gaagtgcctc actgttctcg tgacctggag
6481 tt
//