LOCUS Z15005 8257 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens CENP-E mRNA.
ACCESSION Z15005
VERSION Z15005.1
KEYWORDS kinetochore motor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8257)
AUTHORS Yen T.J., Li G., Schaar B.T., Szilak I., Cleveland D.W.
TITLE CENP-E is a putative kinetochore motor that accumulates just before
mitosis
JOURNAL Nature 359(6395), 536-539(1992).
PUBMED 1406971
REFERENCE 2 (bases 1 to 8257)
AUTHORS Cleveland D.W.
JOURNAL Submitted (27-AUG-1992) to the INSDC. Don W. Cleveland, Biological
Chemistry, Johns Hopkins University, School of Medicine, 725 N.
Wolfe St., Baltimore, Maryland, 21205, USA
FEATURES Location/Qualifiers
source 1..8257
/db_xref="H-InvDB:HIT000326516"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="CENPE"
/db_xref="taxon:9606"
CDS 91..8082
/product="CENP-E"
/db_xref="GOA:Q02224"
/db_xref="H-InvDB:HIT000326516.14"
/db_xref="HGNC:HGNC:1856"
/db_xref="InterPro:IPR001752"
/db_xref="InterPro:IPR019821"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR027640"
/db_xref="InterPro:IPR036961"
/db_xref="PDB:1T5C"
/db_xref="PDB:5JVP"
/db_xref="UniProtKB/Swiss-Prot:Q02224"
/protein_id="CAA78727.1"
/translation="MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS
KSFNFDRVFHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDH
LGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGE
PSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQ
VGGFINYRDSKLTRILQNSLGGNPKTRIICTITPVSFDETLTALQFASTAKYMKNTPY
VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE
KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKT
HKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD
NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHR
EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK
QTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM
QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALR
EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI
GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK
FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPLQTVEREKTLIT
EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES
LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT
ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR
LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNV
QEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV
LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT
AQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDS
TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK
IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE
MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN
ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQLNIKQISEVQENVNELKQ
FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK
ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI
RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV
HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK
EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET
QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRRVEET
LKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ
KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEPNYLCKCEM
DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVK
PEKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFHRIM
KKLKYVLSYVTKIKEEQHECINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD
LKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLK
NGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFK
NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKES
KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEH
TDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSN
NQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDP
VPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSG
KDVPECKTQ"
BASE COUNT 3429 a 1263 c 1677 g 1888 t
ORIGIN
1 taaatttaaa ggcggggcgg cctgtgagcc ctgaagtgcc ggccgcggag ggtcctggcc
61 attttggtgg gaccagttca gcctgatagg atggcggagg aaggagccgt ggccgtctgc
121 gtgcgagtgc ggccgctgaa cagcagagaa gaatcacttg gagaaactgc ccaagtttac
181 tggaaaactg acaataatgt catttatcaa gttgatggaa gtaaatcctt caattttgat
241 cgtgtctttc atggtaatga aactaccaaa aatgtgtatg aagaaatagc agcaccaatc
301 atcgattctg ccatacaagg ctacaatggt actatatttg cctatggaca gactgcttca
361 ggaaaaacat ataccatgat gggttcagaa gatcatttgg gagttatacc cagggcaatt
421 catgacattt tccaaaaaat taagaagttt cctgataggg aatttctctt acgtgtatct
481 tacatggaaa tatacaatga aaccattaca gatttactct gtggcactca aaaaatgaaa
541 cctttaatta ttcgagaaga tgtcaatagg aatgtgtatg ttgctgatct cacagaagaa
601 gttgtatata catcagaaat ggctttgaaa tggattacaa agggagaaaa gagcaggcat
661 tatggagaaa caaaaatgaa tcaaagaagc agtcgttctc ataccatctt taggatgatt
721 ttggaaagca gagagaaggg tgaaccttct aattgtgaag gatctgttaa ggtatcccat
781 ttgaatttgg ttgatcttgc aggcagtgaa agagctgctc aaacaggcgc tgcaggtgtg
841 cggctcaagg aaggctgtaa tataaatcga agcttattta ttttgggaca agtgatcaag
901 aaacttagtg atggacaagt tggtggtttc ataaattatc gagatagcaa gttaacacga
961 attcttcaga attccttggg aggaaatcca aagacacgta ttatctgcac aattactcca
1021 gtatcttttg atgaaactct tactgctctc cagtttgcca gtactgctaa atatatgaag
1081 aatactcctt atgttaatga ggtatcaact gatgaagctc tcctgaaaag gtatagaaaa
1141 gaaataatgg atcttaaaaa acaattagag gaggtttctt tagagacgcg ggctcaggca
1201 atggaaaaag accaattggc ccaacttttg gaagaaaaag atttgcttca gaaagtacag
1261 aatgagaaaa ttgaaaactt aacacggatg ctggtgacct cttcttccct cacgttgcaa
1321 caggaattaa aggctaaaag aaaacgaaga gttacttggt gccttggcaa aattaacaaa
1381 atgaagaact caaactatgc agatcaattt aatataccaa caaatataac aacaaaaaca
1441 cataagcttt ctataaattt attacgagaa attgatgaat ctgtctgttc agagtctgat
1501 gttttcagta acactcttga tacattaagt gagatagaat ggaatccagc aacaaagcta
1561 ctaaatcagg agaatataga aagtgagttg aactcacttc gtgctgacta tgataatctg
1621 gtattagact atgaacaact acgaacagaa aaagaagaaa tggaattgaa attaaaagaa
1681 aagaatgatt tggatgaatt tgaggctcta gaaagaaaaa ctaaaaaaga tcaagagatg
1741 caactaattc atgaaatttc gaacttaaag aatttagtta agcatcgaga agtatataat
1801 caagatcttg agaatgaact cagttcaaaa gtagagctgc ttagagaaaa ggaagaccag
1861 attaagaagc tacaggaata catagactct caaaagctag aaaatataaa aatggacttg
1921 tcatactcat tggaaagcat tgaagaccca aaacaaatga agcagactct gtttgatgct
1981 gaaactgtag cccttgatgc caagagagaa tcagcctttc ttagaagtga aaatctggag
2041 ttgaaggaga aaatgaaaga acttgcaact acatacaagc aaatggaaaa tgatattcag
2101 ttatatcaaa gccaattgga ggcaaaaaag aaaatgcaag ttgatctgga gaaagaatta
2161 caatctgctt ttaatgagat aacaaaactc acctccctta tagatggcaa agttccaaaa
2221 gatttgctct gtaatttgga attggaagga aagattactg atcttcagaa agaactaaat
2281 aaagaagttg aagaaaatga agctttgcgg gaagaagtca ttttgctttc agaattgaaa
2341 tctttacctt ctgaagtaga aaggctgagg aaagagatac aagacaaatc tgaagagctc
2401 catataataa catcagaaaa agataaattg ttttctgaag tagttcataa ggagagtaga
2461 gttcaaggtt tacttgaaga aattgggaaa acaaaagatg acctagcaac tacacagtcg
2521 aattataaaa gcactgatca agaattccaa aatttcaaaa cccttcatat ggactttgag
2581 caaaagtata agatggtcct tgaggagaat gagagaatga atcaggaaat agttaatctc
2641 tctaaagaag cccaaaaatt tgattcgagt ttgggtgctt tgaagaccga gctttcttac
2701 aagacccaag aacttcagga gaaaacacgt gaggttcaag aaagactaaa tgagatggaa
2761 cagctgaagg aacaattaga aaatagagat tctccgctgc aaactgtaga aagggagaaa
2821 acactgatta ctgagaaact gcagcaaact ttagaagaag taaaaacttt aactcaagaa
2881 aaagatgatc taaaacaact ccaagaaagc ttgcaaattg agagggacca actcaaaagt
2941 gatattcacg atactgttaa catgaatata gatactcaag aacaattacg aaatgctctt
3001 gagtctctga aacaacatca agaaacaatt aatacactaa aatcgaaaat ttctgaggaa
3061 gtttccagga atttgcatat ggaggaaaat acaggagaaa ctaaagatga atttcagcaa
3121 aagatggttg gcatagataa aaaacaggat ttggaagcta aaaataccca aacactaact
3181 gcagatgtta aggataatga gataattgag caacaaagga agatattttc tttaatacag
3241 gagaaaaatg aactccaaca aatgttagag agtgttatag cagaaaagga acaattgaag
3301 actgacctaa aggaaaatat tgaaatgacc attgaaaacc aggaagaatt aagacttctt
3361 ggggatgaac ttaaaaagca acaagagata gttgcacaag aaaagaacca tgccataaag
3421 aaagaaggag agctttctag gacctgtgac agactggcag aagttgaaga aaaactaaag
3481 gaaaagagcc agcaactcca agaaaaacag caacaacttc ttaatgtaca agaagagatg
3541 agtgagatgc agaaaaagat taatgaaata gagaatttaa agaatgaatt aaagaacaaa
3601 gaattgacat tggaacatat ggaaacagag aggcttgagt tggctcagaa acttaatgaa
3661 aattatgagg aagtgaaatc tataaccaaa gaaagaaaag ttctaaagga attacagaag
3721 tcatttgaaa cagagagaga ccaccttaga ggatatataa gagaaattga agctacaggc
3781 ctacaaacca aagaagaact aaaaattgct catattcacc taaaagaaca ccaagaaact
3841 attgatgaac taagaagaag cgtatctgag aagacagctc aaataataaa tactcaggac
3901 ttagaaaaat cccataccaa attacaagaa gagatcccag tgcttcatga ggaacaagag
3961 ttactgccta atgtgaaaaa agtcagtgag actcaggaaa caatgaatga actggagtta
4021 ttaacagaac agtccacaac caaggactca acaacactgg caagaataga aatggaaagg
4081 ctcaggttga atgaaaaatt tcaagaaagt caggaagaga taaaatctct aaccaaggaa
4141 agagacaacc ttaaaacgat aaaagaagcc cttgaagtta aacatgacca gctgaaagaa
4201 catattagag aaactttggc taaaatccag gagtctcaaa gcaaacaaga acagtcctta
4261 aatatgaaag aaaaagacaa tgaaactacc aaaatcgtga gtgagatgga gcaattcaaa
4321 cccaaagatt cagcactact aaggatagaa atagaaatgc tcggattgtc caaaagactt
4381 caagaaagtc atgatgaaat gaaatctgta gctaaggaga aagatgacct acagaggctg
4441 caagaagttc ttcaatctga aagtgaccag ctcaaagaaa acataaaaga aattgtagct
4501 aaacacctgg aaactgaaga ggaacttaaa gttgctcatt gttgcctgaa agaacaagag
4561 gaaactatta atgagttaag agtgaatctt tcagagaagg aaactgaaat atcaaccatt
4621 caaaagcagt tagaagcaat caatgataaa ttacagaaca agatccaaga gatttatgag
4681 aaagaggaac aacttaatat aaaacaaatt agtgaggttc aggaaaacgt gaatgaactg
4741 aaacaattca aggagcatcg caaagccaag gattcagcac tacaaagtat agaaagtaag
4801 atgctcgagt tgaccaacag acttcaagaa agtcaagaag aaatacaaat tatgattaag
4861 gaaaaagagg aaatgaaaag agtacaggag gcccttcaga tagagagaga ccaactgaaa
4921 gaaaacacta aagaaattgt agctaaaatg aaagaatctc aagaaaaaga atatcagttt
4981 cttaagatga cagctgtcaa tgagactcag gagaaaatgt gtgaaataga acacttgaag
5041 gagcaatttg agacccagaa gttaaacctg gaaaacatag aaacggagaa tataaggttg
5101 actcagatac tacatgaaaa ccttgaagaa atgagatctg taacaaaaga aagagatgac
5161 cttaggagtg tggaggagac tctcaaagta gagagagacc agctcaagga aaaccttaga
5221 gaaactataa ctagagacct agaaaaacaa gaggagctaa aaattgttca catgcatctg
5281 aaggagcacc aagaaactat tgataaacta agagggattg tttcagagaa aacaaatgaa
5341 atatcaaata tgcaaaagga cttagaacac tcaaatgatg ccttaaaagc acaggatctg
5401 aaaatacaag aggaactaag aattgctcac atgcatctga aagagcagca ggaaactatt
5461 gacaaactca gaggaattgt ttctgagaag acagataaac tatcaaatat gcaaaaagat
5521 ttagaaaatt caaatgctaa attacaagaa aagattcaag aacttaaggc aaatgaacat
5581 caacttatta cgttaaaaaa agatgtcaat gagacacaga aaaaagtgtc tgaaatggag
5641 caactaaaga aacaaataaa agaccaaagc ttaactctga gtaaattaga aatagagaat
5701 ttaaatttgg ctcaagaact tcatgaaaac cttgaagaaa tgaaatctgt aatgaaagaa
5761 agagataatc taagaagagt agaggagaca ctcaaactgg agagagacca actcaaggaa
5821 agcctgcaag aaaccaaagc tagagatctg gaaatacaac aggaactaaa aactgctcgt
5881 atgctatcaa aagaacacaa agaaactgtt gataaactta gagaaaaaat ttcagaaaag
5941 acaattcaaa tttcagacat tcaaaaggat ttagataaat caaaagatga attacagaaa
6001 aagatccaag aacttcagaa aaaagaactt caactgctta gagtgaaaga agatgtcaat
6061 atgagtcata aaaaaattaa tgaaatggaa cagttgaaga agcaatttga gccaaactat
6121 ctatgcaagt gtgagatgga taacttccag ttgactaaga aacttcatga aagccttgaa
6181 gaaataagaa ttgtagctaa agaaagagat gagctaagga ggataaaaga atctctcaaa
6241 atggaaaggg accaattcat agcaacctta agggaaatga tagctagaga ccgacagaac
6301 caccaagtaa aacctgaaaa aaggttacta agtgatggac aacagcacct tatggaaagc
6361 ctgagagaaa agtgctctag aataaaagag cttttgaaga gatactcaga gatggatgat
6421 cattatgagt gcttgaatag attgtctctt gacttggaga aggaaattga attccacaga
6481 atcatgaaga aactgaagta tgtgttaagc tatgttacaa aaataaaaga agaacaacat
6541 gaatgcatca ataaatttga aatggatttt attgatgaag tggaaaagca aaaggaattg
6601 ctaattaaaa tacagcacct tcaacaagat tgtgatgtac catccagaga attaagggat
6661 ctcaaattga accagaatat ggatctacat attgaggaaa ttctcaaaga tttctcagaa
6721 agtgagttcc ctagcataaa gactgaattt caacaagtac taagtaatag gaaagaaatg
6781 acacagtttt tggaagagtg gttaaatact cgttttgata tagaaaagct taaaaatggc
6841 atccagaaag aaaatgatag gatttgtcaa gtgaataact tctttaataa cagaataatt
6901 gccataatga atgaatcaac agagtttgag gaaagaagtg ctaccatatc caaagagtgg
6961 gaacaggacc tgaaatcact gaaagagaaa aatgaaaaac tatttaaaaa ctaccaaaca
7021 ttgaagactt ccttggcatc tggtgcccag gttaatccta ccacacaaga caataagaat
7081 cctcatgtta catcaagagc tacacagtta accacagaga aaattcgaga gctggaaaat
7141 tcactgcatg aagctaaaga aagtgctatg cataaggaaa gcaagattat aaagatgcag
7201 aaagaacttg aggtgactaa tgacataata gcaaaacttc aagccaaagt tcatgaatca
7261 aataaatgcc ttgaaaaaac aaaagagaca attcaagtac ttcaggacaa agttgcttta
7321 ggagctaagc catataaaga agaaattgaa gatctcaaaa tgaagcttgt gaaaatagac
7381 ctagagaaaa tgaaaaatgc caaagaattt gaaaaggaaa tcagtgctac aaaagccact
7441 gtagaatatc aaaaggaagt tataaggcta ttgagagaaa atctcagaag aagtcaacag
7501 gcccaagata cctcagtgat atcagaacat actgatcctc agccttcaaa taaaccctta
7561 acttgtggag gtggcagcgg cattgtacaa aacacaaaag ctcttatttt gaaaagtgaa
7621 catataaggc tagaaaaaga aatttctaag ttaaagcagc aaaatgaaca gctaataaaa
7681 caaaagaatg aattgttaag caataatcag catctttcca atgaggtcaa aacttggaag
7741 gaaagaaccc ttaaaagaga ggctcacaaa caagtaactt gtgagaattc tccaaagtct
7801 cctaaagtga ctggaacagc ttctaaaaag aaacaaatta caccctctca atgcaaggaa
7861 cggaatttac aagatcctgt gccaaaggaa tcaccaaaat cttgtttttt tgatagccga
7921 tcaaagtctt taccatcacc tcatccagtt cgctattttg ataactcaag tttaggcctt
7981 tgtccagagg tgcaaaatgc aggagcagag agtgtggatt ctcagccagg tccttggcac
8041 gcctcctcag gcaaggatgt gcctgagtgc aaaactcagt agactcctct ttgtcacttc
8101 tctggagatc cagcattcct tatttggaaa tgactttgtt tatgtgtcta tccctggtaa
8161 tgatgttgta gtgcagctta atttcaattc agtctttact ttgccactag agttgaaaga
8221 taagggaaca ggaaatgaat gcattgtggt aatttag
//