LOCUS       Z11887                  1132 bp    mRNA    linear   HUM 14-NOV-2006
DEFINITION  H.sapiens PUMP-1 gene encoding PUMP.
ACCESSION   Z11887 S41832
VERSION     Z11887.1
KEYWORDS    pump-1 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Marti H.P., McNeil L.B., Thomas G.H., Davies M.S., Lovett D.H.
  TITLE     Molecular characterization of a low molecular mass matrix
            metalloproteinase secreted by glomerular mesangial cells as PUMP-1
  JOURNAL   Biochem. J. 285, 899-905(1992).
   PUBMED   1497627
REFERENCE   2  (bases 1 to 831)
  AUTHORS   Muller D., Quantin B., Gesnel M.-C., Millon-Collard R.,
            Abecassis J., Breathnach R.
  TITLE     The collagenase gene family in humans consists of at least four
            members
  JOURNAL   Biochem. J. 253(1), 187-192(1988).
   PUBMED   2844164
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Lovett D.H.
  JOURNAL   Submitted (02-APR-1992) to the INSDC. Lovett D. H., University of
            California, San Francisco, Medicine/Nephrology, 4150 Clement St.,
            San Francisco, CA, USA, 94121
FEATURES             Location/Qualifiers
     source          1..1132
                     /db_xref="H-InvDB:HIT000326386"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /sex="male"
                     /clone_lib="lambda gt11"
                     /cell_type="mesangial cell"
                     /tissue_type="Kidney"
                     /db_xref="taxon:9606"
     5'UTR           1..27
     CDS             28..831
                     /gene="pump-1"
                     /product="PUMP"
                     /function="matrix metalloproteinase"
                     /db_xref="GOA:P09237"
                     /db_xref="H-InvDB:HIT000326386.15"
                     /db_xref="HGNC:HGNC:7174"
                     /db_xref="InterPro:IPR001818"
                     /db_xref="InterPro:IPR002477"
                     /db_xref="InterPro:IPR006026"
                     /db_xref="InterPro:IPR021158"
                     /db_xref="InterPro:IPR021190"
                     /db_xref="InterPro:IPR024079"
                     /db_xref="InterPro:IPR028707"
                     /db_xref="InterPro:IPR033739"
                     /db_xref="InterPro:IPR036365"
                     /db_xref="PDB:1MMP"
                     /db_xref="PDB:1MMQ"
                     /db_xref="PDB:1MMR"
                     /db_xref="PDB:2DDY"
                     /db_xref="PDB:2MZE"
                     /db_xref="PDB:2MZH"
                     /db_xref="PDB:2MZI"
                     /db_xref="PDB:2Y6C"
                     /db_xref="PDB:2Y6D"
                     /db_xref="PDB:5UE2"
                     /db_xref="PDB:5UE5"
                     /db_xref="UniProtKB/Swiss-Prot:P09237"
                     /citation=[1]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAA77942.1"
                     /translation="MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYL
                     YDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSP
                     KWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFAR
                     GAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGH
                     SLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK"
     polyA_site      1056..1062
     polyA_site      1075..1083
     variation       1078..1132
                     /replace="a"
                     /note="Alternatively spliced 54 nt eighth exon at 3'
                     untranslated region."
                     /citation=[1]
     misc_feature    1087..1091
                     /note="ATTTA-motif"
     misc_feature    1103..1107
                     /note="ATTTA-motif"
BASE COUNT          321 a          241 c          257 g          313 t
ORIGIN      
        1 aagaacaatt gtctctggac ggcagctatg cgactcaccg tgctgtgtgc tgtgtgcctg
       61 ctgcctggca gcctggccct gccgctgcct caggaggcgg gaggcatgag tgagctacag
      121 tgggaacagg ctcaggacta tctcaagaga ttttatctct atgactcaga aacaaaaaat
      181 gccaacagtt tagaagccaa actcaaggag atgcaaaaat tctttggcct acctataact
      241 ggaatgttaa actcccgcgt catagaaata atgcagaagc ccagatgtgg agtgccagat
      301 gttgcagaat actcactatt tccaaatagc ccaaaatgga cttccaaagt ggtcacctac
      361 aggatcgtat catatactcg agacttaccg catattacag tggatcgatt agtgtcaaag
      421 gctttaaaca tgtggggcaa agagatcccc ctgcatttca ggaaagttgt atggggaact
      481 gctgacatca tgattggctt tgcgcgagga gctcatgggg actcctaccc atttgatggg
      541 ccaggaaaca cgctggctca tgcctttgcg cctgggacag gtctcggagg agatgctcac
      601 ttcgatgagg atgaacgctg gacggatggt agcagtctag ggattaactt cctgtatgct
      661 gcaactcatg aacttggcca ttctttgggt atgggacatt cctctgatcc taatgcagtg
      721 atgtatccaa cctatggaaa tggagatccc caaaatttta aactttccca ggatgatatt
      781 aaaggcattc agaaactata tggaaagaga agtaattcaa gaaagaaata gaaacttcag
      841 gcagaacatc cattcattca ttcattggat tgtatatcat tgttgcacaa tcagaattga
      901 taagcactgt tcctccactc catttagcaa ttatgtcacc cttttttatt gcagttggtt
      961 tttgaatgtc tttcactcct tttattggtt aaactccttt atggtgtgac tgtgtcttat
     1021 tccatctatg agctttgtca gtgcgcgtag atgtcaataa atgttacata cacaaataaa
     1081 taaaatattt aggccatggt aaatttaccg aattccgccg atactgacgg gc
//