LOCUS       Z15115                  3432 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  H.sapiens TOP2 mRNA for DNA topoisomerase II (partial).
ACCESSION   Z15115 S56813
VERSION     Z15115.1
KEYWORDS    DNA topoisomerase II; TOP2 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3432)
  AUTHORS   Austin C.A., Sng J.H., Patel S., Fisher L.M.
  TITLE     Novel HeLa topoisomerase II is the II beta isoform: complete coding
            sequence and homology with other type II topoisomerases
  JOURNAL   Biochim. Biophys. Acta 1172(3), 283-291(1993).
   PUBMED   8383537
REFERENCE   2
  AUTHORS   Chung T.D., Drake F.H., Tan K.B., Per S.R., Crooke S.T.,
            Mirabelli C.K.
  TITLE     Characterization and immunological identification of cDNA clones
            encoding two human DNA topoisomerase II isozymes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86(23), 9431-9435(1989).
   PUBMED   2556712
  REMARK    (sites)
REFERENCE   3
  AUTHORS   Austin C.A., Fisher L.M.
  TITLE     Isolation and characterization of a human cDNA clone encoding a
            novel DNA topoisomerase II homologue from HeLa cells
  JOURNAL   FEBS Lett. 266(1-2), 115-117(1990).
   PUBMED   2163884
  REMARK    (sites)
REFERENCE   4  (bases 1 to 3432)
  AUTHORS   Fisher L.
  JOURNAL   Submitted (14-SEP-1992) to the INSDC. Fisher L., St. George's
            Hospital Medical School, Cranmer Terrace, London, England.
FEATURES             Location/Qualifiers
     source          1..3432
                     /db_xref="H-InvDB:HIT000326537"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             <1..3096
                     /codon_start=1
                     /gene="TOP2"
                     /standard_name="topo II beta"
                     /product="DNA topoisomerase II"
                     /EC_number="5.99.1.3"
                     /note="C-terminal region of protein"
                     /note="Overlaps partial internal cDNA sequence of clones
                     SP11 (Chung et al,GenBank M27504) and CAA5 (Austin and
                     Fisher) and completes the 3' coding sequence of the enzyme
                     "
                     /db_xref="GOA:Q02880"
                     /db_xref="H-InvDB:HIT000326537.13"
                     /db_xref="HGNC:HGNC:11990"
                     /db_xref="InterPro:IPR001241"
                     /db_xref="InterPro:IPR002205"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR012542"
                     /db_xref="InterPro:IPR013506"
                     /db_xref="InterPro:IPR013757"
                     /db_xref="InterPro:IPR013758"
                     /db_xref="InterPro:IPR013759"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR018522"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="InterPro:IPR031660"
                     /db_xref="InterPro:IPR034157"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="PDB:3QX3"
                     /db_xref="PDB:4G0U"
                     /db_xref="PDB:4G0V"
                     /db_xref="PDB:4G0W"
                     /db_xref="PDB:4J3N"
                     /db_xref="PDB:5GWI"
                     /db_xref="PDB:5GWJ"
                     /db_xref="PDB:5ZAD"
                     /db_xref="PDB:5ZEN"
                     /db_xref="PDB:5ZQF"
                     /db_xref="PDB:5ZRF"
                     /db_xref="UniProtKB/Swiss-Prot:Q02880"
                     /citation=[1]
                     /citation=[2]
                     /citation=[3]
                     /protein_id="CAA78821.1"
                     /translation="TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGT
                     STAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR
                     LHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCF
                     KRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGT
                     RLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLI
                     NGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYA
                     VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTV
                     KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFD
                     LRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGY
                     ESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEE
                     LIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGK
                     VGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEE
                     FSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPW
                     SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLE
                     ELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKASPEKSLHDKKSQDFGNLFSFP
                     SYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKR
                     APKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKT
                     TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMF
                     N"
BASE COUNT         1187 a          573 c          741 g          931 t
ORIGIN      
        1 actcctattg taaaggcaag caaaaataag caggaacttt ccttctacag tattcctgaa
       61 tttgacgaat ggaaaaaaca tatagaaaac cagaaagcct ggaaaataaa gtactataaa
      121 ggattgggta ctagtacagc taaagaagca aaggaatatt ttgctgatat ggaaaggcat
      181 cgcatcttgt ttagatatgc tggtcctgaa gatgatgctg ccattacctt ggcatttagt
      241 aagaagaaga ttgatgacag aaaagaatgg ttaacaaatt ttatggaaga ccggagacag
      301 cgtaggctac atggcttacc agagcaattt ttatatggta ctgcaacaaa gcatttgact
      361 tataatgatt tcatcaacaa ggaattgatt ctcttctcaa actcagacaa tgaaagatct
      421 ataccatctc ttgttgatgg ctttaaacct ggccagcgga aagttttatt tacctgtttc
      481 aagaggaatg ataaacgtga agtaaaagtt gcccagttgg ctggctctgt tgctgagatg
      541 tcggcttatc atcatggaga acaagcattg atgatgacta ttgtgaattt ggctcagaac
      601 tttgtgggaa gtaacaacat taacttgctt cagcctattg gtcagtttgg aactcggctt
      661 catggtggca aagatgctgc aagccctcgt tatattttca caatgttaag cactttagca
      721 aggctacttt ttcctgctgt ggatgacaac ctccttaagt tcctttatga tgataatcaa
      781 cgtgtagagc ctgagtggta tattcctata attcccatgg ttttaataaa tggtgctgag
      841 ggcattggta ctggatgggc ttgtaaacta cccaactatg atgctaggga aattgtgaac
      901 aatgtcagac gaatgctaga tggcctggat cctcatccca tgcttccaaa ctacaaaaac
      961 tttaaaggca cgattcaaga acttggtcaa aaccagtatg cagtcagtgg tgaaatattt
     1021 gtagtggaca gaaacacagt agaaattaca gagcttccag ttagaacttg gacacaggta
     1081 tataaagaac aggttttaga acctatgcta aatggaacag ataaaacacc agcattaatt
     1141 tctgattata aagaatatca tactgacaca actgtgaaat ttgtggtgaa aatgactgaa
     1201 gagaaactag cacaagcaga agctgctgga ctgcataaag tttttaaact tcaaactact
     1261 cttacttgta attccatggt actttttgat catatgggat gtctgaagaa atatgaaact
     1321 gtgcaagaca ttctgaaaga attctttgat ttacgattaa gttattacgg tttacgtaag
     1381 gagtggcttg tgggaatgtt gggagcagaa tctacaaagc ttaacaatca agcccgtttc
     1441 attttagaga agatacaagg gaaaattact atagagaata ggtcaaagaa agatttgatt
     1501 caaatgttag tccagagagg ttatgaatct gacccagtga aagcctggaa agaagcacaa
     1561 gaaaaggcag cagaagagga tgaaacacaa aaccagcatg atgatagttc ctccgattca
     1621 ggaactcctt caggcccaga ttttaattat attttaaata tgtctctgtg gtctcttact
     1681 aaagaaaaag ttgaagaact gattaaacag agagatgcaa aagggcgaga ggtcaatgat
     1741 cttaaaagaa aatctccttc agatctttgg aaagaggatt tagcggcatt tgttgaagaa
     1801 ctggataaag tggaatctca agaacgagaa gatgttctgg ctggaatgtc tggaaaagca
     1861 attaaaggta aagttggcaa acctaaggtg aagaaactcc agttggaaga gacaatgccc
     1921 tcaccttatg gcagaagaat aattcctgaa attacagcta tgaaggcaga tgccagcaaa
     1981 aagttgctga agaagaagaa gggtgatctt gatactgcag cagtaaaagt ggaatttgat
     2041 gaagaattca gtggagcacc agtagaaggt gcaggagaag aggcattgac tccatcagtt
     2101 cctataaata aaggtcccaa acctaagagg gagaagaagg agcctggtac cagagtgaga
     2161 aaaacaccta catcatctgg taaacctagt gcaaagaaag tgaagaaacg gaatccttgg
     2221 tcagatgatg aatccaagtc agaaagtgat ttggaagaaa cagaacctgt ggttattcca
     2281 agagattctt tgcttaggag agcagcagcc gaaagaccta aatacacatt tgatttctca
     2341 gaagaagagg atgatgatgc tgatgatgat gatgatgaca ataatgattt agaggaattg
     2401 aaagttaaag catctcccat aacaaatgat ggggaagatg aatttgttcc ttcagatggg
     2461 ttagataaag atgaatatac attttcacca ggcaaatcaa aagccagtcc agaaaaatct
     2521 ttgcatgaca aaaaaagtca ggattttgga aatctcttct catttccttc atattctcag
     2581 aagtcagaag atgattcagc taaatttgac agtaatgaag aagattctgc ttctgttttt
     2641 tcaccatcat ttggtctgaa acagacagat aaagttccaa gtaaaacggt agctgctaaa
     2701 aagggaaaac cgtcttcaga tacagtccct aagcccaaga gagccccaaa acagaagaaa
     2761 gtagtagagg ctgtaaactc tgactcggat tcagaatttg gcattccaaa gaagactaca
     2821 acaccaaaag gtaaaggccg aggggcaaag aaaaggaaag catctggctc tgaaaatgaa
     2881 ggcgattata accctggcag gaaaacatcc aaaacaacaa gcaagaaacc gaagaagaca
     2941 tcttttgatc aggattcaga tgtggacatc ttcccctcag acttccctac tgagccacct
     3001 tctctgccac gaaccggtcg ggctaggaaa gaagtaaaat attttgcaga gtctgatgaa
     3061 gaagaagatg atgttgattt tgcaatgttt aattaagtgc ccaaagagca caaacatttt
     3121 tcaacaaata tcttgtgttg tccttttgtc ttctctgtct cagacttttg tacatctggc
     3181 ttattttaat gtgatgatgt aattgacggt tttttattat tgtggtaggc cttttaacat
     3241 tttgttctta cacatacagt tttatgctct tttttactca ttgaaatgtc acgtactgtc
     3301 tgattggctt gtagaattgt tatagactgc cgtgcattag cacagatttt aattgtcatg
     3361 gttacaaact acagacctgc tttttgaaat gaaatttaaa cattaaaaat ggaactgtga
     3421 aaaaccgaat tc
//