LOCUS Z00014 2908 bp DNA linear HUM 19-NOV-2003
DEFINITION Homo sapiens germline gene for kappa immunoglobulin (subgroup V
kappa I) leader peptide and variable region.
ACCESSION Z00014 X00901
VERSION Z00014.1
KEYWORDS Ig kappa light chain; Ig light chain; immunoglobulin; signal
peptide; variable region.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2908)
AUTHORS Pech M., Jaenichen H.R., Pohlenz H.D., Neumaier P.S., Klobeck H.G.,
Zachau H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176(2), 189-204(1984).
PUBMED 6086934
REFERENCE 2 (bases 2047 to 2749)
AUTHORS Straubinger B., Pech M., Muehlebach K., Jaenichen H.R., Bauer H.G.,
Zachau H.G.
TITLE Molecular footprints of human immunoglobulin gene evolution: a new
sequence family
JOURNAL Nucleic Acids Res. 12(13), 5265-5275(1984).
PUBMED 6087280
REFERENCE 3
AUTHORS Zachau H.G.
JOURNAL Submitted (01-AUG-1984) to the INSDC. Prof. H.G. Zachau,
Universitaet Muenchen, Goethestrasse 33, 8000 Muenchen 2.
COMMENT The sequence is designated Ve in refs. [1] and [2];
the gaps are not included into the numbering.
FEATURES Location/Qualifiers
source 1..2908
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
misc_feature 843..857
/note="put. regulatory element pd"
misc_feature 875..877
/note="put. regulatory element dc defective (due to a
deletion)"
regulatory 896..903
/note="TATA-box"
/regulatory_class="promoter"
CDS join(957..1005,1131..>1426)
/product="kappa immunoglobulin (subgroup V kappa I)"
/protein_id="CAA77301.1"
/translation="MRVPAQLLGLLLLWLPGARCAIRMTQSPSSFSASTGDRVTITCR
ASQGISSYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISCLQSED
FATYYCQQYYSYP"
intron 1006..1130
/note="first intron"
misc_feature 1429..1435
/note="heptanucleotide box"
misc_feature 2137..2619
/note="L-sequence region"
BASE COUNT 885 a 592 c 638 g 793 t
ORIGIN
1 ggatccagct gatttctcca tgtaagttgg caattgcttg ataagggatt gtctctttcc
61 taaagatgtt aacagggagg atggtgtctg ggtcaggatg atgtccctga taaaacgtaa
121 aagaagaaag tggcattgtt ggtgcatgac agggacatgc tccatgcagt ggtcaccctc
181 aataagagag aagaactttg gaaagtaata ctcaatgaca gaaaagaagg tagacaatga
241 aggtgcccaa aacaagaata aggtgaagtg aatttagtct ctgggtatta aagagacctg
301 tagctcttga taatggtgga tgtgtgagtg ctgcatgcat tgaggaaact cggtatcatc
361 tctctgtatc tgtagtaaat tgcttggtct tatagtggta agaacaatgg cataacacca
421 ttacctaata cttacaaata tgtatagcat catgtcaata aattttattt ttaatatttt
481 tagaaaggaa cagtgttaaa actcacagaa atgttgaagt ataggacaaa gtacctcctt
541 ccctaacccg aatcatatga gagtcttttg aagtcctgag aatcatactg tttaacattt
601 tactatgtat ttcctacaaa caagatattc caaataatcc ccatgtgcca atgaaataca
661 ttactccgtc gactcctgag gaatatttca aattttcaaa aaaatacata aaaaatgttt
721 ctcataacaa actactctcc agtagaaaca cattcaccac agacaaattt gtgctaccct
781 ggtctttcct gggacacctg gggatactga gctggtgctg agttactgag atgagccagc
841 cctgcagctg tgcccagtca gccccatccc ctgctcaacc tcctgccctg aagacttatt
901 aataggctgg acacacttca tgcaggagtc agaccctgtc aggacacagc atagacatga
961 gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtaag gaaggagaac
1021 actaggaatt tactcagccc agtgtgcttg gtacagcctg gcccttcagg gaagttctct
1081 tacaacatga ttaattgtat ggacatttgt ttttatgttt ccaatctcag gtgccagatg
1141 tgccatccgg atgacccagt ctccatcctc attctctgca tctacaggag acagagtcac
1201 catcacttgt cgggcgagtc agggtattag cagttattta gcctggtatc agcaaaaacc
1261 agggaaagcc cctaagctcc tgatctatgc tgcatccact ttgcaaagtg gggtcccatc
1321 aaggttcagc ggcagtggat ctgggacaga tttcactctc accatcagct gcctgcagtc
1381 tgaagatttt gcaacttatt actgtcaaca gtattatagt taccctccca cagtgttaca
1441 cacccaaaca aaaaccccca gggaagcaaa tgtgtgaggc tgggctgccc cagctgctcc
1501 tcctgatgcc tccatcgcct gagagtgttc ctcagatgca accacactct gatggtgttg
1561 gtagaggggg acctgaaatc acctctgcaa cccaattcct ttttctttgt aagccccagc
1621 tgcacagaca taacaatgcc tctcctgatt taataaaggc agagatcttg acacctaagg
1681 agtctagttt agggctttgg ttggaattca aataacagag aagaaaccac tatagatatt
1741 ctaagcagga aatgtcttaa tacagaaaat tagagtctaa actactgaag tctaaataaa
1801 atgtagagcg gaatctctaa atttcatgtt ttatttgcaa agaaatgttt gccaaattgg
1861 acacacagga aaactcagtg gtcttcaata tattggaagt acgaagagaa ggttagtgtt
1921 ttatgaaaaa gggaaaatat taccttttgc attttcagaa agttcactgg cactagtaag
1981 ggttgggagc tggcaagctc agactggtaa gcagtggtgg acaaagtgaa ttaggattca
2041 ctaattatat caattatatc aagttgtctc agaagttgca gttaaatgtg aattcaggtt
2101 acaagaagcc aaagcagtga aggttgcaga gaattttctt actaaaatgc caaggattca
2161 ttgtacaccc tgctgctcac cacgcagaaa gccaatctct aaaacaagta ttgccaagaa
2221 acaggcttta atcaggtact gcagccgagg agatgggaca ccatttgcga atgtatctcc
2281 ctgaccaact aaaattaaga ctttatataa cagggacaaa atgtgggaaa acaggaattt
2341 gggaggggta aggaagataa tttggtcaac aggaagcaag aggtcagtta tgcaatcata
2401 atgggtgaag gttctgatgt ctcagtgtcc ggattcagtg atatgtatgt ttcagctcct
2461 tgatagtatc tacgaggcct gatggttggt ttactgaaaa aagaactcag ataagacaaa
2521 tgtaactatc ttgagtttta agactggggg agtcaatttc tgtttattca aaaaaccata
2581 aaccttagtt ccatgggata acagggccta tttcaattgc attctagaaa caatatttta
2641 caccctgagt gcctttcccc actgggtgtc ttggctcttt tgggtataac aagaatgaac
2701 cgatgcctat gattaacgtt cagactacaa cctttcaaag ccaaggatat agtagtcagg
2761 aaagttgata ttagaagcag gattgaatgg cgctcactca gaaaacagaa tgcatctgcc
2821 cttgaagtat gggctatcta accatgtggt cctcagtcct gtctggaagc ttaggggtgg
2881 gagtgttgat gttctcagct tcctgcag
//