LOCUS Z11933 1955 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for N-Oct 3, N-Oct5a, and N-Oct 5b proteins.
ACCESSION Z11933
VERSION Z11933.1
KEYWORDS N-Oct 3 protein; N-Oct 5a protein; N-Oct 5b protein; POU domain.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1955)
AUTHORS Schreiber E., Tobler A., Malipiero U., Schaffner W., Fontana A.
TITLE cDNA cloning of human N-Oct3, a nervous-system specific POU domain
transcription factor binding to the octamer DNA motif
JOURNAL Nucleic Acids Res. 21(2), 253-258(1993).
PUBMED 8441633
REFERENCE 2 (bases 1 to 1955)
AUTHORS Schreiber E., Harshman K., Kemler I., Malipiero U., Schaffner W.,
Fontana A.
TITLE Astrocytes and glioblastoma cells express novel octamer-DNA binding
proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2
proteins
JOURNAL Nucleic Acids Res. 18(18), 5495-5503(1990).
PUBMED 2216722
REFERENCE 3 (bases 997 to 1370)
AUTHORS He X., Treacy M.N., Simmons D.M., Ingraham H.A., Swanson L.W.,
Rosenfeld M.G.
TITLE Expression of a large family of POU-domain regulatory genes in
mammalian brain development
JOURNAL Nature 340(6228), 35-41(1989).
PUBMED 2739723
REFERENCE 4 (bases 1 to 1955)
AUTHORS Hara Y., Rovescalli A.C., Kim Y., Nirenberg M.
TITLE Structure and evolution of four POU domain genes expressed in mouse
brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89(8), 3280-3284(1992).
PUBMED 1565620
REFERENCE 5 (bases 1 to 1952)
AUTHORS Schreiber E.
JOURNAL Submitted (15-APR-1992) to the INSDC. Edgar Schreiber, Department
of Internal Medicine, University Hospital Zurich Division of
Clinical Immunology, 13 Moussonstr., Zurich, CH 8044, Switzerland
REFERENCE 6
AUTHORS Atanasoski S., Schreiber E., Fontana A., Herr W.
TITLE N-Oct 5 is generated by in vitro proteolysis of the neural
POU-domain protein N-Oct 3
JOURNAL Oncogene 14(11), 1287-1294(1997).
PUBMED 9178889
FEATURES Location/Qualifiers
source 1..1955
/db_xref="H-InvDB:HIT000326396"
/organism="Homo sapiens"
/mol_type="mRNA"
/sex="female"
/dev_stage="17 WEEK GESTATION"
/clone_lib="ZAP II STRATAGENE CATALOG NR. 936206"
/clone="NOC1"
/tissue_type="BRAIN"
/db_xref="taxon:9606"
misc_feature 1..1500
/note="unusual high CpG dinucleotide frequency in the
coding region; resembles a CpG island"
CDS 163..1494
/product="N-Oct 3 octamer DNA (ATGCAAAT) binding protein
with brn-2 POU domain"
/function="octamer DNA (ATGCAAAT) binding protein;
transcription activator"
/note="N-OCT 3 is expressed specifically in the
neuroectodermal cell lineage; the brn-2 POU domain that is
found in N-Oct 3 was previously identified by others (He
et al.)."
/db_xref="GOA:P20265"
/db_xref="H-InvDB:HIT000326396.14"
/db_xref="HGNC:HGNC:9215"
/db_xref="InterPro:IPR000327"
/db_xref="InterPro:IPR001356"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR013847"
/db_xref="InterPro:IPR016362"
/db_xref="InterPro:IPR017970"
/db_xref="UniProtKB/Swiss-Prot:P20265"
/citation=[2]
/citation=[3]
/citation=[4]
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA77990.1"
/translation="MATAASNHYSLLTSSASIVHAEPPGAMQQGAGGYREAQSLVQGD
YGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPD
IKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAAN
HHPGPGAWRTAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDA
HDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQ
FKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEE
ADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQ
LEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ"
regulatory 1839..1845
/regulatory_class="polyA_signal_sequence"
regulatory 1934..1938
/note="possible RNA destabilizing determinant"
/regulatory_class="other"
BASE COUNT 449 a 596 c 625 g 285 t
ORIGIN
1 gaattccggg aacagaaggc gtcggagcgg gcgtcggagc tgcccgctgt gggagagaga
61 ggagacagaa agagcgagcg aggagaggga gcccgaggcg aaaaagtaac tgtcaaatgc
121 gcggctcctt taaccggagc gctcagtccg gctccgagag tcatggcgac cgcagcgtct
181 aaccactaca gcctgctcac ctccagcgcc tccatcgtgc acgccgagcc gcccggcgcg
241 atgcagcagg gcgcgggggg ctaccgcgaa gcgcagagcc tggtgcaggg cgactacggc
301 gctctgcaga gcaacggaca cccgctcagc cacgctcacc agtggatcac cgcgctgtcc
361 cacggcggcg gcggcggggg cggtggcggc ggcggggggg gcgggggcgg cggcgggggc
421 ggcggcgacg gctccccgtg gtccaccagc cccctgggcc agccggacat caagccctcg
481 gtggtggtgc agcagggcgg ccgcggagac gagctgcacg ggccaggcgc cctgcagcag
541 cagcatcagc agcagcaaca gcaacagcag cagcaacagc agcaacagca gcagcagcag
601 cagcaacagc ggccgccgca tctggtgcac cacgccgcta accaccaccc gggacccggg
661 gcatggcgga cggcggcggc tgcagcgcac ctcccaccct ccatgggagc gtccaacggc
721 ggcttgctct actcgcagcc cagcttcacg gtgaacggca tgctgggcgc cggcgggcag
781 ccggccgggc tgcaccacca cggcctgcgg gacgcgcacg acgagccaca ccatgccgac
841 caccacccgc acccgcactc gcacccacac cagcagccgc cgcccccgcc gcccccgcag
901 ggtccgcctg gccacccagg cgcgcaccac gacccgcact cggacgagga cacgccgacc
961 tcggacgacc tggagcagtt cgccaagcag ttcaagcagc ggcggatcaa actgggattt
1021 acccaagcgg acgtggggct ggctctgggc accctgtatg gcaacgtgtt ctcgcagacc
1081 accatctgca ggtttgaggc cctgcagctg agcttcaaga acatgtgcaa gctgaagcct
1141 ttgttgaaca agtggttgga ggaggcggac tcgtcctcgg gcagccccac gagcatagac
1201 aagatcgcag cgcaagggcg caagcggaaa aagcggacct ccatcgaggt gagcgtcaag
1261 ggggctctgg agagccattt cctcaaatgc cccaagccct cggcccagga gatcacctcc
1321 ctcgcggaca gcttacagct ggagaaggag gtggtgagag tttggttttg taacaggaga
1381 cagaaagaga aaaggatgac ccctcccgga gggactctgc cgggcgccga ggatgtgtac
1441 ggggggagta gggacactcc accacaccac ggggtgcaga cgcccgtcca gtgaactcga
1501 gctgggggag gggcagagcg cggggctccc cctccccttc ggtccttggc cctttcccgg
1561 ccctcttgtt ccctctctaa cttctgattg ttcttttatt tttaattatt atttccccgt
1621 cccttaaaaa gacaaaaaaa ataaggcaaa aggaaagcaa ctaagacact ggactatcct
1681 ttaaaggtag caggtgtaat gatgtgtttt gacctttgca ggcgagtaac caggcaatgg
1741 agtggagtgt ctcctggaga gagtgaggag agtgtgtgat agctagaaag agagagagac
1801 agagagatgg caagcactga gataaatacc tggcaaaact aaataaatta ccaaaaagga
1861 aaaaaaatcc accaaaccat gataaacaca aaatgcagct tcctgatgct tagagttggc
1921 acatgctgct gtgtttattt attgtggagg aattc
//