LOCUS Z15115 3432 bp mRNA linear HUM 18-APR-2005 DEFINITION H.sapiens TOP2 mRNA for DNA topoisomerase II (partial). ACCESSION Z15115 S56813 VERSION Z15115.1 KEYWORDS DNA topoisomerase II; TOP2 gene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3432) AUTHORS Austin C.A., Sng J.H., Patel S., Fisher L.M. TITLE Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases JOURNAL Biochim. Biophys. Acta 1172(3), 283-291(1993). PUBMED 8383537 REFERENCE 2 AUTHORS Chung T.D., Drake F.H., Tan K.B., Per S.R., Crooke S.T., Mirabelli C.K. TITLE Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86(23), 9431-9435(1989). PUBMED 2556712 REMARK (sites) REFERENCE 3 AUTHORS Austin C.A., Fisher L.M. TITLE Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells JOURNAL FEBS Lett. 266(1-2), 115-117(1990). PUBMED 2163884 REMARK (sites) REFERENCE 4 (bases 1 to 3432) AUTHORS Fisher L. JOURNAL Submitted (14-SEP-1992) to the INSDC. Fisher L., St. George's Hospital Medical School, Cranmer Terrace, London, England. FEATURES Location/Qualifiers source 1..3432 /db_xref="H-InvDB:HIT000326537" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS <1..3096 /codon_start=1 /gene="TOP2" /standard_name="topo II beta" /product="DNA topoisomerase II" /EC_number="5.99.1.3" /note="C-terminal region of protein" /note="Overlaps partial internal cDNA sequence of clones SP11 (Chung et al,GenBank M27504) and CAA5 (Austin and Fisher) and completes the 3' coding sequence of the enzyme " /db_xref="GOA:Q02880" /db_xref="H-InvDB:HIT000326537.13" /db_xref="HGNC:HGNC:11990" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR012542" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR031660" /db_xref="InterPro:IPR034157" /db_xref="InterPro:IPR036890" /db_xref="PDB:3QX3" /db_xref="PDB:4G0U" /db_xref="PDB:4G0V" /db_xref="PDB:4G0W" /db_xref="PDB:4J3N" /db_xref="PDB:5GWI" /db_xref="PDB:5GWJ" /db_xref="PDB:5ZAD" /db_xref="PDB:5ZEN" /db_xref="PDB:5ZQF" /db_xref="PDB:5ZRF" /db_xref="UniProtKB/Swiss-Prot:Q02880" /citation=[1] /citation=[2] /citation=[3] /protein_id="CAA78821.1" /translation="TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGT STAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR LHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCF KRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGT RLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLI NGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYA VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTV KFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFD LRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGY ESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEE LIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGK VGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEE FSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPW SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLE ELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKASPEKSLHDKKSQDFGNLFSFP SYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKR APKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKT TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMF N" BASE COUNT 1187 a 573 c 741 g 931 t ORIGIN 1 actcctattg taaaggcaag caaaaataag caggaacttt ccttctacag tattcctgaa 61 tttgacgaat ggaaaaaaca tatagaaaac cagaaagcct ggaaaataaa gtactataaa 121 ggattgggta ctagtacagc taaagaagca aaggaatatt ttgctgatat ggaaaggcat 181 cgcatcttgt ttagatatgc tggtcctgaa gatgatgctg ccattacctt ggcatttagt 241 aagaagaaga ttgatgacag aaaagaatgg ttaacaaatt ttatggaaga ccggagacag 301 cgtaggctac atggcttacc agagcaattt ttatatggta ctgcaacaaa gcatttgact 361 tataatgatt tcatcaacaa ggaattgatt ctcttctcaa actcagacaa tgaaagatct 421 ataccatctc ttgttgatgg ctttaaacct ggccagcgga aagttttatt tacctgtttc 481 aagaggaatg ataaacgtga agtaaaagtt gcccagttgg ctggctctgt tgctgagatg 541 tcggcttatc atcatggaga acaagcattg atgatgacta ttgtgaattt ggctcagaac 601 tttgtgggaa gtaacaacat taacttgctt cagcctattg gtcagtttgg aactcggctt 661 catggtggca aagatgctgc aagccctcgt tatattttca caatgttaag cactttagca 721 aggctacttt ttcctgctgt ggatgacaac ctccttaagt tcctttatga tgataatcaa 781 cgtgtagagc ctgagtggta tattcctata attcccatgg ttttaataaa tggtgctgag 841 ggcattggta ctggatgggc ttgtaaacta cccaactatg atgctaggga aattgtgaac 901 aatgtcagac gaatgctaga tggcctggat cctcatccca tgcttccaaa ctacaaaaac 961 tttaaaggca cgattcaaga acttggtcaa aaccagtatg cagtcagtgg tgaaatattt 1021 gtagtggaca gaaacacagt agaaattaca gagcttccag ttagaacttg gacacaggta 1081 tataaagaac aggttttaga acctatgcta aatggaacag ataaaacacc agcattaatt 1141 tctgattata aagaatatca tactgacaca actgtgaaat ttgtggtgaa aatgactgaa 1201 gagaaactag cacaagcaga agctgctgga ctgcataaag tttttaaact tcaaactact 1261 cttacttgta attccatggt actttttgat catatgggat gtctgaagaa atatgaaact 1321 gtgcaagaca ttctgaaaga attctttgat ttacgattaa gttattacgg tttacgtaag 1381 gagtggcttg tgggaatgtt gggagcagaa tctacaaagc ttaacaatca agcccgtttc 1441 attttagaga agatacaagg gaaaattact atagagaata ggtcaaagaa agatttgatt 1501 caaatgttag tccagagagg ttatgaatct gacccagtga aagcctggaa agaagcacaa 1561 gaaaaggcag cagaagagga tgaaacacaa aaccagcatg atgatagttc ctccgattca 1621 ggaactcctt caggcccaga ttttaattat attttaaata tgtctctgtg gtctcttact 1681 aaagaaaaag ttgaagaact gattaaacag agagatgcaa aagggcgaga ggtcaatgat 1741 cttaaaagaa aatctccttc agatctttgg aaagaggatt tagcggcatt tgttgaagaa 1801 ctggataaag tggaatctca agaacgagaa gatgttctgg ctggaatgtc tggaaaagca 1861 attaaaggta aagttggcaa acctaaggtg aagaaactcc agttggaaga gacaatgccc 1921 tcaccttatg gcagaagaat aattcctgaa attacagcta tgaaggcaga tgccagcaaa 1981 aagttgctga agaagaagaa gggtgatctt gatactgcag cagtaaaagt ggaatttgat 2041 gaagaattca gtggagcacc agtagaaggt gcaggagaag aggcattgac tccatcagtt 2101 cctataaata aaggtcccaa acctaagagg gagaagaagg agcctggtac cagagtgaga 2161 aaaacaccta catcatctgg taaacctagt gcaaagaaag tgaagaaacg gaatccttgg 2221 tcagatgatg aatccaagtc agaaagtgat ttggaagaaa cagaacctgt ggttattcca 2281 agagattctt tgcttaggag agcagcagcc gaaagaccta aatacacatt tgatttctca 2341 gaagaagagg atgatgatgc tgatgatgat gatgatgaca ataatgattt agaggaattg 2401 aaagttaaag catctcccat aacaaatgat ggggaagatg aatttgttcc ttcagatggg 2461 ttagataaag atgaatatac attttcacca ggcaaatcaa aagccagtcc agaaaaatct 2521 ttgcatgaca aaaaaagtca ggattttgga aatctcttct catttccttc atattctcag 2581 aagtcagaag atgattcagc taaatttgac agtaatgaag aagattctgc ttctgttttt 2641 tcaccatcat ttggtctgaa acagacagat aaagttccaa gtaaaacggt agctgctaaa 2701 aagggaaaac cgtcttcaga tacagtccct aagcccaaga gagccccaaa acagaagaaa 2761 gtagtagagg ctgtaaactc tgactcggat tcagaatttg gcattccaaa gaagactaca 2821 acaccaaaag gtaaaggccg aggggcaaag aaaaggaaag catctggctc tgaaaatgaa 2881 ggcgattata accctggcag gaaaacatcc aaaacaacaa gcaagaaacc gaagaagaca 2941 tcttttgatc aggattcaga tgtggacatc ttcccctcag acttccctac tgagccacct 3001 tctctgccac gaaccggtcg ggctaggaaa gaagtaaaat attttgcaga gtctgatgaa 3061 gaagaagatg atgttgattt tgcaatgttt aattaagtgc ccaaagagca caaacatttt 3121 tcaacaaata tcttgtgttg tccttttgtc ttctctgtct cagacttttg tacatctggc 3181 ttattttaat gtgatgatgt aattgacggt tttttattat tgtggtaggc cttttaacat 3241 tttgttctta cacatacagt tttatgctct tttttactca ttgaaatgtc acgtactgtc 3301 tgattggctt gtagaattgt tatagactgc cgtgcattag cacagatttt aattgtcatg 3361 gttacaaact acagacctgc tttttgaaat gaaatttaaa cattaaaaat ggaactgtga 3421 aaaaccgaat tc //