LOCUS Z15111 1200 bp mRNA linear HUM 18-APR-2005 DEFINITION H.sapiens TOP2 mRNA for DNA topoisomerase II (partial). ACCESSION Z15111 S56813 VERSION Z15111.1 KEYWORDS DNA topoisomerase II; TOP2 gene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1200) AUTHORS Austin C., Sng J., Patel S., Fisher L. TITLE Novel HeLa topoisomerase II is the IIbeta isoform: complete coding sequence and homology with other type II topoisomerases JOURNAL Nucleic Acids Res. 0, 0(1993). REFERENCE 2 AUTHORS Chung T.D., Drake F.H., Tan K.B., Per S.R., Crooke S.T., Mirabelli C.K. TITLE Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86(23), 9431-9435(1989). PUBMED 2556712 REMARK (sites) REFERENCE 3 AUTHORS Austin C.A., Fisher L.M. TITLE Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells JOURNAL FEBS Lett. 266(1-2), 115-117(1990). PUBMED 2163884 REMARK (sites) REFERENCE 4 (bases 1 to 1200) AUTHORS Fisher L. JOURNAL Submitted (14-SEP-1992) to the INSDC. Fisher L., St. George's Hospital Medical School, Cranmer Terrace, London, England. REFERENCE 5 (bases 1 to 1200) AUTHORS Austin C.A., Sng J.H., Patel S., Fisher L.M. TITLE Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases JOURNAL Biochim. Biophys. Acta 1172(3), 283-291(1993). PUBMED 8383537 FEATURES Location/Qualifiers source 1..1200 /db_xref="H-InvDB:HIT000326535" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..>1200 /gene="TOP2" /standard_name="topo II beta" /product="DNA topoisomerase II" /function="N-terminal end" /EC_number="5.99.1.3" /note="Sequence provides immediate 5' end and putative start ATG of topo IIbeta. Sequence overlaps a partial internal cDNA sequence SP11 described by Chung et al (GenBank accession no M27504)." /db_xref="GOA:Q02880" /db_xref="H-InvDB:HIT000326535.13" /db_xref="HGNC:HGNC:11990" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR012542" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR031660" /db_xref="InterPro:IPR034157" /db_xref="InterPro:IPR036890" /db_xref="PDB:3QX3" /db_xref="PDB:4G0U" /db_xref="PDB:4G0V" /db_xref="PDB:4G0W" /db_xref="PDB:4J3N" /db_xref="PDB:5GWI" /db_xref="PDB:5GWJ" /db_xref="PDB:5ZAD" /db_xref="PDB:5ZEN" /db_xref="PDB:5ZQF" /db_xref="PDB:5ZRF" /db_xref="UniProtKB/Swiss-Prot:Q02880" /citation=[1] /citation=[2] /protein_id="CAA78815.1" /translation="MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKL SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFD EILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQ LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTS EAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGK KLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIA TTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQ TKENMTLQ" BASE COUNT 402 a 172 c 290 g 336 t ORIGIN 1 atggccaagt cgggtggctg cggcgcggga gccggcgtgg gcggcggcaa cggggcactg 61 acctgggtga acaatgctgc aaaaaaagaa gagtcagaaa ctgccaacaa aaatgattct 121 tcaaagaagt tgtctgttga gagagtgtat cagaagaaga cacaacttga acacattctt 181 cttcgtcctg atacatatat tgggtcagtg gagccattga cgcagttcat gtgggtgtat 241 gatgaagatg taggaatgaa ttgcagggag gttacctttg tgccaggttt atacaagatc 301 tttgatgaaa ttttggttaa tgctgctgac aataaacaga gggataagaa catgacttgt 361 attaaagttt ctattgatcc tgaatctaac attataagca tttggaataa tgggaaaggc 421 attccagtag tagaacacaa ggtggagaaa gtttatgttc ctgctttaat ttttggacag 481 cttttaacat ccagtaacta tgatgatgat gagaaaaaag ttacaggtgg tcgtaatggt 541 tatggtgcaa aactttgtaa tattttcagt acaaagttta cagtagaaac agcttgcaaa 601 gaatacaaac acagttttaa gcagacatgg atgaataata tgatgaagac ttctgaagcc 661 aaaattaaac attttgatgg tgaagattac acatgcataa cattccaacc agatctgtcc 721 aaatttaaga tggaaaaact tgacaaggat attgtggccc tcatgactag aagggcatat 781 gatttggctg gttcgtgtag aggggtcaag gtcatgttta atggaaagaa attgcctgta 841 aatggatttc gcagttatgt agatctttat gtgaaagaca aattggatga aactggggtg 901 gccctgaaag ttattcatga gcttgcaaat gaaagatggg atgtttgtct cacattgagt 961 gaaaaaggat tccagcaaat cagctttgta aatagtattg caactacaaa aggtggacgg 1021 cacgtggatt atgtggtaga tcaagttgtt ggtaaactga ttgaagtagt taagaaaaag 1081 aacaaagctg gtgtatcagt gaaaccattt caagtaaaaa accatatatg ggtttttatt 1141 aattgcctta ttgaaaatcc aacttttgat tctcagacta aggaaaacat gactctgcag //