LOCUS Z26652 3422 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for FLT3 receptor tyrosine kinase precursor (FLT3
gene).
ACCESSION Z26652 S64785
VERSION Z26652.1
KEYWORDS FLT3 gene; FLT3 receptor tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3422)
AUTHORS Rosnet O., Schiff C., Pebusque M.J., Marchetto S., Tonnelle C.,
Toiron Y., Birg F., Birnbaum D.
TITLE Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic
cells
JOURNAL Blood 82(4), 1110-1119(1993).
PUBMED 8394751
REFERENCE 2 (bases 1 to 3422)
AUTHORS Rosnet O.
JOURNAL Submitted (04-OCT-1993) to the INSDC. Rosnet O., Inserm U119, 27,
bd. Lei Roure, Marseille, FRANCE.
COMMENT data in S64785
FEATURES Location/Qualifiers
source 1..3422
/db_xref="H-InvDB:HIT000326767"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..2982
/gene="FLT3"
/product="FLT3 receptor tyrosine kinase precursor"
/db_xref="GOA:P36888"
/db_xref="H-InvDB:HIT000326767.12"
/db_xref="HGNC:HGNC:3765"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001824"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR013151"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR030118"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1RJB"
/db_xref="PDB:3QS7"
/db_xref="PDB:3QS9"
/db_xref="PDB:4RT7"
/db_xref="PDB:4XUF"
/db_xref="PDB:5X02"
/db_xref="PDB:6IL3"
/db_xref="UniProtKB/Swiss-Prot:P36888"
/protein_id="CAA81393.1"
/translation="MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNND
SSVGKSSSYPMVSESPEDLGCALRPQSSGTVYERAAVEVDVSASITLQVLVDAPGNIS
CLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSI
RNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEE
KVLHELFGMDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVH
VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSK
HPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPC
EQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQA
SCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIK
GFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKY
KKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKV
MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT
LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGS
REVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKG
MEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMA
PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYA
TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNR
RPFSREMDLGLLSPQAQVEDS"
sig_peptide 1..69
mat_peptide 70..2979
/product="FLT3 receptor tyrosine kinase"
3'UTR 2983..3422
regulatory 3401..3405
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1038 a 687 c 758 g 939 t
ORIGIN
1 atgccggcgt tggcgcgcga cggcggccag ctgccgctgc tcgttgtttt ttctgcaatg
61 atatttggga ctattacaaa tcaagatctg cctgtgatca agtgtgtttt aatcaatcat
121 aagaacaatg attcatcagt ggggaagtca tcatcatatc ccatggtatc agaatccccg
181 gaagacctcg ggtgtgcgtt gagaccccag agctcaggga cagtgtacga acgtgccgct
241 gtggaagtgg atgtatctgc ttccatcaca ctgcaagtgc tggtcgatgc cccagggaac
301 atttcctgtc tctgggtctt taagcacagc tccctgaatt gccagccaca ttttgattta
361 caaaacagag gagttgtttc catggtcatt ttgaaaatga cagaaaccca agctggagaa
421 tacctacttt ttattcagag tgaagctacc aattacacaa tattgtttac agtgagtata
481 agaaataccc tgctttacac attaagaaga ccttacttta gaaaaatgga aaaccaggac
541 gccctggtct gcatatctga gagcgttcca gagccgatcg tggaatgggt gctttgcgat
601 tcacaggggg aaagctgtaa agaagaaagt ccagctgttg ttaaaaagga ggaaaaagtg
661 cttcatgaat tatttgggat ggacataagg tgctgtgcca gaaatgaact gggcagggaa
721 tgcaccaggc tgttcacaat agatctaaat caaactcctc agaccacatt gccacaatta
781 tttcttaaag taggggaacc cttatggata aggtgcaaag ctgttcatgt gaaccatgga
841 ttcgggctca cctgggaatt agaaaacaaa gcactcgagg agggcaacta ctttgagatg
901 agtacctatt caacaaacag aactatgata cggattctgt ttgcttttgt atcatcagtg
961 gcaagaaacg acaccggata ctacacttgt tcctcttcaa agcatcccag tcaatcagct
1021 ttggttacca tcgtagaaaa gggatttata aatgctacca attcaagtga agattatgaa
1081 attgaccaat atgaagagtt ttgtttttct gtcaggttta aagcctaccc acaaatcaga
1141 tgtacgtgga ccttctctcg aaaatcattt ccttgtgagc aaaagggtct tgataacgga
1201 tacagcatat ccaagttttg caatcataag caccagccag gagaatatat attccatgca
1261 gaaaatgatg atgcccaatt taccaaaatg ttcacgctga atataagaag gaaacctcaa
1321 gtgctcgcag aagcatcggc aagtcaggcg tcctgtttct cggatggata cccattacca
1381 tcttggacct ggaagaagtg ttcagacaag tctcccaact gcacagaaga gatcacagaa
1441 ggagtctgga atagaaaggc taacagaaaa gtgtttggac agtgggtgtc gagcagtact
1501 ctaaacatga gtgaagccat aaaagggttc ctggtcaagt gctgtgcata caattccctt
1561 ggcacatctt gtgagacgat ccttttaaac tctccaggcc ccttcccttt catccaagac
1621 aacatctcat tctatgcaac aattggtgtt tgtctcctct tcattgtcgt tttaaccctg
1681 ctaatttgtc acaagtacaa aaagcaattt aggtatgaaa gccagctaca gatggtacag
1741 gtgaccggct cctcagataa tgagtacttc tacgttgatt tcagagaata tgaatatgat
1801 ctcaaatggg agtttccaag agaaaattta gagtttggga aggtactagg atcaggtgct
1861 tttggaaaag tgatgaacgc aacagcttat ggaattagca aaacaggagt ctcaatccag
1921 gttgccgtca aaatgctgaa agaaaaagca gacagctctg aaagagaggc actcatgtca
1981 gaactcaaga tgatgaccca gctgggaagc cacgagaata ttgtgaacct gctgggggcg
2041 tgcacactgt caggaccaat ttacttgatt tttgaatact gttgctatgg tgatcttctc
2101 aactatctaa gaagtaaaag agaaaaattt cacaggactt ggacagagat tttcaaggaa
2161 cacaatttca gtttttaccc cactttccaa tcacatccaa attccagcat gcctggttca
2221 agagaagttc agatacaccc ggactcggat caaatctcag ggcttcatgg gaattcattt
2281 cactctgaag atgaaattga atatgaaaac caaaaaaggc tggaagaaga ggaggacttg
2341 aatgtgctta catttgaaga tcttctttgc tttgcatatc aagttgccaa aggaatggaa
2401 tttctggaat ttaagtcgtg tgttcacaga gacctggccg ccaggaacgt gcttgtcacc
2461 cacgggaaag tggtgaagat atgtgacttt ggattggctc gagatatcat gagtgattcc
2521 aactatgttg tcaggggcaa tgcccgtctg cctgtaaaat ggatggcccc cgaaagcctg
2581 tttgaaggca tctacaccat taagagtgat gtctggtcat atggaatatt actgtgggaa
2641 atcttctcac ttggtgtgaa tccttaccct ggcattccgg ttgatgctaa cttctacaaa
2701 ctgattcaaa atggatttaa aatggatcag ccattttatg ctacagaaga aatatacatt
2761 ataatgcaat cctgctgggc ttttgactca aggaaacggc catccttccc taatttgact
2821 tcgtttttag gatgtcagct ggcagatgca gaagaagcga tgtatcagaa tgtggatggc
2881 cgtgtttcgg aatgtcctca cacctaccaa aacaggcgac ctttcagcag agagatggat
2941 ttggggctac tctctccgca ggctcaggtc gaagattcgt agaggaacaa tttagtttta
3001 aggacttcat ccctccacct atccctaaca ggctgtagat taccaaaaca agattaattt
3061 catcactaaa agaaaatcta ttatcaactg ctgcttcacc agacttttct ctagaagctg
3121 tctgcgttta ctcttgtttt caaagggact tttgtaaaat caaatcatcc tgtcacaagg
3181 caggaggagc tgataatgaa ctttattgga gcattgatct gcatccaagg ccttctcagg
3241 ctggcttgag tgaattgtgt acctgaagta cagtatattc ttgtaaatac ataaaacaaa
3301 agcattttgc taaggagaag ctaatatgat tttttaagtc tatgttttaa aataatatgt
3361 aaatttttca gctatttagt gatatatttt atgggtggga ataaaatttc taccgaggat
3421 cc
//