LOCUS Z34811 6572 bp mRNA linear HUM 07-OCT-2008 DEFINITION H.sapiens (HLCC71) mRNA for voltage-dependent L-type Ca channel alpha 1 subunit (splice variant). ACCESSION Z34811 VERSION Z34811.1 KEYWORDS calcium channel alpha-1 subunit; L-type calcium channel; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel; L-type voltage-dependent calcium channel alpha 1 subunit; voltage dependent calcium channel alpha 1 subunit; voltage-dependent calcium channel alpha 1 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4726;4784 to 6572) AUTHORS Soldatov N.M. TITLE Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(10), 4628-4632(1992). PUBMED 1316612 REFERENCE 2 (bases 1 to 6572) AUTHORS Soldatov N.M. TITLE Genomic structure of human L-type Ca2+ channel JOURNAL Genomics 22(1), 77-87(1994). PUBMED 7959794 REFERENCE 3 (bases 1 to 6572) AUTHORS Soldatov N.M. TITLE Functional Expression of Splice Variants of Human L-type Calcium Channel (isoform 1 gene) JOURNAL Unpublished. REFERENCE 4 (bases 1 to 6572) AUTHORS Soldatov N. JOURNAL Submitted (15-JUN-1994) to the INSDC. Nikolai M. Soldatov, Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, CH-3010, Switzerland FEATURES Location/Qualifiers source 1..6572 /db_xref="H-InvDB:HIT000326970" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="fetal" /cell_line="CRL 1475 (ATCC)" /cell_type="fibroblast" /db_xref="taxon:9606" CDS 1..6474 /standard_name="CACNL1A1 isoform 1" /product="voltage-dependent L-type Ca channel alpha 1 subunit" /function="L-type calcium channel (clone HLCC71) splice variant" /note="composed of exons 1-21, 23-30, 32-40, 41A, 42-44, 46-50" /db_xref="GOA:Q13936" /db_xref="H-InvDB:HIT000326970.12" /db_xref="HGNC:HGNC:1390" /db_xref="InterPro:IPR002077" /db_xref="InterPro:IPR005446" /db_xref="InterPro:IPR005451" /db_xref="InterPro:IPR005821" /db_xref="InterPro:IPR014873" /db_xref="InterPro:IPR027359" /db_xref="InterPro:IPR031649" /db_xref="InterPro:IPR031688" /db_xref="PDB:1T0J" /db_xref="PDB:2BE6" /db_xref="PDB:2F3Y" /db_xref="PDB:2F3Z" /db_xref="PDB:2LQC" /db_xref="PDB:3G43" /db_xref="PDB:3OXQ" /db_xref="PDB:5V2P" /db_xref="PDB:5V2Q" /db_xref="PDB:6C0A" /db_xref="PDB:6DAD" /db_xref="PDB:6DAE" /db_xref="PDB:6DAF" /db_xref="UniProtKB/Swiss-Prot:Q13936" /experiment="experimental evidence, no additional details recorded" /protein_id="CAA84342.1" /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS DGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNAL SLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHV SYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNA NINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQA AMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQ SPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLL QRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAE TTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKF IEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEED AGCVRARGAPSEEELQDSRVYVSSL" exon <1..49 /number=1 exon 50..371 /number=2 exon 372..477 /number=3 exon 478..617 /number=4 exon 618..757 /number=5 exon 758..916 /number=6 exon 917..1113 /number=7 exon 1114..1216 /number=8 exon 1217..1390 /number=9 exon 1391..1481 /number=10 exon 1482..1508 /number=11 exon 1509..1669 /number=12 exon 1670..1895 /number=13 exon 1896..2103 /number=14 exon 2104..2224 /number=15 exon 2225..2339 /number=16 exon 2340..2460 /number=17 exon 2461..2530 /number=18 exon 2531..2663 /number=19 exon 2664..2793 /number=20 exon 2794..2853 /number=21 /note="alternative" exon 2854..2965 /number=23 exon 2966..3048 /number=24 exon 3049..3156 /number=25 exon 3157..3209 /number=26 exon 3210..3356 /number=27 exon 3357..3558 /number=28 exon 3559..3717 /number=29 exon 3718..3828 /number=30 exon 3829..3912 /number=32 /note="alternative" exon 3913..3945 /number=33 /note="alternative" exon 3946..4074 /number=34 exon 4075..4140 /number=35 exon 4141..4232 /number=36 exon 4233..4398 /number=37 exon 4399..4526 /number=38 exon 4527..4623 /number=39 exon 4624..4726 /number=40 exon 4727..4885 /number=41 /note="brain-specific exon 41A; extended by 57 nt upstream of alternative splice acceptor site" exon 4886..5013 /number=42 exon 5014..5148 /number=43 exon 5149..5501 /number=44 exon 5502..5630 /number=46 exon 5631..5737 /number=47 exon 5738..5841 /number=48 exon 5842..6174 /number=49 exon 6175..>6572 /number=50 3'UTR 6472..6572 BASE COUNT 1475 a 1944 c 1776 g 1377 t ORIGIN 1 atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat 61 gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct 121 gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg 181 caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag 241 cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg 301 ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt 361 gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc 421 ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa 481 cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc 541 tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt 601 ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg 661 gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc 721 gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc 781 atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc 841 atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac 901 caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg 961 ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag 1021 cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc 1081 accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg 1141 ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt 1201 ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat 1261 ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg 1321 atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag 1381 ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct 1441 ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca 1501 aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca 1561 gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc 1621 attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac 1681 aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg 1741 caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc 1801 ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga 1861 tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg 1921 gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc 1981 ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat 2041 gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt 2101 cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc 2161 ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga 2221 aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag 2281 agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg 2341 actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag 2401 gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag 2461 atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca 2521 gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga 2581 ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt 2641 ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg 2701 atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag 2761 gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt 2821 accaccattt tcaccattga aattgctctg aagatgactg cttatggggc tttcttgcac 2881 aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc 2941 ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg 3001 cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag 3061 tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag 3121 ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac 3181 agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag 3241 gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat 3301 gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg 3361 ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg 3421 gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc 3481 ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt 3541 gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg 3601 aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac 3661 ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac 3721 tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc 3781 ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaagca ctatttctgt 3841 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc 3901 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac 3961 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg 4021 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg 4081 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag 4141 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag 4201 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac 4261 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc 4321 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac 4381 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac 4441 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc 4501 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc 4561 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc 4621 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc 4681 accctgtttg ccctggtcag gacggccctg aggatcaaaa cagaagaggg acccagccca 4741 tcagaggccc accaaggggc tgaggatcct ttccgccctg cagggaacct agaacaagcc 4801 aatgaggagc tgcgggcgat catcaagaag atctggaagc ggaccagcat gaagctgctg 4861 gaccaggtgg tgccccctgc aggtgatgat gaggtcaccg ttggcaagtt ctacgccacg 4921 ttcctgatcc aggagtactt ccggaagttc aagaagcgca aagagcaggg ccttgtgggc 4981 aagccctccc agaggaacgc gctgtctctg caggctggct tgcgcacact gcatgacatc 5041 gggcctgaga tccgacgggc catctctgga gatctcaccg ctgaggagga gctggacaag 5101 gccatgaagg aggctgtgtc cgctgcttct gaagatgaca tcttcaggag ggccggtggc 5161 ctgttcggca accacgtcag ctactaccaa agcgacggcc ggagcgcctt cccccagacc 5221 ttcaccactc agcgcccgct gcacatcaac aaggcgggca gcagccaggg cgacactgag 5281 tcgccatccc acgagaagct ggtggactcc accttcaccc cgagcagcta ctcgtccacc 5341 ggctccaacg ccaacatcaa caacgccaac aacaccgccc tgggtcgcct ccctcgcccc 5401 gccggctacc ccagcacggt cagcactgtg gagggccacg ggcccccctt gtcccctgcc 5461 atccgggtgc aggaggtggc gtggaagctc agctccaaca ggtgccactc ccgggagagc 5521 caggcagcca tggcgggtca ggaggagacg tctcaggatg agacctatga agtgaagatg 5581 aaccatgaca cggaggcctg cagtgagccc agcctgctct ccacagagat gctctcctac 5641 caggatgacg aaaatcggca actgacgctc ccagaggagg acaagaggga catccggcaa 5701 tctccgaaga ggggtttcct ccgctctgcc tcactaggtc gaagggcctc cttccacctg 5761 gaatgtctga agcgacagaa ggaccgaggg ggagacatct ctcagaagac agtcctgccc 5821 ttgcatctgg ttcatcatca ggcattggca gtggcaggcc tgagccccct cctccagaga 5881 agccattccc ctgcctcatt ccctaggcct tttgccaccc caccagccac acctggcagc 5941 cgaggctggc ccccacagcc cgtccccacc ctgcggcttg agggggtcga gtccagtgag 6001 aaactcaaca gcagcttccc atccatccac tgcggctcct gggctgagac cacccccggt 6061 ggcgggggca gcagcgccgc ccggagagtc cggcccgtct ccctcatggt gcccagccag 6121 gctggggccc cagggaggca gttccacggc agtgccagca gcctggtgga agcggtcttg 6181 atttcagaag gactggggca gtttgctcaa gatcccaagt tcatcgaggt caccacccag 6241 gagctggccg acgcctgcga catgaccata gaggagatgg agagcgcggc cgacaacatc 6301 ctcagcgggg gcgccccaca gagccccaat ggcgccctct taccctttgt gaactgcagg 6361 gacgcggggc aggaccgagc cgggggcgag gaggacgcgg gctgtgtgcg cgcgcggggt 6421 gcaccgagtg aggaggagct ccaggacagc agggtctacg tcagcagcct gtagtgggcg 6481 ctgccagatg cgggcttttt tttttttatt tgtttcaatg ttcctaatgg gttcgtttca 6541 gaagtgcctc actgttctcg tgacctggag tt //