LOCUS Z22750 3240 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens GAD67 mRNA for glutamate decarboxylase.
ACCESSION Z22750
VERSION Z22750.1
KEYWORDS glutamate decarboxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3240)
AUTHORS Kelly C.D., Edwards Y., Johnstone A.P., Harfst E., Nogradi A.,
Nussey S.S., Povey S., Carter N.D.
TITLE Nucleotide sequence and chromosomal assignment of a cDNA encoding
the large isoform of human glutamate decarboxylase
JOURNAL Ann. Hum. Genet. 56(Pt 3), 255-265(1992).
PUBMED 1339255
REFERENCE 2 (bases 1 to 3240)
AUTHORS Johnstone A.
JOURNAL Submitted (13-MAY-1993) to the INSDC. Johnstone A., St. George's
Hospital Medical School, Cranmer Terrace, London, UK.
FEATURES Location/Qualifiers
source 1..3240
/db_xref="H-InvDB:HIT000326659"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 184..1968
/gene="GAD67"
/standard_name="Glutamic acid decarboxylase; GAD67"
/product="glutamate decarboxylase"
/function="directs the synthesis of active protein in
eukaryotic system"
/EC_number="4.1.1.15"
/db_xref="GOA:Q99259"
/db_xref="H-InvDB:HIT000326659.13"
/db_xref="HGNC:HGNC:4092"
/db_xref="InterPro:IPR002129"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR021115"
/db_xref="PDB:2OKJ"
/db_xref="PDB:3VP6"
/db_xref="UniProtKB/Swiss-Prot:Q99259"
/citation=[1]
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA80435.1"
/translation="MASSTPSSSATSSNAEPDPNTTNLRPTTYDTWCGVAHGCTRKLG
LKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARD
LLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSD
HPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLNSTANTNMFTYEI
APVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGM
AAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQK
GYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNG
IERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGD
KAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEP
EHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANLF
RMVISNPAATQSDIDFLIEEIERLGQDL"
old_sequence 200..207
/replace="cattt"
/note="sequencing error in publication"
/citation=[1]
misc_binding 1387..1398
/bound_moiety="pyridoxal phosphate"
/note="coding for pyridoxal phosphate binding site"
BASE COUNT 912 a 712 c 775 g 841 t
ORIGIN
1 tccgcagcag cctggaggtg acgccgggca gattacgcct gtcagggccg agccgaacgg
61 atcgctgggc gctgtgcaga ggaaaggcgg gagtgcccgg ctcgctgtcg cagagccgag
121 cctgtttctg cgccggacca gtcgaggact ctggacagta gaggccccgg gacgaccgag
181 ctgatggcgt cttcgacccc atcttcgtcc gcaacctcct cgaacgcgga accggacccc
241 aataccacta acctgcgccc cacaacgtac gatacctggt gcggcgtggc ccacggatgc
301 accagaaaac tgggcctcaa gatctgcggc ttcttgcaaa ggaccaacag cctggaggag
361 aagagtcgcc ttgtgagtgc cttcaaggag aggcaatcct ccaagaacct gctttcctgt
421 gaaaacagcg accgggatgc ccgcttccgg cgcacagaga ctgacttctc taatctgttt
481 gctagagatc tgcttccggc taagaacggt gaggagcaaa ccgtgcaatt cctcctggaa
541 gtggtggaca tactcctcaa ctatgtccgc aagacatttg atcgctccac caaggtgctg
601 gactttcatc acccacacca gttgctggaa ggcatggagg gcttcaactt ggagctctct
661 gaccaccccg agtctctgga gcagatcctg gttgactgca gagacacctt gaagtatggg
721 gttcgcacag gtcatcctcg atttttcaac cagctctcca ctggattgga tattattggc
781 ctagctggag aatggctgaa ctcaacggcc aataccaaca tgtttacata tgaaattgca
841 ccagtgtttg tcctcatgga acaaataaca cttaagaaga tgagagagat agttggatgg
901 tcaagtaaag atggtgatgg gatattttct cctgggggcg ccatatccaa catgtacagc
961 atcatggctg ctcgctacaa gtacttcccg gaagttaaga caaagggcat ggcggctgtg
1021 cctaaactgg tcctcttcac ctcagaacag agtcactatt ccataaagaa agctggggct
1081 gcacttggct ttggaactga caatgtgatt ttgataaagt gcaatgaaag ggggaaaata
1141 attccagctg attttgaggc aaaaattctt gaagccaaac agaagggata tgttcccttt
1201 tatgtcaatg caactgctgg cacgactgtt tatggagctt ttgatccgat acaagagatt
1261 gcagatatat gtgagaaata taacctttgg ttgcatgtcg atgctgcctg gggaggtggg
1321 ctgctcatgt ccaggaagca ccgccataaa ctcaacggca tagaaagggc caactcagtc
1381 acctggaacc ctcacaagat gatgggcgtg ctgttgcagt gctctgccat tctcgtcaag
1441 gaaaagggta tactccaagg atgcaaccag atgtgtgcag gatacctctt ccagccagac
1501 aagcagtatg atgtctccta cgacaccggg gacaaggcaa ttcagtgtgg ccgccacgtg
1561 gatatcttca agttctggct gatgtggaaa gcaaagggca cagtgggatt tgaaaaccag
1621 atcaacaaat gcctggagct ggctgaatac ctctatgcca agattaaaaa cagagaagaa
1681 tttgagatgg ttttcaatgg cgagcctgag cacacaaacg tctgtttttg gtatattcca
1741 caaagcctca ggggtgtgcc agacagccct caacgacggg aaaagctaca caaggtggct
1801 ccaaaaatca aagccctgat gatggagtca ggtacgacca tggttggcta ccagccccaa
1861 ggggacaagg ccaacttatt ccggatggtc atctccaacc cagccgctac ccagtctgac
1921 attgacttcc tcattgagga gatagaaaga ctgggccagg atctgtaatc attccttcgc
1981 agaaccataa gctttatggg aatggccttt tccctctggc acttccagaa caaacctcta
2041 tatgttgctg aaacacacag gccatttatt tgagggaaac ataatatctt gaagatatgt
2101 taaaccttac ttaagcttgt ttgttctagt tagcaggaaa tagtgttctt tttaaaaagt
2161 tgcacattag gaacagagta tatatgtaca gttatacata cctctctcta tatatacatg
2221 tatagtgagt gtggcttagt aatagatcac ggcatgtttc ccgctccaag agaattcact
2281 ttaccttcag cagttaccga ggagctaaac atgctgccaa ccagcttgtc caacaactcc
2341 aggaaaactg tttttcaaac gccatgtcct aggggccaag ggaaatgctg ttggtgagaa
2401 tcgacctcac tgtcagcgtt tctccacctg aaggtgatga tggatgagaa aacacaccaa
2461 tgacagtcac acctcccatt agtatctgtt aggggaaata gtagcagagt cattgttaca
2521 ggtgtactat ggctgtattt ttagagatta atttgtgtag attgtgtaaa ttcctgttgt
2581 ctgaccttgg tggtgggagg gggagactat gtgtcatgat ttcaatgatt gtttaattgt
2641 aggtcaatga aatatttgct tatttatatt cagagatgta ccatgttaaa gaggcgtctt
2701 gtattttctt cccatttgta atgtatctta tttatatatg aagtaagttc tgaaaactgt
2761 ttatggtatt ttcgtgcatt tgtgagccaa agagaaaaga ttaaaattag tgagatttgt
2821 atttatatta gagtgccctt aaataatgat taagcattta ctgtcgttaa gagaattcta
2881 agatggtaca taaagtcata tatatggaaa tcctgttact taaatagcat ctgctcttct
2941 cttacgctct ctgtctggct gtacgtctgg tgtgctcaat gcttttctag caactgttgg
3001 ataataacta gatctcctgt aattttgtag tagttgatga ccaatctctg tgactcgctt
3061 agctgaaacc taaggcaaca tttccgaaga cctcctgaag atctcagata aagtgaccag
3121 gctcacaact gtttttgaag aagggaaatt cacactgtgc gttttagagt atgcaagaag
3181 aatataaata aataaaaata ttctccatgg agaatttgaa caaaaaaaaa aaaaaaaaaa
//