LOCUS Z14310 2413 bp mRNA linear VRL 07-OCT-2008
DEFINITION Human endogenous retrovirus mRNA for tripartite fusion transcript
PLA2L.
ACCESSION Z14310 S55809
VERSION Z14310.1
KEYWORDS HERV-H; HHLA1; otoconin-90.
SOURCE Human endogenous retrovirus
ORGANISM Human endogenous retrovirus
Viruses; Ortervirales; Retroviridae.
REFERENCE 2 (bases 1 to 2413)
AUTHORS Mager D.L.
JOURNAL Submitted (17-AUG-1992) to the INSDC. D.L. Mager, Terry Fox
Laboratory, British Columbia Cancer, Agency, 601 West 10th Avenue,
Vancouver, British Columbia, V5Z1L3, CANADA
REFERENCE 3 (bases 1 to 2413)
AUTHORS Feuchter-Murthy A.E., Freeman J.D., Mager D.L.
TITLE Splicing of a human endogenous retrovirus to a novel phospholipase
A2 related gene
JOURNAL Nucleic Acids Res. 21(1), 135-143(1993).
PUBMED 8382789
REFERENCE 4
AUTHORS Kowalski P.E., Freeman J.D., Mager D.L.
TITLE Intergenic splicing between a HERV-H endogenous retrovirus and two
adjacent human genes
JOURNAL Unpublished.
REFERENCE 5
AUTHORS Wang Y., Kowalski P.E., Thalmann I., Ornitz D.M., Mager D.L.,
Thalmann R.
TITLE Otoconin-90, the mammalian otoconial matrix protein, contains two
domains of homology to secretory phospholipase A2
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95(26), 15345-15350(1998).
PUBMED 9860971
FEATURES Location/Qualifiers
source 1..251
/organism="Human endogenous retrovirus"
/focus
/mol_type="mRNA"
/db_xref="taxon:11827"
source 252..2413
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="NTera2D1 teratocarcinoma"
/db_xref="taxon:9606"
repeat_region 1..106
/rpt_type=LONG_TERMINAL_REPEAT
/note="HERV-H 5'LTR acts as promoter for fusion transcript
which is specifically transcribed in human teratocarcinoma
cells."
CDS 101..2170
/note="tripartite fusion transcript PLA2L"
/db_xref="GOA:Q02509"
/db_xref="HGNC:HGNC:8100"
/db_xref="InterPro:IPR001211"
/db_xref="InterPro:IPR016090"
/db_xref="InterPro:IPR033112"
/db_xref="InterPro:IPR033113"
/db_xref="InterPro:IPR036444"
/db_xref="InterPro:IPR041798"
/db_xref="UniProtKB/Swiss-Prot:Q02509"
/protein_id="CAA78662.1"
/translation="MKFGAVTRIGGPPLGNQSPSSCSLLHEKDPPTTSGPQTDQPKKH
LTNFKSATRRVARTQWLTADRQTWASISSVPWAQTISEKKPGGSLWETRSSPPTTAGT
EEAMNTTSLLAPAAEIMATPGSPSQASPTSGAFTHGTQTPSPTKATAPRYPQTGDLSA
EWPFTAGEEPVLVPRPHQVSRVCSSCCLSPILCSPAMIAFLLTSVLMIPHAGGHPLDT
PHLPQELPPGLPNNINITFFSGMFKNVESVAEIFDCLGAHFTWLQAVFTNFPVLIQFV
NGMKCVAGLCPRDFEDYGCTCRFEMEGLPVDESDSCCFQHRRCCEEAAEMDCLQDPAK
LSTEVDCVGKKIICESKDNCEHLLCTCDKAAIECLARSSLNSSLNLLDTSFCLAQTPE
TTIKEDLTTLLPRVVPVEPTDTSLTALSGEVAAETEADRLITLSKKKAGHDQEGVGAA
RATSPPGSAEIVATRVTAKIVTLVPAGIKSLGLAVSSVENDPEETTEKACDRFTFLHL
GSGDNMQVMPQLGEMLFCLTSRCPEEFESYGCYCGQEGRGEPRDDLDRCCLSHHCCLE
QVRRLGCLLERLPWSPVVCVDHTPKCGGQSLCEKLLCACDQTAAECMTSASFNQSLKS
PSRLGCPGQPAACEDSLHPVPAAPTLGSSSEEDSEEDPPQEDLGRAKRFLRKSLGPLG
IGPLHGR"
misc_feature 101..251
/note="HERV-H"
misc_feature 251^252
/note="intergenic splicing site of HERV-H and HHLA1
fusion"
misc_feature 252..641
/note="HHLA1"
misc_feature 641^642
/note="intergenic splicing site of HHLA1 and otoconin-90
fusion"
misc_feature 642..2413
/note="otoconin-90"
BASE COUNT 548 a 696 c 629 g 540 t
ORIGIN
1 ctgactctct tttcggactc agcccgcctg cacccaggtg aaataaacag ctttattgct
61 cacacaaagc ctgtttggtg gtctcttcac acggacgcgc atgaaatttg gtgccgtcac
121 tcggatcggg ggacctccct tgggaaatca atccccgtcc tcctgttctt tgctccatga
181 gaaagatcca cctacgacct caggtcctca gacagaccag cccaagaaac atctcaccaa
241 tttcaaatcc gctaccagga gggtggccag aactcagtgg ttgacagctg acagacagac
301 gtgggcttcc atatcgtccg tgccctgggc tcagaccatc agtgagaaaa aacctggagg
361 gtctctctgg gaaactcgtt cttccccacc gactactgca gggaccgagg aagccatgaa
421 cactacaagc cttttggcgc ctgctgctga gataatggcc acacctggca gcccatccca
481 ggccagccct acctcgggag cattcaccca tggcacacag actccgagtc caaccaaggc
541 aacagccccc agatatccac aaacaggtga tctctctgca gagtggccat tcactgctgg
601 tgaagagcca gtcctggtcc caagacccca tcaagtttca agagtctgtt ccagttgctg
661 cctaagcccc atcctttgtt ctcctgctat gattgcgttt ctcctcacca gtgtgctgat
721 gatcccccat gccggaggcc atcctctgga cactccacat cttccacagg agctgcctcc
781 aggactccca aacaatatca atatcacttt cttcagtggg atgtttaaaa atgtggaaag
841 tgtggctgaa atttttgatt gcctgggggc ccacttcacc tggctgcagg ctgtcttcac
901 caatttccct gtgctgatcc agtttgtcaa tggtatgaag tgtgtggctg gtctctgccc
961 ccgagacttt gaagactatg gttgcacctg caggtttgag atggaagggt tgcctgtgga
1021 tgaatctgac agctgctgct tccagcaccg caggtgctgt gaggaggccg ctgagatgga
1081 ctgtctccaa gaccccgcca aacttagcac agaggtcgat tgtgtcggca agaagatcat
1141 atgtgagtcc aaggacaact gtgagcacct gctgtgtacc tgtgataagg ctgccataga
1201 gtgcttggct cgatccagcc tcaactcttc cctgaacctt ctggacacct ccttctgcct
1261 ggctcagact ccagagacaa ccatcaagga agacttgaca acacttctgc ccagagtggt
1321 tcctgtggag cccacagaca ccagcctgac agccctttca ggagaagtgg ctgcagagac
1381 tgaggctgac agactgatca ctctctccaa gaagaaagca ggccacgatc aggaaggagt
1441 gggagctgct agggctacgt cccctccagg atctgcagag atagttgcaa caagggttac
1501 agctaaaatt gtaacccttg tccctgctgg cattaaatct ctggggctgg cagtgtcatc
1561 tgttgaaaat gatcctgagg agaccactga aaaagcctgt gacagattca ccttcctgca
1621 cctgggaagt ggggacaaca tgcaggtgat gccacagctt ggagagatgc tcttttgtct
1681 gacatcccgg tgcccggagg aatttgagtc ttatggctgt tactgtggac aagaaggaag
1741 aggcgagcca agggatgacc tagacaggtg ctgcttgtcc catcactgct gcctagagca
1801 agtgagaagg ctgggctgcc tgcttgagag gcttccttgg tcaccggtgg tgtgtgtgga
1861 tcatacgccc aagtgtgggg gccaaagcct gtgtgagaag ttgctctgtg cctgtgacca
1921 gacggcagct gagtgcatga cctctgcctc ctttaaccaa agcctcaagt ccccaagcag
1981 actcgggtgc cctgggcagc cagcagcctg tgaagacagc ctgcaccctg tgcccgcagc
2041 ccccaccctg ggctccagct ctgaggagga cagcgaggag gaccctccac aggaggacct
2101 cggcagagcc aagaggtttc tgcggaagtc actgggtccc ttggggatcg ggcctcttca
2161 tggaagatag atgcccagag aaaatggcta acaccttcag tagcgtggct cctgctccac
2221 cttcagctct ttatctctca gcctcctctg tcccttggag ccttcttccc ttcctttaac
2281 tcagaggcgg ggagggaaca gaggccgtga gccctgccca tgcctcatca gctgtggtca
2341 cctcacaagc caatgtacac ttggagaagg cacaccatgg tacctccatg ctcctttagt
2401 gcactgtgga agc
//