LOCUS Z34813 6539 bp mRNA linear HUM 21-OCT-2008 DEFINITION H.sapiens (HLCC74) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34813 VERSION Z34813.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4693;4751 to 6539) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6539) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 3 (bases 1 to 6539) AUTHORS Soldatov N.M. TITLE Functional Expression of Splice Variants of Human L-type Calcium Channel (isoform 1 gene) JOURNAL Unpublished. REFERENCE 4 (bases 1 to 6539) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland FEATURES Location/Qualifiers source 1..6539 /db_xref="H-InvDB:HIT000326972" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /tissue_type="hippocampus" /db_xref="taxon:9606" CDS 1..6441 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC74) splice variant" /note="composed of exons 1-20, 22-30, 32, 34-40, 41A, 42-44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326972.12" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84344.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLF RVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALND TTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPC GSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYD PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLF ALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLD QVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHD IGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAF PQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALG RLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQD ETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSAS LGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPR PFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAA RRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADA CDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGAPS EEELQDSRVYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=22 /note="alternative" exon 2854..2965 /number=23 exon 2966..3048 /number=24 exon 3049..3156 /number=25 exon 3157..3209 /number=26 exon 3210..3356 /number=27 exon 3357..3558 /number=28 exon 3559..3717 /number=29 exon 3718..3828 /number=30 exon 3829..3912 /number=32 /note="alternative" exon 3913..4041 /number=34 exon 4042..4107 /number=35 exon 4108..4199 /number=36 exon 4200..4365 /number=37 exon 4366..4493 /number=38 exon 4494..4590 /number=39 exon 4591..4693 /number=40 exon 4694..4852 /number=41 /note="brain-specific exon 41A; extended by 57 nt upstream of alternative splice acceptor site" exon 4853..4980 /number=42 exon 4981..5115 /number=43 exon 5116..5468 /number=44 exon 5469..5597 /number=46 exon 5598..5704 /number=47 exon 5705..5808 /number=48 exon 5809..6141 /number=49 exon 6142..>6539 /number=50 3'UTR 6439..6539 BASE COUNT 1472 a 1933 c 1773 g 1361 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catatcctag gcaatgcaga ctatgtcttc 2821 actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac 2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt 3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc 3901 accgaggtaa acaacgcaga ggaaaactcc cgcatctcca tcaccttctt ccgcctgttc 3961 cgggtcatgc gtctggtgaa gctgctgagc cgtggggagg gcatccggac gctgctgtgg 4021 accttcatca agtccttcca ggccctgccc tatgtggccc tcctgatcgt gatgctgttc 4081 ttcatctacg cggtgatcgg gatgcaggtg tttgggaaaa ttgccctgaa tgataccaca 4141 gagatcaacc ggaacaacaa ctttcagacc ttcccccagg ccgtgctgct cctcttcagg 4201 tgtgccaccg gggaggcctg gcaggacatc atgctggcct gcatgccagg caagaagtgt 4261 gccccagagt ccgagcccag caacagcacg gagggtgaaa caccctgtgg tagcagcttt 4321 gctgtcttct acttcatcag cttctacatg ctctgtgcct tcctgatcat caacctcttt 4381 gtagctgtca tcatggacaa ctttgactac ctgacaaggg actggtccat ccttggtccc 4441 caccacctgg atgagtttaa aagaatctgg gcagagtatg accctgaagc caagggtcgt 4501 atcaaacacc tggatgtggt gaccctcctc cggcggattc agccgccact aggttttggg 4561 aagctgtgcc ctcaccgcgt ggcttgcaaa cgcctggtct ccatgaacat gcctctgaac 4621 agcgacggga cagtcatgtt caatgccacc ctgtttgccc tggtcaggac ggccctgagg 4681 atcaaaacag aagagggacc cagcccatca gaggcccacc aaggggctga ggatcctttc 4741 cgccctgcag ggaacctaga acaagccaat gaggagctgc gggcgatcat caagaagatc 4801 tggaagcgga ccagcatgaa gctgctggac caggtggtgc cccctgcagg tgatgatgag 4861 gtcaccgttg gcaagttcta cgccacgttc ctgatccagg agtacttccg gaagttcaag 4921 aagcgcaaag agcagggcct tgtgggcaag ccctcccaga ggaacgcgct gtctctgcag 4981 gctggcttgc gcacactgca tgacatcggg cctgagatcc gacgggccat ctctggagat 5041 ctcaccgctg aggaggagct ggacaaggcc atgaaggagg ctgtgtccgc tgcttctgaa 5101 gatgacatct tcaggagggc cggtggcctg ttcggcaacc acgtcagcta ctaccaaagc 5161 gacggccgga gcgccttccc ccagaccttc accactcagc gcccgctgca catcaacaag 5221 gcgggcagca gccagggcga cactgagtcg ccatcccacg agaagctggt ggactccacc 5281 ttcaccccga gcagctactc gtccaccggc tccaacgcca acatcaacaa cgccaacaac 5341 accgccctgg gtcgcctccc tcgccccgcc ggctacccca gcacggtcag cactgtggag 5401 ggccacgggc cccccttgtc ccctgccatc cgggtgcagg aggtggcgtg gaagctcagc 5461 tccaacaggt gccactcccg ggagagccag gcagccatgg cgggtcagga ggagacgtct 5521 caggatgaga cctatgaagt gaagatgaac catgacacgg aggcctgcag tgagcccagc 5581 ctgctctcca cagagatgct ctcctaccag gatgacgaaa atcggcaact gacgctccca 5641 gaggaggaca agagggacat ccggcaatct ccgaagaggg gtttcctccg ctctgcctca 5701 ctaggtcgaa gggcctcctt ccacctggaa tgtctgaagc gacagaagga ccgaggggga 5761 gacatctctc agaagacagt cctgcccttg catctggttc atcatcaggc attggcagtg 5821 gcaggcctga gccccctcct ccagagaagc cattcccctg cctcattccc taggcctttt 5881 gccaccccac cagccacacc tggcagccga ggctggcccc cacagcccgt ccccaccctg 5941 cggcttgagg gggtcgagtc cagtgagaaa ctcaacagca gcttcccatc catccactgc 6001 ggctcctggg ctgagaccac ccccggtggc gggggcagca gcgccgcccg gagagtccgg 6061 cccgtctccc tcatggtgcc cagccaggct ggggccccag ggaggcagtt ccacggcagt 6121 gccagcagcc tggtggaagc ggtcttgatt tcagaaggac tggggcagtt tgctcaagat 6181 cccaagttca tcgaggtcac cacccaggag ctggccgacg cctgcgacat gaccatagag 6241 gagatggaga gcgcggccga caacatcctc agcgggggcg ccccacagag ccccaatggc 6301 gccctcttac cctttgtgaa ctgcagggac gcggggcagg accgagccgg gggcgaggag 6361 gacgcgggct gtgtgcgcgc gcggggtgca ccgagtgagg aggagctcca ggacagcagg 6421 gtctacgtca gcagcctgta gtgggcgctg ccagatgcgg gctttttttt ttttatttgt 6481 ttcaatgttc ctaatgggtt cgtttcagaa gtgcctcact gttctcgtga cctggagtt //