LOCUS Z28339 2694 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for delta 4-3-oxosteroid 5 beta-reductase.
ACCESSION Z28339
VERSION Z28339.1
KEYWORDS delta 4-3-oxosteroid 5 beta-reductase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2694)
AUTHORS Kondo K.H., Kai M.H., Setoguchi Y., Eggertsen G., Sjoblom P.,
Setoguchi T., Okuda K.T., Bjorkhem I.
TITLE Cloning and expression of cDNA of human delta 4-3-oxosteroid 5
beta-reductase and substrate specificity of the expressed enzyme
JOURNAL Eur. J. Biochem. 219(1-2), 357-363(1994).
PUBMED 7508385
REFERENCE 2 (bases 1 to 2694)
AUTHORS Kondo K.
JOURNAL Submitted (18-NOV-1993) to the INSDC. Kazu-Hiro kondo, Surgery 1,
Miyazaki Medical College, 5200 Kiwara, Kiyotake, Miyazaki,
Miyazaki, 889-16, Japan
FEATURES Location/Qualifiers
source 1..2694
/db_xref="H-InvDB:HIT000326833"
/organism="Homo sapiens"
/strain="mongolian"
/isolate="patient 92100"
/mol_type="mRNA"
/clone_lib="pBluescript"
/clone="pH5bR"
/tissue_type="liver"
/db_xref="taxon:9606"
CDS 70..1050
/product="delta 4-3-oxosteroid 5 beta-reductase"
/EC_number="1.3.1.23"
/db_xref="GOA:P51857"
/db_xref="H-InvDB:HIT000326833.14"
/db_xref="HGNC:HGNC:388"
/db_xref="InterPro:IPR018170"
/db_xref="InterPro:IPR020471"
/db_xref="InterPro:IPR023210"
/db_xref="InterPro:IPR036812"
/db_xref="PDB:3BUR"
/db_xref="PDB:3BUV"
/db_xref="PDB:3BV7"
/db_xref="PDB:3CAQ"
/db_xref="PDB:3CAS"
/db_xref="PDB:3CAV"
/db_xref="PDB:3CMF"
/db_xref="PDB:3COT"
/db_xref="PDB:3DOP"
/db_xref="PDB:3G1R"
/db_xref="PDB:3UZW"
/db_xref="PDB:3UZX"
/db_xref="PDB:3UZY"
/db_xref="PDB:3UZZ"
/db_xref="UniProtKB/Swiss-Prot:P51857"
/protein_id="CAA82193.1"
/translation="MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVA
IDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTL
ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDA
GLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITA
YSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFN
LERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDEY"
regulatory 2669..2674
/regulatory_class="polyA_signal_sequence"
BASE COUNT 865 a 520 c 573 g 736 t
ORIGIN
1 ccctaggaca cctttctaaa aagactccct gtggtgttca gaatcactcc tacagtcagg
61 ttctccacaa tggatctcag tgctgcaagt caccgcatac ctctaagtga tggaaacagc
121 attcccatca tcggacttgg tacctactca gaacctaaat cgacccctaa gggagcctgt
181 gcaacatcgg tgaaggttgc tattgacaca gggtaccgac atattgatgg ggcctacatc
241 taccaaaatg aacacgaagt tggggaggcc atcagggaga agatagcaga aggaaaggtg
301 cggagggaag atatcttcta ctgtggaaag ctatgggcta caaatcatgt cccagagatg
361 gtccgcccaa ccctggagag gacactcagg gtcctccagc tagattatgt ggatctttac
421 atcattgaag tacccatggc ctttaagcca ggagatgaaa tataccctag agatgagaat
481 ggcaaatggt tatatcacaa gtcaaatctg tgtgccactt gggaggcgat ggaagcttgc
541 aaagacgctg gcttggtgaa atccctggga gtgtccaatt ttaaccgcag gcagctggag
601 ctcatcctga acaagccagg actcaaacac aagccagtca gcaaccaggt tgagtgccat
661 ccgtatttca cccagccaaa actcttgaaa ttttgccaac aacatgacat tgtcattact
721 gcatatagcc ctttggggac cagtaggaat ccaatctggg tgaatgtttc ttctccacct
781 ttgttaaagg atgcacttct aaactcattg gggaaaaggt acaataagac agcagctcaa
841 attgttttgc gtttcaacat ccagcgaggg gtggttgtca ttcctaaaag ctttaatctt
901 gaaaggatca aagaaaattt tcagatcttt gacttttctc tcactgaaga agaaatgaag
961 gacattgaag ccttgaataa aaatgtccgc tttgtagaat tgctcatgtg gcgcgatcat
1021 cctgaatacc catttcatga tgaatactga ctgccgggag ttcctgaaca gatttttcac
1081 tcccatgagt gccaagacgg tgcaatgggt agtcccctag atgtgaaaat gaagagagag
1141 ggttttacca tcctgagaag aaataatgat ggaaacatgt ttaatgtttg tgcagtgtaa
1201 atgactttga ctcagtcaca ttgaagtaaa aatattaaaa tctgttgaaa taactcttag
1261 gaaattatca actaattttt tcagatcagt atcttctaga ttccagacag aaaaaaatta
1321 cacttcagaa aagacatcaa aggcaacata tgacaacaag taatttatga atctgggtag
1381 tagcgttggt aatctgagtt ctttaagggt tcacaggaca acgaagtgca tgtggcagtg
1441 tgctggcagt ggccttgagg ctttggacca ttggttacaa aacagacaca gccaagataa
1501 gatccacaca cacattatta acaaggaagt gatttgctgc accttgagtt gagaggacta
1561 catgtagaaa agtcttaaaa tagagctaaa caccacagtg gtcaacaaag ccatcataat
1621 gttggtgttt gtttccctcc aatgtatgta tgtttagttt ttatccaacc tgaggaatga
1681 aaacttaact ggatctctct tgcatcctta aagggcctga gtctcaacat ggctgctgat
1741 ccatacttac acatcttact gtcaatcttg cctacattga ttatagaacc actattacgt
1801 gaaaaggctt gaaacaacca acatatacaa ataaaaccct gccttgtaaa atagtaaaag
1861 agaagccata tattggcttt tcttcttaac ttgggagata tattgaaaca aggtgcttta
1921 taagattatt gtacttaaga ctttaatagt gttacttgga tagcttatat gaattttgag
1981 aattttatat gaattttgag aaagcaagtt caaaagaact ctggtaattt tcctgtatgt
2041 acaatttaaa gagtgaataa gattattaga attcagcaat agagatatat ctattttcaa
2101 ttcaactaca gaaatatatt ttattggccg ggtgcggtgg ctcatgccta taatcccagc
2161 actttgggag gccaaggtgg gcagatcagg aggtcaggag atcgagacca tcttggctaa
2221 caaggtgaaa ccccgtctct actaaaaata caaaaaatta gccaggcgcg gtggcggggg
2281 cctgtaatcc cagctactca ggaggctgag gcagaagaat ggcatgaacc cgggaggagg
2341 agcttgcagt gagccgagat agcgccactg cagtccggcc tgggtgaaag agcgagactc
2401 cgtctcaaaa acaaaaaaaa aaaagaaaag aaatatattt tattcattca cattaggtca
2461 ctgtcatact gtcataggct gagagagttc ttcaaaaatt atgttttccc aagatcagtt
2521 gcttatagat aatgttcaat gacctcaaga catatatttt tgagaaatta tcattttaaa
2581 aaatttggtc tatactgatt gttttcactg attccaatat tattacttat aacactgacc
2641 tctggaaaat attttgttca caagaaataa taaagtataa tgatttgttg catc
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