LOCUS Z12173 2379 bp mRNA linear HUM 09-SEP-2004
DEFINITION H.sapiens GNS mRNA encoding glucosamine-6-sulphatase.
ACCESSION Z12173 M23657
VERSION Z12173.1
KEYWORDS GNS gene; N-acetylglucosamine-6-sulphatase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 618 to 2379)
AUTHORS Robertson D.A., Freeman C., Nelson P.V., Morris C.P., Hopwood J.J.
TITLE Human glucosamine-6-sulfatase cDNA reveals homology with steroid
sulfatase
JOURNAL Biochem. Biophys. Res. Commun. 157(1), 218-224(1988).
PUBMED 3196333
REFERENCE 3 (bases 1 to 2379)
AUTHORS Morris C.
JOURNAL Submitted (04-JUN-1992) to the INSDC. Morris C., Adelaide
Children's Hospital, Chemical Pathology, 72 King William Road,
North Adelaide, South Australia, Australia, 5006
REFERENCE 4 (bases 1 to 2379)
AUTHORS Robertson D.A., Freeman C., Morris C.P., Hopwood J.J.
TITLE A cDNA clone for human glucosamine-6-sulphatase reveals differences
between arylsulphatases and non-arylsulphatases
JOURNAL Biochem. J. 288, 539-544(1992).
PUBMED 1463457
FEATURES Location/Qualifiers
source 1..2379
/db_xref="H-InvDB:HIT000326426"
/organism="Homo sapiens"
/chromosome="12"
/map="q14"
/mol_type="mRNA"
/clone_lib="Clontech lambda gt11 endothelial cDNA library"
/clone="p6s50, p6s41, p6s18"
/cell_type="Fibroblast"
/tissue_type="Endothelial"
/db_xref="taxon:9606"
CDS 88..1746
/gene="GNS"
/product="N-acetylglucosamine-6-sulphatase"
/function="hydrolysis of heparan sulphate"
/EC_number="3.1.6.14"
/note="glucosamine-6-sulphatase"
/db_xref="GOA:P15586"
/db_xref="H-InvDB:HIT000326426.14"
/db_xref="HGNC:HGNC:4422"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR012251"
/db_xref="InterPro:IPR015981"
/db_xref="InterPro:IPR017850"
/db_xref="InterPro:IPR024607"
/db_xref="UniProtKB/Swiss-Prot:P15586"
/citation=[1]
/citation=[4]
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA78164.1"
/translation="MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGT
RRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGK
YPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAG
GLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDY
KSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTP
MTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQF
SLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMD
GMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNN
TYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLM
MLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL"
sig_peptide 88..195
/citation=[4]
/experiment="experimental evidence, no additional details
recorded"
mat_peptide 217..1743
/product="N-acetylglucosamine-6-sulphatase"
/citation=[4]
/experiment="experimental evidence, no additional details
recorded"
BASE COUNT 615 a 583 c 553 g 628 t
ORIGIN
1 ggaattccgg tcggcctctc gcccttcagc tacctgtgcg tccctccgtc ccgtcccgtc
61 ccggggtcac cccggagcct gtccgctatg cggctcctgc ctctagcccc aggtcggctc
121 cggcggggca gcccccgcca cctgccctcc tgcagcccag cgctgctact gctggtgctg
181 ggcggctgcc tgggggtctt cggggtggct gcgggaaccc ggaggcccaa cgtggtgctg
241 ctcctcacgg acgaccagga cgaagtgctc ggcggcatga caccactaaa gaaaaccaaa
301 gctctcatcg gagagatggg gatgactttt tccagtgctt atgtgccaag tgctctctgc
361 tgccccagca gagccagtat cctgacagga aagtacccac ataatcatca cgttgtgaac
421 aacactctgg aggggaactg cagtagtaag tcctggcaga agatccaaga accaaatact
481 ttcccagcaa ttctcagatc aatgtgtggt tatcagacct tttttgcagg gaaatattta
541 aatgagtacg gagccccaga tgcaggtgga ctagaacacg ttcctctggg ttggagttac
601 tggtatgcct tggaaaagaa ttctaagtat tataattaca ccctgtctat caatgggaag
661 gcacggaagc atggtgaaaa ctatagtgtg gactacctga cagatgtttt ggctaatgtc
721 tccttggact ttctggacta caagtccaac tttgagccct tcttcatgat gatcgccact
781 ccagcgcctc attcgccttg gacagctgca cctcagtacc agaaggcttt ccagaatgtc
841 tttgcaccaa gaaacaagaa cttcaacatc catggaacga acaagcactg gttaattagg
901 caagccaaga ctccaatgac taattcttca atacagtttt tagataatgc atttaggaaa
961 aggtggcaaa ctctcctctc agttgatgac cttgtggaga aactggtcaa gaggctggag
1021 ttcactgggg agctcaacaa cacttacatc ttctatacct cagacaatgg ctatcacaca
1081 ggacagtttt ccttgccaat agacaagaga cagctgtatg agtttgatat caaagttcca
1141 ctgttggttc gaggacctgg gatcaaacca aatcagacaa gcaagatgct ggttgccaac
1201 attgacttgg gtcctactat tttggacatt gctggctacg acctaaataa gacacagatg
1261 gatgggatgt ccttattgcc cattttgaga ggtgccagta acttgacctg gcgatcagat
1321 gtcctggtgg aataccaagg agaaggccgt aacgtcactg acccaacatg cccttccctg
1381 agtcctggcg tatctcaatg cttcccagac tgtgtatgtg aagatgctta taacaatacc
1441 tatgcctgtg tgaggacaat gtcagcattg tggaatttgc agtattgcga gtttgatgac
1501 caggaggtgt ttgtagaagt ctataatctg actgcagacc cagaccagat cactaacatt
1561 gctaaaacca tagacccaga gcttttagga aagatgaact atcggttaat gatgttacag
1621 tcctgttctg ggccaacctg tcgcactcca ggggtttttg accccggata caggtttgac
1681 ccccgtctca tgttcagcaa tcgcggcagt gtcaggactc gaagattttc caaacatctt
1741 ctgtagcgac ctcacacagc ctctgcagat ggatccctgc acgcctcttt ctgatgaagt
1801 gattgtagta ggtgtctgta gctagtcttc aagaccacac ctggaagagt ttctgggctg
1861 gctttaagtc ctgtttgaaa aagcaaccca gtcagctgac ttcctcgtgc aatgtgttaa
1921 actgtgaact ctgcccatgt gtcaggagtg gctgtctctg gtctcttcct ttagctgaca
1981 aggacactcc tgaggtcttt gttctcactg tatttttttt atcctggggc cacagttctt
2041 gattattcct cttgtggtta aagactgaat ttgtaaaccc attcagataa atggcagtac
2101 tttaggacac acacaaacac acagatacac cttttgatat gtaagcttga cctaaagtca
2161 aaggacctgt gtagcatttc agattgagca cttcactatc aaaaatacta acatcacatg
2221 gcttgaagag taaccatcag agctgaatca tccaagtaag aacaagtacc attgttgatt
2281 gataagtaga gatacatttt ttatgatgtt catcacagtg tggtaaggtt gcaaattcaa
2341 aacatgtcac ccaagctctg ttcatgtttt tgtgaattc
//