LOCUS       Z15111                  1200 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  H.sapiens TOP2 mRNA for DNA topoisomerase II (partial).
ACCESSION   Z15111 S56813
VERSION     Z15111.1
KEYWORDS    DNA topoisomerase II; TOP2 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Austin C., Sng J., Patel S., Fisher L.
  TITLE     Novel HeLa topoisomerase II is the IIbeta isoform: complete coding
            sequence and homology with other type II topoisomerases
  JOURNAL   Nucleic Acids Res. 0, 0(1993).
REFERENCE   2
  AUTHORS   Chung T.D., Drake F.H., Tan K.B., Per S.R., Crooke S.T.,
            Mirabelli C.K.
  TITLE     Characterization and immunological identification of cDNA clones
            encoding two human DNA topoisomerase II isozymes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86(23), 9431-9435(1989).
   PUBMED   2556712
  REMARK    (sites)
REFERENCE   3
  AUTHORS   Austin C.A., Fisher L.M.
  TITLE     Isolation and characterization of a human cDNA clone encoding a
            novel DNA topoisomerase II homologue from HeLa cells
  JOURNAL   FEBS Lett. 266(1-2), 115-117(1990).
   PUBMED   2163884
  REMARK    (sites)
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Fisher L.
  JOURNAL   Submitted (14-SEP-1992) to the INSDC. Fisher L., St. George's
            Hospital Medical School, Cranmer Terrace, London, England.
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Austin C.A., Sng J.H., Patel S., Fisher L.M.
  TITLE     Novel HeLa topoisomerase II is the II beta isoform: complete coding
            sequence and homology with other type II topoisomerases
  JOURNAL   Biochim. Biophys. Acta 1172(3), 283-291(1993).
   PUBMED   8383537
FEATURES             Location/Qualifiers
     source          1..1200
                     /db_xref="H-InvDB:HIT000326535"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             1..>1200
                     /gene="TOP2"
                     /standard_name="topo II beta"
                     /product="DNA topoisomerase II"
                     /function="N-terminal end"
                     /EC_number="5.99.1.3"
                     /note="Sequence provides immediate 5' end and putative
                     start ATG of topo IIbeta. Sequence overlaps a partial
                     internal cDNA sequence SP11 described by Chung et al
                     (GenBank accession no M27504)."
                     /db_xref="GOA:Q02880"
                     /db_xref="H-InvDB:HIT000326535.13"
                     /db_xref="HGNC:HGNC:11990"
                     /db_xref="InterPro:IPR001241"
                     /db_xref="InterPro:IPR002205"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR012542"
                     /db_xref="InterPro:IPR013506"
                     /db_xref="InterPro:IPR013757"
                     /db_xref="InterPro:IPR013758"
                     /db_xref="InterPro:IPR013759"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR018522"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="InterPro:IPR031660"
                     /db_xref="InterPro:IPR034157"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="PDB:3QX3"
                     /db_xref="PDB:4G0U"
                     /db_xref="PDB:4G0V"
                     /db_xref="PDB:4G0W"
                     /db_xref="PDB:4J3N"
                     /db_xref="PDB:5GWI"
                     /db_xref="PDB:5GWJ"
                     /db_xref="PDB:5ZAD"
                     /db_xref="PDB:5ZEN"
                     /db_xref="PDB:5ZQF"
                     /db_xref="PDB:5ZRF"
                     /db_xref="UniProtKB/Swiss-Prot:Q02880"
                     /citation=[1]
                     /citation=[2]
                     /protein_id="CAA78815.1"
                     /translation="MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKL
                     SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFD
                     EILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQ
                     LLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTS
                     EAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGK
                     KLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIA
                     TTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQ
                     TKENMTLQ"
BASE COUNT          402 a          172 c          290 g          336 t
ORIGIN      
        1 atggccaagt cgggtggctg cggcgcggga gccggcgtgg gcggcggcaa cggggcactg
       61 acctgggtga acaatgctgc aaaaaaagaa gagtcagaaa ctgccaacaa aaatgattct
      121 tcaaagaagt tgtctgttga gagagtgtat cagaagaaga cacaacttga acacattctt
      181 cttcgtcctg atacatatat tgggtcagtg gagccattga cgcagttcat gtgggtgtat
      241 gatgaagatg taggaatgaa ttgcagggag gttacctttg tgccaggttt atacaagatc
      301 tttgatgaaa ttttggttaa tgctgctgac aataaacaga gggataagaa catgacttgt
      361 attaaagttt ctattgatcc tgaatctaac attataagca tttggaataa tgggaaaggc
      421 attccagtag tagaacacaa ggtggagaaa gtttatgttc ctgctttaat ttttggacag
      481 cttttaacat ccagtaacta tgatgatgat gagaaaaaag ttacaggtgg tcgtaatggt
      541 tatggtgcaa aactttgtaa tattttcagt acaaagttta cagtagaaac agcttgcaaa
      601 gaatacaaac acagttttaa gcagacatgg atgaataata tgatgaagac ttctgaagcc
      661 aaaattaaac attttgatgg tgaagattac acatgcataa cattccaacc agatctgtcc
      721 aaatttaaga tggaaaaact tgacaaggat attgtggccc tcatgactag aagggcatat
      781 gatttggctg gttcgtgtag aggggtcaag gtcatgttta atggaaagaa attgcctgta
      841 aatggatttc gcagttatgt agatctttat gtgaaagaca aattggatga aactggggtg
      901 gccctgaaag ttattcatga gcttgcaaat gaaagatggg atgtttgtct cacattgagt
      961 gaaaaaggat tccagcaaat cagctttgta aatagtattg caactacaaa aggtggacgg
     1021 cacgtggatt atgtggtaga tcaagttgtt ggtaaactga ttgaagtagt taagaaaaag
     1081 aacaaagctg gtgtatcagt gaaaccattt caagtaaaaa accatatatg ggtttttatt
     1141 aattgcctta ttgaaaatcc aacttttgat tctcagacta aggaaaacat gactctgcag
//