LOCUS Z26317 3516 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for desmoglein 2.
ACCESSION Z26317 S64273
VERSION Z26317.1
KEYWORDS desmoglein; desmoglein type 2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3516)
AUTHORS Schaefer S., Troyanovsky S.J., Heid H.W., Eshkind L., Koch P.J.,
Franke W.W.
TITLE Cytoskeletal architecture and epithelial differentiation: Molecular
determinations of cell interactions cytoskeletal filament anchorage
JOURNAL C. R. Seances Acad. Sci. III 316, 1316-1323(1993).
REFERENCE 2 (bases 1 to 1987)
AUTHORS Koch P.J., Goldschmidt M.D., Walsh M.J., Zimbelmann R., Franke W.W.
TITLE Complete amino acid sequence of the epidermal desmoglein precursor
polypeptide and identification of a second type of desmoglein gene
JOURNAL Eur. J. Cell Biol. 55(2), 200-208(1991).
PUBMED 1935985
REFERENCE 3 (bases 1 to 3516)
AUTHORS Zimbelmann R.
JOURNAL Submitted (16-SEP-1993) to the INSDC. Zimbelmann R., German Cancer
Research Center, Division of Cell Biology, Im Neuenheimer Feld 280,
69120 Heidelberg, Fed. Rep. of Germany
REFERENCE 4 (bases 1 to 3516)
AUTHORS Schafer S., Koch P.J., Franke W.W.
TITLE Identification of the ubiquitous human desmoglein, Dsg2, and the
expression catalogue of the desmoglein subfamily of desmosomal
cadherins
JOURNAL Exp. Cell Res. 211(2), 391-399(1994).
PUBMED 8143788
FEATURES Location/Qualifiers
source 1..3516
/db_xref="H-InvDB:HIT000326726"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="Colon Carcinoma CaCo2 cDNA library"
/clone="hdsg2"
/cell_line="Colon Carcinoma CaCo2"
/db_xref="taxon:9606"
CDS 12..3365
/product="desmoglein 2"
/db_xref="GOA:Q14126"
/db_xref="H-InvDB:HIT000326726.14"
/db_xref="HGNC:HGNC:3049"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR009122"
/db_xref="InterPro:IPR009123"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="PDB:2YQG"
/db_xref="PDB:5ERD"
/db_xref="PDB:5J5J"
/db_xref="PDB:6QNT"
/db_xref="PDB:6QNU"
/db_xref="UniProtKB/Swiss-Prot:Q14126"
/protein_id="CAA81226.1"
/translation="MARTRDRVRLLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLV
RQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFV
FNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQ
DVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGE
IYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVL
EGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT
LIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVI
SIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAK
LPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHD
AEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSE
IQFLISDNQGFSCPEKQVLTLTVCEVLHGSGCREAQHDSYVGLGPAAIALMILAFLLL
LLVPLLLLMCHCGKGAKAFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVG
RNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMT
TETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVY
SQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKP
ATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSR
QAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPAST
LVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQP
TLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFG
LEESGHSNSTITTSSTRVTKHSTVQHSYS"
mat_peptide 156..3362
/product="desmoglein 2"
BASE COUNT 1097 a 745 c 803 g 871 t
ORIGIN
1 tcgagggtgc gatggcgcgg acgcgggacc gcgtacgcct gctgcttctc ctgatctgct
61 ttaacgttgg aagtggactt cacttacagg tcttaagcac aagaaatgaa aataagctgc
121 ttcctaaaca tcctcattta gtgcggcaaa agcgcgcctg gatcaccgcc cccgtggctc
181 ttcgggaggg agaggatctg tccaagaaga atccaattgc caagatacat tctgatcttg
241 cagaagaaag aggactcaaa attacttaca aatacactgg aaaagggatt acagagccac
301 cttttggtat atttgtcttt aacaaagata ctggagaact gaatgttacc agcattcttg
361 atcgagaaga aacaccattt tttctgctaa caggttacgc tttggatgca agaggaaaca
421 atgtagagaa acccttagag ctacgcatta aggttcttga tatcaatgac aacgaaccag
481 tgttcacaca ggatgtcttt gttgggtctg ttgaagagtt gagtgcagca catactcttg
541 tgatgaaaat caatgcaaca gatgcagatg agcccaatac cctgaattcg aaaatttcct
601 atagaatcgt atctctggag cctgcttatc ctccagtgtt ctacctaaat aaagatacag
661 gagagattta tacaaccagt gttaccttgg acagagagga acacagcagc tacactttga
721 cagtagaagc aagagatggc aatggagaag ttacagacaa acctgtaaaa caagctcaag
781 ttcagattcg tattttggat gtcaatgaca atatacctgt agtagaaaat aaagtgcttg
841 aagggatggt tgaagaaaat caagtcaatg tagaagttac gcgcataaaa gtgttcgatg
901 cagatgaaat aggttctgat aattggctgg caaattttac atttgcatca ggaaatgaag
961 gaggttattt ccacatagaa acagatgctc aaactaacga aggaattgtg acccttatta
1021 aggaagtaga ttatgaagaa atgaagaatc ttgacttcag tgttattgtc gctaataaag
1081 cagcttttca caagtcgatt aggagtaaat acaagcctac acccattccc atcaaggtca
1141 aagtgaaaaa tgtgaaagaa ggcattcatt ttaaaagcag cgtcatctca atttatgtta
1201 gcgagagcat ggatagatca agcaaaggcc aaataattgg aaattttcaa gcttttgatg
1261 aggacactgg actaccagcc catgcaagat atgtaaaatt agaagataga gataattgga
1321 tctctgtgga ttctgtcaca tctgaaatta aacttgcaaa acttcctgat tttgaatcta
1381 gatatgttca aaatggcaca tacactgtaa agattgtggc catatcagaa gattatccta
1441 gaaaaaccat cactggcaca gtccttatca atgttgaaga catcaacgac aactgtccca
1501 cactgataga gcctgtgcag acaatctgtc acgatgcaga gtatgtgaat gttactgcag
1561 aggacctgga tggacaccca aacagtggcc ctttcagttt ctccgtcatt gacaaaccac
1621 ctggcatggc agaaaaatgg aaaatagcac gccaagaaag taccagtgtg ctgctgcaac
1681 aaagtgagaa aaagcttggg agaagtgaaa ttcagttcct gatttcagac aatcagggtt
1741 ttagttgtcc tgaaaagcag gtccttacac tcacagtttg tgaggttctg catggcagcg
1801 gctgcaggga agcacagcat gactcctatg tgggcctggg acccgcagca attgcgctca
1861 tgattttggc ctttctgctc ctgctattgg taccactttt actgctgatg tgccattgcg
1921 gaaagggcgc caaagcgttt acccccatac ctggcaccat agagatgctg catccttgga
1981 ataatgaagg agcaccacct gaagacaagg tggtgccatc atttctgcca gtggatcaag
2041 ggggcagtct agtaggaaga aatggagtag gaggtatggc caaggaagcc acgatgaaag
2101 gaagtagctc tgcttccatt gtcaaagggc aacatgagat gtccgagatg gatggaaggt
2161 gggaagaaca cagaagcctg ctttctggta gagctaccca gtttacaggg gccacaggcg
2221 ctatcatgac cactgaaacc acgaagaccg caagggccac aggggcttcc agagacatgg
2281 ccggagctca ggcagctgct gttgcactga acgaagaatt cttaagaaat tatttcactg
2341 ataaagcggc ctcttacact gaggaagatg aaaatcacac agccaaagat tgccttctgg
2401 tttattctca ggaagaaact gaatcgctga atgcttctat tggttgttgc agttttattg
2461 aaggagagct agatgaccgc ttcttagatg atttgggact taaattcaag acgctagctg
2521 aagtttgcct gggtcaaaaa atagatataa ataaggaaat tgagcagaga caaaaacctg
2581 ccacagaaac aagtatgaac acagcttcac attcactctg tgagcaaact atggttaatt
2641 cagagaatac ctactcctct ggcagtagct tcccagttcc aaaatctttg caagaagcca
2701 atgcagagaa agtaactcag gaaatagtca ctgaaagatc tgtgtcttct aggcaggcgc
2761 aaaaggtagc tacacctctt cctgacccaa tggcttctag aaatgtgata gcaacagaaa
2821 cttcctatgt cacagggtcc actatgccac caaccactgt gatcctgggt cctagccagc
2881 cacagagcct tattgtgaca gagagggtgt atgctccagc ttctaccttg gtagatcagc
2941 cttatgctaa tgaaggtaca gttgtggtca ctgaaagagt aatacagcct catgggggtg
3001 gatcgaatcc tctggaaggc actcagcatc ttcaagatgt accttacgtc atggtgaggg
3061 aaagagagag cttccttgcc cccagctcag gtgtgcagcc tactctggcc atgcctaata
3121 tagcagtagg acagaatgtg acagtgacag aaagagttct agcacctgct tccactctgc
3181 aatccagtta ccagattccc actgaaaatt ctatgacggc taggaacacc acggtgtctg
3241 gagctggagt ccctggccct ctgccagatt ttggtttaga ggaatctggt cattctaatt
3301 ctaccataac cacatcttcc accagagtca ccaagcatag cactgtacag cattcttact
3361 cctaaacagc agtcagccac aaactgaccc agagtttaat tagcagtgac taatttcatg
3421 tttccaatgt acctgatttt tcatgagcct tacagacaca cagagacaca tacacattga
3481 tcttaaaatt tttctcagtc actgatatgc aaagga
//